Published in Mol Cancer on July 13, 2010
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci (2012) 4.96
Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis (2013) 3.07
A novel microfluidic platform for high-resolution imaging of a three-dimensional cell culture under a controlled hypoxic environment. Lab Chip (2012) 1.12
Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation. Cell Death Dis (2013) 1.00
Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc Natl Acad Sci U S A (2015) 0.96
TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells. BMC Cancer (2012) 0.96
The fate of chemoresistance in triple negative breast cancer (TNBC). BBA Clin (2015) 0.94
Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types. PLoS One (2012) 0.86
Understanding the colon cancer stem cells and perspectives on treatment. Cancer Cell Int (2015) 0.86
Cobalt chloride decreases fibroblast growth factor-21 expression dependent on oxidative stress but not hypoxia-inducible factor in Caco-2 cells. Toxicol Appl Pharmacol (2012) 0.84
Silencing of Apoptosis-Inducing factor and poly(ADP-ribose) glycohydrolase reveals novel roles in breast cancer cell death after chemotherapy. Mol Cancer (2012) 0.83
Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells. PLoS One (2016) 0.80
Effects of melatonin on HIF-1α and VEGF expression and on the invasive properties of hepatocarcinoma cells. Oncol Lett (2016) 0.80
Hypoxia/HIF1α induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2. Oncotarget (2015) 0.80
Anti-proliferation and anti-invasion effects of diosgenin on gastric cancer BGC-823 cells with HIF-1α shRNAs. Int J Mol Sci (2012) 0.80
Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer. Breast Cancer Res (2014) 0.79
Valproic acid overcomes hypoxia-induced resistance to apoptosis. Oncol Rep (2011) 0.78
Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy. Int J Mol Sci (2015) 0.77
Antiapoptotic Effects of EGb 761. Evid Based Complement Alternat Med (2013) 0.77
Association of Pretreatment Anemia with Pathological Response and Survival of Breast Cancer Patients Treated with Neoadjuvant Chemotherapy: A Population-Based Study. PLoS One (2015) 0.76
Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF‑2α expression in lung cancer cells under normoxia and hypoxia. Oncol Rep (2015) 0.76
Lead Phytochemicals for Anticancer Drug Development. Front Plant Sci (2016) 0.75
Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia. Sci Rep (2016) 0.75
Contextual Refinement of Regulatory Targets Reveals Effects on Breast Cancer Prognosis of the Regulome. PLoS Comput Biol (2017) 0.75
Oxygen-carbon nanotubes as a chemotherapy sensitizer for paclitaxel in breast cancer treatment. PLoS One (2014) 0.75
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A (1995) 24.77
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (2001) 22.06
Hypoxia--a key regulatory factor in tumour growth. Nat Rev Cancer (2002) 20.51
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (1998) 9.56
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst (2001) 8.57
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem (2008) 7.71
Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst (2007) 7.10
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev (2002) 7.08
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res (1998) 5.86
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci U S A (2000) 4.50
Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev (2007) 4.46
Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res (1991) 4.12
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res (2002) 3.75
Apo2L/TRAIL and its death and decoy receptors. Cell Death Differ (2003) 3.66
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res (2001) 3.27
The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res (1999) 2.91
Hypoxia and cancer. J Mol Med (Berl) (2007) 2.89
Hypoxia-responsive transcription factors. Pflugers Arch (2005) 2.64
Mcl-1 is a potential therapeutic target in multiple types of cancer. Cell Mol Life Sci (2009) 2.31
Paclitaxel-induced cell death: where the cell cycle and apoptosis come together. Cancer (2000) 2.29
Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha. J Biol Chem (1999) 2.28
Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat Rev (2003) 2.25
