|
1
|
Drugs for bad bugs: confronting the challenges of antibacterial discovery.
|
Nat Rev Drug Discov
|
2006
|
15.21
|
|
2
|
Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK).
|
Biochem J
|
2003
|
1.48
|
|
3
|
Genomic approaches to antibacterial discovery.
|
Methods Mol Biol
|
2004
|
1.46
|
|
4
|
Validation of antibacterial mechanism of action using regulated antisense RNA expression in Staphylococcus aureus.
|
FEMS Microbiol Lett
|
2004
|
1.32
|
|
5
|
A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function.
|
J Mol Microbiol Biotechnol
|
2003
|
1.31
|
|
6
|
Characterization of a novel fucose-regulated promoter (PfcsK) suitable for gene essentiality and antibacterial mode-of-action studies in Streptococcus pneumoniae.
|
J Bacteriol
|
2003
|
1.30
|
|
7
|
Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes.
|
Antimicrob Agents Chemother
|
2003
|
1.21
|
|
8
|
Horizontal transfer of drug-resistant aminoacyl-transfer-RNA synthetases of anthrax and Gram-positive pathogens.
|
EMBO Rep
|
2003
|
1.20
|
|
9
|
Stepwise exposure of Staphylococcus aureus to pleuromutilins is associated with stepwise acquisition of mutations in rplC and minimally affects susceptibility to retapamulin.
|
Antimicrob Agents Chemother
|
2007
|
1.15
|
|
10
|
Genetic characterization of Vga ABC proteins conferring reduced susceptibility to pleuromutilins in Staphylococcus aureus.
|
Antimicrob Agents Chemother
|
2008
|
1.15
|
|
11
|
Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth.
|
J Bacteriol
|
2004
|
1.01
|
|
12
|
Contextual modulation involves suppression and facilitation from the center and the surround.
|
J Vis
|
2007
|
0.93
|
|
13
|
Identification of antimicrobial targets using a comprehensive genomic approach.
|
Pharmacogenomics
|
2004
|
0.93
|
|
14
|
Spatial and temporal dependencies of cross-orientation suppression in human vision.
|
Proc Biol Sci
|
2007
|
0.92
|
|
15
|
Clinical and research issues regarding chronic advanced coronary artery disease: part I: Contemporary and emerging therapies.
|
Am Heart J
|
2008
|
0.92
|
|
16
|
Novel antibacterials: a genomics approach to drug discovery.
|
Curr Drug Targets Infect Disord
|
2002
|
0.88
|
|
17
|
New benzylidenethiazolidinediones as antibacterial agents.
|
Bioorg Med Chem Lett
|
2003
|
0.84
|
|
18
|
Orientation masking and cross-orientation suppression (XOS): implications for estimates of filter bandwidth.
|
J Vis
|
2010
|
0.82
|
|
19
|
Synthesis of macrolones with central piperazine ring in the linker and its influence on antibacterial activity.
|
Bioorg Med Chem
|
2011
|
0.81
|
|
20
|
Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like event.
|
Antimicrob Agents Chemother
|
2008
|
0.81
|
|
21
|
The promoter of a cold-shock-like gene has pleiotropic effects on Streptomyces antibiotic biosynthesis.
|
FEMS Microbiol Lett
|
2003
|
0.77
|
|
22
|
Remote facilitation in the Fourier domain.
|
Vision Res
|
2006
|
0.77
|
|
23
|
Synthesis and activity of new macrolones: conjugates between 6(7)-(2'-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2'-hydroxyethyl) amides and 4″-propenoyl-azithromycin.
|
Bioorg Med Chem
|
2011
|
0.77
|
|
24
|
6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile.
|
Bioorg Med Chem
|
2010
|
0.76
|
|
25
|
Synthesis and properties of macrolones characterized by two ether bonds in the linker.
|
Bioorg Med Chem
|
2010
|
0.76
|
|
26
|
Synthesis and biological activity of 4''-O-acyl derivatives of 14- and 15-membered macrolides linked to omega-quinolone-carboxylic unit.
|
Bioorg Med Chem
|
2010
|
0.76
|