Published in Mol Pharm on September 17, 2010
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Uncharacterized 4,5-dihydroxy-2,3-pentanedione (DPD) molecules revealed through NMR spectroscopy: implications for a greater signaling diversity in bacterial species. Angew Chem Int Ed Engl (2012) 1.55
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A vaccine strategy that induces protective immunity against heroin. J Med Chem (2011) 1.47
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Investigations using immunization to attenuate the psychoactive effects of nicotine. Bioorg Med Chem (2004) 1.37
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Impact of distinct chemical structures for the development of a methamphetamine vaccine. J Am Chem Soc (2011) 1.31
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The use of small molecules to investigate molecular mechanisms and therapeutic targets for treatment of botulinum neurotoxin A intoxication. ACS Chem Biol (2006) 1.26
A critical evaluation of a nicotine vaccine within a self-administration behavioral model. Mol Pharm (2010) 1.26
Bimodal modulation of the botulinum neurotoxin protein-conducting channel. Proc Natl Acad Sci U S A (2009) 1.26
Identification of a botulinum neurotoxin A protease inhibitor displaying efficacy in a cellular model. Chem Commun (Camb) (2006) 1.25
Dynamic vaccine blocks relapse to compulsive intake of heroin. Proc Natl Acad Sci U S A (2013) 1.24
Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis. Proc Natl Acad Sci U S A (2004) 1.21
A credit-card library approach for disrupting protein-protein interactions. Bioorg Med Chem (2005) 1.20
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Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Mol Ther (2011) 1.18
A method for the generation of combinatorial antibody libraries using pIX phage display. Proc Natl Acad Sci U S A (2002) 1.18
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Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice. J Neurosci (2009) 1.16
Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors. J Am Chem Soc (2010) 1.14
An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues. J Am Chem Soc (2008) 1.14
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Analysis of epitope information related to Bacillus anthracis and Clostridium botulinum. Expert Rev Vaccines (2008) 1.13
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Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals. J Am Chem Soc (2009) 1.12
A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats. Biol Psychiatry (2012) 1.11
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A molecular link between the active component of marijuana and Alzheimer's disease pathology. Mol Pharm (2006) 1.09
Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms. Cancer Res (2006) 1.08
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Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects. Neuropsychopharmacology (2011) 1.07
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Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate. Biochemistry (2006) 1.04
Soluble polymers as scaffolds for recoverable catalysts and reagents. Chem Rev (2002) 1.04
Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL. Angew Chem Int Ed Engl (2014) 1.03
Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure. Alcohol Clin Exp Res (2004) 1.03
Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network. Br J Haematol (2011) 1.02
A previously undescribed chemical link between smoking and metabolic disease. Proc Natl Acad Sci U S A (2002) 1.02
Cocaine pharmacology and current pharmacotherapies for its abuse. Bioorg Med Chem (2004) 1.02
Human antibodies against spores of the genus Bacillus: a model study for detection of and protection against anthrax and the bioterrorist threat. Proc Natl Acad Sci U S A (2002) 1.01
A new strategy for improved nicotine vaccines using conformationally constrained haptens. J Am Chem Soc (2003) 1.00
Repositioning of an existing drug for the neglected tropical disease Onchocerciasis. Proc Natl Acad Sci U S A (2010) 1.00
Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease. Org Lett (2010) 0.99
Identification and characterization of single chain anti-cocaine catalytic antibodies. J Mol Biol (2006) 0.99
Toward cocaine esterase therapeutics. J Am Chem Soc (2005) 0.99
Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance. J Med Chem (2012) 0.99
Liposomes containing monophosphoryl lipid A: a potent adjuvant system for inducing antibodies to heroin hapten analogs. Vaccine (2013) 0.98
Catalytic antibodies: hapten design strategies and screening methods. Bioorg Med Chem (2004) 0.98
Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity. Toxicon (2009) 0.97
Technological advancements for the detection of and protection against biological and chemical warfare agents. Chem Soc Rev (2007) 0.97
The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior. Behav Brain Res (2010) 0.96
Complete reaction cycle of a cocaine catalytic antibody at atomic resolution. Structure (2006) 0.96
Quantitative mass spectrometry identifies drug targets in cancer stem cell-containing side population. Stem Cells (2008) 0.96
Presynaptic delta opioid receptors regulate ethanol actions in central amygdala. J Pharmacol Exp Ther (2006) 0.96
Bacterial quorum sensing: a new target for anti-infective immunotherapy. Expert Opin Biol Ther (2008) 0.96
Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens. Proc Natl Acad Sci U S A (2003) 0.96
Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus. J Virol (2006) 0.96
Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins. Toxicon (2009) 0.96