|
1
|
Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.
|
Science
|
2009
|
2.96
|
|
2
|
Hepatitis C virus infects the endothelial cells of the blood-brain barrier.
|
Gastroenterology
|
2011
|
2.51
|
|
3
|
The blood-brain barrier in brain homeostasis and neurological diseases.
|
Biochim Biophys Acta
|
2008
|
2.26
|
|
4
|
Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway.
|
EMBO Rep
|
2011
|
1.86
|
|
5
|
The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies.
|
J Neurochem
|
2008
|
1.66
|
|
6
|
Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling.
|
FASEB J
|
2007
|
1.63
|
|
7
|
Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier.
|
J Physiol
|
2008
|
1.59
|
|
8
|
Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line.
|
J Leukoc Biol
|
2009
|
1.57
|
|
9
|
The hCMEC/D3 cell line as a model of the human blood brain barrier.
|
Fluids Barriers CNS
|
2013
|
1.56
|
|
10
|
Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies.
|
J Cereb Blood Flow Metab
|
2007
|
1.54
|
|
11
|
Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation.
|
Fluids Barriers CNS
|
2012
|
1.44
|
|
12
|
Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells.
|
Biochem Pharmacol
|
2008
|
1.41
|
|
13
|
Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models.
|
J Neurosci Methods
|
2011
|
1.40
|
|
14
|
Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling.
|
J Neurosci
|
2008
|
1.36
|
|
15
|
How do extracellular pathogens cross the blood-brain barrier?
|
Trends Microbiol
|
2002
|
1.35
|
|
16
|
ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.
|
J Neurochem
|
2008
|
1.32
|
|
17
|
Microvilli-like structures are associated with the internalization of virulent capsulated Neisseria meningitidis into vascular endothelial cells.
|
J Cell Sci
|
2002
|
1.31
|
|
18
|
Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells.
|
Neurosci Lett
|
2003
|
1.26
|
|
19
|
Role of KCNMA1 gene in breast cancer invasion and metastasis to brain.
|
BMC Cancer
|
2009
|
1.26
|
|
20
|
Human blood-brain barrier disruption by retroviral-infected lymphocytes: role of myosin light chain kinase in endothelial tight-junction disorganization.
|
J Immunol
|
2007
|
1.26
|
|
21
|
Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP.
|
J Biol Chem
|
2004
|
1.25
|
|
22
|
Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.
|
Mol Pharm
|
2011
|
1.25
|
|
23
|
Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration.
|
J Immunol
|
2003
|
1.21
|
|
24
|
Rat brain endothelial cell lines for the study of blood-brain barrier permeability and transport functions.
|
Cell Mol Neurobiol
|
2005
|
1.19
|
|
25
|
TAL-1/SCL and its partners E47 and LMO2 up-regulate VE-cadherin expression in endothelial cells.
|
Mol Cell Biol
|
2007
|
1.17
|
|
26
|
Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans.
|
Eukaryot Cell
|
2009
|
1.17
|
|
27
|
Plasmodium falciparum adhesion on human brain microvascular endothelial cells involves transmigration-like cup formation and induces opening of intercellular junctions.
|
PLoS Pathog
|
2010
|
1.16
|
|
28
|
Lymphocyte migration into the central nervous system: implication of ICAM-1 signalling at the blood-brain barrier.
|
Vascul Pharmacol
|
2002
|
1.12
|
|
29
|
A functional in vitro model of rat blood-brain barrier for molecular analysis of efflux transporters.
|
Brain Res
|
2007
|
1.11
|
|
30
|
The metastatic microenvironment: brain-residing melanoma metastasis and dormant micrometastasis.
|
Int J Cancer
|
2011
|
1.11
|
|
31
|
Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.
|
Mol Pharm
|
2012
|
1.09
|
|
32
|
JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation.
|
J Cell Biol
|
2008
|
1.09
|
|
33
|
Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes.
