Published in FASEB J on June 28, 2010
Valsartan Upregulates Kir2.1 in Rats Suffering from Myocardial Infarction via Casein Kinase 2. Cardiovasc Drugs Ther (2015) 2.04
MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation. J Clin Invest (2013) 1.49
Novel molecular targets for atrial fibrillation therapy. Nat Rev Drug Discov (2012) 1.42
Structural bases for the different anti-fibrillatory effects of chloroquine and quinidine. Cardiovasc Res (2011) 0.93
Attraction of rotors to the pulmonary veins in paroxysmal atrial fibrillation: a modeling study. Biophys J (2014) 0.92
Chloroquine terminates stretch-induced atrial fibrillation more effectively than flecainide in the sheep heart. Circ Arrhythm Electrophysiol (2012) 0.87
Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics. Curr Opin Pharmacol (2013) 0.81
Inward rectifiers and their regulation by endogenous polyamines. Front Physiol (2014) 0.79
Mechanisms for Kir channel inhibition by quinacrine: acute pore block of Kir2.x channels and interference in PIP2 interaction with Kir2.x and Kir6.2 channels. Pflugers Arch (2011) 0.79
Mechanisms of atrial fibrillation: rotors, ionic determinants, and excitation frequency. Cardiol Clin (2014) 0.79
Gold nanoparticle-spermidine complex blocks the inward rectifier potassium channel. Am J Cardiovasc Dis (2014) 0.78
NOS1AP modulates intracellular Ca(2+) in cardiac myocytes and is up-regulated in dystrophic cardiomyopathy. Int J Physiol Pathophysiol Pharmacol (2014) 0.78
Molecular mechanisms of chloroquine inhibition of heterologously expressed Kir6.2/SUR2A channels. Mol Pharmacol (2012) 0.76
Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.76
STRUCTURAL AND FUNCTIONAL BASES OF CARDIAC FIBRILLATION. DIFFERENCES AND SIMILARITIES BETWEEN ATRIA AND VENTRICLES. JACC Clin Electrophysiol (2016) 0.75
The Major Role of IK1 in Mechanisms of Rotor Drift in the Atria: A Computational Study. Clin Med Insights Cardiol (2016) 0.75
Electrophysiologic effects of the IK1 inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts. Physiol Rep (2017) 0.75
Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference. Naunyn Schmiedebergs Arch Pharmacol (2017) 0.75
PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. J Biomed Sci (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res (2007) 13.94
Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol Rev (2010) 5.31
A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene. Circ Res (2005) 3.75
Rectification of the background potassium current: a determinant of rotor dynamics in ventricular fibrillation. Circ Res (2001) 3.36
Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nat Neurosci (2005) 3.22
A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation. Biochem Biophys Res Commun (2005) 2.55
Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome). J Clin Invest (2002) 2.48
Activation of inward rectifier potassium channels accelerates atrial fibrillation in humans: evidence for a reentrant mechanism. Circulation (2006) 2.47
Ventricular fibrillation with prominent early repolarization associated with a rare variant of KCNJ8/KATP channel. J Cardiovasc Electrophysiol (2009) 2.20
The influence of geometry, surface character, and flexibility on the permeation of ions and water through biological pores. Phys Biol (2004) 2.13
Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation. Biophys J (2005) 1.96
Phosphoinositide-mediated gating of inwardly rectifying K(+) channels. Pflugers Arch (2007) 1.92
Electrocardiographic features in Andersen-Tawil syndrome patients with KCNJ2 mutations: characteristic T-U-wave patterns predict the KCNJ2 genotype. Circulation (2005) 1.77
Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart. Neuron (2002) 1.69
The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis. Heart Rhythm (2005) 1.69
Up-regulation of the inward rectifier K+ current (I K1) in the mouse heart accelerates and stabilizes rotors. J Physiol (2006) 1.65
Cholinergic atrial fibrillation: I(K,ACh) gradients determine unequal left/right atrial frequencies and rotor dynamics. Cardiovasc Res (2003) 1.54
Nonstationary vortexlike reentrant activity as a mechanism of polymorphic ventricular tachycardia in the isolated rabbit heart. Circulation (1995) 1.52
Blockade of currents by the antimalarial drug chloroquine in feline ventricular myocytes. J Pharmacol Exp Ther (2001) 1.32
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. Proc Natl Acad Sci U S A (2008) 1.30
Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteers. PLoS Clin Trials (2007) 1.28
Human inward rectifier potassium channels in chronic and postoperative atrial fibrillation. Cardiovasc Res (2002) 1.15
Molecular aspects of ATP-sensitive K+ channels in the cardiovascular system and K+ channel openers. Pharmacol Ther (2000) 1.14
Inward rectifier potassium currents as a target for atrial fibrillation therapy. J Cardiovasc Pharmacol (2008) 1.12
Chloroquine and hydroxychloroquine in the treatment of cardiac arrhythmias. N Engl J Med (1958) 1.12
