PubRank

Emily J Parker

Author PubWeight™ 32.14‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A symbiosis expressed non-ribosomal peptide synthetase from a mutualistic fungal endophyte of perennial ryegrass confers protection to the symbiotum from insect herbivory. Mol Microbiol 2005 1.46
2 The genetic basis for indole-diterpene chemical diversity in filamentous fungi. Mycol Res 2007 1.10
3 The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes. J Mol Biol 2005 1.04
4 Four gene products are required for the fungal synthesis of the indole-diterpene, paspaline. FEBS Lett 2006 1.04
5 Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis. J Biol Chem 2010 1.00
6 Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis. J Biol Chem 2011 0.99
7 Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6s)-6-fluoroshikimate. J Am Chem Soc 2004 0.98
8 Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase: an ancestral 3-deoxyald-2-ulosonate-phosphate synthase? Biochemistry 2005 0.96
9 Defining paxilline biosynthesis in Penicillium paxilli: functional characterization of two cytochrome P450 monooxygenases. J Biol Chem 2007 0.93
10 Engineering allosteric control to an unregulated enzyme by transfer of a regulatory domain. Proc Natl Acad Sci U S A 2013 0.92
11 Three sites and you are out: ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosis. J Mol Biol 2012 0.92
12 Cloning and characterisation of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis. Biochim Biophys Acta 2009 0.92
13 Change in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed rates. ACS Chem Biol 2013 0.92
14 Characterization of a recombinant type II 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Helicobacter pylori. Biochem J 2005 0.91
15 Expression, purification, and characterization of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Pyrococcus furiosus. Protein Expr Purif 2004 0.91
16 Dynamic cross-talk among remote binding sites: the molecular basis for unusual synergistic allostery. J Mol Biol 2011 0.89
17 Deletion and gene expression analyses define the paxilline biosynthetic gene cluster in Penicillium paxilli. Toxins (Basel) 2013 0.88
18 Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 0.85
19 An evaluation of the ConfoScan3 for corneal endothelial morphology analysis. Optom Vis Sci 2007 0.83
20 Calculated pKa Variations Expose Dynamic Allosteric Communication Networks. J Am Chem Soc 2016 0.83
21 Neisseria meningitidis expresses a single 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine. Protein Sci 2013 0.82
22 The C-terminal regulatory domain is required for catalysis by Neisseria meningitidis alpha-isopropylmalate synthase. Biochem Biophys Res Commun 2010 0.81
23 Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design. J Biol Chem 2011 0.81
24 Reversing evolution: re-establishing obligate metal ion dependence in a metal-independent KDO8P synthase. J Mol Biol 2009 0.79
25 The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition. Biochemistry 2013 0.79
26 Biochemical and structural characterisation of dehydroquinate synthase from the New Zealand kiwifruit Actinidia chinensis. Arch Biochem Biophys 2013 0.78
27 Removal of the C-terminal regulatory domain of α-isopropylmalate synthase disrupts functional substrate binding. Biochemistry 2012 0.78
28 Using a combination of computational and experimental techniques to understand the molecular basis for protein allostery. Adv Protein Chem Struct Biol 2012 0.78
29 Molecular modeling studies of peptide inhibitors highlight the importance of conformational prearrangement for inhibition of calpain. Biochemistry 2010 0.78
30 Stereospecific deuteration of 2-deoxyerythrose 4-phosphate using 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. Bioorg Med Chem Lett 2005 0.77
31 Synthesis and evaluation of dual site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. Bioorg Med Chem Lett 2011 0.77
32 Amino-acid substitutions at the domain interface affect substrate and allosteric inhibitor binding in α-isopropylmalate synthase from Mycobacterium tuberculosis. Biochem Biophys Res Commun 2013 0.77
33 Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate synthase. Bioorg Med Chem Lett 2006 0.77
34 An extended β7α7 substrate-binding loop is essential for efficient catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Biochemistry 2011 0.77
35 Mechanistic divergence of two closely related aldol-like enzyme-catalysed reactions. Org Biomol Chem 2005 0.77
36 Allosteric inhibitor specificity of Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. FEBS Lett 2013 0.76
37 Specificity and mutational analysis of the metal-dependent 3-deoxy-D-manno-octulosonate 8-phosphate synthase from Acidithiobacillus ferrooxidans. Biochim Biophys Acta 2010 0.76
38 Expression, Purification, and Characterisation of Dehydroquinate Synthase from Pyrococcus furiosus. Enzyme Res 2011 0.75
39 Key targets and relevant inhibitors for the drug discovery of tuberculosis. Curr Drug Targets 2013 0.75
40 Change in Heat Capacity for Enzyme Catalysis Determines Temperature Dependence of Enzyme Catalyzed Rates. ACS Chem Biol 2017 0.75
41 Arg314 is essential for catalysis by N-acetyl neuraminic acid synthase from Neisseria meningitidis. Biochemistry 2013 0.75
42 Fluorinated substrates result in variable leakage of a reaction intermediate during catalysis by dehydroquinate synthase. Org Biomol Chem 2011 0.75
43 Arabinose 5-phosphate analogues as mechanistic probes for Neisseria meningitidis 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Bioorg Med Chem 2008 0.75
44 Substrate-mediated control of the conformation of an ancillary domain delivers a competent catalytic site for N-acetylneuraminic acid synthase. Proteins 2014 0.75
45 Synthesis and evaluation of tetrahedral intermediate mimic inhibitors of 3-deoxy-d-manno-octulosonate 8-phosphate synthase. Bioorg Med Chem Lett 2011 0.75
46 Enzymic synthesis of 3-[3- 13C]dehydroquinic acid. Org Biomol Chem 2003 0.75
47 Investigating the role of the hydroxyl groups of substrate erythrose 4-phosphate in the reaction catalysed by the first enzyme of the shikimate pathway. Bioorg Med Chem Lett 2011 0.75
48 Examining the role of intersubunit contacts in catalysis by 3-deoxy-d-manno-octulosonate 8-phosphate synthase. Biochemistry 2013 0.75
49 Targeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase. Biochemistry 2011 0.75