Published in Br J Pharmacol on July 01, 2010
The CatSper channel: a polymodal chemosensor in human sperm. EMBO J (2012) 1.40
Heterogeneous function of ryanodine receptors, but not IP3 receptors, in hamster cremaster muscle feed arteries and arterioles. Am J Physiol Heart Circ Physiol (2011) 0.98
Structural insights into phospholipase C-β function. Mol Pharmacol (2013) 0.92
Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles. J Physiol (2012) 0.92
Direct activation of human phospholipase C by its well known inhibitor u73122. J Biol Chem (2011) 0.85
Chemotaxis of MDCK-F cells toward fibroblast growth factor-2 depends on transient receptor potential canonical channel 1. Pflugers Arch (2010) 0.84
Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11. Front Cardiovasc Med (2015) 0.81
Identification of Leptospira interrogans phospholipase C as a novel virulence factor responsible for intracellular free calcium ion elevation during macrophage death. PLoS One (2013) 0.80
Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells. Oncotarget (2015) 0.80
Excitation-contraction coupling of human induced pluripotent stem cell-derived cardiomyocytes. Front Cell Dev Biol (2015) 0.79
Stimulation of α1a adrenergic receptors induces cellular proliferation or antiproliferative hypertrophy dependent solely on agonist concentration. PLoS One (2013) 0.79
The PI-PLC inhibitor U-73122 is a potent inhibitor of the SERCA pump in smooth muscle. Br J Pharmacol (2010) 0.79
Mechanisms underlying capsaicin effects in canine coronary artery: implications for coronary spasm. Cardiovasc Res (2014) 0.78
Impact of calcium signaling during infection of Neisseria meningitidis to human brain microvascular endothelial cells. PLoS One (2014) 0.76
Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122. Br J Pharmacol (2016) 0.75
Endoplasmic Reticulum-Mitochondrial Ca(2+) Fluxes Underlying Cancer Cell Survival. Front Oncol (2017) 0.75
Pharmacological and Biochemical Characterization of TLQP-21 Activation of a Binding Site on CHO Cells. Front Pharmacol (2017) 0.75
A mathematical model of calcium dynamics in HSY cells. PLoS Comput Biol (2017) 0.75
Regional Heterogeneity in the Mechanisms of Myogenic Tone in Hamster Arterioles. Am J Physiol Heart Circ Physiol (2017) 0.75
The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells. Sci Rep (2017) 0.75
Calcium/calmodulin-dependent kinase 2 (CaMKII) mediates Epac-induced spontaneous transient outward currents (STOCs) in rat vascular smooth muscle. J Physiol (2017) 0.75
Guide to Receptors and Channels (GRAC), 4th Edition. Br J Pharmacol (2009) 8.07
Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J Pharmacol Exp Ther (1990) 3.55
Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J Pharmacol Exp Ther (1990) 2.89
Calcium signalling--an overview. Semin Cell Dev Biol (2001) 2.06
U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells. J Biol Chem (1992) 1.83
The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation. J Biol Chem (1991) 1.55
Intracellular calcium events activated by ATP in murine colonic myocytes. Am J Physiol Cell Physiol (2000) 1.25
U-73122, an aminosteroid phospholipase C antagonist, noncompetitively inhibits thyrotropin-releasing hormone effects in GH3 rat pituitary cells. Endocrinology (1992) 1.20
A role for phospholipase C activity but not ryanodine receptors in the initiation and propagation of intercellular calcium waves. J Cell Sci (1995) 1.13
In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin. J Cell Sci (2005) 1.12
Mitochondrial regulation of the cytosolic Ca2+ concentration and the InsP3-sensitive Ca2+ store in guinea-pig colonic smooth muscle. J Physiol (1999) 1.04
In vivo activity of a phospholipase C inhibitor, 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions. J Pharmacol Exp Ther (2004) 1.03
Two distinct signaling pathways for regulation of spontaneous local Ca2+ release by phospholipase C in airway smooth muscle cells. Pflugers Arch (2006) 1.03
