Human adipose-derived stromal cells stimulate autogenous skeletal repair via paracrine Hedgehog signaling with calvarial osteoblasts.

PubWeight™: 1.17‹?› | Rank: Top 10%

🔗 View Article (PMC 3128781)

Published in Stem Cells Dev on October 12, 2010

Authors

Benjamin Levi1, Aaron W James, Emily R Nelson, Shuli Li, Michelle Peng, George W Commons, Min Lee, Benjamin Wu, Michael T Longaker

Author Affiliations

1: Hagey Laboratory for Pediatric Regenerative Medicine, Plastic and Reconstructive Surgery Division, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305-5148, USA.

Articles citing this

Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen. Osteoarthritis Cartilage (2012) 1.96

Concise review: adipose-derived stromal cells for skeletal regenerative medicine. Stem Cells (2011) 1.16

Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair. Stem Cells (2011) 1.11

Perivascular stem cells: a prospectively purified mesenchymal stem cell population for bone tissue engineering. Stem Cells Transl Med (2012) 1.08

An abundant perivascular source of stem cells for bone tissue engineering. Stem Cells Transl Med (2012) 1.04

Additive effects of sonic hedgehog and Nell-1 signaling in osteogenic versus adipogenic differentiation of human adipose-derived stromal cells. Stem Cells Dev (2012) 0.98

Acute skeletal injury is necessary for human adipose-derived stromal cell-mediated calvarial regeneration. Plast Reconstr Surg (2011) 0.94

The utility of hedgehog signaling pathway inhibition for cancer. Oncologist (2012) 0.94

Adipose-derived mesenchymal cells for bone regereneration: state of the art. Biomed Res Int (2013) 0.93

Enhancement of human adipose-derived stromal cell angiogenesis through knockdown of a BMP-2 inhibitor. Plast Reconstr Surg (2012) 0.92

Canonical and non-canonical Hedgehog signalling and the control of metabolism. Semin Cell Dev Biol (2014) 0.89

Adipose-derived stromal/stem cells: a primer. Organogenesis (2013) 0.89

Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts. PLoS One (2013) 0.86

Sonic Hedgehog contributes to gastric mucosal restitution after injury. Lab Invest (2012) 0.86

Use of human perivascular stem cells for bone regeneration. J Vis Exp (2012) 0.84

The acid-secreting parietal cell as an endocrine source of Sonic Hedgehog during gastric repair. Endocrinology (2013) 0.83

Undifferentiated human adipose-derived stromal/stem cells loaded onto wet-spun starch-polycaprolactone scaffolds enhance bone regeneration: nude mice calvarial defect in vivo study. J Biomed Mater Res A (2013) 0.83

Effects of aging on osteogenic response and heterotopic ossification following burn injury in mice. Stem Cells Dev (2015) 0.82

Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells. Int J Nanomedicine (2014) 0.79

A new platelet cryoprecipitate glue promoting bone formation after ectopic mesenchymal stromal cell-loaded biomaterial implantation in nude mice. Stem Cell Res Ther (2013) 0.79

Calvarial Defect Healing Induced by Small Molecule Smoothened Agonist. Tissue Eng Part A (2016) 0.78

Adipose-derived mesenchymal stem cells from ventral hernia repair patients demonstrate decreased vasculogenesis. Biomed Res Int (2014) 0.78

Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification. Mol Ther (2017) 0.75

Articles cited by this

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science (1996) 8.14

FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature (2005) 3.50

Craniofacial tissue engineering by stem cells. J Dent Res (2006) 2.48

Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. J Craniomaxillofac Surg (2004) 2.38

Induction of osteogenic differentiation by hedgehog proteins. Biochem Biophys Res Commun (1997) 2.05

FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development (1998) 2.03

Human adipose derived stromal cells heal critical size mouse calvarial defects. PLoS One (2010) 2.01

Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg (2009) 1.97

Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications. Front Biosci (Landmark Ed) (2009) 1.76

Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation. J Cell Sci (2001) 1.74

Regional anatomic and age effects on cell function of human adipose-derived stem cells. Ann Plast Surg (2008) 1.61

Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. J Cell Biol (2002) 1.58

Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation. J Biol Chem (2007) 1.55

The role of fibroblast growth factors in tumor growth. Curr Cancer Drug Targets (2009) 1.52

Genetic and epigenetic instability of human bone marrow mesenchymal stem cells expanded in autologous serum or fetal bovine serum. Int J Dev Biol (2008) 1.42

