Published in JAMA on August 11, 2010
2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ (2010) 6.37
Oral bisphosphonates and risk of cancer of oesophagus, stomach, and colorectum: case-control analysis within a UK primary care cohort. BMJ (2010) 4.92
European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int (2012) 4.88
Exposure to bisphosphonates and risk of gastrointestinal cancers: series of nested case-control studies with QResearch and CPRD data. BMJ (2013) 3.34
Reduced colon cancer incidence and mortality in postmenopausal women treated with an oral bisphosphonate--Danish National Register Based Cohort Study. Osteoporos Int (2012) 3.13
American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocr Pract (2011) 2.29
Use of bisphosphonates and reduced risk of colorectal cancer. J Clin Oncol (2011) 1.84
Evaluating the impact of database heterogeneity on observational study results. Am J Epidemiol (2013) 1.83
Bridging differences in outcomes of pharmacoepidemiological studies: design and first results of the PROTECT project. Curr Clin Pharmacol (2014) 1.73
Interpreting observational studies: why empirical calibration is needed to correct p-values. Stat Med (2013) 1.72
Bisphosphonates for treatment of osteoporosis: expected benefits, potential harms, and drug holidays. Can Fam Physician (2014) 1.63
Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis. Calcif Tissue Int (2011) 1.50
Epidemiology and risk factors for gastroesophageal junction tumors: understanding the rising incidence of this disease. Semin Radiat Oncol (2013) 1.28
Beyond aspirin-cancer prevention with statins, metformin and bisphosphonates. Nat Rev Clin Oncol (2013) 1.20
Exposure to oral bisphosphonates and risk of cancer. Int J Cancer (2012) 1.17
Bisphosphonates and colon cancer. Osteoporos Int (2012) 1.07
Can the risk of secondary cancer induction after breast conserving therapy be reduced using intraoperative radiotherapy (IORT) with low-energy x-rays? Radiat Oncol (2011) 1.05
Antiresorptive therapies for osteoporosis: a clinical overview. Nat Rev Endocrinol (2011) 1.04
Current and future treatment options in osteoporosis. Eur J Clin Pharmacol (2011) 0.98
Pharmacovigilance. Br J Clin Pharmacol (2012) 0.98
Bisphosphonates and risk of upper gastrointestinal cancer--a case control study using the General Practice Research Database (GPRD). PLoS One (2012) 0.96
Gastric adenocarcinoma has a unique microRNA signature not present in esophageal adenocarcinoma. Cancer (2013) 0.95
Bisphosphonate use and gastrointestinal tract cancer risk: meta-analysis of observational studies. World J Gastroenterol (2012) 0.95
Bisphosphonate drug holiday: choosing appropriate candidates. Curr Osteoporos Rep (2013) 0.93
Bisphosphonate treatment and risk of esophageal cancer: a meta-analysis of observational studies. Osteoporos Int (2012) 0.92
Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications. Osteoporos Int (2012) 0.91
A higher dosage of oral alendronate will increase the subsequent cancer risk of osteoporosis patients in Taiwan: a population-based cohort study. PLoS One (2012) 0.91
Does design matter? Systematic evaluation of the impact of analytical choices on effect estimates in observational studies. Ther Adv Drug Saf (2013) 0.90
American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis: executive summary of recommendations. Endocr Pract (2011) 0.88
Management of osteoporosis of the oldest old. Osteoporos Int (2014) 0.87
Exposure to bisphosphonates and risk of cancer: a protocol for nested case-control studies using the QResearch primary care database. BMJ Open (2012) 0.87
Clinical role of bisphosphonate therapy. Int J Womens Health (2012) 0.85
Bisphosphonates in the treatment of osteoporosis: a review of their contribution and controversies. Skeletal Radiol (2011) 0.82
Evaluation of fracture risk and potential drug holidays for postmenopausal women on long-term bisphosphonate therapy. Int J Womens Health (2014) 0.82
Long-term safety concerns of antiresorptive therapy. Rheum Dis Clin North Am (2011) 0.81
Oral bisphosphonates and the risk of Barrett's esophagus: case-control analysis of US veterans. Am J Gastroenterol (2013) 0.81
Nephrotic syndrome after oral bisphosphonate (alendronate) administration in a patient with osteoporosis. Osteoporos Int (2012) 0.80
Oral Bisphosphonate and Risk of Esophageal Cancer: A Nationwide Claim Study. J Bone Metab (2015) 0.80
Clinical utility of denosumab for treatment of bone loss in men and women. Clin Interv Aging (2011) 0.79
Oral bisphosphonates and upper gastrointestinal toxicity: a study of cancer and early signals of esophageal injury. Osteoporos Int (2014) 0.78
Oral Bisphosphonate Exposure and the Risk of Upper Gastrointestinal Cancers. PLoS One (2015) 0.78
