Published in Exp Eye Res on August 13, 2010
Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal (2013) 1.48
From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma. Curr Eye Res (2013) 1.31
Neurodegenerative and inflammatory pathway components linked to TNF-α/TNFR1 signaling in the glaucomatous human retina. Invest Ophthalmol Vis Sci (2011) 1.17
The complex role of neuroinflammation in glaucoma. Cold Spring Harb Perspect Med (2014) 1.13
Novel role for the innate immune receptor Toll-like receptor 4 (TLR4) in the regulation of the Wnt signaling pathway and photoreceptor apoptosis. PLoS One (2012) 0.98
An astrocyte-specific proteomic approach to inflammatory responses in experimental rat glaucoma. Invest Ophthalmol Vis Sci (2012) 0.97
Enhanced insight into the autoimmune component of glaucoma: IgG autoantibody accumulation and pro-inflammatory conditions in human glaucomatous retina. PLoS One (2013) 0.95
Immune regulation toward immunomodulation for neuroprotection in glaucoma. Curr Opin Pharmacol (2012) 0.93
Status of systemic oxidative stresses in patients with primary open-angle glaucoma and pseudoexfoliation syndrome. PLoS One (2012) 0.93
Proteomics analyses of human optic nerve head astrocytes following biomechanical strain. Mol Cell Proteomics (2011) 0.88
Good news-bad news: the Yin and Yang of immune privilege in the eye. Front Immunol (2012) 0.88
The D₁ dopamine receptor agonist, SKF83959, attenuates hydrogen peroxide-induced injury in RGC-5 cells involving the extracellular signal-regulated kinase/p38 pathways. Mol Vis (2012) 0.86
Immunoproteomic analysis of potential serum biomarker candidates in human glaucoma. Invest Ophthalmol Vis Sci (2012) 0.86
The association of glutathione S-transferase GSTT1 and GSTM1 gene polymorphism with pseudoexfoliative glaucoma in a Pakistani population. Mol Vis (2010) 0.84
A decade of proteomics studies of glaucomatous neurodegeneration. Proteomics Clin Appl (2014) 0.84
A proteomics view of the molecular mechanisms and biomarkers of glaucomatous neurodegeneration. Prog Retin Eye Res (2013) 0.83
Molecular biomarkers in glaucoma. Invest Ophthalmol Vis Sci (2013) 0.81
ROS detoxification and proinflammatory cytokines are linked by p38 MAPK signaling in a model of mature astrocyte activation. PLoS One (2013) 0.81
Proteomics Analysis of Molecular Risk Factors in the Ocular Hypertensive Human Retina. Invest Ophthalmol Vis Sci (2015) 0.80
Current perspective of neuroprotection and glaucoma. Clin Ophthalmol (2015) 0.80
Antioxidant Treatment Limits Neuroinflammation in Experimental Glaucoma. Invest Ophthalmol Vis Sci (2016) 0.79
Retinal transcriptome profiling at transcription start sites: a cap analysis of gene expression early after axonal injury. BMC Genomics (2014) 0.78
An approach to predict the risk of glaucoma development by integrating different attribute data. Springerplus (2012) 0.78
[Complement activation after induction of ocular hypertension in an animal model]. Ophthalmologe (2015) 0.77
A mouse ocular explant model that enables the study of living optic nerve head events after acute and chronic intraocular pressure elevation: Focusing on retinal ganglion cell axons and mitochondria. Exp Eye Res (2017) 0.76
Retinal stem cells transplantation combined with copolymer-1 immunization reduces interferon-gamma levels in an experimental model of glaucoma. Int J Ophthalmol (2011) 0.76
Rationale for the use of multifunctional drugs as neuroprotective agents for glaucoma. Neural Regen Res (2012) 0.76
The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study. Oncotarget (2016) 0.75
Early remodelling of the extracellular matrix proteins tenascin-C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma model. J Cell Mol Med (2016) 0.75
Glioprotection of Retinal Astrocytes After Intravitreal Administration of Memantine in the Mouse Optic Nerve Crush Model. Med Sci Monit (2017) 0.75
Changes in Retinal N-Acylethanolamines and their Oxylipin Derivatives During the Development of Visual Impairment in a Mouse Model for Glaucoma. Lipids (2016) 0.75
Non-amyloidogenic effects of α2 adrenergic agonists: implications for brimonidine-mediated neuroprotection. Cell Death Dis (2016) 0.75
Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective. Proc Natl Acad Sci U S A (2017) 0.75
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science (2005) 14.43
Origin and physiological roles of inflammation. Nature (2008) 11.68
The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol (2002) 11.38
Regeneration beyond the glial scar. Nat Rev Neurosci (2004) 11.00
The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron (2008) 10.19
The classical complement cascade mediates CNS synapse elimination. Cell (2007) 9.06