Adipose-derived stromal cells--their utility and potential in bone formation. Int J Obes Relat Metab Disord (2000) 1.39

Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. PLoS One (2009) 1.35

Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling. Proc Natl Acad Sci U S A (2006) 1.34

Sonic Hedgehog influences the balance of osteogenesis and adipogenesis in mouse adipose-derived stromal cells. Tissue Eng Part A (2010) 1.32

Osteogenesis versus chondrogenesis by BMP-2 and BMP-7 in adipose stem cells. Biochem Biophys Res Commun (2006) 1.31

Role of gender and anatomical region on induction of osteogenic differentiation of human adipose-derived stem cells. Ann Plast Surg (2008) 1.29

Proliferation, osteogenic differentiation, and fgf-2 modulation of posterofrontal/sagittal suture-derived mesenchymal cells in vitro. Plast Reconstr Surg (2008) 1.25

Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells. Curr Stem Cell Res Ther (2009) 1.25

Depot-specific variation in the osteogenic and adipogenic potential of human adipose-derived stromal cells. Plast Reconstr Surg (2010) 1.23

Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells. Bone (2003) 1.23

Differential effects of BMP-2 and TGF-beta1 on chondrogenic differentiation of adipose derived stem cells. Cell Prolif (2007) 1.22

Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors. J Cell Biochem (2005) 1.22

Effects of the temperature, the duration of frozen storage, and the freezing container on in vitro measurements in human peripheral blood mononuclear cells. Transfusion (1996) 1.19

Sonic hedgehog is involved in osteoblast differentiation by cooperating with BMP-2. J Cell Physiol (2002) 1.16

Tissue-engineered bone from BMP-2-transduced stem cells derived from human fat. Plast Reconstr Surg (2005) 1.14

Hedgehog signaling in skeletal development. Birth Defects Res C Embryo Today (2006) 1.10

Sonic hedgehog gene-enhanced tissue engineering for bone regeneration. Gene Ther (2005) 1.08

Biomolecular mechanisms of calvarial bone induction: immature versus mature dura mater. Plast Reconstr Surg (2000) 1.08

Characterization of human bone morphogenetic protein (BMP)-4 and -7 gene promoters: activation of BMP promoters by Gli, a sonic hedgehog mediator. Bone (2001) 1.07

Cryopreservation of stromal vascular fraction of adipose tissue in a serum-free freezing medium. J Tissue Eng Regen Med (2010) 1.05

Hedgehog promotes primary osteoblast differentiation and increases PTHrP mRNA expression and iPTHrP secretion. Bone (2003) 1.05

Applications of an athymic nude mouse model of nonhealing critical-sized calvarial defects. J Craniofac Surg (2008) 1.04

Dura mater biology: autocrine and paracrine effects of fibroblast growth factor 2. Plast Reconstr Surg (2002) 1.02

Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells. Tissue Eng Part A (2009) 1.01

Studies in cranial suture biology: part II. Role of the dura in cranial suture fusion. Plast Reconstr Surg (1996) 1.01

Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling. Ann N Y Acad Sci (2007) 1.01

Studies in cranial suture biology: regional dura mater determines in vitro cranial suture fusion. Plast Reconstr Surg (1997) 0.98

Studies in cranial suture biology: regional dura mater determines overlying suture biology. Plast Reconstr Surg (1998) 0.95

Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh. Dev Dyn (2007) 0.95

Clinical study of the efficiency of combined cell transplant on the basis of multipotent mesenchymal stromal adipose tissue cells in patients with pronounced deficit of the maxillary and mandibulary bone tissue. Bull Exp Biol Med (2008) 0.95

Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation. Mol Cancer (2009) 0.95

Bone induction in craniofacial defects. Orthod Craniofac Res (2005) 0.93

Human adipose-derived stromal cells respond to and elaborate bone morphogenetic protein-2 during in vitro osteogenic differentiation. Plast Reconstr Surg (2010) 0.92

Co-culture of osteoblasts with immature dural cells causes an increased rate and degree of osteoblast differentiation. Plast Reconstr Surg (2002) 0.92

Expression of Indian Hedgehog, BMP-4 and Noggin in craniosynostosis induced by fetal constraint. Ann Plast Surg (2007) 0.90

Paracrine interaction between adipose-derived stromal cells and cranial suture-derived mesenchymal cells. Plast Reconstr Surg (2010) 0.90

