PubRank

Hirokazu Tamamura

Author PubWeight™ 70.21‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol 2004 4.22
2 Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 2005 2.16
3 Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers. J Biol Chem 2005 2.10
4 CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer. Mol Cancer Ther 2004 1.74
5 CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. Am J Pathol 2007 1.64
6 A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists. J Biol Chem 2002 1.59
7 Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells. J Neurosci Res 2004 1.55
8 Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells. Angew Chem Int Ed Engl 2002 1.42
9 Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients. Cancer Res 2005 1.40
10 Mutations conferring resistance to human immunodeficiency virus type 1 fusion inhibitors are restricted by gp41 and Rev-responsive element functions. J Virol 2005 1.28
11 Development of a 111In-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors. Nucl Med Biol 2006 1.22
12 Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists. J Biol Chem 2003 1.19
13 Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents. Biopolymers 2007 1.10
14 The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury. Cell Mol Immunol 2011 1.05
15 CXCR4 engagement promotes dendritic cell survival and maturation. Biochem Biophys Res Commun 2007 1.04
16 Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds. J Virol 2010 1.01
17 Fluorophore labeling enables imaging and evaluation of specific CXCR4-ligand interaction at the cell membrane for fluorescence-based screening. Bioconjug Chem 2008 0.98
18 Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries. Angew Chem Int Ed Engl 2003 0.97
19 The involvement of stromal derived factor 1alpha in homing and progression of multiple myeloma in the 5TMM model. Haematologica 2006 0.96
20 Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells. J Am Chem Soc 2010 0.95
21 Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity. Bioorg Med Chem Lett 2005 0.95
22 Induction of myogenic differentiation by SDF-1 via CXCR4 and CXCR7 receptors. Muscle Nerve 2010 0.94
23 CD4 mimics targeting the mechanism of HIV entry. Bioorg Med Chem Lett 2009 0.92
24 Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation. Blood 2004 0.92
25 The therapeutic potential of CXCR4 antagonists in the treatment of HIV. Expert Opin Investig Drugs 2003 0.90
26 HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus. Biochem Biophys Res Commun 2004 0.90
27 Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities. J Med Chem 2007 0.90
28 HIV-1 gp120 enhances giant depolarizing potentials via chemokine receptor CXCR4 in neonatal rat hippocampus. Eur J Neurosci 2006 0.89
29 A new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptor. J Med Chem 2009 0.88
30 CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. Bioorg Med Chem Lett 2010 0.87
31 Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation. J Biol Chem 2006 0.86
32 CD4 mimics as HIV entry inhibitors: lead optimization studies of the aromatic substituents. Bioorg Med Chem 2013 0.84
33 HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent protein kinase A signaling in cultured rat microglia. Glia 2011 0.83
34 Peptide HIV-1 integrase inhibitors from HIV-1 gene products. J Med Chem 2010 0.83
35 Small molecular CD4 mimics as HIV entry inhibitors. Bioorg Med Chem 2011 0.83
36 Regio- and stereoselective synthesis of (E)-alkene trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-S(N)2' reactions. J Org Chem 2002 0.82
37 Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs. Antimicrob Agents Chemother 2008 0.82
38 Modulation of network-driven, GABA-mediated giant depolarizing potentials by SDF-1alpha in the developing hippocampus. Dev Neurosci 2007 0.82
39 Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in culture. Arthritis Rheum 2003 0.81
40 Diastereoselective synthesis of new psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type alkene dipeptide isosteres by organocopper reagents and application to conformationally restricted cyclic RGD peptidomimetics. J Org Chem 2002 0.80
41 Diastereoselective synthesis of psi[(E)-CMe=CH]- and psi[(E)-CMe=CMe]- type dipeptide isosteres based on organocopper-mediated anti-S(N)2' reaction. Org Lett 2002 0.80
42 Effects of DNA binding of the zinc finger and linkers for domain fusion on the catalytic activity of sequence-specific chimeric recombinases determined by a facile fluorescent system. Biochemistry 2012 0.80
43 Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells and rat proliferating endothelial cells. Mol Ther 2008 0.80
44 Application of samarium diiodide (SmI2)-induced reduction of gamma-acetoxy-alpha,beta-enoates with alpha-specific kinetic electrophilic trapping for the synthesis of amino acid derivatives. Chem Commun (Camb) 2003 0.79
45 Role of CXCR4 and SDF-1 in mammary tumor metastasis in the cat. J Vet Med Sci 2003 0.79
