Published in ACS Chem Biol on November 19, 2010
The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab (2016) 1.48
Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist. ACS Chem Biol (2010) 1.22
Action of RORs and their ligands in (patho)physiology. Trends Endocrinol Metab (2012) 1.08
The REV-ERBs and RORs: molecular links between circadian rhythms and lipid homeostasis. Future Med Chem (2011) 1.08
Small molecule modifiers of circadian clocks. Cell Mol Life Sci (2012) 1.03
Regulation of p53 stability and apoptosis by a ROR agonist. PLoS One (2012) 0.99
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RORα decreases oxidative stress through the induction of SOD2 and GPx1 expression and thereby protects against nonalcoholic steatohepatitis in mice. Antioxid Redox Signal (2014) 0.83
Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Toxicol Appl Pharmacol (2012) 0.82
RORα, a potential tumor suppressor and therapeutic target of breast cancer. Int J Mol Sci (2012) 0.82
Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A (2015) 0.81
Small molecule amides as potent ROR-γ selective modulators. Bioorg Med Chem Lett (2012) 0.81
Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα). PLoS One (2012) 0.79
The mammalian clock and chronopharmacology. Bioorg Med Chem Lett (2013) 0.79
Antiobesity Effect of a Small Molecule Repressor of RORγ. Mol Pharmacol (2015) 0.78
Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chem Biol (2016) 0.78
Identification of New Nonsteroidal RORα Ligands; Related Structure-Activity Relationships and Docking Studies. ACS Med Chem Lett (2013) 0.77
DGCR14 induces Il17a gene expression through the RORγ/BAZ1B/RSKS2 complex. Mol Cell Biol (2014) 0.76
Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism. ACS Chem Neurosci (2015) 0.76
The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis. EBioMedicine (2016) 0.76
Molecular Targets for Small-Molecule Modulators of Circadian Clocks. Curr Drug Metab (2016) 0.75
Circadian molecular clock in lung pathophysiology. Am J Physiol Lung Cell Mol Physiol (2015) 0.75
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2007) 13.29
Role of LXRs in control of lipogenesis. Genes Dev (2000) 6.98
Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science (2007) 4.68
Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Nat Struct Mol Biol (2007) 4.10
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal (2009) 3.19
Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science (2008) 3.17
The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist. Mol Pharmacol (2009) 2.30
X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha. Structure (2002) 2.05
Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands. J Biol Chem (2009) 2.02
Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol Endocrinol (2010) 1.98
Regulation of adipogenesis by natural and synthetic REV-ERB ligands. Endocrinology (2010) 1.88
Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A. J Biol Chem (2004) 1.87
T0901317 is a dual LXR/FXR agonist. Mol Genet Metab (2004) 1.50
The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity. J Biol Chem (2008) 1.48
Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha. J Biol Chem (2010) 1.29
A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). Biochim Biophys Acta (2010) 1.28
Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation. Mol Endocrinol (2003) 1.16
Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics. Curr Opin Lipidol (2010) 1.09
In vitro and in vivo evidence for orphan nuclear receptor RORalpha function in bone metabolism. Proc Natl Acad Sci U S A (2000) 1.05
A natural product ligand of the oxysterol receptor, liver X receptor. J Pharmacol Exp Ther (2003) 0.98
Autophagy regulates lipid metabolism. Nature (2009) 13.33
Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J (2003) 5.78
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature (2010) 5.01
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature (2011) 4.44
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature (2011) 4.23
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature (2011) 4.19
Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Nat Struct Mol Biol (2007) 4.10
Autophagy regulates adipose mass and differentiation in mice. J Clin Invest (2009) 3.95
Stroke and stroke care in China: huge burden, significant workload, and a national priority. Stroke (2011) 3.94
Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis. Circulation (2013) 3.57
Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature (2008) 3.44
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature (2012) 3.24
Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry. Anal Chem (2006) 2.89
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology (2009) 2.78
JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology (2006) 2.70
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature (2012) 2.67
Partial agonists activate PPARgamma using a helix 12 independent mechanism. Structure (2007) 2.57
Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science (2011) 2.52
Regulation of carbohydrate metabolism by the farnesoid X receptor. Endocrinology (2004) 2.44
