Published in Toxicology on June 30, 2010
Low-dose memantine attenuated morphine addictive behavior through its anti-inflammation and neurotrophic effects in rats. J Neuroimmune Pharmacol (2011) 0.87
Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis. Med Sci Monit Basic Res (2015) 0.79
Heroin-related overdose: The unexplored influences of markets, marketing and source-types in the United States. Soc Sci Med (2015) 0.78
Toxic effects of xylazine on endothelial cells in combination with cocaine and 6-monoacetylmorphine. Toxicol In Vitro (2014) 0.76
Xylazine as a drug of abuse and its effects on the generation of reactive species and DNA damage on human umbilical vein endothelial cells. J Toxicol (2014) 0.75
Changes in apoptotic factors in hypothalamus and hippocampus after acute and subchronic stress induction during conditioned place preference paradigm. EXCLI J (2013) 0.75
S-Glutathionylation and Redox Protein Signaling in Drug Addiction. Prog Mol Biol Transl Sci (2015) 0.75
Is biological aging accelerated in drug addiction? Curr Opin Behav Sci (2017) 0.75
Differential alterations of intracellular [Ca(2+)] dynamics induced by cocaine and methylphenidate in thalamocortical ventrobasal neurons. Transl Brain Rhythm (2017) 0.75
Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity. J Neurochem (2004) 1.58
Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness? Exp Neurol (2012) 1.50
Unaltered hepatic oxidative phosphorylation and mitochondrial permeability transition in wistar rats treated with nimesulide: Relevance for nimesulide toxicity characterization. J Biochem Mol Toxicol (2007) 1.39
Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases. Neurochem Res (2003) 1.34
Insulin in central nervous system: more than just a peripheral hormone. J Aging Res (2012) 1.33
Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice. J Neurochem (2007) 1.32
Anticancer activity of phenolic acids of natural or synthetic origin: a structure-activity study. J Med Chem (2003) 1.31
Cytochrome c oxidase is decreased in Alzheimer's disease platelets. Neurobiol Aging (2004) 1.30
Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. J Neurosci (2005) 1.29
Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway. J Neurosci (2009) 1.23
Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors. J Neurosci (2006) 1.19
Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures. J Neurosci (2005) 1.19
Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers Dis (2007) 1.19
Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol (2007) 1.18
An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity. Neurobiol Dis (2006) 1.17
CXCL12/CXCR4 promotes motility and proliferation of glioma cells. Cancer Biol Ther (2010) 1.17
Alzheimer disease and the role of free radicals in the pathogenesis of the disease. CNS Neurol Disord Drug Targets (2008) 1.15
Chromone: a valid scaffold in medicinal chemistry. Chem Rev (2014) 1.15
Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors. Eur J Med Chem (2012) 1.14
Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy (2007) 1.14
Synthesis and cytotoxic profile of 3,4-methylenedioxymethamphetamine ("ecstasy") and its metabolites on undifferentiated PC12 cells: A putative structure-toxicity relationship. Chem Res Toxicol (2006) 1.13
Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum. J Neurochem (2005) 1.11
Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs. Brain Res Rev (2008) 1.11
Metformin promotes isolated rat liver mitochondria impairment. Mol Cell Biochem (2007) 1.10
The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiol Dis (2008) 1.09
An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease. J Alzheimers Dis (2009) 1.08
Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets. Cell Biol Toxicol (2008) 1.08
Oxidative stress involvement in alpha-synuclein oligomerization in Parkinson's disease cybrids. Antioxid Redox Signal (2009) 1.08
8-Substituted 3-arylcoumarins as potent and selective MAO-B inhibitors: synthesis, pharmacological evaluation, and docking studies. ChemMedChem (2012) 1.08
Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background. Mitochondrion (2008) 1.07
Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes. J Neurol Sci (2007) 1.07
Effect of amyloid beta-peptide on permeability transition pore: a comparative study. J Neurosci Res (2002) 1.07
Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview. Mini Rev Med Chem (2008) 1.07
Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats. Eur J Neurosci (2003) 1.06
Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine. Brain Res (2006) 1.05
Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure. J Biol Chem (2006) 1.05
Methamphetamine-induced early increase of IL-6 and TNF-alpha mRNA expression in the mouse brain. Ann N Y Acad Sci (2008) 1.04
Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress. Diabetes (2006) 1.04