|
J Cell Sci
|
2006
|
1.07
|
|
34
|
Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging.
|
FASEB J
|
2012
|
1.05
|
|
35
|
Molecular mechanism of systemic delivery of neural precursor cells to the brain: assembly of brain endothelial apical cups and control of transmigration by CD44.
|
Stem Cells
|
2008
|
1.04
|
|
36
|
Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: a new target cell type for the immunodeficiency virus-1?
|
FASEB J
|
2002
|
1.01
|
|
37
|
CCL2 disrupts the adherens junction: implications for neuroinflammation.
|
Lab Invest
|
2012
|
1.01
|
|
38
|
Surface characteristics of nanoparticles determine their intracellular fate in and processing by human blood-brain barrier endothelial cells in vitro.
|
Mol Ther
|
2010
|
1.00
|
|
39
|
Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown.
|
PLoS One
|
2010
|
1.00
|
|
40
|
Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?
|
BMC Neurosci
|
2014
|
1.00
|
|
41
|
Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells.
|
Mol Pharmacol
|
2008
|
0.99
|
|
42
|
Regulation of cerebral endothelial cell morphology by extracellular calcium.
|
Phys Med Biol
|
2007
|
0.98
|
|
43
|
Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier.
|
J Neurosci Methods
|
2012
|
0.98
|
|
44
|
Uptake and cytotoxicity of citrate-coated gold nanospheres: Comparative studies on human endothelial and epithelial cells.
|
Part Fibre Toxicol
|
2012
|
0.98
|
|
45
|
Angiotensin II facilitates breast cancer cell migration and metastasis.
|
PLoS One
|
2012
|
0.97
|
|
46
|
Guanine nucleotide-binding protein Gαi2: a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cells.
|
J Cereb Blood Flow Metab
|
2012
|
0.97
|
|
47
|
Alteration of blood-brain barrier integrity by retroviral infection.
|
PLoS Pathog
|
2008
|
0.97
|
|
48
|
Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide.
|
J Biotechnol
|
2011
|
0.96
|
|
49
|
Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium.
|
Eur J Cell Biol
|
2010
|
0.95
|
|
50
|
Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line.
|
Eur J Pharm Biopharm
|
2010
|
0.95
|
|
51
|
Tissue-type plasminogen activator is a regulator of monocyte diapedesis through the brain endothelial barrier.
|
J Immunol
|
2008
|
0.95
|
|
52
|
Characterization of genetically modified human retinal pigment epithelial cells developed for in vitro and transplantation studies.
|
Invest Ophthalmol Vis Sci
|
2002
|
0.95
|
|
53
|
Lymphocyte trafficking through the blood-brain barrier is dependent on endothelial cell heterotrimeric G-protein signaling.
|
FASEB J
|
2002
|
0.94
|
|
54
|
Cooperation between β- and γ-cytoplasmic actins in the mechanical regulation of endothelial microparticle formation.
|
FASEB J
|
2012
|
0.94
|
|
55
|
Role of astrocytic leptin receptor subtypes on leptin permeation across hCMEC/D3 human brain endothelial cells.
|
J Neurochem
|
2010
|
0.92
|
|
56
|
Pcbs and tight junction expression.
|
Environ Toxicol Pharmacol
|
2008
|
0.92
|
|
57
|
Metabolic acidosis induced by Plasmodium falciparum intraerythrocytic stages alters blood-brain barrier integrity.
|
J Cereb Blood Flow Metab
|
2010
|
0.91
|
|
58
|
Lamotrigine is a substrate for OCT1 in brain endothelial cells.
|
Biochem Pharmacol
|
2011
|
0.91
|
|
59
|
Modulation of blood-brain barrier permeability by neutrophils: in vitro and in vivo studies.
|
Brain Res
|
2009
|
0.90
|
|
60
|
Human brain endothelial cells are responsive to adenosine receptor activation.
