PubRank

Douglas C Wallace

Author PubWeight™ 147.16‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005 10.11
2 Natural selection shaped regional mtDNA variation in humans. Proc Natl Acad Sci U S A 2002 6.95
3 Effects of purifying and adaptive selection on regional variation in human mtDNA. Science 2004 5.87
4 The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature 2004 5.85
5 mtDNA mutations increase tumorigenicity in prostate cancer. Proc Natl Acad Sci U S A 2005 4.66
6 An enhanced MITOMAP with a global mtDNA mutational phylogeny. Nucleic Acids Res 2006 4.51
7 A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations. Science 2008 3.95
8 A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes. Am J Hum Genet 2002 3.71
9 MITOMAP: a human mitochondrial genome database--2004 update. Nucleic Acids Res 2005 3.35
10 Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat Genet 2011 3.16
11 Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. Proc Natl Acad Sci U S A 2004 2.77
12 The basal proton conductance of mitochondria depends on adenine nucleotide translocase content. Biochem J 2005 2.05
13 Evidence for adaptive selection acting on the tRNA and rRNA genes of human mitochondrial DNA. Hum Mutat 2006 1.98
14 Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nat Genet 2007 1.98
15 Elevated male European and female African contributions to the genomes of African American individuals. Hum Genet 2006 1.97
16 Data structures and compression algorithms for genomic sequence data. Bioinformatics 2009 1.96
17 The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations. Proc Natl Acad Sci U S A 2005 1.88
18 Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PLoS One 2011 1.73
19 Functional estrogen receptors in the mitochondria of breast cancer cells. Mol Biol Cell 2006 1.72
20 The role of mtDNA background in disease expression: a new primary LHON mutation associated with Western Eurasian haplogroup J. Hum Genet 2002 1.65
21 The dual origin and Siberian affinities of Native American Y chromosomes. Am J Hum Genet 2001 1.65
22 Adenine nucleotide translocase 1 deficiency results in dilated cardiomyopathy with defects in myocardial mechanics, histopathological alterations, and activation of apoptosis. JACC Cardiovasc Imaging 2011 1.60
23 Ancient mtDNA genetic variants modulate mtDNA transcription and replication. PLoS Genet 2009 1.58
24 Control region mtDNA variants: longevity, climatic adaptation, and a forensic conundrum. Proc Natl Acad Sci U S A 2003 1.57
25 Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origins of Native American haplogroups. Ann Hum Genet 2005 1.54
26 A mitochondrial etiology of Alzheimer and Parkinson disease. Biochim Biophys Acta 2011 1.52
27 A novel NDUFA1 mutation leads to a progressive mitochondrial complex I-specific neurodegenerative disease. Mol Genet Metab 2009 1.47
28 Mitochondrial DNA-like sequences in the nucleus (NUMTs): insights into our African origins and the mechanism of foreign DNA integration. Hum Mutat 2004 1.39
29 Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder. PLoS One 2009 1.36
30 Mouse mtDNA mutant model of Leber hereditary optic neuropathy. Proc Natl Acad Sci U S A 2012 1.35
31 VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. PLoS One 2010 1.34
32 Adaptive selection of mitochondrial complex I subunits during primate radiation. Gene 2006 1.31
33 Landscape of the mitochondrial Hsp90 metabolome in tumours. Nat Commun 2013 1.29
34 Mitochondrial DNA haplogroups influence AIDS progression. AIDS 2008 1.29
35 Analysis of mitochondrial DNA diversity in the aleuts of the commander islands and its implications for the genetic history of beringia. Am J Hum Genet 2002 1.29
36 Traces of early Eurasians in the Mansi of northwest Siberia revealed by mitochondrial DNA analysis. Am J Hum Genet 2002 1.27
37 Mitochondrial DNA haplogroups associated with age-related macular degeneration. Invest Ophthalmol Vis Sci 2009 1.26
38 The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment. PLoS Genet 2008 1.24
39 Mitochondrial DNA haplogroups influence lipoatrophy after highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2009 1.24
40 Valosin containing protein associated inclusion body myopathy: abnormal vacuolization, autophagy and cell fusion in myoblasts. Neuromuscul Disord 2009 1.23
41 A mitochondrial etiology of neurodegenerative diseases: evidence from Parkinson's disease. Ann N Y Acad Sci 2008 1.22
42 Differences of sperm motility in mitochondrial DNA haplogroup U sublineages. Gene 2005 1.21
43 Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans. Proc Natl Acad Sci U S A 2012 1.21
44 Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis 2010 1.19
45 Mitochondrial cardiomyopathies: how to identify candidate pathogenic mutations by mitochondrial DNA sequencing, MITOMASTER and phylogeny. Eur J Hum Genet 2010 1.15
46 Association of mitochondrial SOD deficiency with salt-sensitive hypertension and accelerated renal senescence. J Appl Physiol (1985) 2006 1.15
47 ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter. Mol Biol Cell 2002 1.11
48 MITOMASTER: a bioinformatics tool for the analysis of mitochondrial DNA sequences. Hum Mutat 2009 1.10
49 Mitochondrial genome diversity in arctic Siberians, with particular reference to the evolutionary history of Beringia and Pleistocenic peopling of the Americas. Am J Hum Genet 2008 1.10
