Published in Carcinogenesis on May 26, 2010
Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis. Genes Cancer (2011) 2.18
The landscape of viral expression and host gene fusion and adaptation in human cancer. Nat Commun (2013) 2.17
A cancer theory kerfuffle can lead to new lines of research. J Natl Cancer Inst (2014) 1.91
p53, Stem Cells, and Reprogramming: Tumor Suppression beyond Guarding the Genome. Genes Cancer (2011) 1.54
Antagonistic regulation of apoptosis and differentiation by the Cut transcription factor represents a tumor-suppressing mechanism in Drosophila. PLoS Genet (2012) 1.49
New plays in the p53 theater. Curr Opin Genet Dev (2010) 1.19
VEGF is essential for the growth and migration of human hepatocellular carcinoma cells. Mol Biol Rep (2011) 1.05
Modeling familial cancer with induced pluripotent stem cells. Cell (2015) 1.02
p53 counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition. Cell Death Differ (2012) 0.99
Regulation of p53 is critical for vertebrate limb regeneration. Proc Natl Acad Sci U S A (2013) 0.98
Wild-type tumor repressor protein 53 (Trp53) promotes ovarian cancer cell survival. Endocrinology (2012) 0.95
Caught in the cross fire: p53 in inflammation. Carcinogenesis (2014) 0.95
p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity. Cell Death Differ (2013) 0.93
p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress. Cell Death Differ (2014) 0.89
Induction of p53, p21 and apoptosis by silencing the NF90/NF45 complex in human papilloma virus-transformed cervical carcinoma cells. Oncogene (2012) 0.89
SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63. Mol Cell Biol (2011) 0.88
Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors. J Oncol (2010) 0.86
Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells. Cell Death Differ (2017) 0.85
Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy. Oxid Med Cell Longev (2016) 0.85
p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1. Stem Cells Dev (2013) 0.84
ATM/CHK/p53 Pathway Dependent Chemopreventive and Therapeutic Activity on Lung Cancer by Pterostilbene. PLoS One (2016) 0.83
Genome-wide analysis of the p53 gene regulatory network in the developing mouse kidney. Physiol Genomics (2013) 0.83
Alternative splicing targeting the hTAF4-TAFH domain of TAF4 represses proliferation and accelerates chondrogenic differentiation of human mesenchymal stem cells. PLoS One (2013) 0.83
Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing. Oncotarget (2015) 0.83
P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development. Cell Death Dis (2016) 0.82
p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity. Genes Dev (2017) 0.81
Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs. Toxicology (2011) 0.80
Integrins and p53 pathways in glioblastoma resistance to temozolomide. Front Oncol (2012) 0.80
Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells. Korean J Physiol Pharmacol (2013) 0.79
GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. PLoS One (2012) 0.78
Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells. Stem Cell Res Ther (2014) 0.78
Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans. Mol Cancer Res (2014) 0.78
Characterization of the altered gene expression profile in early porcine embryos generated from parthenogenesis and somatic cell chromatin transfer. PLoS One (2014) 0.76
Gene expression profiles resulting from stable loss of p53 mirrors its role in tissue differentiation. PLoS One (2013) 0.76
Measuring cell cycle progression kinetics with metabolic labeling and flow cytometry. J Vis Exp (2012) 0.76
Altered S-nitrosylation of p53 is responsible for impaired antioxidant response in skeletal muscle during aging. Aging (Albany NY) (2016) 0.75
The Epigenetic Regulator HDAC1 Modulates Transcription of a Core Cardiogenic Program in Human Cardiac Mesenchymal Stromal Cells Through a p53-Dependent Mechanism. Stem Cells (2016) 0.75
Indispensable role of Mdm2/p53 interaction during the embryonic and postnatal inner ear development. Sci Rep (2017) 0.75
Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens. Sci Rep (2016) 0.75
Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation. Cell Death Differ (2015) 0.75
Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(-/-) Hematopoietic Stem and Progenitor Cells. Stem Cell Reports (2016) 0.75
p53 Mediates Failure of Human Definitive Hematopoiesis in Dyskeratosis Congenita. Stem Cell Reports (2017) 0.75
Osteosarcoma: Molecular Pathogenesis and iPSC Modeling. Trends Mol Med (2017) 0.75
When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer (2009) 5.86
Mutant p53 gain-of-function in cancer. Cold Spring Harb Perspect Biol (2010) 3.65
Proapoptotic BID is an ATM effector in the DNA-damage response. Cell (2005) 2.21
Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues. Nat Genet (2012) 2.20
Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis. Genes Cancer (2011) 2.18
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. Mol Syst Biol (2008) 2.04
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc Natl Acad Sci U S A (2002) 2.04
Efficacy of three hygienic protocols in reducing biofilm adherence to removable thermoplastic appliance. Angle Orthod (2013) 2.03
Modulation of the vitamin D3 response by cancer-associated mutant p53. Cancer Cell (2010) 1.95
Activated p53 suppresses the histone methyltransferase EZH2 gene. Oncogene (2004) 1.94
Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell (2013) 1.86
Transcriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformation. Cancer Res (2005) 1.86
The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. J Clin Invest (2003) 1.82
Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells. Cancer Res (2007) 1.64
Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype. Cancer Res (2003) 1.64
