Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Marine natural products of fungal origin.
|
Nat Prod Rep
|
2007
|
2.18
|
2
|
Human, rat, and mouse metabolism of resveratrol.
|
Pharm Res
|
2002
|
1.62
|
3
|
Antimicrobial natural products: an update on future antibiotic drug candidates.
|
Nat Prod Rep
|
2009
|
1.43
|
4
|
An update on bioactive plant lignans.
|
Nat Prod Rep
|
2005
|
1.10
|
5
|
In vivo anti-inflammatory and antinociceptive effects of liriodendrin isolated from the stem bark of Acanthopanax senticosus.
|
Planta Med
|
2003
|
1.01
|
6
|
Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity.
|
Cancer Lett
|
2002
|
1.00
|
7
|
Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten.
|
Brain Res
|
2003
|
0.99
|
8
|
The seed extract of Cassia obtusifolia ameliorates learning and memory impairments induced by scopolamine or transient cerebral hypoperfusion in mice.
|
J Pharmacol Sci
|
2007
|
0.97
|
9
|
Anti-inflammatory effect of caffeic acid methyl ester and its mode of action through the inhibition of prostaglandin E2, nitric oxide and tumor necrosis factor-alpha production.
|
Biochem Pharmacol
|
2004
|
0.94
|
10
|
Sulfuretin isolated from heartwood of Rhus verniciflua inhibits LPS-induced inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines expression via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells.
|
Int Immunopharmacol
|
2010
|
0.92
|
11
|
Identification of new dicaffeoylquinic acids from Chrysanthemum morifolium and their antioxidant activities.
|
Planta Med
|
2005
|
0.91
|
12
|
Arvelexin from Brassica rapa suppresses NF-κB-regulated pro-inflammatory gene expression by inhibiting activation of IκB kinase.
|
Br J Pharmacol
|
2011
|
0.89
|
13
|
Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols.
|
Jpn J Cancer Res
|
2002
|
0.88
|
14
|
Identification of tyrosinase inhibitors from Glycyrrhiza uralensis.
|
Planta Med
|
2005
|
0.87
|
15
|
Synthesis and antitubercular activity of monocyclic nitroimidazoles: insights from econazole.
|
Bioorg Med Chem Lett
|
2011
|
0.86
|
16
|
Cyclooxygenase inhibitors: scope of their use and development in cancer chemotherapy.
|
Med Res Rev
|
2011
|
0.86
|
17
|
Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction.
|
Carcinogenesis
|
2012
|
0.86
|
18
|
Acteoside inhibits human promyelocytic HL-60 leukemia cell proliferation via inducing cell cycle arrest at G0/G1 phase and differentiation into monocyte.
|
Carcinogenesis
|
2007
|
0.86
|
19
|
Secondary metabolites from Opuntia ficus-indica var. saboten.
|
Phytochemistry
|
2006
|
0.85
|
20
|
Constituents of the stems and fruits of Opuntia ficus-indica var. saboten.
|
Arch Pharm Res
|
2003
|
0.84
|
21
|
A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.
|
Bioorg Med Chem Lett
|
2002
|
0.83
|
22
|
Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors.
|
Bioorg Med Chem Lett
|
2007
|
0.83
|
23
|
Involvement of ceramide in ischemic tolerance induced by preconditioning with sublethal oxygen-glucose deprivation in primary cultured cortical neurons of rats.
|
Biol Pharm Bull
|
2010
|
0.83
|
24
|
A new chromone, 11-hydroxy-sec-O-glucosylhamaudol from Ostericum koreanum.
|
Chem Pharm Bull (Tokyo)
|
2007
|
0.82
|
25
|
Taraxinic acid, a hydrolysate of sesquiterpene lactone glycoside from the Taraxacum coreanum NAKAI, induces the differentiation of human acute promyelocytic leukemia HL-60 cells.
|
Biol Pharm Bull
|
2002
|
0.81
|
26
|
Anti-inflammatory and antinociceptive effects of sinapyl alcohol and its glucoside syringin.
|
Planta Med
|
2004
|
0.81
|
27
|
Major role of the PI3K/Akt pathway in ischemic tolerance induced by sublethal oxygen-glucose deprivation in cortical neurons in vitro.