46 Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids. Org Biomol Chem 2009 0.79
47 Multimerized CHR-derived peptides as HIV-1 fusion inhibitors. Bioorg Med Chem 2013 0.79
48 Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins. Bioorg Med Chem 2012 0.78
49 A synthetic C34 trimer of HIV-1 gp41 shows significant increase in inhibition potency. ChemMedChem 2012 0.78
50 Pharmacophore-based small molecule CXCR4 ligands. Bioorg Med Chem Lett 2012 0.78
51 Low-molecular-weight CXCR4 ligands with variable spacers. ChemMedChem 2012 0.78
52 Synthesis of protein kinase Cdelta C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding. J Pept Sci 2009 0.78
53 Fluorogenically active leucine zipper peptides as tag-probe pairs for protein imaging in living cells. Angew Chem Int Ed Engl 2009 0.78
54 Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation. Chem Commun (Camb) 2004 0.78
55 Azamacrocyclic metal complexes as CXCR4 antagonists. ChemMedChem 2011 0.77
56 Cell-permeable stapled peptides based on HIV-1 integrase inhibitors derived from HIV-1 gene products. ACS Chem Biol 2013 0.77
57 A CD4 mimic as an HIV entry inhibitor: pharmacokinetics. Bioorg Med Chem 2013 0.77
58 SDF-1 controls the muscle and blood vessel formation of the somite. Int J Dev Biol 2016 0.77
59 The successes and failures of HIV drug discovery. Expert Opin Drug Discov 2011 0.77
60 Anti-HIV-1 peptide derivatives based on the HIV-1 Co-receptor CXCR4. ChemMedChem 2013 0.77
61 Retrograde migration of pectoral girdle muscle precursors depends on CXCR4/SDF-1 signaling. Histochem Cell Biol 2014 0.76
62 Generation of a replication-competent simian-human immunodeficiency virus, the neutralization sensitivity of which can be enhanced in the presence of a small-molecule CD4 mimic. J Gen Virol 2013 0.76
63 Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore. Org Biomol Chem 2008 0.76
64 SmI2-mediated reduction of gamma,gamma-difluoro-alpha,beta-enoates with application to the synthesis of functionalized (Z)-fluoroalkene-type dipeptide isosteres. J Org Chem 2004 0.76
65 Remodeling of dynamic structures of HIV-1 envelope proteins leads to synthetic antigen molecules inducing neutralizing antibodies. Bioconjug Chem 2010 0.76
66 Diastereoselective synthesis of psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type dipeptide isosteres by organocopper-mediated anti-S(N)2' reaction. Org Lett 2002 0.76
67 Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies. Bioorg Med Chem 2010 0.75
68 Palladium(0)-Catalyzed Isomerization Reactions of Aziridines Bearing an alpha,beta-Unsaturated Ester Group: A Thermodynamic Preference for Chiral Alkyl (2E)-4,5-cis-4,5-Epimino-N-(alkyl- or arylsulfonyl) 2-Enoates over the Other Three Stereoisomers. J Org Chem 1997 0.75
69 Rapid hematopoietic progenitor mobilization by sulfated colominic acid. Biochem Biophys Res Commun 2007 0.75
70 Photolabile protection for one-pot sequential native chemical ligation. Chembiochem 2005 0.75
71 Fluorescent-responsive synthetic C1b domains of protein kinase Cδ as reporters of specific high-affinity ligand binding. Bioconjug Chem 2010 0.75
72 Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-SN2' reactions and their use in the preparation of low-molecule CXCR4 antagonists. J Org Chem 2006 0.75
73 Development of crosslink-type tag-probe pairs for fluorescent imaging of proteins. Biopolymers 2010 0.75
74 Synthetic caged DAG-lactones for photochemically controlled activation of protein kinase C. Chembiochem 2011 0.75
75 CXCR4-derived synthetic peptides inducing anti-HIV-1 antibodies. Bioorg Med Chem 2013 0.75
76 Trivalent ligands for CXCR4 bearing polyproline linkers show specific recognition for cells with increased CXCR4 expression. Org Biomol Chem 2015 0.75
77 Screening for protein kinase C ligands using fluorescence resonance energy transfer. Chem Pharm Bull (Tokyo) 2014 0.75
78 Intense blue fluorescence in a leucine zipper assembly. Chembiochem 2011 0.75
79 Isostere-based design of 8-azacoumarin-type photolabile protecting groups: a hydrophilicity-increasing strategy for coumarin-4-ylmethyls. Org Lett 2014 0.75
80 [Development of site-specific DNA methylase for epigenetic regulation of gene expression]. Seikagaku 2010 0.75
81 [Peptidomimetic-based medicinal chemistry]. Seikagaku 2010 0.75
82 Peptide-based ligand screening and functional analysis of protein kinase C. Biopolymers 2013 0.75
83 Inhibitory effect of newly developed CXC-chemokine receptor 4 antagonists on the infection with feline immunodeficiency virus. J Vet Med Sci 2009 0.75
84 Fluorescence-quenching screening of protein kinase C ligands with an environmentally sensitive fluorophore. Bioconjug Chem 2011 0.75
85 Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines. Bioorg Med Chem 2012 0.75
86 Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins. Org Biomol Chem 2014 0.75
87 Stereoselective formation of trisubstituted (Z)-chloroalkenes adjacent to a tertiary carbon stereogenic center by organocuprate-mediated reduction/alkylation. Org Lett 2012 0.75