Published in Nat Methods on May 30, 2010
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Cellular prion protein (PrPC) of the neuron cell transformed to a PK-resistant protein under oxidative stress, comprising main mitochondrial damage in prion diseases. J Mol Neurosci (2013) 0.77
Grass plants bind, retain, uptake, and transport infectious prions. Cell Rep (2015) 0.77
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Red-backed vole brain promotes highly efficient in vitro amplification of abnormal prion protein from macaque and human brains infected with variant Creutzfeldt-Jakob disease agent. PLoS One (2013) 0.77
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Protein misfolding cyclic amplification for diagnosis and prion propagation studies. Methods Enzymol (2006) 2.04
In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapie. J Gen Virol (2008) 1.86
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Reduction of prion infectivity in packed red blood cells. Biochem Biophys Res Commun (2008) 0.97
In vitro generation of infectious scrapie prions. Cell (2005) 6.86
Ultra-efficient replication of infectious prions by automated protein misfolding cyclic amplification. J Biol Chem (2006) 2.98
A novel human disease with abnormal prion protein sensitive to protease. Ann Neurol (2008) 2.95
Prion strain mutation determined by prion protein conformational compatibility and primary structure. Science (2010) 2.71
Detection of prions in blood. Nat Med (2005) 2.66
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J (2003) 2.34
Cell-free propagation of prion strains. EMBO J (2008) 2.20
Presymptomatic detection of prions in blood. Science (2006) 2.14
Crossing the species barrier by PrP(Sc) replication in vitro generates unique infectious prions. Cell (2008) 2.09
Protein misfolding cyclic amplification for diagnosis and prion propagation studies. Methods Enzymol (2006) 2.04
Converting a peptide into a drug: strategies to improve stability and bioavailability. Curr Med Chem (2002) 2.02
Accelerated high fidelity prion amplification within and across prion species barriers. PLoS Pathog (2008) 1.89
Isolation and characterization of a proteinase K-sensitive PrPSc fraction. Biochemistry (2006) 1.86
Detection of infectious prions in urine. FEBS Lett (2008) 1.85
De novo generation of infectious prions in vitro produces a new disease phenotype. PLoS Pathog (2009) 1.83
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The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity. J Neurosci (2005) 1.74
Production of cattle lacking prion protein. Nat Biotechnol (2006) 1.63
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. Proc Natl Acad Sci U S A (2008) 1.60
Stressing out the ER: a role of the unfolded protein response in prion-related disorders. Curr Mol Med (2006) 1.49
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The prion strain phenomenon: molecular basis and unprecedented features. Biochim Biophys Acta (2006) 1.39
Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease. J Biol Chem (2003) 1.34
Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases. J Neurosci (2010) 1.33
Prion protein glycosylation is not required for strain-specific neurotropism. J Virol (2009) 1.31
In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms. PLoS Genet (2009) 1.29
Amyloid formation modulates the biological activity of a bacterial protein. J Biol Chem (2005) 1.27
Misfolded protein aggregates: mechanisms, structures and potential for disease transmission. Semin Cell Dev Biol (2011) 1.25
Perturbation of endoplasmic reticulum homeostasis facilitates prion replication. J Biol Chem (2007) 1.13
Generation of a new form of human PrP(Sc) in vitro by interspecies transmission from cervid prions. J Biol Chem (2011) 1.12
Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress. PLoS One (2010) 1.11
Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide. FASEB J (2002) 1.11
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Protein misfolding cyclic amplification of infectious prions. Nat Protoc (2012) 1.10
Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases. PLoS Pathog (2013) 1.10
High-resolution structure of infectious prion protein: the final frontier. Nat Struct Mol Biol (2012) 1.09
Cellular factors implicated in prion replication. FEBS Lett (2010) 1.07
Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts. Am J Pathol (2004) 1.04
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Passage of murine scrapie prion protein across the mouse vascular blood-brain barrier. Biochem Biophys Res Commun (2004) 0.92
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Smoking exacerbates amyloid pathology in a mouse model of Alzheimer's disease. Nat Commun (2013) 0.90
Molecular barriers to zoonotic transmission of prions. Emerg Infect Dis (2014) 0.90
A homogeneous 384-well high-throughput binding assay for a TNF receptor using alphascreen technology. J Biomol Screen (2003) 0.89
Changes in the glycosylation pattern of prion protein in murine scrapie. Implications for the mechanism of neurodegeneration in prion diseases. J Biol Chem (2002) 0.89
Role of calcineurin in neurodegeneration produced by misfolded proteins and endoplasmic reticulum stress. Curr Opin Cell Biol (2011) 0.88
Generation of prions in vitro and the protein-only hypothesis. Prion (2010) 0.88
Calcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survival. PLoS Pathog (2010) 0.88
Brains from non-Alzheimer's individuals containing amyloid deposits accelerate Aβ deposition in vivo. Acta Neuropathol Commun (2013) 0.87
Molecular mechanisms of neurotoxicity of pathological prion protein. Curr Mol Med (2004) 0.86
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Computational selection of inhibitors of Abeta aggregation and neuronal toxicity. Bioorg Med Chem (2009) 0.85
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Exploring the zoonotic potential of animal prion diseases: in vivo and in vitro approaches. Prion (2014) 0.84
Natural animal models of neurodegenerative protein misfolding diseases. Curr Pharm Des (2012) 0.81
Kosmotropic anions promote conversion of recombinant prion protein into a PrPSc-like misfolded form. PLoS One (2012) 0.81
The prion protein protease sensitivity, stability and seeding activity in variably protease sensitive prionopathy brain tissue suggests molecular overlaps with sporadic Creutzfeldt-Jakob disease. Acta Neuropathol Commun (2014) 0.80
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HIV/AIDS: modified stem cells in the spotlight. Cell Mol Life Sci (2014) 0.79
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A short protocol using dexamethasone and monophosphoryl lipid A generates tolerogenic dendritic cells that display a potent migratory capacity to lymphoid chemokines. J Transl Med (2013) 0.79
Initial fate of prions upon peripheral infection: half-life, distribution, clearance, and tissue uptake. FASEB J (2011) 0.79
Protein misfolding disorders and rational design of antimisfolding agents. Methods Mol Biol (2006) 0.78
Reversibility of prion-induced neurodegeneration. Lancet Neurol (2007) 0.76
The extent of protease resistance of misfolded prion protein is highly dependent on the salt concentration. J Biol Chem (2013) 0.76
Animal models for neurodegenerative diseases associated to accumulation of misfolded protein aggregates. Curr Pharm Des (2012) 0.75
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