Published in Chem Commun (Camb) on June 17, 2010
Fluorine in pharmaceuticals: looking beyond intuition. Science (2007) 8.98
Interactions with aromatic rings in chemical and biological recognition. Angew Chem Int Ed Engl (2003) 5.63
Aromatic rings in chemical and biological recognition: energetics and structures. Angew Chem Int Ed Engl (2011) 2.48
Orthogonal multipolar interactions in structural chemistry and biology. Angew Chem Int Ed Engl (2005) 1.54
Systematic investigation of halogen bonding in protein-ligand interactions. Angew Chem Int Ed Engl (2011) 1.54
Predicting and tuning physicochemical properties in lead optimization: amine basicities. ChemMedChem (2007) 1.48
Spirocyclic oxetanes: synthesis and properties. Angew Chem Int Ed Engl (2008) 1.44
The pleasure and importance of printed journals. Nature (2009) 1.39
Molecular recognition in chemical and biological systems. Angew Chem Int Ed Engl (2015) 1.28
Quantification of cation-pi interactions in protein-ligand complexes: crystal-structure analysis of Factor Xa bound to a quaternary ammonium ion ligand. Angew Chem Int Ed Engl (2005) 1.20
Super-electron donors: bis-pyridinylidene formation by base treatment of pyridinium salts. Org Lett (2008) 1.20
Structural aspects of fullerene chemistry--a journey through fullerene chirality. Chem Rev (2006) 1.17
Phosphate recognition in structural biology. Angew Chem Int Ed Engl (2007) 1.17
The generation of aryl anions by double electron transfer to aryl iodides from a neutral ground-state organic super-electron donor. Angew Chem Int Ed Engl (2007) 1.17
Regio- and stereoselective tether-directed remote functionalization of C60 with derivatives of the Tröger base. Angew Chem Int Ed Engl (2004) 1.15
Theoretical bond dissociation energies of halo-heterocycles: trends and relationships to regioselectivity in palladium-catalyzed cross-coupling reactions. J Am Chem Soc (2009) 1.12
Steroids in Molecular Recognition. Chem Rev (1997) 1.09
Expanding the chemical space for push-pull chromophores by non-concerted [2+2] and [4+2] cycloadditions: access to a highly functionalised 6,6-dicyanopentafulvene with an intense, low-energy charge-transfer band. Chem Commun (Camb) (2011) 1.06
Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles. Chembiochem (2004) 0.99
Container molecules with portals: Reversibly switchable cycloalkane complexation. Angew Chem Int Ed Engl (2007) 0.99
A two-dimensional polymer prepared by organic synthesis. Nat Chem (2012) 0.98
Nature of intermediates in organo-SOMO catalysis of alpha-arylation of aldehydes. J Am Chem Soc (2010) 0.98
One-carbon extrusion from a tetraazafulvalene. Isolation of aldehydes and a study of their origin. J Am Chem Soc (2009) 0.97
Modification of supramolecular binding motifs induced by substrate registry: formation of self-assembled macrocycles and chain-like patterns. Chemistry (2009) 0.97
Amphiphilic dendrimers: novel self-assembling vectors for efficient gene delivery. Angew Chem Int Ed Engl (2003) 0.96
Orthogonal dipolar interactions between amide carbonyl groups. Proc Natl Acad Sci U S A (2008) 0.95
Structure-based drug design: exploring the proper filling of apolar pockets at enzyme active sites. J Org Chem (2008) 0.95
Allenes in molecular materials. Angew Chem Int Ed Engl (2012) 0.95
Pentafluorosulfanyl as a novel building block for enzyme inhibitors: trypanothione reductase inhibition and antiprotozoal activities of diarylamines. Chembiochem (2009) 0.94
Supramolecular patterned surfaces driven by cooperative assembly of C60 and porphyrins on metal substrates. Angew Chem Int Ed Engl (2004) 0.93
Geometrically precisely defined multinanometer expansion/contraction motions in a resorcin[4]arene cavitand based molecular switch. Angew Chem Int Ed Engl (2005) 0.93
A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions. Org Biomol Chem (2004) 0.93
A weak attractive interaction between organic fluorine and an amide group. Angew Chem Int Ed Engl (2004) 0.92
Cation-pi interactions at the active site of factor Xa: dramatic enhancement upon stepwise N-alkylation of ammonium ions. Angew Chem Int Ed Engl (2009) 0.92
The fluorine-iminium ion gauche effect: proof of principle and application to asymmetric organocatalysis. Angew Chem Int Ed Engl (2009) 0.92
Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding. J Mol Biol (2007) 0.91
Molecular pair analysis: C-H...F interactions in the crystal structure of fluorobenzene? And related matters. Chemistry (2006) 0.90
A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions. Angew Chem Int Ed Engl (2003) 0.90
Directed rotations of single porphyrin molecules controlled by localized force spectroscopy. ACS Nano (2012) 0.89
Designing fluorinated cinchona alkaloids for enantioselective catalysis: controlling internal rotation by a fluorine-ammonium ion gauche effect (φ(NCCF)). Chemistry (2012) 0.89
The search for tricyanomethane (cyanoform). Chemistry (2010) 0.89
Inhibitors of the herbicidal target IspD: allosteric site binding. Angew Chem Int Ed Engl (2011) 0.88
The state of the art of chemical biology. Chembiochem (2009) 0.88
Redox reactions in palladium catalysis: on the accelerating and/or inhibiting effects of copper and silver salt additives in cross-coupling chemistry involving electron-rich phosphine ligands. Angew Chem Int Ed Engl (2012) 0.88
