Published in Mol Pharmacol on May 01, 1978
Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants. Biophys J (1995) 1.56
Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons. J Physiol (1993) 1.39
Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site. Proc Natl Acad Sci U S A (2006) 1.22
Two distinct interactions of barbiturates and chlormethiazole with the GABAA receptor complex in rat cuneate nucleus in vitro. Br J Pharmacol (1983) 1.15
Distinction between the effects of barbiturates, benzodiazepines and phenytoin on responses to gamma-aminobutyric acid receptor activation and antagonism by bicuculline and picrotoxin. Br J Pharmacol (1981) 1.12
Biochemical dissection of the gamma-aminobutyrate synapse. Biochem J (1983) 0.99
Pentobarbitone interference with inhibitory synaptic transmission in crayfish stretch receptor neurones. J Physiol (1981) 0.95
On the action of the anticonvulsant 5,5-diphenylhydantoin and the convulsant picrotoxin in crayfish stretch receptor. J Physiol (1981) 0.89
Stimulation of receptors of gamma-aminobutyric acid modulates the release of cholecystokinin-like immunoreactivity from slices of rat neostriatum. Br J Pharmacol (1986) 0.86
Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology (2010) 0.86
The effects of acute and chronic ethanol administration and its withdrawal on gamma-aminobutyric acid receptor binding in rat brain. Br J Pharmacol (1980) 0.85
Actions of picrotoxinin and related compounds on the frog spinal cord: the role of a hydroxyl-group at the 6-position in antagonizing the actions of amino acids and presynaptic inhibition. Br J Pharmacol (1984) 0.82
Histidine modification with diethyl pyrocarbonate shows heterogeneity of benzodiazepine receptors. Proc Natl Acad Sci U S A (1981) 0.81
The permeability of gamma-aminobutyric acid-gated chloride channels is described by the binding of a "cage" convulsant, t-butylbicyclophosphoro[35S]thionate. Proc Natl Acad Sci U S A (1986) 0.79
Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. J Neurophysiol (2013) 0.78
Electrophysiological study of SR 42641, a novel aminopyridazine derivative of GABA: antagonist properties and receptor selectivity of GABAA versus GABAB responses. Br J Pharmacol (1987) 0.75
Tetramethylenedisulfotetramine: pest control gone awry. Ann N Y Acad Sci (2016) 0.75
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Influence of gamma-aminobutyric acid on the changes of blood pressure in rats. Korean J Intern Med (1990) 0.75
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International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacol Rev (1998) 4.37
GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Nature (1999) 3.88
Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans. Proc Natl Acad Sci U S A (2003) 3.35
Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice. Proc Natl Acad Sci U S A (1999) 2.88
GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc Natl Acad Sci U S A (2006) 2.53
Drug interactions at the GABA receptor-ionophore complex. Annu Rev Pharmacol Toxicol (1982) 2.17
Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proc Natl Acad Sci U S A (1997) 2.16
Functional domains of GABAA receptors. Trends Pharmacol Sci (1995) 2.10
Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome. J Neurosci (1998) 2.09
An update on GABAA receptors. Brain Res Brain Res Rev (1999) 1.84
GABA-benzodiazepine-barbiturate receptor interactions. J Neurochem (1981) 1.75
A novel alpha subunit in rat brain GABAA receptors. Neuron (1989) 1.51
Progress in the purification of the cholinergic receptor protein from Electrophorus electricus by affinity chromatography. FEBS Lett (1972) 1.47
Acyl phosphatidylglycerol. A new phospholipid from Salmonella typhimurium. J Biol Chem (1971) 1.42
Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513. Proc Natl Acad Sci U S A (2006) 1.41
Binding of the GABA(A) receptor-associated protein (GABARAP) to microtubules and microfilaments suggests involvement of the cytoskeleton in GABARAPGABA(A) receptor interaction. J Neurochem (2000) 1.37
Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment. Brain Res Mol Brain Res (1998) 1.33
Studies on the cholinergic receptor protein from Electrophorus electricus. Effect of detergents on some hydrodynamic properties of the receptor protein in solution. FEBS Lett (1972) 1.32
Some physical properties of the cholinergic receptor protein from Electrophorus electricus revealed by a tritiated alpha-toxin from Naja nigricollis venom. Biochemistry (1972) 1.30
The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc Natl Acad Sci U S A (2000) 1.28
The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics. Proc Natl Acad Sci U S A (2000) 1.25
Interaction of barbiturates with dihydropicrotoxinin binding sites related to the GABA receptor-ionophore system. Life Sci (1978) 1.23
Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex. Eur J Pharmacol (1984) 1.22
The effect of Ca2+ antagonists on mechanical responses and Ca2+ movements in guinea pig ileal longitudinal smooth muscle. Can J Physiol Pharmacol (1979) 1.22
Chronic intermittent ethanol treatment in rats increases GABA(A) receptor alpha4-subunit expression: possible relevance to alcohol dependence. J Neurochem (1997) 1.21
The kindling model of alcohol dependence: similar persistent reduction in seizure threshold to pentylenetetrazol in animals receiving chronic ethanol or chronic pentylenetetrazol. Alcohol Clin Exp Res (1993) 1.20
Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates. J Pharmacol Exp Ther (1989) 1.18
Chloride-dependent enhancement by barbiturates of gamma-aminobutyric acid receptor binding. J Neurosci (1982) 1.15
Regulation of NMDA receptors by ethanol. Prog Drug Res (2000) 1.12
Barbiturate receptor sites are coupled to benzodiazepine receptors. Proc Natl Acad Sci U S A (1980) 1.11
Tyrosine kinase phosphorylation of GABAA receptors. Brain Res Mol Brain Res (1995) 1.11
The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs. Mol Cell Biochem (1981) 1.09
Pharmacological effects of Withania somnifera root extract on GABAA receptor complex. Indian J Med Res (1991) 1.09
Chronic ethanol treatment differentially regulates NMDA receptor subunit mRNA expression in rat brain. Brain Res Mol Brain Res (1995) 1.06
Gamma-aminobutyric acidA receptor structure and function. J Biol Chem (1992) 1.05
Angelman syndrome: correlations between epilepsy phenotypes and genotypes. Ann Neurol (1998) 1.04
Identification of a [3H]muscimol photoaffinity substrate in the bovine gamma-aminobutyric acidA receptor alpha subunit. J Biol Chem (1994) 1.04
Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development? Br J Pharmacol (2008) 1.04
Basis of the gabamimetic profile of ethanol. Alcohol Clin Exp Res (2006) 1.03
Effects of drugs on gamma-aminobutyric acid receptors, uptake, release and synthesis in vitro. Brain Res (1978) 1.02
Chronic ethanol-mediated up-regulation of the N-methyl-D-aspartate receptor polypeptide subunits in mouse cortical neurons in culture. J Biol Chem (1996) 1.02
Binding characteristics and interactions of depressant drugs with [35S]t-butylbicyclophosphorothionate, a ligand that binds to the picrotoxinin site. J Neurochem (1984) 1.02
The 2.6 A resolution structure of Rhodobacter capsulatus bacterioferritin with metal-free dinuclear site and heme iron in a crystallographic 'special position'. Acta Crystallogr D Biol Crystallogr (2001) 1.01
Immunohistochemical, ultrastructural, and molecular features of Kindler syndrome distinguish it from dystrophic epidermolysis bullosa. Arch Dermatol (1997) 1.00
Chronic ethanol treatment upregulates the NMDA receptor function and binding in mammalian cortical neurons. Brain Res Mol Brain Res (1995) 0.99
Alteration in the sensitivity of GABA(A) receptors to allosteric modulatory drugs in rat hippocampus after chronic intermittent ethanol treatment. Alcohol Clin Exp Res (1998) 0.99
Protein kinase C and cAMP-dependent protein kinase phosphorylate the beta subunit of the purified gamma-aminobutyric acid A receptor. Proc Natl Acad Sci U S A (1990) 0.99
Ethanol potentiation of GABAergic transmission in cultured spinal cord neurons involves gamma-aminobutyric acidA-gated chloride channels. J Pharmacol Exp Ther (1988) 0.99
Trace and contextual fear conditioning is enhanced in mice lacking the alpha4 subunit of the GABA(A) receptor. Neurobiol Learn Mem (2009) 0.99
Convulsant and anticonvulsant drug binding sites related to GABA-regulated chloride ion channels. Adv Biochem Psychopharmacol (1981) 0.98
Chronic benzodiazepine treatment of cells expressing recombinant GABA(A) receptors uncouples allosteric binding: studies on possible mechanisms. J Neurochem (2001) 0.98
Ethanol enhances GABA-induced 36Cl-influx in primary spinal cord cultured neurons. Brain Res Bull (1986) 0.96
Chronic ethanol administration alters gamma-aminobutyric acidA receptor gene expression. Mol Pharmacol (1992) 0.95
Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines. J Neurosci (1994) 0.95
Malignant Langerhans cell tumour. Br J Dermatol (1992) 0.94
Persistent reduction of GABA(A) receptor-mediated inhibition in rat hippocampus after chronic intermittent ethanol treatment. Brain Res (1996) 0.94
Antibodies specific for GABAA receptor alpha subunits reveal that chronic alcohol treatment down-regulates alpha-subunit expression in rat brain regions. J Neurochem (1993) 0.94
Chronic benzodiazepine agonist treatment produces functional uncoupling of the gamma-aminobutyric acid-benzodiazepine receptor ionophore complex in cortical neurons. Mol Pharmacol (1994) 0.94
