Published in Invest Ophthalmol Vis Sci on June 23, 2010
Noncanonical autophagy promotes the visual cycle. Cell (2013) 1.74
The mammalian cone visual cycle promotes rapid M/L-cone pigment regeneration independently of the interphotoreceptor retinoid-binding protein. J Neurosci (2011) 1.33
New insights into retinoid metabolism and cycling within the retina. Prog Retin Eye Res (2012) 1.16
Regeneration of photopigment is enhanced in mouse cone photoreceptors expressing RPE65 protein. J Neurosci (2011) 1.05
Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. J Physiol (2015) 0.87
Membrane receptors and transporters involved in the function and transport of vitamin A and its derivatives. Biochim Biophys Acta (2011) 0.84
M-opsin protein degradation is inhibited by MG-132 in Rpe65⁻/⁻ retinal explant culture. Mol Vis (2012) 0.82
A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids. Invest Ophthalmol Vis Sci (2012) 0.80
Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium. Sci Rep (2016) 0.78
Light prevents exogenous 11-cis retinal from maintaining cone photoreceptors in chromophore-deficient mice. Invest Ophthalmol Vis Sci (2011) 0.78
Systemic Retinaldehyde Treatment Corrects Retinal Oxidative Stress, Rod Dysfunction, and Impaired Visual Performance in Diabetic Mice. Invest Ophthalmol Vis Sci (2015) 0.76
Human cellular retinaldehyde-binding protein has secondary thermal 9-cis-retinal isomerase activity. J Am Chem Soc (2013) 0.75
A subpopulation of activated retinal macrophages selectively migrated to regions of cone photoreceptor stress, but had limited protective effect on cone death in a mouse model for type 2 Leber congenital amaurosis. Mol Cell Neurosci (2017) 0.75
Loss of ERK1/2 in the retinal pigment epithelium leads to RPE65 decrease and retinal degeneration. Mol Cell Biol (2017) 0.75
Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med (2008) 17.21
Effect of gene therapy on visual function in Leber's congenital amaurosis. N Engl J Med (2008) 15.30
Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet (1998) 7.57
Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci (1995) 4.83
Pre-lumirhodopsin and the bleaching of visual pigments. Nature (1963) 4.27
A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest (1992) 4.21
Morphological, physiological, and biochemical changes in rhodopsin knockout mice. Proc Natl Acad Sci U S A (1999) 3.71
The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning. Neuron (2000) 3.61
Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci U S A (2000) 2.60
New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis. Nat Genet (2001) 2.44
Human cone photoreceptor dependence on RPE65 isomerase. Proc Natl Acad Sci U S A (2007) 2.21
Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem (2002) 2.11
Downregulation of cone-specific gene expression and degeneration of cone photoreceptors in the Rpe65-/- mouse at early ages. Invest Ophthalmol Vis Sci (2005) 1.98
Cone opsin mislocalization in Rpe65-/- mice: a defect that can be corrected by 11-cis retinal. Invest Ophthalmol Vis Sci (2005) 1.95
Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out mice. Proc Natl Acad Sci U S A (2003) 1.94
Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med (2005) 1.83
Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci (2008) 1.76
Reduction of all-trans-retinal limits regeneration of visual pigment in mice. Vision Res (1998) 1.69
Kallistatin is a new inhibitor of angiogenesis and tumor growth. Blood (2002) 1.54
Correlation of regenerable opsin with rod ERG signal in Rpe65-/- mice during development and aging. Invest Ophthalmol Vis Sci (2003) 1.52
Drug delivery for posterior segment eye disease. Invest Ophthalmol Vis Sci (2000) 1.43
Rpe65-/- and Lrat-/- mice: comparable models of leber congenital amaurosis. Invest Ophthalmol Vis Sci (2008) 1.43
Adult vitreous structure and postnatal changes. Eye (Lond) (2008) 1.40
Quantitative determination of retinals with complete retention of their geometric configuration. Biochim Biophys Acta (1980) 1.17
Evaluation of different recording parameters to establish a standard for flash electroretinography in rodents. Vision Res (2001) 0.93
9-cis Retinal increased in retina of RPE65 knockout mice with decrease in coat pigmentation. Photochem Photobiol (2007) 0.89
In vitro sustained human transscleral drug delivery of fluorescein-labeled dexamethasone and methotrexate with fibrin sealant. Curr Eye Res (2005) 0.89
Development of in situ thermosensitive drug vehicles for glaucoma therapy. Biomaterials (2003) 0.87
Pharmacotherapy of age-related macular degeneration. Expert Opin Pharmacother (2008) 0.78
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction. Nature (2005) 4.08
Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function. Am J Pathol (2005) 2.38
Breaking the covalent bond--a pigment property that contributes to desensitization in cones. Neuron (2005) 2.36
CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression. Cancer Res (2010) 2.13
MicroRNA 23b regulates autophagy associated with radioresistance of pancreatic cancer cells. Gastroenterology (2013) 2.00
Downregulation of cone-specific gene expression and degeneration of cone photoreceptors in the Rpe65-/- mouse at early ages. Invest Ophthalmol Vis Sci (2005) 1.98
Cone opsin mislocalization in Rpe65-/- mice: a defect that can be corrected by 11-cis retinal. Invest Ophthalmol Vis Sci (2005) 1.95
Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out mice. Proc Natl Acad Sci U S A (2003) 1.94
Retinyl esters are the substrate for isomerohydrolase. Biochemistry (2003) 1.85
CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice. J Clin Invest (2011) 1.82
Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci (2008) 1.76
Pivotal advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms. J Leukoc Biol (2010) 1.59
Identification of the RPE65 protein in mammalian cone photoreceptors. Invest Ophthalmol Vis Sci (2002) 1.57
Structure-function analysis of rods and cones in juvenile, adult, and aged C57bl/6 and Balb/c mice. Vis Neurosci (2003) 1.55
Visual cycle: Dependence of retinol production and removal on photoproduct decay and cell morphology. J Gen Physiol (2006) 1.54
Correlation of regenerable opsin with rod ERG signal in Rpe65-/- mice during development and aging. Invest Ophthalmol Vis Sci (2003) 1.52
Post-translational modifications of aquaporin 0 (AQP0) in the normal human lens: spatial and temporal occurrence. Biochemistry (2004) 1.51
Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. Invest Ophthalmol Vis Sci (2002) 1.46
Opsin activation of transduction in the rods of dark-reared Rpe65 knockout mice. J Physiol (2005) 1.45
Rpe65-/- and Lrat-/- mice: comparable models of leber congenital amaurosis. Invest Ophthalmol Vis Sci (2008) 1.43
An evaluation of 2537 gastrointestinal stromal tumors for a proposed clinical staging system. Arch Surg (2009) 1.42
Reduction of all-trans retinal to all-trans retinol in the outer segments of frog and mouse rod photoreceptors. Biophys J (2004) 1.39
Interphotoreceptor retinoid-binding protein is the physiologically relevant carrier that removes retinol from rod photoreceptor outer segments. Biochemistry (2007) 1.38
Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2. Am J Physiol Regul Integr Comp Physiol (2009) 1.36
RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle. J Biol Chem (2005) 1.36
The C terminus of lens aquaporin 0 interacts with the cytoskeletal proteins filensin and CP49. Invest Ophthalmol Vis Sci (2006) 1.35
Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J (2003) 1.34
The mammalian cone visual cycle promotes rapid M/L-cone pigment regeneration independently of the interphotoreceptor retinoid-binding protein. J Neurosci (2011) 1.33
11-cis-retinal reduces constitutive opsin phosphorylation and improves quantum catch in retinoid-deficient mouse rod photoreceptors. J Biol Chem (2002) 1.33
Physiological and microfluorometric studies of reduction and clearance of retinal in bleached rod photoreceptors. J Gen Physiol (2004) 1.29
Retinol dehydrogenases (RDHs) in the visual cycle. Exp Eye Res (2010) 1.28
One-step one-phase synthesis of monodisperse noble-metallic nanoparticles and their colloidal crystals. J Am Chem Soc (2006) 1.26
Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone. Clin Exp Metastasis (2008) 1.25
Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immunol (2011) 1.25
Water permeability of C-terminally truncated aquaporin 0 (AQP0 1-243) observed in the aging human lens. Invest Ophthalmol Vis Sci (2003) 1.24
Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epithelium. Invest Ophthalmol Vis Sci (2013) 1.22
Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone. PLoS One (2009) 1.20
Spatial localization of A2E in the retinal pigment epithelium. Invest Ophthalmol Vis Sci (2011) 1.19
miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression. J Hepatol (2012) 1.19
Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest (2010) 1.19
Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinal. J Biol Chem (2012) 1.18
Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem (2011) 1.18
New insights into retinoid metabolism and cycling within the retina. Prog Retin Eye Res (2012) 1.16
LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils. Am J Physiol Lung Cell Mol Physiol (2004) 1.14
The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasL. Mol Oncol (2012) 1.11
Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation-deficient rhodopsin. J Biol Chem (2005) 1.10
Interphotoreceptor retinoid-binding protein as the physiologically relevant carrier of 11-cis-retinol in the cone visual cycle. J Neurosci (2011) 1.10
Age-related deterioration of rod vision in mice. J Neurosci (2010) 1.10
Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma cell lines by targeting c-myc. Biochem Biophys Res Commun (2011) 1.10
Identification of RDH10, an All-trans Retinol Dehydrogenase, in Retinal Muller Cells. Invest Ophthalmol Vis Sci (2004) 1.09
The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. Invest Ophthalmol Vis Sci (2009) 1.07
Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. J Immunol (2009) 1.07
Role of the 9-methyl group of retinal in cone visual pigments. Biochemistry (2004) 1.07
One-step nanocasting synthesis of highly ordered single crystalline indium oxide nanowire arrays from mesostructured frameworks. J Am Chem Soc (2003) 1.06
The action of 11-cis-retinol on cone opsins and intact cone photoreceptors. J Biol Chem (2009) 1.05
Self-adjusted synthesis of ordered stable mesoporous minerals by acid-base pairs. Nat Mater (2003) 1.05
Regeneration of photopigment is enhanced in mouse cone photoreceptors expressing RPE65 protein. J Neurosci (2011) 1.05
Pattern recognition receptor-dependent mechanisms of acute lung injury. Mol Med (2009) 1.04
11-cis- and all-trans-retinols can activate rod opsin: rational design of the visual cycle. Biochemistry (2008) 1.03
Visual cycle retinoid processing proteins are present in HEK293S cells. Vision Res (2003) 1.02
Chromophore switch from 11-cis-dehydroretinal (A2) to 11-cis-retinal (A1) decreases dark noise in salamander red rods. J Physiol (2007) 1.02
Adhesion of malignant mammary tumor cells MDA-MB-231 to microvessel wall increases microvascular permeability via degradation of endothelial surface glycocalyx. J Appl Physiol (1985) (2012) 1.02
Mass spectrometry provides accurate and sensitive quantitation of A2E. Photochem Photobiol Sci (2010) 1.02
Normal cone function requires the interphotoreceptor retinoid binding protein. J Neurosci (2009) 1.01
A population-based study of DNA repair gene variants in relation to non-melanoma skin cancer as a marker of a cancer-prone phenotype. Carcinogenesis (2012) 1.01
Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress. J Biol Chem (2013) 1.00
Palmitoylation stabilizes unliganded rod opsin. Proc Natl Acad Sci U S A (2010) 0.99
Hepatitis E virus genotype 4, Nanjing, China, 2001-2011. Emerg Infect Dis (2013) 0.99
Nonionic block copolymer synthesis of large-pore cubic mesoporous single crystals by use of inorganic salts. J Am Chem Soc (2002) 0.99
Dual role of Ski in pancreatic cancer cells: tumor-promoting versus metastasis-suppressive function. Carcinogenesis (2009) 0.98
Activating transcription factor 4 is critical for proliferation and survival in primary bone marrow stromal cells and calvarial osteoblasts. J Cell Biochem (2008) 0.98
Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65. J Biol Chem (2008) 0.97
Vascular endothelial growth factor enhances cancer cell adhesion to microvascular endothelium in vivo. Exp Physiol (2009) 0.96
Critical role of AKT protein in myeloma-induced osteoclast formation and osteolysis. J Biol Chem (2013) 0.95
Strong superconducting proximity effect in pb-bi(2)te(3) hybrid structures. Sci Rep (2012) 0.95
Cone outer segment morphology and cone function in the Rpe65-/- Nrl-/- mouse retina are amenable to retinoid replacement. Invest Ophthalmol Vis Sci (2009) 0.94
On the adsorption of tetracycline by calcined magnesium-aluminum hydrotalcites. J Environ Qual (2009) 0.94
RPE65 is present in human green/red cones and promotes photopigment regeneration in an in vitro cone cell model. J Neurosci (2011) 0.93
Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry (2009) 0.93
Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion in mice: a role for interleukin 10. Hepatology (2004) 0.92
Dissection of a complex enhancer element: maintenance of keratinocyte specificity but loss of differentiation specificity. Mol Cell Biol (2002) 0.92
Association of Toll-like receptor signaling and reactive oxygen species: a potential therapeutic target for posttrauma acute lung injury. Mediators Inflamm (2010) 0.92
Phosphorylation and glycosylation of bovine lens MP20. Invest Ophthalmol Vis Sci (2005) 0.91
Capecitabine-based chemotherapy for metastatic colorectal cancer. J Cancer Res Clin Oncol (2010) 0.91
Low-level expression of Smad7 correlates with lymph node metastasis and poor prognosis in patients with pancreatic cancer. Ann Surg Oncol (2009) 0.91
Primary adenocarcinoma of the urinary bladder: a single site analysis of 21 cases. Int Urol Nephrol (2012) 0.91
Retinol-binding site in interphotoreceptor retinoid-binding protein (IRBP): a novel hydrophobic cavity. Invest Ophthalmol Vis Sci (2009) 0.91
A general route to diverse mesoporous metal oxide submicrospheres with highly crystalline frameworks. Angew Chem Int Ed Engl (2008) 0.91
Rod outer segment retinol formation is independent of Abca4, arrestin, rhodopsin kinase, and rhodopsin palmitylation. Invest Ophthalmol Vis Sci (2011) 0.91