The antimalarial agent mefloquine inhibits ATP-sensitive K-channels. Br J Pharmacol (2000) 1.11
Genetics of cardiac arrhythmias and sudden cardiac death. Ann N Y Acad Sci (2004) 1.11
Long-term effectiveness of antimalarial drugs in rheumatic diseases. Ann Rheum Dis (1998) 1.01
Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions. J Pharmacol Exp Ther (2009) 1.01
Theoretical possibilities for the development of novel antiarrhythmic drugs. Curr Med Chem (2004) 0.99
Functional and clinical characterization of a mutation in KCNJ2 associated with Andersen-Tawil syndrome. J Med Genet (2006) 0.91
Chloroquine blocks the background potassium current in guinea pig atrial myocytes. Naunyn Schmiedebergs Arch Pharmacol (2000) 0.90
Report of the NASPE/NHLBI round table on future research directions in atrial fibrillation. Pacing Clin Electrophysiol (2001) 0.90
Inhibition of HERG potassium channels by the antimalarial agent halofantrine. Br J Pharmacol (2000) 0.89
Mechanism of acceleration of functional reentry in the ventricle: effects of ATP-sensitive potassium channel opener. Circulation (1999) 0.86
Sudden cardiac death in Andersen-Tawil syndrome. Europace (2007) 0.85
Comparative cardiac effects of halofantrine and chloroquine plus chlorpheniramine in children with acute uncomplicated falciparum malaria. Trans R Soc Trop Med Hyg (1999) 0.79
Spectral analysis identifies sites of high-frequency activity maintaining atrial fibrillation in humans. Circulation (2005) 4.75
A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene. Circ Res (2005) 3.75
Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure. Circ Res (2007) 3.51
Prevention of atrial fibrillation: report from a national heart, lung, and blood institute workshop. Circulation (2009) 3.50
Arrhythmogenic mechanisms in a mouse model of catecholaminergic polymorphic ventricular tachycardia. Circ Res (2007) 3.20
Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization. Anal Biochem (2004) 3.02
Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method. Circ Res (2012) 2.91
Real-time dominant frequency mapping and ablation of dominant frequency sites in atrial fibrillation with left-to-right frequency gradients predicts long-term maintenance of sinus rhythm. Heart Rhythm (2008) 2.79
Activation of inward rectifier potassium channels accelerates atrial fibrillation in humans: evidence for a reentrant mechanism. Circulation (2006) 2.47
Mechanisms of wave fractionation at boundaries of high-frequency excitation in the posterior left atrium of the isolated sheep heart during atrial fibrillation. Circulation (2006) 2.30
Mother rotors and fibrillatory conduction: a mechanism of atrial fibrillation. Cardiovasc Res (2002) 2.29
Optical imaging of voltage and calcium in cardiac cells & tissues. Circ Res (2012) 2.19
Rotor meandering contributes to irregularity in electrograms during atrial fibrillation. Heart Rhythm (2008) 2.11
Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation. Biophys J (2005) 1.96
Electrotonic myofibroblast-to-myocyte coupling increases propensity to reentrant arrhythmias in two-dimensional cardiac monolayers. Biophys J (2008) 1.90
SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res (2008) 1.87
Intra-atrial pressure increases rate and organization of waves emanating from the superior pulmonary veins during atrial fibrillation. Circulation (2003) 1.86
Heterogeneous atrial wall thickness and stretch promote scroll waves anchoring during atrial fibrillation. Cardiovasc Res (2012) 1.83
Cardiac fibrillation: from ion channels to rotors in the human heart. Heart Rhythm (2008) 1.82
Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res (2011) 1.82
A unique carbohydrate binding domain targets the lafora disease phosphatase to glycogen. J Biol Chem (2001) 1.78
Epicardial neural ganglionated plexus of ovine heart: anatomic basis for experimental cardiac electrophysiology and nerve protective cardiac surgery. Heart Rhythm (2010) 1.76
Frequency-dependent breakdown of wave propagation into fibrillatory conduction across the pectinate muscle network in the isolated sheep right atrium. Circ Res (2002) 1.74
Blockade of the inward rectifying potassium current terminates ventricular fibrillation in the guinea pig heart. J Cardiovasc Electrophysiol (2003) 1.71
Endoscopic fluorescence mapping of the left atrium: a novel experimental approach for high resolution endocardial mapping in the intact heart. Heart Rhythm (2007) 1.70
Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP. J Am Chem Soc (2007) 1.70
The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis. Heart Rhythm (2005) 1.69
Up-regulation of the inward rectifier K+ current (I K1) in the mouse heart accelerates and stabilizes rotors. J Physiol (2006) 1.65
Immunohistochemical characterization of the intrinsic cardiac neural plexus in whole-mount mouse heart preparations. Heart Rhythm (2011) 1.63
Atrioventricular conduction in mammalian species: hemodynamic and electrical scaling. Heart Rhythm (2005) 1.62