50 Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle. J Appl Physiol (1985) 2013 1.10
51 Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production. PLoS One 2009 1.07
52 Mitochondrial disease genetic diagnostics: optimized whole-exome analysis for all MitoCarta nuclear genes and the mitochondrial genome. Discov Med 2012 1.06
53 Accumulation of mitochondrial DNA damage in keratoconus corneas. Invest Ophthalmol Vis Sci 2005 1.06
54 Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort. Neurobiol Aging 2010 1.05
55 Late-onset Leigh syndrome in a patient with mitochondrial complex I NDUFS8 mutations. Neurology 2004 0.99
56 Mitochondrial mutations and polymorphisms in psychiatric disorders. Front Genet 2012 0.98
57 Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup. Proc Natl Acad Sci U S A 2013 0.97
58 Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration. PLoS One 2013 0.96
59 Mitochondrial DNA diversity in Southeast Asian populations. Hum Biol 2002 0.94
60 Adenine nucleotide translocator 1 deficiency increases resistance of mouse brain and neurons to excitotoxic insults. Biochim Biophys Acta 2009 0.93
61 MITOCHIP assessment of differential gene expression in the skeletal muscle of Ant1 knockout mice: coordinate regulation of OXPHOS, antioxidant, and apoptotic genes. Biochim Biophys Acta 2008 0.93
62 Reversible optic neuropathy with OPA1 exon 5b mutation. Ann Neurol 2008 0.93
63 mtDNA lineage analysis of mouse L-cell lines reveals the accumulation of multiple mtDNA mutants and intermolecular recombination. Genes Dev 2012 0.92
64 Mitochondrial dysfunction in CA1 hippocampal neurons of the UBE3A deficient mouse model for Angelman syndrome. Neurosci Lett 2009 0.91
65 Aggregation of actin and cofilin in identical twins with juvenile-onset dystonia. Ann Neurol 2002 0.89
66 Molecular research technologies in mitochondrial diseases: the microarray approach. IUBMB Life 2005 0.89
67 Assessment of mitochondrial membrane potential using an on-chip microelectrode in a microfluidic device. Lab Chip 2010 0.89
68 Metabolically induced heteroplasmy shifting and l-arginine treatment reduce the energetic defect in a neuronal-like model of MELAS. Biochim Biophys Acta 2012 0.89
69 Eliminating the Ant1 isoform produces a mouse with CPEO pathology but normal ocular motility. Invest Ophthalmol Vis Sci 2005 0.87
70 Increased adenine nucleotide translocator 1 in reactive astrocytes facilitates glutamate transport. Exp Neurol 2003 0.87
71 Characterization of retinal and blood mitochondrial DNA from age-related macular degeneration patients. Invest Ophthalmol Vis Sci 2010 0.86
72 Multiplex analysis of mitochondrial DNA pathogenic and polymorphic sequence variants. Biol Chem 2010 0.86
73 TGF-beta1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factors. BMC Neurosci 2004 0.84
74 Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium. J Mol Cell Cardiol 2013 0.84
75 Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Ab42-induced neurodegeneration. Aging Cell 2014 0.84
76 Hydrogen peroxide causes mitochondrial DNA damage in corneal epithelial cells. Cornea 2009 0.83
77 Mitochondrial haplogroups are associated with risk of neuroretinal disorder in HIV-positive patients. J Acquir Immune Defic Syndr 2010 0.83
78 Mitochondrial and ion channel gene alterations in autism. Biochim Biophys Acta 2012 0.83
79 PNA-mediated PCR clamping. Applications and methods. Methods Mol Biol 2002 0.82
80 An inherited heteroplasmic mutation in mitochondrial gene COI in a patient with prostate cancer alters reactive oxygen, reactive nitrogen and proliferation. Biomed Res Int 2012 0.82
81 Differential gene expression reveals mitochondrial dysfunction in an imprinting center deletion mouse model of Prader-Willi syndrome. Clin Transl Sci 2013 0.81
82 Heteroplasmic mutations of the mitochondrial genome cause paradoxical effects on mitochondrial functions. FASEB J 2012 0.80
83 Toward a mtDNA locus-specific mutation database using the LOVD platform. Hum Mutat 2012 0.80
84 Wafer-scale mitochondrial membrane potential assays. Lab Chip 2012 0.80
85 Comparison of male chimeric mice generated from microinjection of JM8.N4 embryonic stem cells into C57BL/6J and C57BL/6NTac blastocysts. Transgenic Res 2012 0.79
86 Nanofluidic platform for single mitochondria analysis using fluorescence microscopy. Anal Chem 2013 0.79
87 Assessing bioenergetic compromise in autism spectrum disorder with 31P magnetic resonance spectroscopy: preliminary report. J Child Neurol 2013 0.79
88 Genetics: Mitochondrial DNA in evolution and disease. Nature 2016 0.79
89 Detection of low levels of the mitochondrial tRNALeu(UUR) 3243A>G mutation in blood derived from patients with diabetes. Mol Diagn Ther 2006 0.79
90 Retinal function and structure in Ant1-deficient mice. Invest Ophthalmol Vis Sci 2010 0.78
91 Profiling genes related to mitochondrial function in mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Biochem Biophys Res Commun 2003 0.77
92 Complete mitochondrial DNA sequence analysis in a family with early-onset dystonia and optic atrophy. Mov Disord 2004 0.75
93 American Indian prehistory as written in the mitochondrial DNA: a review. 1992. Hum Biol 2009 0.75
94 The eyes of mito-mouse: mouse models of mitochondrial disease. J Neuroophthalmol 2002 0.75
95 Corrigendum: Landscape of the mitochondrial Hsp90 metabolome in tumours. Nat Commun 2015 0.75