The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation. Mol Syst Biol (2005) 1.60
Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells. J Exp Med (2010) 1.60
Transactivation of the EGR1 gene contributes to mutant p53 gain of function. Cancer Res (2004) 1.59
p53, a novel regulator of lipid metabolism pathways. J Hepatol (2011) 1.58
p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner. PLoS One (2008) 1.55
Genome-wide profiling of histone h3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis. PLoS One (2009) 1.54
'Cancer associated fibroblasts'--more than meets the eye. Trends Mol Med (2013) 1.52
Wide-scale analysis of human functional transcription factor binding reveals a strong bias towards the transcription start site. PLoS One (2007) 1.40
p53-dependent down-regulation of telomerase is mediated by p21waf1. J Biol Chem (2004) 1.39
Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy. Cell Cycle (2008) 1.36
hTERT-immortalized prostate epithelial and stromal-derived cells: an authentic in vitro model for differentiation and carcinogenesis. Cancer Res (2006) 1.33
TP53 in hematological cancer: low incidence of mutations with significant clinical relevance. Hum Mutat (2003) 1.30
Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect. Cancer Cell (2007) 1.29
Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants. Oncogene (2003) 1.28
Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation. PLoS One (2008) 1.27
Targeted inactivation of dystrophin gene product Dp71: phenotypic impact in mouse retina. Hum Mol Genet (2003) 1.27
Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II. Mol Cell Biol (2007) 1.22
tBID Homooligomerizes in the mitochondrial membrane to induce apoptosis. J Biol Chem (2002) 1.22
On a fundamental structure of gene networks in living cells. Proc Natl Acad Sci U S A (2012) 1.21
TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model. PLoS One (2011) 1.15
Regulation of lipid metabolism by p53 - fighting two villains with one sword. Trends Endocrinol Metab (2012) 1.15
Modulated expression of WFDC1 during carcinogenesis and cellular senescence. Carcinogenesis (2008) 1.13
The role of p53 in base excision repair following genotoxic stress. Carcinogenesis (2003) 1.13
Convergence of logic of cellular regulation in different premalignant cells by an information theoretic approach. BMC Syst Biol (2011) 1.13
Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells. BMC Genomics (2010) 1.10
p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways. Cancer Res (2010) 1.08
Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate. Aging (Albany NY) (2009) 1.07
Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer. PLoS One (2011) 1.03
Prostate stromal cells produce CXCL-1, CXCL-2, CXCL-3 and IL-8 in response to epithelia-secreted IL-1. Carcinogenesis (2009) 1.03
Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations. J Mol Biol (2008) 1.03
The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA. Carcinogenesis (2002) 1.02
A novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype. PLoS One (2010) 1.00
Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature. J Cell Sci (2012) 1.00
Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species. J Cell Sci (2012) 0.99
ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters. OMICS (2011) 0.99
Middle Pleistocene dental remains from Qesem Cave (Israel). Am J Phys Anthropol (2010) 0.98
Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth. Cancer Res (2003) 0.98
p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production. Cancer Metab (2013) 0.98
Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate-induced death by attenuating activating transcription factor 3 induction. Cancer Res (2006) 0.98
Differential influence of normal and cancer-associated fibroblasts on the growth of human epithelial cells in an in vitro cocultivation model of prostate cancer. Mol Cancer Res (2009) 0.97
p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes. Development (2011) 0.95
p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One (2013) 0.94
Mutant p53 gain of function is interwoven into the hallmarks of cancer. J Pathol (2011) 0.94
Deconstruction of p53 functions and regulation. Oncogene (2002) 0.94
Diverse functions of IGF/insulin signaling in malignant and noncancerous prostate cells: proliferation in cancer cells and differentiation in noncancerous cells. Endocrinology (2012) 0.94
Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53. Carcinogenesis (2012) 0.93
The paradigm of mutant p53-expressing cancer stem cells and drug resistance. Carcinogenesis (2014) 0.92
The onset of p53-dependent apoptosis plays a role in terminal differentiation of human normoblasts. Oncogene (2003) 0.92
Transcriptional control of the proliferation cluster by the tumor suppressor p53. Mol Biosyst (2009) 0.91
Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model. Exp Cell Res (2010) 0.90
Nanog inhibits the switch of myogenic cells towards the osteogenic lineage. Biochem Biophys Res Commun (2007) 0.89
SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63. Mol Cell Biol (2011) 0.88
Hypoxia-dependent regulation of PHD1: cloning and characterization of the human PHD1/EGLN2 gene promoter. FEBS Lett (2004) 0.88
Myocardin in tumor suppression and myofibroblast differentiation. Cell Cycle (2007) 0.87
The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene. Int J Cancer (2009) 0.87
p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss. FEBS Lett (2010) 0.86
DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response. J Clin Invest (2004) 0.85
Identification of gene networks associated with erythroid differentiation. Blood Cells Mol Dis (2009) 0.84
Inactivation of the p53 tumor suppressor gene and activation of the Ras oncogene: cooperative events in tumorigenesis. Discov Med (2010) 0.84