The carcinogenicity of alendronate in patients with osteoporosis: evidence from cohort studies. PLoS One (2015) 0.77
Bisphosphonate Treatment in Osteoporosis: Optimal Duration of Therapy and the Incorporation of a Drug Holiday. HSS J (2015) 0.77
Safety of drugs used in the treatment of osteoporosis. Ther Adv Drug Saf (2011) 0.77
Combination of Micronutrients for Bone (COMB) Study: bone density after micronutrient intervention. J Environ Public Health (2012) 0.77
How long should we treat? Osteoporos Int (2014) 0.75
Venous thromboembolism in adults screened for sickle cell trait: a population-based cohort study with nested case-control analysis. BMJ Open (2017) 0.75
Bisphosphonates and evidence for association with esophageal and gastric cancer: a systematic review and meta-analysis. BMJ Open (2015) 0.75
Bisphosphonates as potential adjuvants for patients with cancers of the digestive system. World J Gastroenterol (2016) 0.75
Oral Bisphosphonates and Upper Gastrointestinal Cancer Risks in Asians with Osteoporosis: A Nested Case-Control Study Using National Retrospective Cohort Sample Data from Korea. PLoS One (2016) 0.75
Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program. Cancer (2015) 0.75
[Not Available]. Orthopade (2012) 0.75
Risedronate's Role in Reducing Hip Fracture in Postmenopausal Women with Established Osteoporosis. Clin Med Insights Arthritis Musculoskelet Disord (2012) 0.75
Osteoporosis in 2010: building bones and (safely) preventing breaks. Nat Rev Rheumatol (2011) 0.75
Decreased risk of breast cancer associated with oral bisphosphonate therapy. Breast Cancer (Dove Med Press) (2012) 0.75
Therapy: Bisphosphonate users: cancer risk. Nat Rev Rheumatol (2010) 0.75
ACP Journal Club. Use of bisphosphonates was not associated with increased risk for esophageal or gastric cancer. Ann Intern Med (2010) 0.75
Statistical methods in cancer research. Volume II--The design and analysis of cohort studies. IARC Sci Publ (1987) 27.11
Validation of information recorded on general practitioner based computerised data resource in the United Kingdom. BMJ (1991) 17.91
Reports of esophageal cancer with oral bisphosphonate use. N Engl J Med (2009) 7.09
The General Practice Research Database: quality of morbidity data. Popul Trends (1997) 7.07
Esophagitis associated with the use of alendronate. N Engl J Med (1996) 4.89
An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J Clin Invest (2004) 4.03
A systematic review of persistence and compliance with bisphosphonates for osteoporosis. Osteoporos Int (2007) 3.50
Calcium-channel blockers and risk of cancer. Lancet (1997) 2.53
Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity. Br J Haematol (1997) 2.14
Prescribing of hormone therapy for menopause, tibolone, and bisphosphonates in women in the UK between 1991 and 2005. Eur J Clin Pharmacol (2007) 1.88
More on reports of esophageal cancer with oral bisphosphonate use. N Engl J Med (2009) 1.50
Zoledronic acid induces apoptosis and inhibits adhesion to mineralized matrix in prostate cancer cells via inhibition of protein prenylation. BJU Int (2004) 1.45
Effect of the Women's Health Initiative on osteoporosis therapy and expenditure in Medicaid. J Bone Miner Res (2006) 1.43
Antitumor effects of bisphosphonates: promising preclinical evidence. Cancer Treat Rev (2008) 1.40
More on reports of esophageal cancer with oral bisphosphonate use. N Engl J Med (2009) 1.31
Effect of clinical trial publicity on HRT prescribing in Ireland. Eur J Clin Pharmacol (2006) 1.15
Alendronate-induced esophagitis: case report of a recently recognized form of severe esophagitis with esophageal stricture--radiographic features. Radiology (1998) 1.08
More on reports of esophageal cancer with oral bisphosphonate use. N Engl J Med (2009) 0.91
Tea drinking habits and oesophageal cancer in a high risk area in northern Iran: population based case-control study. BMJ (2009) 5.79
Smoking and mortality--beyond established causes. N Engl J Med (2015) 5.54
Association of coffee drinking with total and cause-specific mortality. N Engl J Med (2012) 5.31
Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China. Int J Cancer (2005) 4.69
Risk of malignant progression in Barrett's esophagus patients: results from a large population-based study. J Natl Cancer Inst (2011) 4.31
Association between smoking and risk of bladder cancer among men and women. JAMA (2011) 4.31
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
Coffee intake is associated with lower rates of liver disease progression in chronic hepatitis C. Hepatology (2009) 3.50
Serum vitamin D concentration and prostate cancer risk: a nested case-control study. J Natl Cancer Inst (2008) 3.04
Opposing risks of gastric cardia and noncardia gastric adenocarcinomas associated with Helicobacter pylori seropositivity. J Natl Cancer Inst (2006) 2.97