Computational study of factors controlling the boat and chair transition states of Ireland-Claisen rearrangements. J Org Chem (2010) 0.88
Solvent effect on palladium-catalyzed cross-coupling reactions and implications on the active catalytic species. Angew Chem Int Ed Engl (2011) 0.88
Improved inhibitors of trypanothione reductase by combination of motifs: synthesis, inhibitory potency, binding mode, and antiprotozoal activities. ChemMedChem (2010) 0.88
Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV. Angew Chem Int Ed Engl (2006) 0.87
Conjugated oligoenynes based on the diethynylethene unit. Chem Rev (2005) 0.87
Efficient stacking on protein amide fragments. ChemMedChem (2013) 0.87
Supramolecular [60]fullerene chemistry on surfaces. Chem Soc Rev (2006) 0.87
Property tuning in charge-transfer chromophores by systematic modulation of the spacer between donor and acceptor. Chemistry (2007) 0.87
Molecular torsion balances: evidence for favorable orthogonal dipolar interactions between organic fluorine and amide groups. Angew Chem Int Ed Engl (2007) 0.87
From lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clusters. Chemistry (2012) 0.87
Electron transfer to benzenes by photoactivated neutral organic electron donor molecules. Angew Chem Int Ed Engl (2012) 0.86
Theoretical and X-ray crystallographic evidence of a fluorine-imine gauche effect: an addendum to Dunathan's stereoelectronic hypothesis. Chemistry (2011) 0.85
Reactivity and stability of dinuclear Pd(I) complexes: studies on the active catalytic species, insights into precatalyst activation and deactivation, and application in highly selective cross-coupling reactions. J Am Chem Soc (2011) 0.85
Structure elucidation of hexabromocyclododecanes--a class of compounds with a complex stereochemistry. Chemosphere (2005) 0.85
Calculation of binding free energies of inhibitors to plasmepsin II. J Comput Chem (2011) 0.85
Molecular recognition at the active site of factor Xa: cation-π interactions, stacking on planar peptide surfaces, and replacement of structural water. Chemistry (2011) 0.85
Triply fused Zn(II)-porphyrin oligomers: synthesis, properties, and supramolecular interactions with single-walled carbon nanotubes (SWNTs). Chemistry (2006) 0.84
Halogen bonding of (iodoethynyl)benzene derivatives in solution. Org Lett (2014) 0.84
Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy. Angew Chem Int Ed Engl (2006) 0.84
Reactions of the HCN-tetramer with aldehydes. Chem Biodivers (2007) 0.84
A fluorine scan at the catalytic center of thrombin: C--F, C--OH, and C--OMe bioisosterism and fluorine effects on pKa and log D values. ChemMedChem (2006) 0.84
A multistep single-crystal-to-single-crystal bromodiacetylene dimerization. Nat Chem (2013) 0.83
Practical, highly active, and enantioselective ferrocenyl-imidazoline palladacycle catalysts (FIPs) for the aza-Claisen rearrangement of N-para-methoxyphenyl trifluoroacetimidates. Angew Chem Int Ed Engl (2006) 0.83
Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy. ChemMedChem (2007) 0.83
Soluble poly(diacetylene)s using the perfluorophenyl-phenyl motif as a supramolecular synthon. J Am Chem Soc (2008) 0.83
Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor. Angew Chem Int Ed Engl (2009) 0.83
Shape-persistent chiral alleno-acetylenic macrocycles and cyclophanes by acetylenic scaffolding with 1,3-diethynylallenes. Angew Chem Int Ed Engl (2005) 0.83
Cryogenic 35GHz pulse ENDOR probehead accommodating large sample sizes: Performance and applications. J Magn Reson (2009) 0.83
A supramolecular multiposition rotary device. Angew Chem Int Ed Engl (2007) 0.83
Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis. ChemMedChem (2008) 0.83
Nanoscale engineering of molecular porphyrin wires on insulating surfaces. Small (2008) 0.83
Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei. ChemMedChem (2010) 0.83
Perfluorophenyl-phenyl interactions in the crystallization and topochemical polymerization of triacetylene monomers. Chemistry (2009) 0.83
Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum. ChemMedChem (2010) 0.83
Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors. Chemistry (2011) 0.82
Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities. Org Biomol Chem (2008) 0.82
Halogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environments. ChemMedChem (2011) 0.82
Two-dimensional acetylenic scaffolding: extended donor-substituted perethynylated dehydroannulenes. Chem Asian J (2006) 0.82
Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis. Org Biomol Chem (2008) 0.82
Fluorinated quinine alkaloids: synthesis, X-ray structure analysis and antimalarial parasite chemotherapy. Chemistry (2009) 0.82
1,2,3-triazoles as conjugative pi-linkers in push-pull chromophores: importance of substituent positioning on intramolecular charge-transfer. Org Lett (2008) 0.82
Acetylene-derived strong organic acceptors for planar and nonplanar push-pull chromophores. Acc Chem Res (2009) 0.82
Regio- and diastereoselective synthesis of bis- and tetrakisadducts of C70 by directed remote functionalization using Tröger base tethers. Chemistry (2006) 0.81