|
Arch Pharm Res
|
2011
|
0.81
|
28
|
Two new antioxidant stilbene dimers, parthenostilbenins A and B from Parthenocissus tricuspidata.
|
Planta Med
|
2005
|
0.81
|
29
|
Caffeoylglycolic and caffeoylamino acid derivatives, halfmers of L-chicoric acid, as new HIV-1 integrase inhibitors.
|
Eur J Med Chem
|
2007
|
0.81
|
30
|
Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors.
|
Bioorg Med Chem Lett
|
2005
|
0.80
|
31
|
First pharmacophoric hypothesis for T-type calcium channel blockers.
|
Bioorg Med Chem
|
2004
|
0.80
|
32
|
Antioxidant caffeic acid derivatives from leaves of Parthenocissus tricuspidata.
|
Arch Pharm Res
|
2004
|
0.79
|
33
|
A new anti-HIV flavonoid glucuronide from Chrysanthemum morifolium.
|
Planta Med
|
2003
|
0.79
|
34
|
Functional nucleotides of U5 LTR determining substrate specificity of prototype foamy virus integrase.
|
J Microbiol Biotechnol
|
2008
|
0.79
|
35
|
Saucernetin-7 and saucernetin-8 isolated from Saururus chinensis inhibit the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells.
|
Planta Med
|
2003
|
0.79
|
36
|
Lupane glycosides from the leaves of Acanthopanax koreanum.
|
Chem Pharm Bull (Tokyo)
|
2008
|
0.78
|
37
|
A new diarylheptanoid glycoside from the stem bark of Alnus hirsuta and protective effects of diarylheptanoid derivatives in human HepG2 cells.
|
Chem Pharm Bull (Tokyo)
|
2010
|
0.78
|
38
|
Synthesis and anticancer activity of lavendustin A derivatives containing arylethenylchromone substituents.
|
Eur J Med Chem
|
2006
|
0.78
|
39
|
Protective effects of 6-hydroxy-1-methylindole-3-acetonitrile on cisplatin-induced oxidative nephrotoxicity via Nrf2 inactivation.
|
Food Chem Toxicol
|
2013
|
0.78
|
40
|
Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers.
|
Bioorg Med Chem Lett
|
2005
|
0.78
|
41
|
The n-butanolic extract of Opuntia ficus-indica var. saboten enhances long-term memory in the passive avoidance task in mice.
|
Prog Neuropsychopharmacol Biol Psychiatry
|
2010
|
0.78
|
42
|
Neuroprotective and antioxidant effects of the ethyl acetate fraction prepared from Tussilago farfara L.
|
Biol Pharm Bull
|
2005
|
0.78
|
43
|
4'-bromo-5,6,7-trimethoxyflavone represses lipopolysaccharide-induced iNOS and COX-2 expressions by suppressing the NF-κB signaling pathway in RAW 264.7 macrophages.
|
Bioorg Med Chem Lett
|
2011
|
0.78
|
44
|
New diarylheptanoids from the stems of Carpinus cordata.
|
J Nat Prod
|
2002
|
0.77
|
45
|
Novel amides and esters prodrugs of olmesartan: Synthesis, bioconversion, and pharmacokinetic evaluation.
|
Bioorg Med Chem Lett
|
2010
|
0.77
|
46
|
Synthesis and anticancer activity of chromone-based analogs of lavendustin A.
|
Eur J Med Chem
|
2010
|
0.77
|
47
|
Glucose-containing flavones--their synthesis and antioxidant and neuroprotective activities.
|
Bioorg Med Chem Lett
|
2009
|
0.77
|
48
|
Development of fecal microbial enzyme mix for mutagenicity assay of natural products.
|
J Microbiol Biotechnol
|
2012
|
0.77
|
49
|
Styrylquinazolines: a new class of inhibitors on prostaglandin E2 production in lipopolysaccharide-activated macrophage cells.
|
Arch Pharm (Weinheim)
|
2004
|
0.76
|
50
|
Catechol-substituted L-chicoric acid analogues as HIV integrase inhibitors.