Enantioselective synthesis of 1,5-anti- and 1,5-syn-diols using a highly diastereoselective one-pot double allylboration reaction sequence. J Am Chem Soc (2002) 2.31
The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist. Mol Pharmacol (2009) 2.30
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands. J Biol Chem (2009) 2.02
Spinal Implants Can Be Inserted in Patients With Deep Spine Infection: Results From a Large Cohort Study. Spine (Phila Pa 1976) (2017) 2.02
Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer. Structure (2010) 1.96
Insular hypocretin transmission regulates nicotine reward. Proc Natl Acad Sci U S A (2008) 1.94
Diabetes and poor outcomes within 6 months after acute ischemic stroke: the China National Stroke Registry. Stroke (2011) 1.91
Regulation of adipogenesis by natural and synthetic REV-ERB ligands. Endocrinology (2010) 1.88
Rapid analysis of protein structure and dynamics by hydrogen/deuterium exchange mass spectrometry. J Biomol Tech (2003) 1.85
HD desktop: an integrated platform for the analysis and visualization of H/D exchange data. J Am Soc Mass Spectrom (2008) 1.82
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. J Biol Chem (2005) 1.80
HDX workbench: software for the analysis of H/D exchange MS data. J Am Soc Mass Spectrom (2012) 1.80
Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum (2012) 1.67
A two-stage differential hydrogen deuterium exchange method for the rapid characterization of protein/ligand interactions. J Biomol Tech (2007) 1.65
DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex. Nat Struct Mol Biol (2011) 1.59
Hydrogen/deuterium-exchange (H/D-Ex) of PPARgamma LBD in the presence of various modulators. Protein Sci (2006) 1.59
Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions. Proc Natl Acad Sci U S A (2003) 1.54
Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX. Structure (2011) 1.54
Biomedical importance of indoles. Molecules (2013) 1.53
Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis. J Biol Chem (2002) 1.50
T0901317 is a dual LXR/FXR agonist. Mol Genet Metab (2004) 1.50
Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol (2008) 1.47
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. Cancer Res (2013) 1.46
Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nat Med (2013) 1.46
Effect of spiritual intelligence, emotional intelligence, psychological ownership and burnout on caring behaviour of nurses: a cross-sectional study. J Clin Nurs (2013) 1.46
Analysis of BAC-end sequences (BESs) and development of BES-SSR markers for genetic mapping and hybrid purity assessment in pigeonpea (Cajanus spp.). BMC Plant Biol (2011) 1.45
Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab (2008) 1.45
Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions. Expert Rev Proteomics (2011) 1.45
The vinylogous intramolecular Morita-Baylis-Hillman reaction: synthesis of functionalized cyclopentenes and cyclohexenes with trialkylphosphines as nucleophilic catalysts. J Am Chem Soc (2002) 1.44
Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain. Nat Chem (2011) 1.44
BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci (2011) 1.44
F-wave latencies in patients with diabetes mellitus. Muscle Nerve (2014) 1.42
Enantioselective synthesis of 2-methyl-1,2-syn- and 2-methyl-1,2-anti-3-butenediols via allene hydroboration-aldehyde allylboration reaction sequences. J Am Chem Soc (2009) 1.41
Stereoselective synthesis of gamma-substituted (Z)-allylic boranes via kinetically controlled hydroboration of allenes with 10-TMS-9-borabicyclo[3.3.2]decane. J Am Chem Soc (2009) 1.41
Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2. Dev Cell (2009) 1.41
PM2.5 mass and light extinction reconstruction in IMPROVE. J Air Waste Manag Assoc (2003) 1.40
Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha. J Biol Chem (2008) 1.39
Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones. Antimicrob Agents Chemother (2003) 1.39
Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange. Anal Chem (2010) 1.38
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method. Proc Natl Acad Sci U S A (2008) 1.38
Using recombinant tissue plasminogen activator to treat acute ischemic stroke in China: analysis of the results from the Chinese National Stroke Registry (CNSR). Stroke (2011) 1.37
Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene. J Biol Chem (2010) 1.36
Efficient protiodesilylation of unactivated C(sp3)-SiMe2Ph bonds using tetrabutylammonium fluoride. Org Lett (2005) 1.35
Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem Biol (2010) 1.34
Synthesis of the C(1)-C(25) fragment of amphidinol 3: application of the double-allylboration reaction for synthesis of 1,5-diols. Org Lett (2005) 1.34
Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα. Nat Immunol (2012) 1.34
Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity. J Biol Chem (2009) 1.30
Evidence that gabapentin reduces neuropathic pain by inhibiting the spinal release of glutamate. J Neurochem (2005) 1.30
Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha. J Biol Chem (2010) 1.29
Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem Biol (2012) 1.29
A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). Biochim Biophys Acta (2010) 1.28