Published in Cell Tissue Res on June 04, 2010
Plakins, a versatile family of cytolinkers: roles in skin integrity and in human diseases. J Invest Dermatol (2013) 1.01
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
A greedy algorithm for aligning DNA sequences. J Comput Biol (2000) 47.89
dbEST--database for "expressed sequence tags". Nat Genet (1993) 41.10
Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol (2000) 29.28
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res (1990) 20.53
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science (2003) 16.80
Understanding alternative splicing: towards a cellular code. Nat Rev Mol Cell Biol (2005) 13.21
Improved splice site detection in Genie. J Comput Biol (1997) 11.57
Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum Gene Ther (1996) 7.12
Splice site prediction in Arabidopsis thaliana pre-mRNA by combining local and global sequence information. Nucleic Acids Res (1996) 6.13
How did alternative splicing evolve? Nat Rev Genet (2004) 3.88
Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma. Hum Mol Genet (2000) 3.39
Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol (2001) 3.31
Working out the strength and flexibility of desmosomes. Nat Rev Mol Cell Biol (2004) 2.63
Biochemical and immunological characterization of desmoplakins I and II, the major polypeptides of the desmosomal plaque. J Mol Biol (1983) 2.27
Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J Cell Biol (1998) 2.14
Structure of the human desmoplakins. Implications for function in the desmosomal plaque. J Biol Chem (1990) 2.13
The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes. J Cell Biol (1997) 1.93
Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins. J Cell Biol (1994) 1.87
The desmoplakin carboxyl terminus coaligns with and specifically disrupts intermediate filament networks when expressed in cultured cells. J Cell Biol (1992) 1.80
Defining the interactions between intermediate filaments and desmosomes. J Cell Biol (1998) 1.78
Desmoplakins of epithelial and myocardial desmosomes are immunologically and biochemically related. Differentiation (1982) 1.73
Functional analysis of desmoplakin domains: specification of the interaction with keratin versus vimentin intermediate filament networks. J Cell Biol (1993) 1.65
Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly. J Cell Biol (1996) 1.64
Loss of desmoplakin isoform I causes early onset cardiomyopathy and heart failure in a Naxos-like syndrome. J Med Genet (2006) 1.64
Two-hybrid analysis reveals fundamental differences in direct interactions between desmoplakin and cell type-specific intermediate filaments. J Biol Chem (1997) 1.59
The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins. Eur J Cell Biol (2006) 1.57
Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma. Hum Mol Genet (1999) 1.52
Desmoplakin I and desmoplakin II. Purification and characterization. J Biol Chem (1989) 1.49
Striate palmoplantar keratoderma resulting from desmoplakin haploinsufficiency. J Invest Dermatol (1999) 1.47
Desmoplakin II expression is not restricted to stratified epithelia. J Cell Sci (1990) 1.44
Loss of desmoplakin tail causes lethal acantholytic epidermolysis bullosa. Am J Hum Genet (2005) 1.43
Molecular map of the desmosomal plaque. J Cell Sci (1999) 1.39
Antidesmosomal monoclonal antibody in the diagnosis of intracranial tumours. J Pathol (1987) 1.35
Molecular structure of the human desmoplakin I and II amino terminus. Proc Natl Acad Sci U S A (1992) 1.31
The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes. Implications for cutaneous disease. J Biol Chem (1999) 1.21
Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability. J Cell Sci (2003) 1.16
Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus. Mol Biol Cell (2003) 1.14
Phosphorylation of the desmoplakin COOH terminus negatively regulates its interaction with keratin intermediate filament networks. J Biol Chem (1994) 1.13
Plakophilin 1 interferes with plakoglobin binding to desmoplakin, yet together with plakoglobin promotes clustering of desmosomal plaque complexes at cell-cell borders. J Cell Sci (2001) 1.13
Early death from cardiomyopathy in a family with autosomal dominant striate palmoplantar keratoderma and woolly hair associated with a novel insertion mutation in desmoplakin. J Invest Dermatol (2006) 1.12
Desmoplakin expression and organization at human umbilical vein endothelial cell-to-cell junctions. J Cell Sci (1996) 1.00
Desmoplakin expression and distribution in cultured rat bladder epithelial cells of varying tumorigenic potential. Exp Cell Res (1991) 0.95
Increased keratinocyte proliferation initiated through downregulation of desmoplakin by RNA interference. Exp Cell Res (2007) 0.95
Structure of desmoplakin and its association with intermediate filaments. J Dermatol (1992) 0.92
Endothelial and virgultar cell formations in the mammalian lymph node sinus: endothelial differentiation morphotypes characterized by a special kind of junction (complexus adhaerens). Cell Tissue Res (2008) 0.92
Skin and heart: une liaison dangereuse. Exp Dermatol (2009) 0.90
Structure and function of desmosomal transmembrane core and plaque molecules. Biophys Chem (1994) 0.89
Unique epidermolytic bullous dermatosis with associated lethal cardiomyopathy related to novel desmoplakin mutations. J Cutan Pathol (2008) 0.87
Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J Acquir Immune Defic Syndr (2007) 4.67
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A (2011) 3.10
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. Nat Genet (2006) 2.81
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. Am J Hum Genet (2003) 2.73
Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1). Hum Mol Genet (2002) 2.41
Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med (2011) 2.41
Raltegravir versus Efavirenz regimens in treatment-naive HIV-1-infected patients: 96-week efficacy, durability, subgroup, safety, and metabolic analyses. J Acquir Immune Defic Syndr (2010) 2.37
Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis. Neuron (2002) 2.33
Long-term efficacy and safety of Raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: week 96 results of the BENCHMRK 1 and 2 Phase III trials. Clin Infect Dis (2010) 2.14
Radiofrequency ablation of arrhythmias guided by non-fluoroscopic catheter location: a prospective randomized trial. Eur Heart J (2006) 2.00
Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome. J Invest Dermatol (2004) 1.95
Resolution of dyssynchronous left ventricular failure via cardiac resynchronization and subsequent radiofrequency ablation in an infant with pre-excitation. Pediatr Cardiol (2010) 1.94
Highwire regulates presynaptic BMP signaling essential for synaptic growth. Neuron (2004) 1.91
Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection. J Acquir Immune Defic Syndr (2009) 1.83
Intermediate filament-membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength. J Cell Biol (2002) 1.83
Efficacy and safety of raltegravir for treatment of HIV for 5 years in the BENCHMRK studies: final results of two randomised, placebo-controlled trials. Lancet Infect Dis (2013) 1.78
Long-term treatment with raltegravir or efavirenz combined with tenofovir/emtricitabine for treatment-naive human immunodeficiency virus-1-infected patients: 156-week results from STARTMRK. Clin Infect Dis (2011) 1.77
Extracellular matrix protein 1 gene (ECM1) mutations in lipoid proteinosis and genotype-phenotype correlation. J Invest Dermatol (2003) 1.67
Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event. Cancer Res (2005) 1.59
Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression. J Invest Dermatol (2007) 1.57
Catheter ablation for atrial fibrillation on uninterrupted warfarin: can it be done without echo guidance? J Cardiovasc Electrophysiol (2010) 1.52
Durable efficacy and safety of raltegravir versus efavirenz when combined with tenofovir/emtricitabine in treatment-naive HIV-1-infected patients: final 5-year results from STARTMRK. J Acquir Immune Defic Syndr (2013) 1.48
FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. PLoS One (2009) 1.48
Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection. Infect Immun (2006) 1.41
Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer (2007) 1.39
Autoantibodies to extracellular matrix protein 1 in lichen sclerosus. Lancet (2003) 1.39
Chest pain and ST elevation. BMJ (2012) 1.38
Cell-cell connectivity: desmosomes and disease. J Pathol (2011) 1.36
Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry. PLoS One (2013) 1.32
Equivalence of ELISpot assays demonstrated between major HIV network laboratories. PLoS One (2010) 1.30
Induction of human epithelial stem/progenitor expansion by FOXM1. Cancer Res (2010) 1.27
RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. Am J Hum Genet (2012) 1.18
Long-term efficacy and safety of the HIV integrase inhibitor raltegravir in patients with limited treatment options in a Phase II study. J Acquir Immune Defic Syndr (2010) 1.17
Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability. J Cell Sci (2003) 1.16
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug Metab Dispos (2010) 1.16
Compound heterozygosity for non-sense and mis-sense mutations in desmoplakin underlies skin fragility/woolly hair syndrome. J Invest Dermatol (2002) 1.15
Early death from cardiomyopathy in a family with autosomal dominant striate palmoplantar keratoderma and woolly hair associated with a novel insertion mutation in desmoplakin. J Invest Dermatol (2006) 1.12
Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. Am J Hum Genet (2008) 1.10
Retrotransposition of limited deletion type of intracisternal A-particle elements in the myeloid leukemia Clls of C3H/He mice. J Radiat Res (2004) 1.08
ABCA12 is the major harlequin ichthyosis gene. J Invest Dermatol (2006) 1.08
p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma. J Invest Dermatol (2004) 1.08
Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa. Cancer Res (2012) 1.07
Transbaffle mapping and ablation for atrial tachycardias after mustard, senning, or Fontan operations. J Am Heart Assoc (2013) 1.05
Effects of clinical characteristics on successful open access scheduling. Health Care Manag Sci (2007) 1.04
Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. J Cell Sci (2007) 1.04
Alterations in desmosome size and number coincide with the loss of keratinocyte cohesion in skin with homozygous and heterozygous defects in the desmosomal protein plakophilin 1. J Invest Dermatol (2003) 1.04
Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1. PLoS One (2011) 1.03
Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical Wnt signalling is repressed. PLoS One (2012) 1.02
Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen. J Cell Sci (2009) 1.01
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. J Med Chem (2009) 1.01
Mathematical modeling of cancer cell invasion of tissue: biological insight from mathematical analysis and computational simulation. J Math Biol (2010) 1.00
Human-like immune responses in CD46 transgenic mice. J Immunol (2005) 1.00
The design and optimization of RNA trans-splicing molecules for skin cancer therapy. Mol Oncol (2013) 0.99
Germline Mutation in EXPH5 Implicates the Rab27B Effector Protein Slac2-b in Inherited Skin Fragility. Am J Hum Genet (2012) 0.99
Mutations in CSTA, encoding Cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion. Am J Hum Genet (2011) 0.98
Novel microsatellite markers and single nucleotide polymorphisms refine the tylosis with oesophageal cancer (TOC) minimal region on 17q25 to 42.5 kb: sequencing does not identify the causative gene. Hum Genet (2004) 0.96
Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. Oncogene (2002) 0.95
Frameshift mutation in the V2 domain of human keratin 1 results in striate palmoplantar keratoderma. J Invest Dermatol (2002) 0.95
Key functions for gap junctions in skin and hearing. Biochem J (2011) 0.95
Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene. Int J Cancer (2011) 0.95
Increased keratinocyte proliferation initiated through downregulation of desmoplakin by RNA interference. Exp Cell Res (2007) 0.95
A missense mutation in the MBTPS2 gene underlies the X-linked form of Olmsted syndrome. J Invest Dermatol (2012) 0.94
Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma. Am J Hum Genet (2013) 0.94
Clinical and genetic heterogeneity of erythrokeratoderma variabilis. J Invest Dermatol (2005) 0.94
Agrobacterium-mediated insertional mutagenesis (AIM) of the entomopathogenic fungus Beauveria bassiana. Curr Genet (2003) 0.94
Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus. J Clin Invest (2004) 0.93
Connexin interaction patterns in keratinocytes revealed morphologically and by FRET analysis. J Cell Sci (2005) 0.93
Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α. Gut (2012) 0.93
Cloning, expression, and purification of mouse heparanase. Protein Expr Purif (2002) 0.92
Connexins in epidermal homeostasis and skin disease. Biochim Biophys Acta (2011) 0.92
Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. PLoS One (2010) 0.92
Premature terminal differentiation and a reduction in specific proteases associated with loss of ABCA12 in Harlequin ichthyosis. Am J Pathol (2009) 0.92
Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling. PLoS One (2012) 0.91
Association of a BMP9 haplotype with ossification of the posterior longitudinal ligament (OPLL) in a Chinese population. PLoS One (2012) 0.91
Properties of human connexin 31, which is implicated in hereditary dermatological disease and deafness. Proc Natl Acad Sci U S A (2006) 0.91
Long-term safety from the raltegravir clinical development program. Curr HIV Res (2011) 0.91
Effect of rat Schwann cell secretion on proliferation and differentiation of human neural stem cells. Biomed Environ Sci (2003) 0.90
A deafness-associated mutant human connexin 26 improves the epithelial barrier in vitro. J Membr Biol (2007) 0.90
Stability, pKa and plasma protein binding of roscovitine. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.90
The use of non-nutritive sucking to decrease the physiologic pain response during neonatal circumcision: a randomized controlled trial. Am J Obstet Gynecol (2005) 0.89
p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis. Dev Cell (2011) 0.89
Characterization of a 500 kb region on 17q25 and the exclusion of candidate genes as the familial Tylosis Oesophageal Cancer (TOC) locus. Oncogene (2002) 0.89
The molecular skin pathology of familial primary localized cutaneous amyloidosis. Exp Dermatol (2010) 0.89
Defective trafficking and cell death is characteristic of skin disease-associated connexin 31 mutations. Hum Mol Genet (2002) 0.88
Mutational analysis of selected genes in the TGFbeta, Wnt, pRb, and p53 pathways in primary uveal melanoma. Invest Ophthalmol Vis Sci (2002) 0.87
Functional studies of human skin disease- and deafness-associated connexin 30 mutations. Biochem Biophys Res Commun (2002) 0.86
Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics. Exp Cell Res (2012) 0.86
Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris. J Pathol (2012) 0.86
EKV mutant connexin 31 associated cell death is mediated by ER stress. Hum Mol Genet (2009) 0.86
Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis. Int J Cancer (2012) 0.86
A mutation in GJB3 is associated with recessive erythrokeratodermia variabilis (EKV) and leads to defective trafficking of the connexin 31 protein. Hum Mol Genet (2002) 0.85
MyD88-dependent signaling affects the development of meningococcal sepsis by nonlipooligosaccharide ligands. Infect Immun (2006) 0.85
Rhomboid proteins: a role in keratinocyte proliferation and cancer. Cell Tissue Res (2012) 0.85
Homozygous mutations in the 5' region of the JUP gene result in cutaneous disease but normal heart development in children. J Invest Dermatol (2010) 0.85