Environmental causes of esophageal cancer. Gastroenterol Clin North Am (2009) 2.80
Cigarette smoking and subsequent risk of lung cancer in men and women: analysis of a prospective cohort study. Lancet Oncol (2008) 2.71
Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the Linxian General Population Nutrition Intervention Trial. J Natl Cancer Inst (2009) 2.43
The incidence of esophageal cancer and high-grade dysplasia in Barrett's esophagus: a systematic review and meta-analysis. Am J Epidemiol (2008) 2.34
A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes. Am J Epidemiol (2007) 2.31
Prospective study of ultraviolet radiation exposure and mortality risk in the United States. Am J Epidemiol (2013) 2.30
Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. Carcinogenesis (2009) 2.17
Cohort Profile: The Golestan Cohort Study--a prospective study of oesophageal cancer in northern Iran. Int J Epidemiol (2009) 2.10
Prospective study of serum 25-hydroxyvitamin D concentration and mortality in a Chinese population. Am J Epidemiol (2012) 2.08
Opium use and risk of mortality from digestive diseases: a prospective cohort study. Am J Gastroenterol (2013) 2.07
Opium use and mortality in Golestan Cohort Study: prospective cohort study of 50,000 adults in Iran. BMJ (2012) 2.07
The gastro-esophageal malignancies in Northern Iran research project: impact on the health research and health care systems in Iran. Arch Iran Med (2013) 2.01
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet (2012) 2.00
Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study. World J Gastroenterol (2007) 1.96
Circulating 25-hydroxyvitamin D and the risk of rarer cancers: Design and methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol (2010) 1.95
Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis. Cancer Epidemiol Biomarkers Prev (2006) 1.90
Prevalence, awareness and risk factors of hypertension in a large cohort of Iranian adult population. J Hypertens (2013) 1.86
Methods of calculating prostate-specific antigen velocity. Eur Urol (2006) 1.84
Clustering of metabolic syndrome risk factors and arterial stiffness in young adults: the Northern Ireland Young Hearts Project. J Hypertens (2007) 1.84
Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohort. J Natl Cancer Inst (2010) 1.81
Socio-economic status and oesophageal cancer: results from a population-based case-control study in a high-risk area. Int J Epidemiol (2009) 1.77
Fruit and vegetable consumption and bone mineral density: the Northern Ireland Young Hearts Project. Am J Clin Nutr (2004) 1.77
Cardiorespiratory fitness, physical activity, and arterial stiffness: the Northern Ireland Young Hearts Project. Hypertension (2004) 1.72
Polycyclic aromatic hydrocarbon exposure in oesophageal tissue and risk of oesophageal squamous cell carcinoma in north-eastern Iran. Gut (2010) 1.71
Prospective study of serum vitamin E levels and esophageal and gastric cancers. J Natl Cancer Inst (2003) 1.68
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. Nat Genet (2013) 1.67
Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke, and total death. Am J Clin Nutr (2004) 1.65
Can physical activity modulate pancreatic cancer risk? a systematic review and meta-analysis. Int J Cancer (2010) 1.64
Cigarette smoking and adenocarcinomas of the esophagus and esophagogastric junction: a pooled analysis from the international BEACON consortium. J Natl Cancer Inst (2010) 1.60
High exposure to polycyclic aromatic hydrocarbons may contribute to high risk of esophageal cancer in northeastern Iran. Anticancer Res (2005) 1.57
Genes of the interleukin-18 pathway are associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma. Am J Gastroenterol (2012) 1.54
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nat Genet (2012) 1.52
Mendelian randomization: how it can--and cannot--help confirm causal relations between nutrition and cancer. Cancer Prev Res (Phila) (2009) 1.51
Verbal autopsy: reliability and validity estimates for causes of death in the Golestan Cohort Study in Iran. PLoS One (2010) 1.47
Ecologic study of serum selenium and upper gastrointestinal cancers in Iran. World J Gastroenterol (2004) 1.47
Dietary patterns and breast cancer risk: a systematic review and meta-analysis. Am J Clin Nutr (2010) 1.46
Nonsteroidal anti-inflammatory drug use reduces risk of adenocarcinomas of the esophagus and esophagogastric junction in a pooled analysis. Gastroenterology (2011) 1.44
Fruit and vegetable intake and esophageal cancer in a large prospective cohort study. Int J Cancer (2007) 1.32
Nonsteroidal anti-inflammatory drugs and the esophageal inflammation-metaplasia-adenocarcinoma sequence. Cancer Res (2006) 1.32
Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland). Cancer Causes Control (2006) 1.31
Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium. Int J Epidemiol (2012) 1.30
Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study. Int J Cancer (2008) 1.28
Using lowess to remove systematic trends over time in predictor variables prior to logistic regression with quantile categories. Stat Med (2003) 1.26
Germline genetic contributions to risk for esophageal adenocarcinoma, Barrett's esophagus, and gastroesophageal reflux. J Natl Cancer Inst (2013) 1.25
The association between alcohol and reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. Gastroenterology (2008) 1.25
Prospective study of ultraviolet radiation exposure and risk of cancer in the United States. Int J Cancer (2012) 1.23
Urinary prostaglandin E2 metabolite and gastric cancer risk in the Shanghai women's health study. Cancer Epidemiol Biomarkers Prev (2009) 1.23
Esophageal cancer in young people: a case series of 109 cases and review of the literature. PLoS One (2010) 1.21
Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China. Cancer Epidemiol Biomarkers Prev (2003) 1.20
Prospective investigation of the cigarette smoking-head and neck cancer association by sex. Cancer (2007) 1.20
A population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence. Gastroenterology (2010) 1.19
Diabetes mellitus and its correlates in an Iranian adult population. PLoS One (2011) 1.19
Alcohol intake and risk of oesophageal adenocarcinoma: a pooled analysis from the BEACON Consortium. Gut (2011) 1.18
Menstrual and reproductive factors and gastric cancer risk in a large prospective study of women. Gut (2007) 1.17
Exposure to oral bisphosphonates and risk of cancer. Int J Cancer (2012) 1.17
Cytologic detection of esophageal squamous cell carcinoma and its precursor lesions using balloon samplers and liquid-based cytology in asymptomatic adults in Llinxian, China. Acta Cytol (2008) 1.16
A prospective cohort study of obesity and risk of oesophageal and gastric adenocarcinoma in the NIH-AARP Diet and Health Study. Gut (2011) 1.14
Tobacco smoking increases the risk of high-grade dysplasia and cancer among patients with Barrett's esophagus. Gastroenterology (2011) 1.14
Through the looking glass at early-life exposures and breast cancer risk. Cancer Invest (2005) 1.13
Population-based study reveals new risk-stratification biomarker panel for Barrett's esophagus. Gastroenterology (2012) 1.13
Serum 25-hydroxyvitamin D and cancer mortality in the NHANES III study (1988-2006). Cancer Res (2010) 1.12
Human papillomavirus serology and the risk of esophageal and gastric cancers: results from a cohort in a high-risk region in China. Int J Cancer (2006) 1.12
Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil. BMC Cancer (2006) 1.10
InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers. J Natl Cancer Inst (2012) 1.09
Meat consumption and risk of esophageal and gastric cancer in a large prospective study. Am J Gastroenterol (2010) 1.09
Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population. Carcinogenesis (2013) 1.08
Fruits, vegetables, and antioxidants and risk of gastric cancer among male smokers. Cancer Epidemiol Biomarkers Prev (2005) 1.08
Patterns of food and nutrient consumption in northern Iran, a high-risk area for esophageal cancer. Nutr Cancer (2009) 1.07
Serum pepsinogens and risk of esophageal squamous dysplasia. Int J Cancer (2009) 1.07
No association between HPV infection and the neoplastic progression of esophageal squamous cell carcinoma: result from a cross-sectional study in a high-risk region of China. Int J Cancer (2006) 1.07
Opium: an emerging risk factor for gastric adenocarcinoma. Int J Cancer (2013) 1.06
Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev (2004) 1.06
No role for human papillomavirus in esophageal squamous cell carcinoma in China. Int J Cancer (2010) 1.06
Polymorphisms in interleukin -2, -6, and -10 are not associated with gastric cardia or esophageal cancer in a high-risk chinese population. Cancer Epidemiol Biomarkers Prev (2004) 1.06
Glycemic index, glycemic load, and risk of digestive tract neoplasms: a systematic review and meta-analysis. Am J Clin Nutr (2008) 1.05
High levels of carcinogenic polycyclic aromatic hydrocarbons in mate drinks. Cancer Epidemiol Biomarkers Prev (2008) 1.05
The association of menstrual and reproductive factors with upper gastrointestinal tract cancers in the NIH-AARP cohort. Cancer (2010) 1.05
Squamous dysplasia--the precursor lesion for esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev (2013) 1.04
Tracking of physical activity, fitness, body composition and diet from adolescence to young adulthood: The Young Hearts Project, Northern Ireland. Int J Behav Nutr Phys Act (2004) 1.03