PubRank

David J Harrison

Author PubWeight™ 115.34‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Orphan CpG islands identify numerous conserved promoters in the mammalian genome. PLoS Genet 2010 3.38
2 Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes. Genome Res 2011 2.15
3 Counting alleles to predict recurrence of early-stage colorectal cancers. Lancet 2002 1.96
4 Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer. Proc Natl Acad Sci U S A 2011 1.82
5 Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer. Breast Cancer Res 2010 1.65
6 Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns. Genome Biol 2012 1.63
7 Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells. Cancer Res 2010 1.62
8 Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab. Cancer Res 2009 1.59
9 The cost of treating skeletal-related events in patients with prostate cancer. Am J Manag Care 2008 1.56
10 Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology 2003 1.55
11 WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to fibronectin via integrin alpha3. Cancer Res 2009 1.25
12 While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable. Mol Cell Biol 2003 1.24
13 Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. J Pathol 2004 1.24
14 Clinical utility of an epigenetic assay to detect occult prostate cancer in histopathologically negative biopsies: results of the MATLOC study. J Urol 2012 1.19
15 Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes. J Pathol 2003 1.17
16 Hematopoietic stem cell trafficking in liver injury. FASEB J 2005 1.16
17 Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans. PLoS One 2009 1.16
18 What can molecular pathology contribute to the management of renal cell carcinoma? Nat Rev Urol 2011 1.15
19 TNF-alpha induced DNA damage in primary murine hepatocytes. Int J Mol Med 2003 1.15
20 Prognostic relevance of DNA copy number changes in colorectal cancer. J Pathol 2010 1.14
21 Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression. Nucleic Acids Res 2012 1.12
22 Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery. Genome Biol 2013 1.11
23 New strategies for targeting the hypoxic tumour microenvironment in breast cancer. Cancer Treat Rev 2012 1.08
24 Costs of tumor necrosis factor blockers per treated patient using real-world drug data in a managed care population. J Manag Care Pharm 2013 1.08
25 The impact of itch symptoms in psoriasis: results from physician interviews and patient focus groups. Health Qual Life Outcomes 2009 1.07
26 Systems pathology--taking molecular pathology into a new dimension. Nat Rev Clin Oncol 2009 1.06
27 Annual acquisition and administration cost of biologic response modifiers per patient with rheumatoid arthritis, psoriasis, psoriatic arthritis, or ankylosing spondylitis. J Med Econ 2013 1.05
28 Sprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapy. PLoS One 2011 1.05
29 Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget 2012 1.04
30 The effect of VEGF-targeted therapy on biomarker expression in sequential tissue from patients with metastatic clear cell renal cancer. Clin Cancer Res 2013 1.04
31 ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates. J Pathol 2005 1.03
32 Trastuzumab and pertuzumab produce changes in morphology and estrogen receptor signaling in ovarian cancer xenografts revealing new treatment strategies. Clin Cancer Res 2011 1.00
33 Bone marrow stem cells contribute to alcohol liver fibrosis in humans. Stem Cells Dev 2010 0.98
34 Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis. Exp Cell Res 2007 0.97
35 Qualitative and quantitative MALDI imaging of the positron emission tomography ligands raclopride (a D2 dopamine antagonist) and SCH 23390 (a D1 dopamine antagonist) in rat brain tissue sections using a solvent-free dry matrix application method. Anal Chem 2011 0.97
36 Improved retention of zymogen granules in cultured murine pancreatic acinar cells and induction of acinar-ductal transdifferentiation in vitro. Pancreas 2005 0.94
37 HER2 expression in ovarian carcinoma: caution and complexity in biomarker analysis. J Clin Pathol 2012 0.94
38 Two possible mechanisms of epithelial to mesenchymal transition in invasive ductal breast cancer. Clin Exp Metastasis 2011 0.94
39 Annual costs of tumor necrosis factor inhibitors using real-world data in a commercially insured population in the United States. J Med Econ 2011 0.93
40 Cyclin D1 and p21 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms. Hum Pathol 2003 0.93
41 The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma. PLoS One 2012 0.92
42 Treatment patterns and annual drug costs of biologic therapies across indications from the Humana commercial database. J Manag Care Spec Pharm 2014 0.92
43 Comparison of methods for measuring dose escalation of the subcutaneous TNF antagonists for rheumatoid arthritis patients treated in routine clinical practice. Curr Med Res Opin 2010 0.92