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J Biol Chem (1998) 2.23
Role of hypoxia in the hallmarks of human cancer. J Cell Biochem (2009) 2.20
Hypoxia and drug resistance. Cancer Metastasis Rev (1994) 2.18
Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment. Cancer Metastasis Rev (2007) 2.15
Mcl-1. Int J Biochem Cell Biol (2005) 1.96
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci U S A (2009) 1.95
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol (2004) 1.77
Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine. Clin Cancer Res (2004) 1.68
Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene. Cancer Chemother Pharmacol (2006) 1.67
Tumour hypoxia affects the responsiveness of cancer cells to chemotherapy and promotes cancer progression. Anticancer Agents Med Chem (2008) 1.60
Is HIF-1alpha a pro- or an anti-apoptotic protein? Biochem Pharmacol (2002) 1.50
Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancer. Cancer Sci (2007) 1.48
Modulation of death receptors by cancer therapeutic agents. Cancer Biol Ther (2007) 1.41
Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J Biol Chem (2001) 1.39
Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis. J Biol Chem (2004) 1.31
Effects of hypoxia on tumor metabolism. Cancer Metastasis Rev (2007) 1.25
Mitochondrial autophagy: life and breath of the cell. Autophagy (2008) 1.13
Efficacy of cytotoxic agents used in the treatment of testicular germ cell tumours under normoxic and hypoxic conditions in vitro. Br J Cancer (2003) 1.12
Regulation of gene expression by hypoxia: integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element. Clin Chim Acta (2008) 1.10
Role of Jun and Jun kinase in resistance of cancer cells to therapy. Drug Resist Updat (2003) 1.09
Current options in treatment of anthracycline-resistant breast cancer. Cancer Treat Rev (1999) 1.04
Chronic hypoxia promotes hypoxia-inducible factor-1alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells. Mol Cancer Ther (2006) 1.03
Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity. Mol Cancer (2008) 1.01
Tumor hypoxia, drug resistance, and metastases. J Natl Cancer Inst (1990) 1.00
Transcriptional regulation by transforming growth factor beta of the expression of retinoic acid and retinoid X receptor genes in osteoblastic cells is mediated through AP-1. J Biol Chem (1996) 1.00
Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts. J Biol Chem (2001) 0.99
Knockdown of hypoxia-inducible factor-1alpha in breast carcinoma MCF-7 cells results in reduced tumor growth and increased sensitivity to methotrexate. Biochem Biophys Res Commun (2006) 0.97
Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway. Exp Cell Res (2006) 0.97
Efficient TRAIL-R1/DR4-mediated apoptosis in melanoma cells by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Invest Dermatol (2005) 0.96
Antiapoptotic action of hypoxia-inducible factor-1 alpha in human endothelial cells. Lab Invest (2004) 0.96
Differential effects of hypoxia on etoposide-induced apoptosis according to the cancer cell lines. Mol Cancer (2007) 0.94
Effect of hypoxia-inducible factor-1alpha silencing on the sensitivity of human brain glioma cells to doxorubicin and etoposide. Neurochem Res (2008) 0.93
HIF-1alpha has an anti-apoptotic effect in human airway epithelium that is mediated via Mcl-1 gene expression. J Cell Biochem (2006) 0.89
Can gene therapy overcome the problem of hypoxia in radiotherapy? J Radiat Res (2000) 0.87
Sequence effect of epirubicin and paclitaxel treatment on pharmacokinetics and toxicity. J Clin Oncol (2000) 0.87
TOP2A and HER2 gene amplification as predictors of response to anthracycline treatment in breast cancer. Acta Oncol (2006) 0.86
Epirubicin HCl toxicity in human-liver derived hepatoma G2 cells. Pol J Pharmacol (2004) 0.83
Death receptor 4 (DR4) efficiently kills breast cancer cells irrespective of their sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Cancer Gene Ther (2004) 0.80
Paclitaxel: epirubicin in metastatic breast cancer--a review. Ann Oncol (2001) 0.80
Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest. Biochem Pharmacol (2006) 0.80
Hypoxia-mediated fenretinide (4-HPR) resistance in childhood acute lymphoblastic leukemia cells. Cancer Chemother Pharmacol (2006) 0.78
