1
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Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial.
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J Natl Cancer Inst
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2008
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6.13
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2
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Systematic aortic and pelvic lymphadenectomy versus resection of bulky nodes only in optimally debulked advanced ovarian cancer: a randomized clinical trial.
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J Natl Cancer Inst
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2005
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3.64
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3
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Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: an open-label, single-arm, phase 2 trial.
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Lancet Oncol
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2013
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3.28
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4
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Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study.
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J Clin Oncol
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2002
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2.27
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5
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A randomized trial of goal directed vs. standard fluid therapy in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.
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J Gastrointest Surg
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2015
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2.04
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6
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Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): an open-label, single-arm phase 2 trial.
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Lancet Oncol
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2012
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2.03
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7
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Impact of five prophylactic filgrastim schedules on hematologic toxicity in early breast cancer patients treated with epirubicin and cyclophosphamide.
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J Clin Oncol
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2005
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1.87
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8
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Sequencing of BRAF inhibitors and ipilimumab in patients with metastatic melanoma: a possible algorithm for clinical use.
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J Transl Med
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2012
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1.60
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9
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Gemcitabine-based combinations for inoperable pancreatic cancer: have we made real progress? A meta-analysis of 20 phase 3 trials.
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Cancer
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2007
|
1.58
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10
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Chordoma: clinical characteristics, management and prognosis of a case series of 25 patients.
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BMC Cancer
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2010
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1.52
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11
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A phase III randomized study on the sequencing of radiotherapy and chemotherapy in the conservative management of early-stage breast cancer.
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Int J Radiat Oncol Biol Phys
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2005
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1.49
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12
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Benefit of taxanes as adjuvant chemotherapy for early breast cancer: pooled analysis of 15,500 patients.
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Cancer
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2006
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1.47
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13
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Does granulocyte colony-stimulating factor worsen anemia in early breast cancer patients treated with epirubicin and cyclophosphamide?
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J Clin Oncol
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2006
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1.45
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14
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Prognostic significance of lymphocyte morphology in patients with advanced chronic lymphocytic leukemia treated with first line therapy of fludarabine + prednisone.
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Haematologica
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2002
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1.39
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15
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Adjuvant chemotherapy for bladder cancer: the chance for meta-analyses comparison.
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Eur Urol
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2006
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1.38
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16
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Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10 mg/kg within an expanded access programme.
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Cancer Immunol Immunother
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2013
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1.30
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17
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Cardiotoxicity and incidence of brain metastases after adjuvant trastuzumab for early breast cancer: the dark side of the moon? A meta-analysis of the randomized trials.
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Breast Cancer Res Treat
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2007
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1.30
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18
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Ipilimumab experience in heavily pretreated patients with melanoma in an expanded access program at the University Hospital of Siena (Italy).
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Cancer Immunol Immunother
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2010
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1.24
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19
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Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced melanoma.
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Cancer Immunol Immunother
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2014
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1.23
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20
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A novel clinical prognostic score incorporating the number of resected lymph-nodes to predict recurrence and survival in non-small-cell lung cancer.
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Lung Cancer
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2009
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1.17
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21
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Can patient selection for bladder preservation be based on response to chemotherapy?
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Cancer
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2003
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1.16
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22
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Zoledronic-acid-induced circulating level modifications of angiogenic factors, metalloproteinases and proinflammatory cytokines in metastatic breast cancer patients.
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Oncology
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2005
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1.15
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23
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Does hormone treatment added to radiotherapy improve outcome in locally advanced prostate cancer?: meta-analysis of randomized trials.
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Cancer
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2009
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1.13
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24
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IgD multiple myeloma a descriptive report of 17 cases: survival and response to therapy.
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J Exp Clin Cancer Res
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2012
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1.13
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25
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Clinical features and outcome of familial chronic lymphocytic leukemia.
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Haematologica
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2006
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1.05
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26
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Adjuvant chemotherapy in muscle-invasive bladder carcinoma: a pooled analysis from phase III studies.
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Cancer
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2006
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1.04
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27
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Impact of specific mutant KRAS on clinical outcome of EGFR-TKI-treated advanced non-small cell lung cancer patients with an EGFR wild type genotype.
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Lung Cancer
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2012
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1.02
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28
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Weekly docetaxel as second line chemotherapy for advanced non-small-cell lung cancer: meta-analysis of randomized trials.
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Cancer Treat Rev
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2006
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1.01
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29
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Magnitude of benefit of the addition of bevacizumab to first-line chemotherapy for metastatic colorectal cancer: meta-analysis of randomized clinical trials.
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J Exp Clin Cancer Res
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2010
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1.00
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30
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Do adjuvant aromatase inhibitors increase the cardiovascular risk in postmenopausal women with early breast cancer? Meta-analysis of randomized trials.