Actions of hedgehog proteins on skeletal cells. Crit Rev Oral Biol Med (1999) 0.88

Regional dura mater differentially regulates osteoblast gene expression. J Craniofac Surg (2003) 0.88

Intra- and interindividual variation in gene expression in human adipose tissue. Pflugers Arch (2006) 0.87

Molecular and cellular characterization of mouse calvarial osteoblasts derived from neural crest and paraxial mesoderm. Plast Reconstr Surg (2007) 0.87

Depot specific differences during adipogenesis of porcine stromal-vascular cells. Cell Biol Int (2008) 0.87

Recent progress in the study of Hedgehog signaling. J Genet Genomics (2008) 0.86

New strategies for craniofacial repair and replacement: a brief review. J Craniofac Surg (2003) 0.81

Effects of defined medium, fetal bovine serum, and human serum on growth and chemosensitivities of human breast cancer cells in primary culture: inference for in vitro assays. In Vitro Cell Dev Biol (1987) 0.78

Articles by these authors

Wound repair and regeneration. Nature (2008) 12.30

Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen (2009) 7.29

Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med (2006) 6.04

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature (2010) 5.05

A nonviral minicircle vector for deriving human iPS cells. Nat Methods (2010) 4.42

Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. Nat Biotechnol (2004) 4.16

Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci U S A (2009) 3.57

Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci Transl Med (2012) 3.53

Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip. Nature (2011) 3.03

The embrace device significantly decreases scarring following scar revision surgery in a randomized controlled trial. Plast Reconstr Surg (2014) 2.66

Extended follow-up of methotrexate-free immunosuppression using sirolimus and tacrolimus in related and unrelated donor peripheral blood stem cell transplantation. Blood (2007) 2.57

Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg (2004) 2.46

High-risk neuroblastoma treated with tandem autologous peripheral-blood stem cell-supported transplantation: long-term survival update. J Clin Oncol (2006) 2.40

Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell (2013) 2.33

Major deficit in the number of underrepresented minority academic surgeons persists. Ann Surg (2008) 2.20

The BMP antagonist noggin regulates cranial suture fusion. Nature (2003) 2.09

Studies in Fat Grafting: Part V. Cell-Assisted Lipotransfer to Enhance Fat Graft Retention Is Dose Dependent. Plast Reconstr Surg (2015) 2.09

On the ethics of composite tissue allotransplantation (facial transplantation). Plast Reconstr Surg (2006) 2.08

Human adipose derived stromal cells heal critical size mouse calvarial defects. PLoS One (2010) 2.01

Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation. Microbiome (2013) 1.98

Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol (2007) 1.95

Cranial sutures: a brief review. Plast Reconstr Surg (2008) 1.92

Rituximab, bevacizumab and CHOP (RA-CHOP) in untreated diffuse large B-cell lymphoma: safety, biomarker and pharmacokinetic analysis. Leuk Lymphoma (2006) 1.89

Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J (2007) 1.87

High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo. Tissue Eng Part A (2011) 1.87

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat Med (2011) 1.86

Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice. Nature (2007) 1.83

Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration. Development (2008) 1.82

Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling. Genesis (2011) 1.78

Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells. Am J Physiol Cell Physiol (2005) 1.76

Microfluidic single-cell analysis shows that porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation. Circ Res (2012) 1.74

Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells. Proc Natl Acad Sci U S A (2006) 1.74

Regulation of human adipose-derived stromal cell osteogenic differentiation by insulin-like growth factor-1 and platelet-derived growth factor-alpha. Plast Reconstr Surg (2010) 1.72

Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays. PLoS One (2007) 1.72

Surgical approaches to create murine models of human wound healing. J Biomed Biotechnol (2010) 1.71

Sirolimus and thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant (2005) 1.70

Innovation in surgery: a historical perspective. Ann Surg (2006) 1.66

Basic science review on adipose tissue for clinicians. Plast Reconstr Surg (2010) 1.62

Medial canthal reconstruction using a medially based upper eyelid myocutaneous flap. Plast Reconstr Surg (2002) 1.62

Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts. J Biol Chem (2004) 1.60

Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies. Ann Surg (2011) 1.58

Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold. Biomaterials (2011) 1.58

Scarless fetal wound healing: a basic science review. Plast Reconstr Surg (2010) 1.56