Primary open-angle glaucoma. Lancet (2004) 7.63
Microglial physiology: unique stimuli, specialized responses. Annu Rev Immunol (2009) 6.79
Human optic nerve fiber count and optic disc size. Invest Ophthalmol Vis Sci (1992) 2.94
Para-inflammation in the aging retina. Prog Retin Eye Res (2009) 2.71
Why is Wallerian degeneration in the CNS so slow? Annu Rev Neurosci (2007) 2.70
Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog Retin Eye Res (2006) 2.49
The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol (1999) 2.46
The small heat-shock protein alpha B-crystallin as candidate autoantigen in multiple sclerosis. Nature (1995) 2.44
The optic nerve head in glaucoma: role of astrocytes in tissue remodeling. Prog Retin Eye Res (2000) 2.44
Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma. J Neurosci (2006) 2.37
The effect of age on normal human optic nerve fiber number and diameter. Ophthalmology (1989) 2.18
Chronology of optic nerve head and retinal responses to elevated intraocular pressure. Invest Ophthalmol Vis Sci (2000) 2.13
The blood-brain barrier and immune function and dysfunction. Neurobiol Dis (2009) 2.08
TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes. Invest Ophthalmol Vis Sci (2001) 2.04
Viscoelastic material properties of the peripapillary sclera in normal and early-glaucoma monkey eyes. Invest Ophthalmol Vis Sci (2005) 2.02
Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma. Invest Ophthalmol Vis Sci (2006) 2.00
Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol (2009) 2.00
Microglial senescence: does the brain's immune system have an expiration date? Trends Neurosci (2006) 1.93
Tumor necrosis factor-alpha: a potentially neurodestructive cytokine produced by glia in the human glaucomatous optic nerve head. Glia (2000) 1.87
Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells. J Neurosci (2000) 1.84
Clinical and ocular histopathological findings in a patient with normal-pressure glaucoma. Arch Ophthalmol (1998) 1.78
Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model. Invest Ophthalmol Vis Sci (2007) 1.73
Involvement of ROS in BBB dysfunction. Free Radic Res (2009) 1.73
Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure. Invest Ophthalmol Vis Sci (2004) 1.72
Premise and prediction-how optic nerve head biomechanics underlies the susceptibility and clinical behavior of the aged optic nerve head. J Glaucoma (2008) 1.70
The normal human optic nerve. Axon count and axon diameter distribution. Ophthalmology (1989) 1.69
Retracted Extracellular heat shock proteins in cell signaling and immunity. Ann N Y Acad Sci (2007) 1.65
New roles for astrocytes (stars at last). Trends Neurosci (2003) 1.63
Autoimmunity on alert: naturally occurring regulatory CD4(+)CD25(+) T cells as part of the evolutionary compromise between a 'need' and a 'risk'. Trends Immunol (2002) 1.59
Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head. Arch Ophthalmol (2000) 1.58
Control of glial immune function by neurons. Glia (2001) 1.58
Detection of early neuron degeneration and accompanying microglial responses in the retina of a rat model of glaucoma. Invest Ophthalmol Vis Sci (2002) 1.57
T-cell immunosenescence: lessons learned from mouse models of aging. Trends Immunol (2009) 1.55
The immune system and glaucoma. Curr Opin Ophthalmol (2004) 1.51
Estimating the rate of progressive visual field damage in those with open-angle glaucoma, from cross-sectional data. Invest Ophthalmol Vis Sci (2008) 1.47
Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma. Am J Ophthalmol (1998) 1.46
Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes. Invest Ophthalmol Vis Sci (2006) 1.45
Age-related changes in the extracellular matrix of the human optic nerve head. Am J Ophthalmol (1989) 1.43
Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma. Invest Ophthalmol Vis Sci (2005) 1.42
From ocular hypertension to ganglion cell death: a theoretical sequence of events leading to glaucoma. Can J Ophthalmol (2007) 1.42
TNF-alpha signaling in glaucomatous neurodegeneration. Prog Brain Res (2008) 1.40
Astrocytes in glaucomatous optic neuropathy. Prog Brain Res (2008) 1.39
Caspase-independent component of retinal ganglion cell death, in vitro. Invest Ophthalmol Vis Sci (2004) 1.38
Macrophages and microglia in central nervous system injury: are they helpful or harmful? J Cereb Blood Flow Metab (2003) 1.38
Retinal synthesis and deposition of complement components induced by ocular hypertension. Exp Eye Res (2006) 1.37
Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia (2007) 1.36
Ocular autoimmunity: the price of privilege? Immunol Rev (2006) 1.35
Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucoma. Invest Ophthalmol Vis Sci (2003) 1.35
