Published in Cell Cycle on August 20, 2010
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging. Aging (Albany NY) (2011) 2.72
Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging. Aging (Albany NY) (2012) 2.59
Answering the ultimate question "what is the proximal cause of aging?". Aging (Albany NY) (2012) 2.04
Circadian clock protein BMAL1 regulates cellular senescence in vivo. Cell Cycle (2011) 1.87
Emerging models and paradigms for stem cell ageing. Nat Cell Biol (2011) 1.77
Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. Aging (Albany NY) (2011) 1.74
Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience (2012) 1.58
BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY) (2014) 1.48
Rapalogs in cancer prevention: anti-aging or anticancer? Cancer Biol Ther (2012) 1.40
Molecular damage in cancer: an argument for mTOR-driven aging. Aging (Albany NY) (2011) 1.29
CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle (2012) 1.29
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. Aging (Albany NY) (2012) 1.24
Rapamycin extends life- and health span because it slows aging. Aging (Albany NY) (2013) 1.19
Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells. Cell Cycle (2011) 1.17
Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy. Oncotarget (2011) 1.16
Rejuvenating immunity: "anti-aging drug today" eight years later. Oncotarget (2015) 1.13
Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions. Oncotarget (2012) 1.11
Hormesis does not make sense except in the light of TOR-driven aging. Aging (Albany NY) (2011) 1.10
Gerosuppressant metformin: less is more. Aging (Albany NY) (2011) 1.08
Progeria, rapamycin and normal aging: recent breakthrough. Aging (Albany NY) (2011) 1.06
Relationship of electrophilic stress to aging. Free Radic Biol Med (2011) 1.06
Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging (Albany NY) (2012) 1.05
Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression? Aging (Albany NY) (2012) 1.02
Embryonic anti-aging niche. Aging (Albany NY) (2011) 1.02
Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling. Aging (Albany NY) (2011) 1.01
Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians' offspring. Aging (Albany NY) (2012) 1.01
Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents. Cell Cycle (2013) 1.00
In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry. Cytometry A (2014) 0.99
Aging is not programmed: genetic pseudo-program is a shadow of developmental growth. Cell Cycle (2013) 0.98
Berberine suppresses gero-conversion from cell cycle arrest to senescence. Aging (Albany NY) (2013) 0.98
Hypoxia and gerosuppression: the mTOR saga continues. Cell Cycle (2012) 0.96
Healthy aging: what can we learn from Caenorhabditis elegans? Z Gerontol Geriatr (2013) 0.96
Some highlights of research on aging with invertebrates, 2010. Aging Cell (2010) 0.95
Caloric restriction: is mammalian life extension linked to p53? Aging (Albany NY) (2012) 0.94
Big mice die young but large animals live longer. Aging (Albany NY) (2013) 0.93
Koschei the immortal and anti-aging drugs. Cell Death Dis (2014) 0.93
Human amniotic fluid stem cells as a model for functional studies of genes involved in human genetic diseases or oncogenesis. Oncotarget (2011) 0.92
Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan. Cell Cycle (2012) 0.91
Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells. Oncotarget (2011) 0.89
Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3. Aging (Albany NY) (2012) 0.89
Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells. Oncotarget (2012) 0.88
The aging-disease false dichotomy: understanding senescence as pathology. Front Genet (2015) 0.87
Identification of a DNA methylation signature in blood cells from persons with Down Syndrome. Aging (Albany NY) (2015) 0.86
Recent discoveries in the cycling, growing and aging of the p53 field. Aging (Albany NY) (2012) 0.85
Why the disposable soma theory cannot explain why women live longer and why we age. Aging (Albany NY) (2010) 0.85
What is the Proximal Cause of Aging? Front Genet (2012) 0.85
Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases. J Transl Med (2015) 0.85
Phenolic secoiridoids in extra virgin olive oil impede fibrogenic and oncogenic epithelial-to-mesenchymal transition: extra virgin olive oil as a source of novel antiaging phytochemicals. Rejuvenation Res (2012) 0.84
Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan. Cell Cycle (2014) 0.83
cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad. Aging (Albany NY) (2012) 0.83
Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes. Oncotarget (2012) 0.82
Exceptional longevity is associated with decreased reproduction. Aging (Albany NY) (2011) 0.82
Metformin and sex: Why suppression of aging may be harmful to young male mice. Aging (Albany NY) (2010) 0.82
The FoxO3 gene and cause-specific mortality. Aging Cell (2016) 0.82
Understanding PLZF: two transcriptional targets, REDD1 and smooth muscle α-actin, define new questions in growth control, senescence, self-renewal and tumor suppression. Cell Cycle (2011) 0.81
Gene Expression Changes Associated With the Developmental Plasticity of Sea Urchin Larvae in Response to Food Availability. Biol Bull (2015) 0.80
Milk--A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation. Int J Mol Sci (2015) 0.80
Retracted A negative-feedback loop between the detoxification/antioxidant response factor SKN-1 and its repressor WDR-23 matches organism needs with environmental conditions. Mol Cell Biol (2013) 0.80
Rapamycin induces pluripotent genes associated with avoidance of replicative senescence. Cell Cycle (2013) 0.80
The pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitus. Curr Diabetes Rev (2015) 0.80
p53 mutations associated with aging-related rise in cancer incidence rates. Cell Cycle (2013) 0.79
Circadian clocks govern calorie restriction-mediated life span extension through BMAL1- and IGF-1-dependent mechanisms. FASEB J (2015) 0.79
Multifaceted aging and rapamycin. Aging (Albany NY) (2013) 0.78
Pleiotropy and life history evolution in Drosophila melanogaster: uncoupling life span and early fecundity. J Gerontol A Biol Sci Med Sci (2012) 0.77
Glutamate transporter-dependent mTOR phosphorylation in Müller glia cells. ASN Neuro (2012) 0.77
Developmental Drift and the Role of Wnt Signaling in Aging. Cancers (Basel) (2016) 0.76
miR-34a promotes fibrosis in aged lungs by inducing alveolar epithelial dysfunctions. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
The hammer of TORC1! Cell Cycle (2015) 0.75
Effect of aging on stem cells. World J Exp Med (2017) 0.75
"Age" in lung transplantation: factors related to outcomes and other considerations. Curr Pulmonol Rep (2016) 0.75
Evidence that a mitochondrial death spiral underlies antagonistic pleiotropy. Aging Cell (2017) 0.75
Amniotic fluid stem cells to study mTOR signaling in differentiation. Organogenesis (2012) 0.75
Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to. Aging (Albany NY) (2012) 1.41
Rapamycin-induced glucose intolerance: hunger or starvation diabetes. Cell Cycle (2011) 1.13
Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal. Cell Cycle (2010) 1.13
Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells. Oncotarget (2012) 0.88
MTOR-driven quasi-programmed aging as a disposable soma theory: blind watchmaker vs. intelligent designer. Cell Cycle (2013) 0.82