44 An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer. PLoS One 2011 0.91
45 p53 deficiency exacerbates pleiotropic mitotic defects, changes in nuclearity and polyploidy in transdifferentiating pancreatic acinar cells. Oncogene 2005 0.91
46 Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network. Eur J Pharm Sci 2011 0.91
47 Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury. Lab Invest 2003 0.91
48 Differential expression of prognostic proteomic markers in primary tumour, venous tumour thrombus and metastatic renal cell cancer tissue and correlation with patient outcome. PLoS One 2013 0.91
49 Phosphoprotein pathway profiling of ovarian carcinoma for the identification of potential new targets for therapy. Eur J Cancer 2011 0.91
50 5-hydroxymethylcytosine profiling as an indicator of cellular state. Epigenomics 2013 0.90
51 Additive effect of p53, p21 and Rb deletion in triple knockout primary hepatocytes. Oncogene 2004 0.90
52 The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice. Exp Cell Res 2005 0.90
53 Potential of hematopoietic stem cell therapy in hepatology: a critical review. Stem Cells 2004 0.90
54 A Critical Re-Examination of the Intraluminal Filament MCAO Model: Impact of External Carotid Artery Transection. Transl Stroke Res 2011 0.90
55 Use of a validated algorithm to estimate the annual cost of effective biologic treatment for rheumatoid arthritis. J Med Econ 2014 0.89
56 Microarray analysis of gene expression of mouse hepatocytes of different ploidy. Mamm Genome 2007 0.89
57 Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications. Protein Eng Des Sel 2014 0.89
58 MBD1, MBD2 and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers. Oncogene 2003 0.88
59 Validation of a molecular and pathological model for five-year mortality risk in patients with early stage lung adenocarcinoma. J Thorac Oncol 2015 0.87
60 Relationship between preventative physical health care and mental health in individuals with schizophrenia: a survey of caregivers. Ment Health Serv Res 2005 0.87
61 Cost and effectiveness of biologics for rheumatoid arthritis in a commercially insured population. J Manag Care Spec Pharm 2015 0.87
62 Modulation of HER3 is a marker of dynamic cell signaling in ovarian cancer: implications for pertuzumab sensitivity. Mol Cancer Res 2009 0.87
63 Further evaluation of a claims-based algorithm to determine the effectiveness of biologics for rheumatoid arthritis using commercial claims data. Arthritis Res Ther 2013 0.86
64 Functional analysis of mouse hepatocytes differing in DNA content: volume, receptor expression, and effect of IFNgamma. J Cell Physiol 2002 0.86
65 Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation. J Proteomics 2012 0.86
66 Heterogeneity mapping of protein expression in tumors using quantitative immunofluorescence. J Vis Exp 2011 0.85
67 Cost per patient-year in response using a claims-based algorithm for the 2 years following biologic initiation in patients with rheumatoid arthritis. J Med Econ 2015 0.85
68 Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer. J Transl Med 2014 0.85
69 Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest. BMC Cancer 2007 0.85
70 Determining tamoxifen sensitivity using primary breast cancer tissue in collagen-based three-dimensional culture. Biomaterials 2011 0.84
71 Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition. Cell Signal 2011 0.84
72 Beta1 integrin in tissue remodelling and repair: from phenomena to concepts. Pharmacol Ther 2008 0.84
73 Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest. BMC Cell Biol 2002 0.84
74 The use of reverse phase protein arrays (RPPA) to explore protein expression variation within individual renal cell cancers. J Vis Exp 2013 0.84
75 Reducing exposure to laboratory animal allergens. Comp Med 2003 0.84
76 Cancer systems biology. Methods Mol Biol 2010 0.84
77 Diversity of matriptase expression level and function in breast cancer. PLoS One 2012 0.84
78 Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells. DNA Repair (Amst) 2007 0.83
79 TMA Navigator: Network inference, patient stratification and survival analysis with tissue microarray data. Nucleic Acids Res 2013 0.83
80 Impact of atypical antipsychotics on outcomes of care in schizophrenia. Am J Manag Care 2005 0.83
81 Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition. Cell Signal 2010 0.83
82 Structure, properties, and engineering of the major zinc binding site on human albumin. J Biol Chem 2009 0.83
83 Functional Smoothened is required for expression of GLI3 in colorectal carcinoma cells. Cancer Lett 2004 0.82
84 Change in framingham risk score in patients with schizophrenia: a post hoc analysis of a randomized, double-blind, 6-week trial of ziprasidone and olanzapine. Prim Care Companion J Clin Psychiatry 2006 0.82
85 TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21Cip1 or Rb status. BMC Cancer 2008 0.82
86 Pharmacoeconomic analysis of sertraline treatment of depression in patients with unstable angina or a recent myocardial infarction. J Clin Psychiatry 2005 0.82
