Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus.

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Published in J Clin Invest on July 26, 2010

Authors

Federica Di Nicolantonio1, Sabrina Arena, Josep Tabernero, Stefano Grosso, Francesca Molinari, Teresa Macarulla, Mariangela Russo, Carlotta Cancelliere, Davide Zecchin, Luca Mazzucchelli, Takehiko Sasazuki, Senji Shirasawa, Massimo Geuna, Milo Frattini, José Baselga, Margherita Gallicchio, Stefano Biffo, Alberto Bardelli

Author Affiliations

1: Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment, IRCC, University of Turin Medical School, Turin, Italy.

Associated clinical trials:

Erlotinib and Temsirolimus for Solid Tumors | NCT00770263

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