Employing tumor hypoxia for oncolytic therapy in breast cancer. J Mammary Gland Biol Neoplasia (2005) 0.77
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site. Arterioscler Thromb Vasc Biol (2007) 3.02
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis. Cancer Res (2011) 2.96
A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans. Science (2008) 2.33
Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells. J Biol Chem (2003) 2.00
CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2. Ann N Y Acad Sci (2002) 1.69
Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies. Cancer Res (2006) 1.62
Tumour hypoxia affects the responsiveness of cancer cells to chemotherapy and promotes cancer progression. Anticancer Agents Med Chem (2008) 1.60
Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner. Mol Cell Biol (2007) 1.54
Autophagy as a mediator of chemotherapy-induced cell death in cancer. Biochem Pharmacol (2011) 1.53
The importance of catch-up growth after early malnutrition for the programming of obesity in male rat. Obesity (Silver Spring) (2006) 1.53
Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. PLoS One (2012) 1.53
Molecular aspects of cancer cell resistance to chemotherapy. Biochem Pharmacol (2013) 1.50
The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity. Proc Natl Acad Sci U S A (2008) 1.50
Is HIF-1alpha a pro- or an anti-apoptotic protein? Biochem Pharmacol (2002) 1.50
Evaluation of three-dimensional gel electrophoresis to improve quantitative profiling of complex proteomes. Proteomics (2013) 1.42
Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity. J Biol Chem (2003) 1.39
Endothelial von Willebrand factor recruits platelets to atherosclerosis-prone sites in response to hypercholesterolemia. Blood (2002) 1.33
Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations. Am J Pathol (2009) 1.33
Hypoxia-inducible factor-1-dependent overexpression of myeloid cell factor-1 protects hypoxic cells against tert-butyl hydroperoxide-induced apoptosis. J Biol Chem (2004) 1.31
Recruitment of P-TEFb (Cdk9-Pch1) to chromatin by the cap-methyl transferase Pcm1 in fission yeast. EMBO J (2007) 1.23
Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression. J Biol Chem (2009) 1.21
Regulation of gene expression by oxygen: NF-kappaB and HIF-1, two extremes. Free Radic Biol Med (2002) 1.20
Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1. Exp Cell Res (2004) 1.13
Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth. Biochim Biophys Acta (2008) 1.11
Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: role of fatty acid beta-oxidation and glucose. J Lipid Res (2005) 1.09
CREB activation induced by mitochondrial dysfunction triggers triglyceride accumulation in 3T3-L1 preadipocytes. J Cell Sci (2006) 1.08
Microarray analyses of the effects of NF-kappaB or PI3K pathway inhibitors on the LPS-induced gene expression profile in RAW264.7 cells: synergistic effects of rapamycin on LPS-induced MMP9-overexpression. Cell Signal (2009) 1.07
Global analysis of quorum sensing targets in the intracellular pathogen Brucella melitensis 16 M. J Proteome Res (2010) 1.02
Role of ERK and calcium in the hypoxia-induced activation of HIF-1. J Cell Physiol (2003) 1.02
Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity. Mol Cancer (2008) 1.01
Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions. FEBS J (2007) 0.99
Functional and morphological impact of ER stress on mitochondria. J Cell Physiol (2013) 0.97
Role for casein kinase 2 in the regulation of HIF-1 activity. Int J Cancer (2005) 0.97
Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway. Exp Cell Res (2006) 0.97
Role of TGF-beta1-independent changes in protein neosynthesis, p38alphaMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis. Free Radic Biol Med (2008) 0.96
TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells. BMC Cancer (2012) 0.96
Impact of ageing on proteasome structure and function in human lymphocytes. Int J Biochem Cell Biol (2003) 0.95
The role of hypoxia-inducible factor 1α in determining the properties of castrate-resistant prostate cancers. PLoS One (2013) 0.94
Differential effects of hypoxia on etoposide-induced apoptosis according to the cancer cell lines. Mol Cancer (2007) 0.94