|
Bioorg Med Chem Lett
|
2003
|
0.76
|
51
|
Arvelexin inhibits colonic inflammation by suppression of NF-κB activation in dextran sulfate sodium-induced mice and TNF-α-induced colonic epithelial cells.
|
J Agric Food Chem
|
2012
|
0.76
|
52
|
Synthesis of chromone carboxamide derivatives with antioxidative and calpain inhibitory properties.
|
Eur J Med Chem
|
2011
|
0.76
|
53
|
Synthesis and biological evaluation of cyclopentane-linked alkyl phosphocholines as potential anticancer agents that act by inhibiting Akt phosphorylation.
|
Eur J Med Chem
|
2011
|
0.76
|
54
|
Angiotensin converting enzyme inhibitory phenylpropanoid glycosides from Clerodendron trichotomum.
|
J Ethnopharmacol
|
2003
|
0.76
|
55
|
Styrylquinazoline derivatives as HIV-1 integrase inhibitors.
|
Arch Pharm (Weinheim)
|
2002
|
0.76
|
56
|
A new epicatechin gallate and calpain inhibitory activity from Orostachys japonicus.
|
Fitoterapia
|
2008
|
0.76
|
57
|
Role of metabolism by human intestinal microflora in geniposide-induced toxicity in HepG2 cells.
|
Arch Pharm Res
|
2012
|
0.76
|
58
|
Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines.
|
Bioorg Med Chem
|
2013
|
0.76
|
59
|
Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives.
|
Eur J Med Chem
|
2008
|
0.76
|
60
|
Synthesis of tyrosinase inhibitory (4-oxo-4H-pyran-2-yl)acrylic acid ester derivatives.
|
Bioorg Med Chem Lett
|
2008
|
0.76
|
61
|
Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors.
|
Bioorg Med Chem Lett
|
2008
|
0.75
|
62
|
An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK.
|
Br J Pharmacol
|
2013
|
0.75
|
63
|
HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata.
|
Planta Med
|
2002
|
0.75
|
64
|
Suppressive effect of inducible nitric oxide synthase (iNOS) expression by the methanol extract of Actinodaphne lancifolia.
|
Phytother Res
|
2004
|
0.75
|
65
|
Chromone and chromanone derivatives as strand transfer inhibitors of HIV-1 integrase.
|
Arch Pharm Res
|
2008
|
0.75
|
66
|
Synthesis and biological evaluation of 2-substituted quinoline 6-carboxamides as potential mGluR1 antagonists for the treatment of neuropathic pain.
|
Chem Pharm Bull (Tokyo)
|
2014
|
0.75
|
67
|
Synthesis of indolyl-3-acetonitrile derivatives and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.
|
Bioorg Med Chem Lett
|
2013
|
0.75
|
68
|
Synthesis of cinnamoyl ketoamides as hybrid structures of antioxidants and calpain inhibitors.
|
Bioorg Med Chem Lett
|
2011
|
0.75
|
69
|
New imidazo[2,1-b]thiazole derivatives: synthesis, in vitro anticancer evaluation, and in silico studies.
|
Eur J Med Chem
|
2011
|
0.75
|
70
|
Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus.
|
J Nat Prod
|
2006
|
0.75
|
71
|
Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells.
|
Bioorg Med Chem Lett
|
2011
|
0.75
|
72
|
Haplophytin-A induces caspase-8-mediated apoptosis via the formation of death-inducing signaling complex in human promyelocytic leukemia HL-60 cells.
|
Chem Biol Interact
|
2010
|
0.75
|
73
|
A new pterocarpan, (-)-maackiain sulfate, from the roots of Sophora subprostrata.
|
Arch Pharm Res
|
2003
|
0.75
|
74
|
New iridoids from Asperula maximowiczii.
|
J Nat Prod
|
2002
|
0.75
|
75
|
Caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors.
|
Bioorg Med Chem
|
2003
|
0.75
|
76
|
Synthesis of styrylbenzofuran derivatives as styrylquinoline analogues for HIV-1 integrase inhibitor.
|
Farmaco
|
2003
|
0.75
|
77
|
7-Substituted-[1,4]dioxano[2,3-g]quinazolines as inhibitors of epidermal growth factor receptor kinase.
|
Arch Pharm (Weinheim)
|
2002
|
0.75
|