|
Purinergic Signal
|
2011
|
0.90
|
|
61
|
Identification of peptide ligands for targeting to the blood-brain barrier.
|
Pharm Res
|
2010
|
0.90
|
|
62
|
Invading basement membrane matrix is sufficient for MDA-MB-231 breast cancer cells to develop a stable in vivo metastatic phenotype.
|
PLoS One
|
2011
|
0.90
|
|
63
|
Insights into the putative catechin and epicatechin transport across blood-brain barrier.
|
Food Funct
|
2010
|
0.90
|
|
64
|
PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells.
|
J Neurochem
|
2007
|
0.89
|
|
65
|
Immature mesenchymal stem cell-like pericytes as mediators of immunosuppression in human malignant glioma.
|
J Neuroimmunol
|
2013
|
0.89
|
|
66
|
IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells.
|
J Neuroimmunol
|
2010
|
0.89
|
|
67
|
Hyperosmotic stress induces Axl activation and cleavage in cerebral endothelial cells.
|
J Neurochem
|
2008
|
0.88
|
|
68
|
Primary angiitis of the central nervous system: description of the first fifty-two adults enrolled in the French cohort of patients with primary vasculitis of the central nervous system.
|
Arthritis Rheumatol
|
2014
|
0.88
|
|
69
|
Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells.
|
J Biol Chem
|
2010
|
0.87
|
|
70
|
Design of fluorescently tagged poly(alkyl cyanoacrylate) nanoparticles for human brain endothelial cell imaging.
|
Chem Commun (Camb)
|
2010
|
0.86
|
|
71
|
TWEAK/Fn14 pathway modulates properties of a human microvascular endothelial cell model of blood brain barrier.
|
J Neuroinflammation
|
2013
|
0.85
|
|
72
|
The brain microvascular endothelium supports T cell proliferation and has potential for alloantigen presentation.
|
PLoS One
|
2013
|
0.84
|
|
73
|
Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS.
|
Sci Rep
|
2013
|
0.84
|
|
74
|
The involvement of a Na⁺- and Cl⁻-dependent transporter in the brain uptake of amantadine and rimantadine.
|
Mol Pharm
|
2012
|
0.83
|
|
75
|
Localization microscopy (SPDM) reveals clustered formations of P-glycoprotein in a human blood-brain barrier model.
|
PLoS One
|
2012
|
0.83
|
|
76
|
Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4.
|
Int Immunol
|
2015
|
0.82
|
|
77
|
Differential expression of the bone and the liver tissue non-specific alkaline phosphatase isoforms in brain tissues.
|
Cell Tissue Res
|
2010
|
0.82
|
|
78
|
The metastatic microenvironment: Claudin-1 suppresses the malignant phenotype of melanoma brain metastasis.
|
Int J Cancer
|
2014
|
0.82
|
|
79
|
Astrocytes facilitate melanoma brain metastasis via secretion of IL-23.
|
J Pathol
|
2015
|
0.81
|
|
80
|
High-density lipoprotein-based therapy reduces the hemorrhagic complications associated with tissue plasminogen activator treatment in experimental stroke.
|
Stroke
|
2013
|
0.81
|
|
81
|
Temporal profile of matrix metalloproteinases and their inhibitors in a human endothelial cell culture model of cerebral ischemia.
|
Cerebrovasc Dis
|
2013
|
0.81
|
|
82
|
Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment.
|
J Neuroimmunol
|
2009
|
0.81
|
|
83
|
Expression and localization of claudins-3 and -12 in transformed human brain endothelium.
|
Fluids Barriers CNS
|
2012
|
0.81
|
|
84
|
Temozolomide down-regulates P-glycoprotein in human blood-brain barrier cells by disrupting Wnt3 signaling.
|
Cell Mol Life Sci
|
2013
|
0.81
|
|
85
|
A novel vascular targeting strategy for brain-derived endothelial cells using a TCR mimic antibody.