Site-directed mutagenesis studies of the hypoxia-inducible factor-1alpha DNA-binding domain. Biochim Biophys Acta (2002) 0.94
Meta-analysis of archived DNA microarrays identifies genes regulated by hypoxia and involved in a metastatic phenotype in cancer cells. BMC Cancer (2010) 0.93
Assessment of some tools for the characterization of the human osteoarthritic cartilage proteome. J Biomol Tech (2005) 0.93
The proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells. J Proteome Res (2009) 0.93
Kinases as upstream regulators of the HIF system: their emerging potential as anti-cancer drug targets. Curr Pharm Des (2009) 0.91
Hypoxia-induced decrease in p53 protein level and increase in c-jun DNA binding activity results in cancer cell resistance to etoposide. Neoplasia (2009) 0.91
Anti-cancer activities of pH- or heat-modified pectin. Front Pharmacol (2013) 0.90
Identification of 30 protein species involved in replicative senescence and stress-induced premature senescence. FEBS Lett (2002) 0.89
Mitochondrial biogenesis in mtDNA-depleted cells involves a Ca2+-dependent pathway and a reduced mitochondrial protein import. FEBS J (2005) 0.89
Intermittent hypoxia is an angiogenic inducer for endothelial cells: role of HIF-1. Angiogenesis (2009) 0.89
Upregulation of pentraxin-3 in human endothelial cells after lysophosphatidic acid exposure. Arterioscler Thromb Vasc Biol (2007) 0.89
Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level. J Cell Sci (2006) 0.89
Intermittent hypoxia changes HIF-1alpha phosphorylation pattern in endothelial cells: unravelling of a new PKA-dependent regulation of HIF-1alpha. Biochim Biophys Acta (2007) 0.88
Up-regulation of 94-kDa glucose-regulated protein by hypoxia-inducible factor-1 in human endothelial cells in response to hypoxia. FEBS Lett (2005) 0.88
Mitochondria permeability transition-dependent tert-butyl hydroperoxide-induced apoptosis in hepatoma HepG2 cells. Biochem Pharmacol (2004) 0.88
Proteomic profiling of human keratinocytes undergoing UVB-induced alternative differentiation reveals TRIpartite Motif Protein 29 as a survival factor. PLoS One (2010) 0.88
Mild mitochondrial uncoupling induces 3T3-L1 adipocyte de-differentiation by a PPARgamma-independent mechanism, whereas TNFalpha-induced de-differentiation is PPARgamma dependent. J Cell Sci (2008) 0.87
Antibody-functionalized nanoparticles for imaging cancer: influence of conjugation to gold nanoparticles on the biodistribution of 89Zr-labeled cetuximab in mice. Contrast Media Mol Imaging (2013) 0.87
Low-LET proton irradiation of A549 non-small cell lung adenocarcinoma cells: dose response and RBE determination. Radiat Res (2013) 0.87
Copper and myeloperoxidase-modified LDLs activate Nrf2 through different pathways of ROS production in macrophages. Antioxid Redox Signal (2010) 0.87
Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types. PLoS One (2012) 0.86
Differential protein expression profiles in anterior gills of Eriocheir sinensis during acclimation to cadmium. Aquat Toxicol (2005) 0.85
Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif. PLoS One (2012) 0.85
The peroxynitrite donor 3-morpholinosydnonimine activates Nrf2 and the UPR leading to a cytoprotective response in endothelial cells. Cell Signal (2011) 0.85
Phosphate starvation triggers production and secretion of an extracellular lipoprotein in Caulobacter crescentus. PLoS One (2010) 0.85
ERK and calcium in activation of HIF-1. Ann N Y Acad Sci (2002) 0.85
Hybrid shell engineering of animal cells for immune protections and regulation of drug delivery: towards the design of "artificial organs". PLoS One (2011) 0.85
High TMEM45A expression is correlated to epidermal keratinization. Exp Dermatol (2014) 0.85
BNIP3 protects HepG2 cells against etoposide-induced cell death under hypoxia by an autophagy-independent pathway. Biochem Pharmacol (2010) 0.84
Protein expression profiling in the African clawed frog Xenopus laevis tadpoles exposed to the polychlorinated biphenyl mixture aroclor 1254. Mol Cell Proteomics (2008) 0.84
Effects of the dual TP receptor antagonist and thromboxane synthase inhibitor EV-077 on human endothelial and vascular smooth muscle cells. Biochem Biophys Res Commun (2013) 0.84
Proteomic response to sublethal cadmium exposure in a sentinel fish species, Cottus gobio. J Proteome Res (2010) 0.84