PubRank

Mara Dierssen

Author PubWeight™ 49.85‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice. Mol Cell Biol 2002 2.51
2 Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway. Genes Dev 2008 1.73
3 Cognitive deficits and associated neurological complications in individuals with Down's syndrome. Lancet Neurol 2010 1.61
4 Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes. Neuron 2013 1.34
5 Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system. Brain Res 2003 1.25
6 uPA deficiency exacerbates muscular dystrophy in MDX mice. J Cell Biol 2007 1.22
7 A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. Hum Mol Genet 2009 1.20
8 Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behav Brain Res 2002 1.17
9 Targeting the endocannabinoid system in the treatment of fragile X syndrome. Nat Med 2013 1.16
10 Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Neurobiol Dis 2005 1.16
11 Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans. Mol Nutr Food Res 2013 1.15
12 Down syndrome: from understanding the neurobiology to therapy. J Neurosci 2010 1.13
13 Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A). PLoS One 2008 1.10
14 Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder. Neuropsychopharmacology 2011 1.08
15 Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice. Proc Natl Acad Sci U S A 2012 1.06
16 Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome. Brain Res 2004 1.06
17 RhoE deficiency produces postnatal lethality, profound motor deficits and neurodevelopmental delay in mice. PLoS One 2011 1.05
18 Proteomic analysis of the fetal brain. Proteomics 2002 1.00
19 An animal model of compulsive food-taking behaviour. Addict Biol 2009 0.99
20 Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. J Biol Chem 2012 0.96
21 Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects. Amino Acids 2011 0.96
22 Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A. Neurobiol Dis 2013 0.91
23 DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. Brain 2013 0.91
24 Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease. Neurobiol Dis 2009 0.90
25 Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice. Neurobiol Dis 2009 0.90
26 Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 2012 0.87
27 Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development. Pediatrics 2007 0.87
28 Dissociation between CA3-CA1 synaptic plasticity and associative learning in TgNTRK3 transgenic mice. J Neurosci 2007 0.87
29 Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome. Am J Hum Genet 2008 0.86
30 Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. Hum Mol Genet 2008 0.85
31 Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations. Neurobiol Dis 2010 0.84
32 NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. PLoS One 2013 0.83
33 Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. Alcohol 2012 0.83
34 Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model. J Neurosci 2013 0.82
35 A gel-based proteomic method reveals several protein pathway abnormalities in fetal Down syndrome brain. J Proteomics 2011 0.82
36 Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future. Prog Brain Res 2012 0.81
37 In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model. Amino Acids 2010 0.80
38 Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity. Behav Brain Res 2013 0.79
39 AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway. J Neurochem 2013 0.79
40 DREAM controls the on/off switch of specific activity-dependent transcription pathways. Mol Cell Biol 2013 0.79
41 Long-chain polyunsaturated fatty acids in rat maternal milk, offspring brain and peripheral tissues in essential fatty acid deficiency. Clin Chem Lab Med 2002 0.79
42 Overexpression of α3/α5/β4 nicotinic receptor subunits modifies impulsive-like behavior. Drug Alcohol Depend 2011 0.79
43 Aberrant brain microRNA target and miRISC gene expression in the anx/anx anorexia mouse model. Gene 2012 0.78
44 Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome. PLoS One 2013 0.78
45 Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease. Curr Drug Targets 2017 0.78
46 Insights from mouse models to understand neurodegeneration in Down syndrome. CNS Neurol Disord Drug Targets 2010 0.78
47 Functional implications of hippocampal adult neurogenesis in intellectual disabilities. Amino Acids 2013 0.77
48 Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model. Physiol Genomics 2008 0.77
49 Special interest section--Down's syndrome: postgenomic approaches to neurobiological problems. Genes Brain Behav 2003 0.76
50 Susceptibility to stress in transgenic mice overexpressing TrkC, a model of panic disorder. J Psychiatr Res 2009 0.75
51 Increased opioid dependence in a mouse model of panic disorder. Front Behav Neurosci 2010 0.75
52 Preface. Prog Brain Res 2012 0.75
53 A cluster of protein kinases and phosphatases modulated in fetal Down syndrome (trisomy 21) brain. Amino Acids 2015 0.75