Mitochondrial dysfunction and glaucoma. J Glaucoma (2009) 1.35
Glaucoma: macrocosm to microcosm the Friedenwald lecture. Invest Ophthalmol Vis Sci (2005) 1.33
Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J Neurosci (2008) 1.30
Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray. Glia (2002) 1.30
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes. Glia (2001) 1.29
Immunohistologic evidence for retinal glial cell changes in human glaucoma. Invest Ophthalmol Vis Sci (2002) 1.29
Glaucomatous optic neuropathy: when glia misbehave. Neuroscientist (2003) 1.29
The role of glia, mitochondria, and the immune system in glaucoma. Invest Ophthalmol Vis Sci (2009) 1.29
Friend or foe? Resolving the impact of glial responses in glaucoma. J Glaucoma (2009) 1.27
Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma. Arch Ophthalmol (1999) 1.27
Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. Arch Ophthalmol (2000) 1.26
The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells. J Neurosci (2000) 1.26
The optic nerve head in glaucomatous optic neuropathy. Arch Ophthalmol (1997) 1.26
Gene microarray analysis of experimental glaucomatous retina from cynomologous monkey. Invest Ophthalmol Vis Sci (2003) 1.26
Autoantibodies to small heat shock proteins in glaucoma. Invest Ophthalmol Vis Sci (1998) 1.24
An immunohistochemical study of neuronal and glial cell reactions in retinae of rats with experimental glaucoma. Exp Brain Res (2000) 1.22
Nitric oxide: a potential mediator of retinal ganglion cell damage in glaucoma. Surv Ophthalmol (1999) 1.21
Oxidative stress and the regulation of complement activation in human glaucoma. Invest Ophthalmol Vis Sci (2010) 1.21
Immunoregulation of retinal ganglion cell fate in glaucoma. Exp Eye Res (2009) 1.20
T-cell apoptosis in inflammatory brain lesions: destruction of T cells does not depend on antigen recognition. Am J Pathol (1998) 1.19
Accelerated aging in glaucoma: immunohistochemical assessment of advanced glycation end products in the human retina and optic nerve head. Invest Ophthalmol Vis Sci (2007) 1.17
Mechanisms of immune system activation in glaucoma: oxidative stress-stimulated antigen presentation by the retina and optic nerve head glia. Invest Ophthalmol Vis Sci (2007) 1.16
Mitochondria: Their role in ganglion cell death and survival in primary open angle glaucoma. Exp Eye Res (2010) 1.16
Optic nerve head structure in glaucoma: astrocytes as mediators of axonal damage. Eye (Lond) (2000) 1.15
Age-associated epigenetic modifications in human DNA increase its immunogenicity. Aging (Albany NY) (2010) 1.15
Pathogenesis of ganglion "cell death" in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria. Prog Brain Res (2008) 1.14
Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss. Glia (2010) 1.14
Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. Proc Natl Acad Sci U S A (2007) 1.13
The role of microglia in brain injury. Neurotoxicology (1997) 1.12
Gene expression and functional studies of the optic nerve head astrocyte transcriptome from normal African Americans and Caucasian Americans donors. PLoS One (2008) 1.11
Müller cell response to laser-induced increase in intraocular pressure in rats. Glia (2004) 1.11
Epigenetics, aging, and autoimmunity. Autoimmunity (2008) 1.11
The role of stress factors during aging of the immune system. Ann N Y Acad Sci (2009) 1.11
RAGE on the Toll Road? Cell Mol Immunol (2006) 1.10
Telomere shortening and ageing of the immune system. J Physiol Pharmacol (2008) 1.10
Heat-shock proteins: immunity and autoimmunity. Curr Opin Immunol (1992) 1.10
Early glial responses after acute elevated intraocular pressure in rats. Invest Ophthalmol Vis Sci (2003) 1.07
Phosphorylation-dependent interaction with 14-3-3 in the regulation of bad trafficking in retinal ganglion cells. Invest Ophthalmol Vis Sci (2008) 1.07
Retinal deimination in aging and disease. IUBMB Life (2009) 1.04
Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the rat. Invest Ophthalmol Vis Sci (2002) 1.04
4-Hydroxynonenal, a product of oxidative stress, leads to an antioxidant response in optic nerve head astrocytes. Exp Eye Res (2006) 1.03
Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor. Curr Eye Res (2007) 1.03
Immune reactivity in the nervous system: modulation of T-lymphocyte activation by glial cells. J Exp Biol (1987) 1.03
Dynamic changes in reactive oxygen species and antioxidant levels in retinas in experimental glaucoma. Free Radic Biol Med (2005) 1.03
Retinal microglia differentially express phenotypic markers of antigen-presenting cells in vitro. Invest Ophthalmol Vis Sci (1999) 1.02
Glaucoma: changes in extracellular matrix in the optic nerve head. Ann Med (1993) 1.02