The role of stem cells in aesthetic surgery: fact or fiction? Plast Reconstr Surg (2014) 1.55

Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation. J Biol Chem (2007) 1.55

Hypoxia and VEGF up-regulate BMP-2 mRNA and protein expression in microvascular endothelial cells: implications for fracture healing. Plast Reconstr Surg (2002) 1.53

Wnt3a reestablishes osteogenic capacity to bone grafts from aged animals. J Bone Joint Surg Am (2013) 1.52

Current progress in keloid research and treatment. J Am Coll Surg (2008) 1.52

FGF-2 inhibits osteogenesis in mouse adipose tissue-derived stromal cells and sustains their proliferative and osteogenic potential state. Tissue Eng (2006) 1.50

The diverse surgeons initiative: an effective method for increasing the number of under-represented minorities in academic surgery. J Am Coll Surg (2010) 1.47

An information theoretic, microfluidic-based single cell analysis permits identification of subpopulations among putatively homogeneous stem cells. PLoS One (2011) 1.47

CD105 protein depletion enhances human adipose-derived stromal cell osteogenesis through reduction of transforming growth factor β1 (TGF-β1) signaling. J Biol Chem (2011) 1.46

Studies in fat grafting: Part II. Effects of injection mechanics on material properties of fat. Plast Reconstr Surg (2014) 1.46

Mucositis after allogeneic hematopoietic stem cell transplantation: a cohort study of methotrexate- and non-methotrexate-containing graft-versus-host disease prophylaxis regimens. Biol Blood Marrow Transplant (2005) 1.44

Hypertrophic scar formation following burns and trauma: new approaches to treatment. PLoS Med (2007) 1.42

The SNaP system: biomechanical and animal model testing of a novel ultraportable negative-pressure wound therapy system. Plast Reconstr Surg (2010) 1.41

Ethnic diversity remains scarce in academic plastic and reconstructive surgery. Plast Reconstr Surg (2009) 1.41

Combining Smoothened Agonist (SAG) and NEL-like protein-1 (NELL-1) Enhances Bone Healing. Plast Reconstr Surg (2017) 1.40

Studies in fat grafting: Part I. Effects of injection technique on in vitro fat viability and in vivo volume retention. Plast Reconstr Surg (2014) 1.40

Nell-1-induced bone regeneration in calvarial defects. Am J Pathol (2006) 1.38

Addressing the paucity of underrepresented minorities in academic surgery: can the "Rooney Rule" be applied to academic surgery? Am J Surg (2010) 1.38

What Makes a Plastic Surgery Residency Program Attractive? An Applicant's Perspective. Plast Reconstr Surg (2015) 1.38

Angiogenesis is required for successful bone induction during distraction osteogenesis. J Bone Miner Res (2005) 1.36

NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation. Proc Natl Acad Sci U S A (2013) 1.35

Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. PLoS One (2009) 1.35

Locally applied vascular endothelial growth factor A increases the osteogenic healing capacity of human adipose-derived stem cells by promoting osteogenic and endothelial differentiation. Stem Cells (2011) 1.34

Fetal wound healing: current biology. World J Surg (2003) 1.34

Predictors of improved progression-free survival after nonmyeloablative allogeneic stem cell transplantation for advanced chronic lymphocytic leukemia. Biol Blood Marrow Transplant (2006) 1.34

Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling. Proc Natl Acad Sci U S A (2006) 1.34

Sonic Hedgehog influences the balance of osteogenesis and adipogenesis in mouse adipose-derived stromal cells. Tissue Eng Part A (2010) 1.32

Natural history of mesenchymal stem cells, from vessel walls to culture vessels. Cell Mol Life Sci (2013) 1.31

A study of the role of nell-1 gene modified goat bone marrow stromal cells in promoting new bone formation. Mol Ther (2007) 1.31

IFATS collection: Adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia. Stem Cells (2009) 1.30

Flexor tendon healing in vitro: effects of TGF-beta on tendon cell collagen production. J Hand Surg Am (2002) 1.30

Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors. Nat Protoc (2010) 1.30

Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus. Clin Biochem (2009) 1.30

A primary cilia-dependent etiology for midline facial disorders. Hum Mol Genet (2010) 1.29

Human iPS cell-based therapy: considerations before clinical applications. Cell Cycle (2010) 1.29

Dura mater stimulates human adipose-derived stromal cells to undergo bone formation in mouse calvarial defects. Stem Cells (2011) 1.27