CSAR benchmark exercise of 2010: selection of the protein-ligand complexes. J Chem Inf Model (2011) 1.61
Nerve supply of the human pulmonary veins: an anatomical study. Heart Rhythm (2008) 1.61
Synthesis of voltage-sensitive fluorescence signals from three-dimensional myocardial activation patterns. Biophys J (2003) 1.60
Time- and frequency-domain analyses of atrial fibrillation activation rate: the optical mapping reference. Heart Rhythm (2011) 1.60
Elevated pre-operative serum peptides for collagen I and III synthesis result in post-surgical atrial fibrillation. J Am Coll Cardiol (2012) 1.59
The ionic bases of the action potential in isolated mouse cardiac Purkinje cell. Heart Rhythm (2012) 1.59
Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia. Proc Natl Acad Sci U S A (2012) 1.58
Rotors and the dynamics of cardiac fibrillation. Circ Res (2013) 1.58
Cholinergic atrial fibrillation: I(K,ACh) gradients determine unequal left/right atrial frequencies and rotor dynamics. Cardiovasc Res (2003) 1.54
Mechanisms of fractionated electrograms formation in the posterior left atrium during paroxysmal atrial fibrillation in humans. J Am Coll Cardiol (2011) 1.51
Complex fractionated atrial electrograms: properties of time-domain versus frequency-domain methods. Heart Rhythm (2009) 1.50
Role of conduction velocity restitution and short-term memory in the development of action potential duration alternans in isolated rabbit hearts. Circulation (2008) 1.49
Altered right atrial excitation and propagation in connexin40 knockout mice. Circulation (2005) 1.46
Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome. Mol Cell (2003) 1.46
Inhibition of platelet-derived growth factor-AB signaling prevents electromechanical remodeling of adult atrial myocytes that contact myofibroblasts. Heart Rhythm (2013) 1.45
Nerves projecting from the intrinsic cardiac ganglia of the pulmonary veins modulate sinoatrial node pacemaker function. Cardiovasc Res (2013) 1.44
Adenoviral expression of IKs contributes to wavebreak and fibrillatory conduction in neonatal rat ventricular cardiomyocyte monolayers. Circ Res (2007) 1.44
From mouse to whale: a universal scaling relation for the PR Interval of the electrocardiogram of mammals. Circulation (2004) 1.44
A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther (2013) 1.42
Hydrolytic catalysis and structural stabilization in a designed metalloprotein. Nat Chem (2011) 1.37
Wavebreak formation during ventricular fibrillation in the isolated, regionally ischemic pig heart. Circ Res (2003) 1.35
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. Proc Natl Acad Sci U S A (2008) 1.30
Paroxysmal atrioventricular block: are phase 3 and phase 4 block mechanisms or misnomers? Heart Rhythm (2009) 1.28
Scotty: a web tool for designing RNA-Seq experiments to measure differential gene expression. Bioinformatics (2013) 1.26
Mechanisms of stretch-induced atrial fibrillation in the presence and the absence of adrenocholinergic stimulation: interplay between rotors and focal discharges. Heart Rhythm (2009) 1.24
Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers. Circ Res (2012) 1.24
Atrial septopulmonary bundle of the posterior left atrium provides a substrate for atrial fibrillation initiation in a model of vagally mediated pulmonary vein tachycardia of the structurally normal heart. Circ Arrhythm Electrophysiol (2008) 1.24
Three distinct phases of VF during global ischemia in the isolated blood-perfused pig heart. Am J Physiol Heart Circ Physiol (2007) 1.22
Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes. J Clin Invest (2011) 1.22
KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia. Proc Natl Acad Sci U S A (2013) 1.21
Optical mapping of Langendorff-perfused human hearts: establishing a model for the study of ventricular fibrillation in humans. Am J Physiol Heart Circ Physiol (2007) 1.21
A major role for HERG in determining frequency of reentry in neonatal rat ventricular myocyte monolayer. Circ Res (2010) 1.21
Conformational changes in the M2 muscarinic receptor induced by membrane voltage and agonist binding. J Physiol (2011) 1.21
Identifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coils. Proc Natl Acad Sci U S A (2007) 1.19
CSAR benchmark exercise 2011-2012: evaluation of results from docking and relative ranking of blinded congeneric series. J Chem Inf Model (2013) 1.17
Venice Chart international consensus document on atrial fibrillation ablation: 2011 update. J Cardiovasc Electrophysiol (2012) 1.16
Action potential duration restitution portraits of mammalian ventricular myocytes: role of calcium current. Biophys J (2006) 1.15
RXP-E: a connexin43-binding peptide that prevents action potential propagation block. Circ Res (2008) 1.15
Universal scaling law of electrical turbulence in the mammalian heart. Proc Natl Acad Sci U S A (2007) 1.13
High-resolution x-ray structure and functional analysis of the murine norovirus 1 capsid protein protruding domain. J Virol (2010) 1.13