Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Dickkopf-1 is a master regulator of joint remodeling.
|
Nat Med
|
2007
|
7.29
|
2
|
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.
|
J Bone Miner Res
|
2008
|
4.82
|
3
|
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL.
|
J Bone Miner Res
|
2009
|
2.51
|
4
|
Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice.
|
Circulation
|
2008
|
2.44
|
5
|
Rapid skeletal turnover in a radiographic mimic of osteopetrosis.
|
J Bone Miner Res
|
2014
|
2.00
|
6
|
Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.
|
Bone
|
2011
|
1.96
|
7
|
Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women.
|
J Clin Endocrinol Metab
|
2010
|
1.87
|
8
|
Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production.
|
Blood
|
2002
|
1.84
|
9
|
Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones.
|
J Bone Miner Res
|
2011
|
1.70
|
10
|
Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats.
|
J Bone Miner Res
|
2010
|
1.65
|
11
|
Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis.
|
Clin Exp Metastasis
|
2007
|
1.42
|
12
|
Tumor cyclooxygenase 2-dependent suppression of dendritic cell function.
|
Clin Cancer Res
|
2003
|
1.33
|
13
|
Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading.
|
J Bone Miner Res
|
2013
|
1.29
|
14
|
Prevention of glucocorticoid-induced bone loss in mice by inhibition of RANKL.
|
Arthritis Rheum
|
2009
|
1.27
|
15
|
Rodent preclinical models for developing novel antiarthritic molecules: comparative biology and preferred methods for evaluating efficacy.
|
J Biomed Biotechnol
|
2010
|
1.16
|
16
|
Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKL.
|
J Biol Chem
|
2010
|
1.10
|
17
|
RANKL inhibition with osteoprotegerin increases bone strength by improving cortical and trabecular bone architecture in ovariectomized rats.
|
J Bone Miner Res
|
2008
|
1.06
|
18
|
Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury.
|
J Bone Miner Res
|
2011
|
1.05
|
19
|
Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys.
|
Bone
|
2011
|
1.03
|
20
|
Additive bone-protective effects of anabolic treatment when used in conjunction with RANKL and tumor necrosis factor inhibition in two rat arthritis models.
|
Arthritis Rheum
|
2005
|
1.02
|
21
|
Increased bone formation and bone mass induced by sclerostin antibody is not affected by pretreatment or cotreatment with alendronate in osteopenic, ovariectomized rats.
|
Endocrinology
|
2011
|
1.00
|
22
|
Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis.
|
Ann Rheum Dis
|
2013
|
0.99
|
23
|
One year of transgenic overexpression of osteoprotegerin in rats suppressed bone resorption and increased vertebral bone volume, density, and strength.
|
J Bone Miner Res
|
2009
|
0.99
|
24
|
Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin.
|
Bone
|
2009
|
0.98
|
25
|
Transient muscle paralysis degrades bone via rapid osteoclastogenesis.
|
FASEB J
|
2011
|
0.97
|
26
|
Tumor necrosis factor alpha and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis.
|
Arthritis Rheum
|
2009
|
0.97
|
27
|
Analysis of the kinetics of osteoclastogenesis in arthritic rats.
|
Arthritis Rheum
|
2005
|
0.96
|
28
|
Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus.
|
J Bone Miner Res
|
2013
|
0.94
|
29
|
Early response of bone marrow osteoprogenitors to skeletal unloading and sclerostin antibody.
|
Calcif Tissue Int
|
2012
|
0.93
|
30
|
Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4.
|
Blood
|
2002
|
0.91
|
31
|
Regulatory effects of novel neurotrophin-1/b cell-stimulating factor-3 (cardiotrophin-like cytokine) on B cell function.
|
J Immunol
|
2002
|
0.89
|
32
|
Bone turnover markers in peripheral blood and marrow plasma reflect trabecular bone loss but not endocortical expansion in aging mice.
|
Bone
|
2011
|
0.89
|
33
|
Novel genetic models of osteoporosis by overexpression of human RANKL in transgenic mice.
|
J Bone Miner Res
|
2014
|
0.87
|
34
|
Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels.
|
J Bone Miner Res
|
2013
|
0.87
|
35
|
Evaluation of cartilage damage by measuring collagen degradation products in joint extracts in a traumatic model of osteoarthritis.
|
Biomarkers
|
2008
|
0.82
|
36
|
Progressive increases in bone mass and bone strength in an ovariectomized rat model of osteoporosis after 26 weeks of treatment with a sclerostin antibody.
|
Endocrinology
|
2014
|
0.82
|
37
|
A novel modality of BAFF-specific inhibitor AMG623 peptibody reduces B-cell number and improves outcomes in murine models of autoimmune disease.
|
Clin Exp Rheumatol
|
2012
|
0.80
|
38
|
RANKL-targeted therapy inhibits bone resorption in experimental Staphylococcus aureus-induced arthritis.
|
Bone
|
2009
|
0.79
|
39
|
Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model.
|
J Orthop Res
|
2013
|
0.79
|
40
|
Local delivery of recombinant osteoprotegerin enhances postorthodontic tooth stability.
|
Calcif Tissue Int
|
2012
|
0.78
|