87 Integrin characterization in pulmonary bronchioles. Exp Mol Pathol 2005 0.81
88 Health-related quality of life of pediatric patients with moderate to severe plaque psoriasis: comparisons to four common chronic diseases. Eur J Pediatr 2011 0.81
89 Thermal denaturation of spinach plastocyanin: effect of copper site oxidation state and molecular oxygen. Biochemistry 2003 0.81
90 An analytical approach differentiates between individual and collective cancer invasion. Anal Cell Pathol (Amst) 2011 0.81
91 Geographic disparities in patient travel for dialysis in the United States. J Rural Health 2013 0.80
92 p21(Waf1/Cip1) regulates proliferation and apoptosis in airway epithelial cells and alternative forms have altered binding activities. Exp Lung Res 2004 0.80
93 GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines. BMC Cancer 2011 0.80
94 Genetic interactions between the Wilms' tumor 1 gene and the p53 gene. Cancer Res 2002 0.80
95 Etanercept treatment patterns in managed-care patients with psoriasis or psoriatic arthritis. J Med Econ 2010 0.79
96 A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen. BMC Syst Biol 2012 0.79
97 Dynamic computational modeling in the search for better breast cancer drug therapy. Pharmacogenomics 2007 0.79
98 Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer. Cell Signal 2012 0.79
99 MBD4 interacts with and recruits USP7 to heterochromatic foci. J Cell Biochem 2015 0.79
100 Pertuzumab for the treatment of ovarian cancer. Expert Opin Biol Ther 2010 0.79
101 Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes. Oncogene 2002 0.79
102 Is the adult mouse striatum a hostile host for neural transplant survival? Neuroreport 2013 0.79
103 Long-term culture of human breast cancer specimens and their analysis using optical projection tomography. J Vis Exp 2011 0.79
104 Induction of p21 and nuclear accumulation of TAp73alpha and c-abl during apoptosis of cisplatin-treated primary pancreatic acinar cells. Int J Oncol 2004 0.79
105 Effect of initial ziprasidone dose on length of therapy in schizophrenia. Schizophr Res 2006 0.78
106 Allosteric modulation of beta1 integrin function induces lung tissue repair. Adv Pharmacol Sci 2012 0.78
107 Medication effectiveness with the use of tumor necrosis factor inhibitors among Texas Medicaid patients diagnosed with rheumatoid arthritis. J Manag Care Spec Pharm 2014 0.78
108 Growth factor attenuation of IFNgamma-mediated hepatocyte apoptosis requires p21waf-1. Int J Exp Pathol 2006 0.78
109 Utilizing mRNA extracted from small, archival formalin-fixed paraffin-embedded prostate samples for translational research: assessment of the effect of increasing sample age and storage temperature. Int Urol Nephrol 2011 0.78
110 The importance of growth factors and steroid hormones in ovarian cancer. Onkologie 2009 0.77
111 Routinely obtained diagnostic material as a source of RNA for personalized medicine in lung cancer patients. J Thorac Oncol 2011 0.77
112 Impaired sensitivity to Pavlovian stimulus-outcome learning after excitotoxic lesion of the ventrolateral neostriatum. Behav Brain Res 2011 0.77
113 How can systems pathology help us personalize cancer therapy? Discov Med 2009 0.77
114 Apoptosis and DNA methylation. Cancers (Basel) 2011 0.77
115 Use of microarray analysis to investigate EMT gene signatures. Methods Mol Biol 2013 0.76
116 Glutathione and p53 independently mediate responses against oxidative stress in ES cells. Free Radic Biol Med 2002 0.76
117 Lack of health insurance and overall health. N Engl J Med 2002 0.75
118 Characterising the tumour morphological response to therapeutic intervention: an ex vivo model. Dis Model Mech 2012 0.75
119 The use of percutaneous lumbar fixation screws for bilateral pedicle fractures with an associated dislocation of a lumbar disc prosthesis. Case Rep Orthop 2013 0.75
120 Molecular pathology in therapeutics: where are we now, and where are we going? Curr Drug Targets 2012 0.75
121 Total synthesis of dehaloperophoramidine using a highly diastereoselective Hosomi-Sakurai reaction. Chem Commun (Camb) 2016 0.75
122 Multidisciplinary urological engagement in translational renal cancer research. BJU Int 2014 0.75
123 Effect of initial ziprasidone dose on treatment persistence in schizophrenia. Schizophr Res 2006 0.75
124 Validation and response to treatment of a pruritus self-assessment tool in patients with moderate to severe psoriasis. J Am Acad Dermatol 2010 0.75
125 Independent regulation of P53 stabilisation and activation after Rb deletion in primary epithelial cells. Int J Oncol 2010 0.75
126 Human tissue in systems medicine. FEBS J 2013 0.75
127 Superior mesenteric artery syndrome following sleeve gastrectomy: case report, review of the literature, and video on technique for surgical correction. Surg Endosc 2014 0.75
128 Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396). Transgenic Res 2007 0.75