Ca2+ microdomains in smooth muscle. Cell Calcium (2006) 1.02
Differential Expression of Markers and Activities in a Group of PC12 Nerve Cell Clones. Eur J Neurosci (1992) 1.01
Effect of the aminosteroid, U73122, on Ca2+ uptake and release properties of rat liver microsomes. Eur J Biochem (1995) 1.01
Single cell analysis and temporal profiling of agonist-mediated inositol 1,4,5-trisphosphate, Ca2+, diacylglycerol, and protein kinase C signaling using fluorescent biosensors. J Biol Chem (2005) 0.98
A single luminally continuous sarcoplasmic reticulum with apparently separate Ca2+ stores in smooth muscle. J Biol Chem (2007) 0.98
Ca2+ signalling mechanisms of the beta 2 integrin on neutrophils: involvement of phospholipase C gamma 2 and Ins(1,4,5)P3. Biochem J (1996) 0.97
Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow. Biochem Pharmacol (1995) 0.92
Evidence for separate effects of U73122 on phospholipase C and calcium channels in human platelets. Biochem Pharmacol (1998) 0.89
The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J Pharmacol Exp Ther (1997) 0.89
The sarcoplasmic reticulum and sarcolemma together form a passive Ca2+ trap in colonic smooth muscle. Cell Calcium (2004) 0.87
FK506-binding protein (FKBP12) regulates ryanodine receptor-evoked Ca2+ release in colonic but not aortic smooth muscle. Cell Calcium (2007) 0.86
Effects of U73122 and U73343 on human platelet calcium signalling and protein tyrosine phosphorylation. Biochim Biophys Acta (1997) 0.84
Phospholipase C mediated Ca2+ signals in murine urinary bladder smooth muscle. Eur J Pharmacol (2009) 0.82
Calcium homeostasis in mouse fibroblast cells: affected by U-73122, a putative phospholipase C beta blocker, via multiple mechanisms. Br J Pharmacol (1995) 0.81
Ca(2+) regulation in guinea-pig colonic smooth muscle: the role of the Na(+)-Ca(2+) exchanger and the sarcoplasmic reticulum. J Physiol (2002) 0.81
Activation of P2Y receptors by ATP and by its analogue, ADPbetaS, triggers two calcium signal pathways in the longitudinal muscle of mouse distal colon. Eur J Pharmacol (2008) 0.80
U-73122 does not specifically inhibit phospholipase C in rat pancreatic islets and insulin-secreting beta-cell lines. Life Sci (1994) 0.77
Inward rectifier K+ currents in smooth muscle cells from rat resistance-sized cerebral arteries. Am J Physiol (1993) 1.80
Single calcium channels in resistance-sized cerebral arteries from rats. Am J Physiol (1993) 1.20
Depolarization-evoked increases in cytosolic calcium concentration in isolated smooth muscle cells of rat portal vein. J Physiol (1996) 1.20
The temporal profile of calcium transients in voltage clamped gastric myocytes from Bufo marinus. J Physiol (1996) 1.09
Functionally separate intracellular Ca2+ stores in smooth muscle. J Biol Chem (2001) 0.98
Regulation by FK506 and rapamycin of Ca2+ release from the sarcoplasmic reticulum in vascular smooth muscle: the role of FK506 binding proteins and mTOR. Br J Pharmacol (2009) 0.95
Regulation of the cytosolic Ca2+ concentration by Ca2+ stores in single smooth muscle cells from rat cerebral arteries. J Physiol (1997) 0.92
Ca2+ removal mechanisms in rat cerebral resistance size arteries. Biophys J (1998) 0.84
Release of [3H]-noradrenaline from the sympathetic nerves to bovine mesenteric lymphatic vessels and its modification by alpha-agonists and antagonists. Br J Pharmacol (1988) 0.84
Calcium-calmodulin-dependent mechanisms accelerate calcium decay in gastric myocytes from Bufo marinus. J Physiol (1998) 0.79
Transient excitatory responses to sustained stimulation of intramural nerves in isolated bovine lymphatic vessels. Q J Exp Physiol (1988) 0.78
Beta-adrenoceptor-mediated facilitation of [3H]-noradrenaline release from the intramural nerves of bovine mesenteric lymphatic vessels. Br J Pharmacol (1989) 0.78
Striatal neurones show sustained recovery from severe hypoglycaemic insult. J Neurochem (2003) 0.78
ATP inhibits Ins(1,4,5)P3-evoked Ca2+ release in smooth muscle via P2Y1 receptors. J Cell Sci (2012) 0.76