Published in J Nat Prod on June 25, 2010
Anti-cancer natural products isolated from chinese medicinal herbs. Chin Med (2011) 1.39
Oridonin inhibits tumor growth and metastasis through anti-angiogenesis by blocking the Notch signaling. PLoS One (2014) 0.93
Molecular Insight in the Multifunctional Effects of Oridonin. Drugs R D (2015) 0.84
Anti-tumour activity of longikaurin A (LK-A), a novel natural diterpenoid, in nasopharyngeal carcinoma. J Transl Med (2013) 0.78
Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway. Oncotarget (2016) 0.78
Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species. Oncotarget (2016) 0.77
Inhibition of caspase-9 by oridonin, a diterpenoid isolated from Rabdosia rubescens, augments apoptosis in human laryngeal cancer cells. Int J Oncol (2015) 0.76
Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach. PLoS One (2012) 0.76
Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound. Int J Mol Sci (2016) 0.75
Antiangiogenic effects of oridonin. BMC Complement Altern Med (2017) 0.75
Synergistic suppression of t(8;21)-positive leukemia cell growth by combining oridonin and MAPK1/ERK2 inhibitors. Oncotarget (2017) 0.75
Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett (2007) 3.19
The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem (2009) 2.90
Early effects of salinity on water transport in Arabidopsis roots. Molecular and cellular features of aquaporin expression. Plant Physiol (2005) 2.60
Pannexin 1: the molecular substrate of astrocyte "hemichannels". J Neurosci (2009) 2.48
Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Autophagy (2011) 2.47
Sebaceous carcinoma in situ. Am J Dermatopathol (2010) 2.27
Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development (2006) 2.09
Pannexin1 channels contain a glycosylation site that targets the hexamer to the plasma membrane. J Biol Chem (2007) 2.05
Injury in First Nations communities in Ontario. Can J Public Health (2009) 2.00
Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition. Mol Biosyst (2012) 2.00
Prognostic value of metabolic tumor burden on 18F-FDG PET in nonsurgical patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging (2011) 1.99
NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage. Ann Neurol (2014) 1.95
Life expectancy after an index hospitalization for patients with heart failure: a population-based study. Am Heart J (2008) 1.92
So called 'de novo intraepidermal epithelioid melanocytic dysplasia' is melanoma in situ. J Cutan Pathol (2007) 1.92
Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol (2009) 1.89
When is a pathology review indicated in endometrial cancer? Obstet Gynecol (2007) 1.81
Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Electrophoresis (2011) 1.75
The genome of the leaf-cutting ant Acromyrmex echinatior suggests key adaptations to advanced social life and fungus farming. Genome Res (2011) 1.70
A meta-analysis of endoscopic submucosal dissection and EMR for early gastric cancer. Gastrointest Endosc (2012) 1.69
Improving cardiopulmonary resuscitation in the emergency department by real-time video recording and regular feedback learning. Resuscitation (2010) 1.66
Natural withanolides: an overview. Nat Prod Rep (2011) 1.64
Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. Antimicrob Agents Chemother (2010) 1.60
Characterization of multiple-antimicrobial-resistant Escherichia coli isolates from diseased chickens and swine in China. J Clin Microbiol (2004) 1.46
The structure of Lethocerus troponin C: insights into the mechanism of stretch activation in muscles. Structure (2007) 1.45
A troponin switch that regulates muscle contraction by stretch instead of calcium. EMBO J (2004) 1.45
Prevalence and characterisation of CTX-M β-lactamases amongst Escherichia coli isolates from healthy food animals in China. Int J Antimicrob Agents (2012) 1.45
Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation. J Pharmacol Sci (2007) 1.43
Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer. Mol Biosyst (2013) 1.37
End-of-life care in lung cancer patients in Ontario: aggressiveness of care in the population and a description of hospital admissions. J Pain Symptom Manage (2008) 1.33
Structure of a hydroxyproline (Hyp)-arabinogalactan polysaccharide from repetitive Ala-Hyp expressed in transgenic Nicotiana tabacum. J Biol Chem (2004) 1.32
p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells. J Pharmacol Sci (2004) 1.31
Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. J Pharmacol Sci (2008) 1.30
Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. Biol Pharm Bull (2007) 1.30
A kernel-based two-class classifier for imbalanced data sets. IEEE Trans Neural Netw (2007) 1.27
Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. Cancer Lett (2010) 1.25
Boron-doped carbon nanotubes as metal-free electrocatalysts for the oxygen reduction reaction. Angew Chem Int Ed Engl (2011) 1.24
miR-144 downregulation increases bladder cancer cell proliferation by targeting EZH2 and regulating Wnt signaling. FEBS J (2013) 1.22
Modular proteins from the Drosophila sallimus (sls) gene and their expression in muscles with different extensibility. J Mol Biol (2007) 1.21
Barhl1 regulates migration and survival of cerebellar granule cells by controlling expression of the neurotrophin-3 gene. J Neurosci (2004) 1.20
First detection of oqxAB in Salmonella spp. isolated from food. Antimicrob Agents Chemother (2012) 1.20
Trafficking dynamics of glycosylated pannexin 1 proteins. Cell Commun Adhes (2008) 1.20
Functional markers developed from multiple loci in GS3 for fine marker-assisted selection of grain length in rice. Theor Appl Genet (2010) 1.17
Why should autophagic flux be assessed? Acta Pharmacol Sin (2013) 1.16
ERK and JNK mediate TNFalpha-induced p53 activation in apoptotic and autophagic L929 cell death. Biochem Biophys Res Commun (2008) 1.16
Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells. Free Radic Res (2008) 1.16
Discovering ordered phases of block copolymers: new results from a generic Fourier-space approach. Phys Rev Lett (2008) 1.15
Glucocorticoid regulates interleukin-37 in systemic lupus erythematosus. J Clin Immunol (2012) 1.13
Infundibular squamous cell carcinoma: a new entity? Am J Dermatopathol (2012) 1.12
Serum and lymphocyte levels of heat shock protein 70 in aging: a study in the normal Chinese population. Cell Stress Chaperones (2004) 1.12
Association of HSP70 and genotoxic damage in lymphocytes of workers exposed to coke-oven emission. Cell Stress Chaperones (2002) 1.09
Genome sequences of wild and domestic bactrian camels. Nat Commun (2012) 1.07
The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials. FEBS J (2009) 1.07
Critical roles of reactive oxygen species in mitochondrial permeability transition in mediating evodiamine-induced human melanoma A375-S2 cell apoptosis. Free Radic Res (2007) 1.04
Plant O-hydroxyproline arabinogalactans are composed of repeating trigalactosyl subunits with short bifurcated side chains. J Biol Chem (2010) 1.04
Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate. Biochemistry (2006) 1.04
Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells. Arch Biochem Biophys (2009) 1.03
Fas-mediated autophagy requires JNK activation in HeLa cells. Biochem Biophys Res Commun (2008) 1.03
The relationship between 1-deoxynojirimycin content and alpha-glucosidase inhibitory activity in leaves of 276 mulberry cultivars (Morus spp.) in Kyoto, Japan. J Nat Med (2007) 1.03
P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells. Acta Pharmacol Sin (2007) 1.03
Removal of methylene blue from aqueous solution by graphene oxide. J Colloid Interface Sci (2011) 1.03
Pharmacodynamic comparison of pantoprazole enantiomers: inhibition of acid-related lesions and acid secretion in rats and guinea-pigs. J Pharm Pharmacol (2005) 1.03
A phase II study of modified FOLFOX as first-line chemotherapy in advanced small bowel adenocarcinoma. Anticancer Drugs (2012) 1.03
Association mapping of seed oil content in Brassica napus and comparison with quantitative trait loci identified from linkage mapping. Genome (2010) 1.02
Norcantharidin induces human melanoma A375-S2 cell apoptosis through mitochondrial and caspase pathways. J Korean Med Sci (2004) 1.02
Folding/aggregation of graphene oxide and its application in Cu2+ removal. J Colloid Interface Sci (2010) 1.01
Hydrophobic plug functions as a gate in voltage-gated proton channels. Proc Natl Acad Sci U S A (2013) 1.01
Basal and inducible levels of Hsp70 in patients with acute heat illness induced during training. Cell Stress Chaperones (2003) 1.01
MicroRNA-27a promotes proliferation and suppresses apoptosis by targeting PLK2 in laryngeal carcinoma. BMC Cancer (2014) 1.01
Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells. Acta Pharmacol Sin (2011) 1.01
Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway. J Pharmacol Sci (2010) 1.00
Expression and localization of FRMD7 in human fetal brain, and a role for F-actin. Mol Vis (2011) 1.00
F33:A-:B- and F2:A-:B- plasmids mediate dissemination of rmtB-blaCTX-M-9 group genes and rmtB-qepA in Enterobacteriaceae isolates from pets in China. Antimicrob Agents Chemother (2011) 1.00
Pseudolaric acid B induces apoptosis, senescence, and mitotic arrest in human breast cancer MCF-7. Acta Pharmacol Sin (2007) 0.99
Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells. J Pharmacol Sci (2012) 0.99