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2008
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0.99
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31
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Laparoscopic and robotic partial nephrectomy without renal ischaemia for tumours larger than 4 cm: perioperative and functional outcomes.
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World J Urol
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0.99
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32
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Survival of hereditary non-polyposis colorectal cancer patients compared with sporadic colorectal cancer patients.
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J Exp Clin Cancer Res
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0.98
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33
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Molecular analyses and prognostic relevance of HPV in head and neck tumours.
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34
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Do HER-2 positive metastatic breast cancer patients benefit from the use of trastuzumab beyond disease progression? A mono-institutional experience and systematic review of observational studies.
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Breast
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2008
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0.98
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35
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Magnitude of benefit of adjuvant chemotherapy for non-small cell lung cancer: meta-analysis of randomized clinical trials.
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0.97
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36
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Magnitude of risks and benefits of the addition of bevacizumab to chemotherapy for advanced breast cancer patients: Meta-regression analysis of randomized trials.
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J Exp Clin Cancer Res
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37
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Differentiating chronic lymphocytic leukemia from monoclonal B-lymphocytosis according to clinical outcome: on behalf of the GIMEMA chronic lymphoproliferative diseases working group.
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Haematologica
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2010
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0.96
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38
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39
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Gemcitabine at fixed dose-rate in patients with advanced soft-tissue sarcomas: a mono-institutional phase II study.
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Cancer Chemother Pharmacol
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0.95
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40
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Eur J Haematol
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0.95
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41
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Impact of hormonal treatment duration in combination with radiotherapy for locally advanced prostate cancer: meta-analysis of randomized trials.
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BMC Cancer
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0.94
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42
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Fixed dose-rate gemcitabine infusion as first-line treatment for advanced-stage carcinoma of the pancreas and biliary tree.
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43
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Letrozole combined with gonadotropin-releasing hormone analog for metastatic male breast cancer.
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Breast Cancer Res Treat
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44
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46
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Vitamin D insufficiency predicts time to first treatment (TFT) in early chronic lymphocytic leukemia (CLL).
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Leuk Res
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47
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Clinical impact of anti-epidermal growth factor receptor monoclonal antibodies in first-line treatment of metastatic colorectal cancer: meta-analytical estimation and implications for therapeutic strategies.
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0.91
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48
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Cell surface overexpression of galectin-3 and the presence of its ligand 90k in the blood plasma as determinants in colon neoplastic lesions.
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Glycobiology
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2004
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49
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Adjuvant treatment for resected renal cell carcinoma: are all strategies equally negative? Potential implications for trial design with targeted agents.
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Clin Genitourin Cancer
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50
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Uterine papillary serous, clear cell, and poorly differentiated endometrioid carcinomas: a comparative study.
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Int J Gynecol Cancer
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51
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Phase II study of fixed dose rate gemcitabine as radiosensitizer for newly diagnosed glioblastoma multiforme.
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Cancer Chemother Pharmacol
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J Antimicrob Chemother
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Breast Cancer Res Treat
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55
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Maintenance bevacizumab beyond first-line paclitaxel plus bevacizumab in patients with Her2-negative hormone receptor-positive metastatic breast cancer: efficacy in combination with hormonal therapy.
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BMC Cancer
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Clinical evaluation of the use of exemestane as further hormonal therapy after nonsteroidal aromatase inhibitors in postmenopausal metastatic breast cancer patients.
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Supracricoid partial laryngectomies after radiation failure: a multi-institutional series.
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Metastases to the cerebellum. Results and prognostic factors in a consecutive series of 44 operated patients.
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63
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A phase II trial of docetaxel and vinorelbine in patients with advanced breast cancer previously treated with anthracyclines.
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Pegylated liposomal doxorubicin in combination with gemcitabine: a phase II study in anthracycline-naïve and anthracycline pretreated metastatic breast cancer patients.
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Cancer Chemother Pharmacol
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Clinical experience with ipilimumab 10 mg/kg in patients with melanoma treated at Italian centres as part of a European expanded access programme.
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J Exp Clin Cancer Res
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Targeting targeted agents: open issues for clinical trial design.
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Serum level of CD26 predicts time to first treatment in early B-chronic lymphocytic leukemia.
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0.83
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68
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Phase II study of epirubicin, oxaliplatin and docetaxel combination in metastatic gastric or gastroesophageal junction adenocarcinoma.
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Gemcitabine treatment of experimental C6 glioma: the effects on cell cycle and apoptotic rate.
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Prognostic relevance of serum levels and cellular expression of adiponectin in B-cell chronic lymphocytic leukemia.
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A phase II trial of gefitinib in combination with capecitabine and oxaliplatin as first-line chemotherapy in patients with advanced colorectal cancer.
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Curr Med Res Opin
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Prolonged gemcitabine infusion in advanced non-small cell lung carcinoma: a randomized phase II study of two different schedules in combination with cisplatin.
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