|
J Cell Physiol
|
2010
|
0.81
|
|
86
|
Somatostatin preserved blood brain barrier against cytokine induced alterations: possible role in multiple sclerosis.
|
Biochem Pharmacol
|
2013
|
0.80
|
|
87
|
A multi-system approach assessing the interaction of anticonvulsants with P-gp.
|
PLoS One
|
2013
|
0.80
|
|
88
|
[Endothelin-1, angiotensin II and cancer].
|
Med Sci (Paris)
|
2006
|
0.80
|
|
89
|
Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: a differential gel electrophoresis study.
|
Proteomics
|
2013
|
0.80
|
|
90
|
A differential proteomic approach identifies structural and functional components that contribute to the differentiation of brain capillary endothelial cells.
|
J Proteomics
|
2011
|
0.80
|
|
91
|
CXCL1/CXCL8 (GROα/IL-8) in human diabetic ketoacidosis plasma facilitates leukocyte recruitment to cerebrovascular endothelium in vitro.
|
Am J Physiol Endocrinol Metab
|
2014
|
0.79
|
|
92
|
Synthesis and in vitro evaluation of BBB permeability, tumor cell uptake, and cytotoxicity of a series of carboranylporphyrin conjugates.
|
J Med Chem
|
2014
|
0.79
|
|
93
|
The metastatic microenvironment: Brain-derived soluble factors alter the malignant phenotype of cutaneous and brain-metastasizing melanoma cells.
|
Int J Cancer
|
2012
|
0.79
|
|
94
|
Effects of Aggregatibacter actinomycetemcomitans leukotoxin on endothelial cells.
|
Microb Pathog
|
2013
|
0.79
|
|
95
|
Purine receptors and Ca(2+) signalling in the human blood-brain barrier endothelial cell line hCMEC/D3.
|
Purinergic Signal
|
2011
|
0.79
|
|
96
|
Solid lipid nanoparticles as a vehicle for brain-targeted drug delivery: two new strategies of functionalization with apolipoprotein E.
|
Nanotechnology
|
2015
|
0.78
|
|
97
|
The angiogenic gene profile of circulating endothelial progenitor cells from ischemic stroke patients.
|
Vasc Cell
|
2013
|
0.78
|
|
98
|
The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family.
|
AAPS J
|
2014
|
0.77
|
|
99
|
Paracrine signalling of inflammatory cytokines from an in vitro blood brain barrier model upon exposure to polymeric nanoparticles.
|
Analyst
|
2013
|
0.77
|
|
100
|
Induced secretion of beta-hexosaminidase by human brain endothelial cells: a novel approach in Sandhoff disease?
|
Neurobiol Dis
|
2009
|
0.77
|
|
101
|
Permeability of PEGylated immunoarsonoliposomes through in vitro blood brain barrier-medulloblastoma co-culture models for brain tumor therapy.
|
Pharm Res
|
2014
|
0.76
|
|
102
|
Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro.
|
PLoS One
|
2012
|
0.76
|
|
103
|
Early alterations of Hedgehog signaling pathway in vascular endothelial cells after peripheral nerve injury elicit blood-nerve barrier disruption, nerve inflammation, and neuropathic pain development.
|
Pain
|
2016
|
0.76
|
|
104
|
Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model.
|
Fluids Barriers CNS
|
2013
|
0.75
|
|
105
|
[Functions of prion protein PrPc].
|
Med Sci (Paris)
|
2007
|
0.75
|
|
106
|
[Transendothelial migration through the neurovascular unit: "a cup to cross the barrier"].
|
Med Sci (Paris)
|
2012
|
0.75
|
|
107
|
Nanoparticle formulation improves the anticonvulsant effect of clonazepam on the pentylenetetrazole-induced seizures: behavior and electroencephalogram.
|
J Pharm Sci
|
2014
|
0.75
|