Overactivation of calcineurin induced by amyloid-beta and prion proteins. Neurochem Int (2008) 1.04
Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation. Brain Res (2012) 1.04
Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin. Eur J Neurosci (2010) 1.03
Cholesterol and statins in Alzheimer's disease: current controversies. Exp Neurol (2009) 1.03
Alzheimer's disease: a lesson from mitochondrial dysfunction. Antioxid Redox Signal (2007) 1.02
Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes. Med Chem (2008) 1.01
Discovery of novel A3 adenosine receptor ligands based on chromone scaffold. Biochem Pharmacol (2012) 0.99
Blood oxidative stress markers in non-alcoholic steatohepatitis and how it correlates with diet. Scand J Gastroenterol (2008) 0.99
Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: role of tight junction proteins and matrix metalloproteinase-9. Brain Res (2011) 0.99
Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis. Free Radic Biol Med (2003) 0.99
Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radic Biol Med (2005) 0.98
Increased vulnerability of brain mitochondria in diabetic (Goto-Kakizaki) rats with aging and amyloid-beta exposure. Diabetes (2003) 0.98
Lipophilic phenolic antioxidants: correlation between antioxidant profile, partition coefficients and redox properties. Bioorg Med Chem (2010) 0.98
Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-beta peptide. J Neurosci Res (2004) 0.98
Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria. Brain Res (2002) 0.98
Structure-property studies on the antioxidant activity of flavonoids present in diet. Free Radic Biol Med (2005) 0.97
Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons. Neurobiol Dis (2007) 0.97
Hydroxycinnamic acid antioxidants: an electrochemical overview. Biomed Res Int (2013) 0.97
Dysfunctional mitochondria uphold calpain activation: contribution to Parkinson's disease pathology. Neurobiol Dis (2009) 0.97
Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: relevance to Parkinson's disease. Neurochem Int (2009) 0.96
Epigenetics in neurodegeneration: a new layer of complexity. Prog Neuropsychopharmacol Biol Psychiatry (2010) 0.96
Subcellular localization of adenosine A(1) receptors in nerve terminals and synapses of the rat hippocampus. Brain Res (2003) 0.96
The R6 lines of transgenic mice: a model for screening new therapies for Huntington's disease. Brain Res Rev (2008) 0.96
Dysfunctional synapse in Alzheimer's disease - A focus on NMDA receptors. Neuropharmacology (2013) 0.95
Adenosine A3 receptors are located in neurons of the rat hippocampus. Neuroreport (2003) 0.95
New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors. Bioorg Med Chem Lett (2010) 0.95
FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures. Neurobiol Dis (2004) 0.94
Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B. Bioorg Med Chem Lett (2010) 0.94
Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5. Aging Cell (2009) 0.94
Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-beta and prion peptides. Cell Cycle (2009) 0.94
Natural/random protein classification models based on star network topological indices. J Theor Biol (2008) 0.93
Oxidative stress: the old enemy in Alzheimer's disease pathophysiology. Curr Alzheimer Res (2005) 0.93
Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers. Aging Cell (2012) 0.93
Lack of evidence for functional TRPV1 vanilloid receptors in rat hippocampal nerve terminals. Neurosci Lett (2006) 0.93
Effects of estrogen in the brain: is it a neuroprotective agent in Alzheimer's disease? Curr Aging Sci (2010) 0.93
4-Oxo-N-phenyl-4H-chromene-2-carboxamide and of a new polymorph of 7-methoxy-4-oxo-N-p-tolyl-4H-chromene-2-carboxamide and its hemihydrate. Acta Crystallogr C (2013) 0.92
Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies. Cell Mol Neurobiol (2007) 0.92
Mitochondrial-associated metabolic changes and neurodegeneration in Huntington's disease - from clinical features to the bench. Curr Drug Targets (2010) 0.92
Microtubule depolymerization potentiates alpha-synuclein oligomerization. Front Aging Neurosci (2010) 0.92
Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex. Epilepsia (2005) 0.92
Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using rat and human renal proximal tubular cells. Arch Toxicol (2002) 0.92
Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons. J Neurochem (2007) 0.92
Insulin is a two-edged knife on the brain. J Alzheimers Dis (2009) 0.92
Lipophilic caffeic and ferulic acid derivatives presenting cytotoxicity against human breast cancer cells. Chem Res Toxicol (2011) 0.92
Antioxidant profile of dihydroxy- and trihydroxyphenolic acids--a structure-activity relationship study. Free Radic Res (2006) 0.92
Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3beta signaling pathways and changes in protein expression. Biochim Biophys Acta (2008) 0.91