PubRank

P J Wedlund

Author PubWeight™ 32.46‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism. Clin Pharmacol Ther 1984 2.19
2 Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness. J Clin Psychopharmacol 2000 1.51
3 A pilot study on risperidone metabolism: the role of cytochromes P450 2D6 and 3A. J Clin Psychiatry 1999 1.51
4 Genetic aspects of drug disposition and therapeutics. J Clin Pharmacol 1992 1.46
5 Phenotypic differences in mephenytoin pharmacokinetics in normal subjects. J Pharmacol Exp Ther 1985 1.38
6 Pharmacokinetics of high-dose etoposide (VP-16-213) administered to cancer patients. Cancer Res 1984 1.11
7 CYP2D6 genetic variation in healthy adults and psychiatric African-American subjects: implications for clinical practice and genetic testing. Pharmacogenomics J 2006 1.05
8 Limitation to the use of the urinary S-/R-mephenytoin ratio in pharmacogenetic studies. Br J Clin Pharmacol 1991 1.00
9 A study of genetic (CYP2D6 and ABCB1) and environmental (drug inhibitors and inducers) variables that may influence plasma risperidone levels. Pharmacopsychiatry 2007 1.00
10 The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: screening costs and influence on clinical outcomes in psychiatry. Clin Pharmacol Ther 1996 0.97
11 Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism. Br J Clin Pharmacol 1990 0.97
12 Pharmacogenetic association between the formation of 4-hydroxymephenytoin and a new metabolite of S-mephenytoin in man. Drug Metab Dispos 1987 0.93
13 Dextromethorphan: enhancing its systemic availability by way of low-dose quinidine-mediated inhibition of cytochrome P4502D6. Clin Pharmacol Ther 1992 0.92
14 Identification of CYP2C23 expressed in rat kidney as an arachidonic acid epoxygenase. J Pharmacol Exp Ther 1993 0.90
15 Direct enantiomeric resolution of mephenytoin and its N-demethylated metabolite in plasma and blood using chiral capillary gas chromatography. J Chromatogr 1984 0.88
16 Cytochrome P-450 in the brain. Potential evolutionary and therapeutic relevance of localization of drug-metabolizing enzymes. Drug Metab Dispos 1992 0.87
17 Racial differences in parathyroid hormone levels in patients with secondary hyperparathyroidism. Clin Nephrol 2002 0.86
18 Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine. Br J Clin Pharmacol 1990 0.82
19 Quantitation of trans-10,11-dihydroxy-10,11-dihydrocarbamazepine in human urine by high-performance liquid chromatography. J Chromatogr 1987 0.82
20 High clearance of (S)-warfarin in a warfarin-resistant subject. Br J Clin Pharmacol 1993 0.81
21 Pilot study of the cytochrome P450-2D6 genotype in a psychiatric state hospital. Am J Psychiatry 1998 0.80
22 Characterization of antipyrine autoinduction in the rat utilizing a new microsampling technique for serial blood sample collections. J Pharm Sci 1986 0.79
23 Age-dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin. Br J Clin Pharmacol 1991 0.78
24 Age and beta-adrenergic receptor sensitivity to S(-)- and R,S(+/-)-propranolol in humans. Clin Pharmacol Ther 1992 0.78
25 Vitamin K epoxide reductase activity and its inhibition by warfarin in young and old rats. Drug Metab Dispos 1991 0.78
26 Hepatic tissue binding and the oral first-pass effect. J Pharm Sci 1984 0.77
27 Simultaneous quantitation of d- and l-hexobarbital in rat blood by high-performance liquid chromatography. J Chromatogr 1987 0.77
28 Time-dependent kinetics VII: effect of diurnal oscillations on the time course of carbamazepine autoinduction in the rhesus monkey. J Pharm Sci 1983 0.77
29 Simplified phenotyping with dextromethorphan by thin-layer chromatography: application to clinical laboratory screening for deficiencies in oxidative drug metabolism. Ther Drug Monit 1988 0.77
30 A genetic bias in clinical trials? Cytochrome P450-2D6 (CYP2D6) genotype in general vs selected healthy subject populations. Br J Clin Pharmacol 1997 0.77
31 Age and propranolol stereoselective disposition in humans. Clin Pharmacol Ther 1992 0.76
32 Correlation between cytochrome P-450 CYP2D6 (CYP2D6) genotype and phenotype. Zhongguo Yao Li Xue Bao 1999 0.76
33 Polymorphisms in oxidative drug metabolism: relationship to food preference. Br J Clin Pharmacol 1991 0.76
34 Pharmacokinetics of representative 3-hydroxypyridin-4-ones in rabbits: CP20 and CP94. Drug Metab Dispos 1993 0.75
35 Steady-state determination of the contribution of lung metabolism to the total body clearance of drugs: application to carbamazepine. J Pharm Sci 1983 0.75
36 Reversible metabolism of vitamin K-vitamin K epoxide: modeling considerations and limitations. J Pharmacokinet Biopharm 1992 0.75
37 Interaction of valproic acid and some analogues with microsomal epoxide hydrolase. Biochem Pharmacol 1992 0.75
38 Investigating aluminium citrate speciation by high performance liquid chromatography. J Trace Elem Electrolytes Health Dis 1990 0.75
39 Mephenytoin stereoselective elimination in the rat: III. Stereoselective time course of induction during chronic hepatic portal vein administration. Eur J Drug Metab Pharmacokinet 1991 0.75
40 Practical considerations for pharmacogenetic testing. MLO Med Lab Obs 2001 0.75
41 Quantification of propranolol enantiomers in small blood samples from rats by reversed-phase high-performance liquid chromatography after chiral derivatization. J Chromatogr 1989 0.75
42 Induction effect of phenobarbital on carbamazepine-10,11-epoxide kinetics in the rhesus monkey. J Pharmacokinet Biopharm 1982 0.75
43 Stereoselective differences in propranolol disposition in female Sprague-Dawley and Dark Agouti rats. Drug Metab Dispos 1991 0.75
44 Mephenytoin stereoselective elimination in the rat: I. Enantiomeric disposition following intravenous administration. Eur J Drug Metab Pharmacokinet 1990 0.75
45 Method for chronic portal vein infusion in unrestrained rats. J Pharmacol Methods 1987 0.75
46 Linear relationship between cytochrome P-450 and carbamazepine clearance in rhesus monkey. Drug Metab Dispos 1983 0.75
47 A problem with quantitation of mephenytoin enantiomers due to chiral interference from its N-demethylated metabolite. J Chromatogr 1986 0.75
48 Mephenytoin stereoselective elimination in the rat: II. Comparison of mephenytoin stereoselective clearance during chronic intravenous and hepatic portal vein administration. Eur J Drug Metab Pharmacokinet 1990 0.75
49 [Distinguishing CYP2D6 homozygous and heterozygous extensive metabolizers by dextromethorphan phenotyping]. Yao Xue Xue Bao 1997 0.75