Interactions of barbiturates of various pharmacological categories with benzodiazepine receptors. Mol Pharmacol (1982) 0.94
Down-regulation of the GABA receptor subunits mRNA levels in mammalian cultured cortical neurons following chronic neurosteroid treatment. Brain Res Mol Brain Res (1996) 0.93
Chronic neurosteroid treatment produces functional heterologous uncoupling at the gamma-aminobutyric acid type A/benzodiazepine receptor complex in mammalian cortical neurons. Mol Pharmacol (1995) 0.93
Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons. Brain Res Mol Brain Res (1996) 0.93
GABAA receptor subtypes: ligand binding heterogeneity demonstrated by photoaffinity labeling and autoradiography. J Neurochem (1993) 0.92
Cage convulsants inhibit picrotoxinin binding. Neuropharmacology (1979) 0.92
Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic. J Med Chem (1999) 0.92
NMDA receptor upregulation: molecular studies in cultured mouse cortical neurons after chronic antagonist exposure. J Neurosci (1996) 0.92
Dihydropicrotoxinin binding to crayfish muscle sites possibly related to gamma-aminobutyric acid receptor-ionophores. Mol Pharmacol (1978) 0.92
Potency of inhibitors for gamma-aminobutyric acid uptake by mouse brain subcellular particles at 0 degrees. Mol Pharmacol (1975) 0.92
Is the reciprocating movement per se able to improve the cyclic fatigue resistance of instruments? Int Endod J (2013) 0.91
A single glycine residue at the entrance to the first membrane-spanning domain of the gamma-aminobutyric acid type A receptor beta(2) subunit affects allosteric sensitivity to GABA and anesthetics. Mol Pharmacol (2000) 0.91
Binding characteristics of the gamma-hydroxybutyric acid receptor antagonist [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid in the rat brain. J Pharmacol Exp Ther (2001) 0.90
[3H]bicuculline methochloride binding to low-affinity gamma-aminobutyric acid receptor sites. J Neurochem (1983) 0.90
Enhancement of diazepam and gamma-aminobutyric acid binding by (+)etomidate and pentobarbital. J Neurochem (1983) 0.90
A refractory case of secondary erythermalgia successfully treated with lumbar sympathetic ganglion block. Br J Dermatol (2000) 0.90
Benzodiazepine/barbiturate/GABA receptor-chloride ionophore complex in a genetic model for generalized epilepsy. Adv Neurol (1986) 0.90
[3H]AMPA binding to glutamate receptor subpopulations in rat brain. Brain Res (1987) 0.89
Autoradiographic localization of low affinity GABA receptors with [3H]bicuculline methochloride. Eur J Pharmacol (1984) 0.89
Dissociation of [35S]t-butylbicyclophosphorothionate binding differentiates convulsant and depressant drugs that modulate GABAergic transmission. J Neurochem (1985) 0.89
Pyrethroid insecticides: stereospecific allosteric interaction with the batrachotoxinin-A benzoate binding site of mammalian voltage-sensitive sodium channels. Mol Pharmacol (1988) 0.89
Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol. Alcohol Clin Exp Res (2001) 0.89
Barbiturate and benzodiazepine modulation of GABA receptor binding and function. Life Sci (1986) 0.88
Biochemical properties of the GABA/barbiturate/benzodiazepine receptor-chloride ion channel complex. Adv Exp Med Biol (1984) 0.88
Role of the cyclic AMP response element binding complex and activation of mitogen-activated protein kinases in synergistic activation of the glycoprotein hormone alpha subunit gene by epidermal growth factor and forskolin. Mol Cell Biol (2000) 0.88
Interaction of anticonvulsants with the barbiturate-benzodiazepine-GABA receptor complex. Eur J Pharmacol (1981) 0.88
Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus. Genes Immun (2010) 0.88
Alterations in gamma-aminobutyric acid receptor sensitivity following acute and chronic ethanol treatments. J Neurochem (1980) 0.87
gamma-Aminobutyric acid/benzodiazepine receptor protein carries binding sites for both ligands on both two major peptide subunits. Biochem Biophys Res Commun (1988) 0.87
Taurine acts on a subclass of GABAA receptors in mammalian brain in vitro. Eur J Pharmacol (1991) 0.87
Chronic flurazepam treatment produces decreased efficacy of the benzodiazepine ligands and pentobarbital with gamma-aminobutyric acidA receptors in cortical neurons. J Pharmacol Exp Ther (1994) 0.87
Characterization of the binding of the GABA agonist [3H]piperidine-4-sulphonic acid to bovine brain synaptic membranes. J Neurochem (1981) 0.87
Novel nonnarcotic analgesics with an improved therapeutic ratio. Structure-activity relationships of 8-(methylthio)- and 8-(acylthio)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines. J Med Chem (1985) 0.87
Effects of 5-HT receptor antagonists on seizure susceptibility and locomotor activity in DBA/2 mice. Brain Res (1992) 0.86
Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res (1976) 0.86