Published in J Transl Med on September 17, 2010
Mitochondrial dysfunction in cancer. Front Oncol (2013) 1.57
The state of molecular biomarkers for the early detection of lung cancer. Cancer Prev Res (Phila) (2012) 1.49
Use of the MLPA assay in the molecular diagnosis of gene copy number alterations in human genetic diseases. Int J Mol Sci (2012) 1.21
Comparative proteomic approach identifies PKM2 and cofilin-1 as potential diagnostic, prognostic and therapeutic targets for pulmonary adenocarcinoma. PLoS One (2011) 1.03
Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling. Glia (2013) 0.95
Expression and functionality of histone H2A variants in cancer. Oncotarget (2014) 0.95
Epigenetics of lung cancer. Transl Res (2014) 0.95
EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer. Oncotarget (2014) 0.94
DNA Methylation profiles as predictors of recurrence in non muscle invasive bladder cancer: an MS-MLPA approach. J Exp Clin Cancer Res (2013) 0.94
Obesity, inflammation, and lung injury (OILI): the good. Mediators Inflamm (2014) 0.91
Inhibitor of differentiation 4 (ID4): From development to cancer. Biochim Biophys Acta (2014) 0.89
Methylated circulating tumor DNA in blood: power in cancer prognosis and response. Endocr Relat Cancer (2016) 0.88
A prospective study of tumor suppressor gene methylation as a prognostic biomarker in surgically resected stage I to IIIA non-small-cell lung cancers. J Thorac Oncol (2014) 0.86
Diagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon-rectum. Virchows Arch (2012) 0.86
Inhibitor of differentiation 4 (ID4) inactivation promotes de novo steroidogenesis and castration-resistant prostate cancer. Mol Endocrinol (2014) 0.86
Promoter methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma. Mol Cancer (2012) 0.86
mRNA-based vaccines synergize with radiation therapy to eradicate established tumors. Radiat Oncol (2014) 0.83
Association of Wnt2 and sFRP4 expression in the third trimester placenta in women with severe preeclampsia. Reprod Sci (2013) 0.81
Amplification of chromosome 8 genes in lung cancer. J Cancer (2015) 0.81
Specific Biomarkers Are Associated with Docetaxeland Gemcitabine-Resistant NSCLC Cell Lines. Transl Oncol (2012) 0.81
Oxidative stress, telomere shortening, and DNA methylation in relation to low-to-moderate occupational exposure to welding fumes. Environ Mol Mutagen (2015) 0.81
Distinguishing Lung Adenocarcinoma from Lung Squamous Cell Carcinoma by Two Hypomethylated and Three Hypermethylated Genes: A Meta-Analysis. PLoS One (2016) 0.81
Hidden treasures in "ancient" microarrays: gene-expression portrays biology and potential resistance pathways of major lung cancer subtypes and normal tissue. Front Oncol (2014) 0.81
Copy number changes of CRISP3 in oral squamous cell carcinoma. Oncol Lett (2011) 0.80
Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1, -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity. Biochimie (2015) 0.80
Deleted in liver cancer-1 (DLC1): an emerging metastasis suppressor gene. Mol Diagn Ther (2014) 0.79
Identification of Gene-Expression Signatures and Protein Markers for Breast Cancer Grading and Staging. PLoS One (2015) 0.79
Promoter hypermethylation profiling of distant breast cancer metastases. Breast Cancer Res Treat (2015) 0.79
Gene methylation of human ovarian carcinoma stromal progenitor cells promotes tumorigenesis. J Transl Med (2015) 0.78
Clinicopathological significance and potential drug target of RUNX3 in non-small cell lung cancer: a meta-analysis. Drug Des Devel Ther (2015) 0.78
Association between RUNX3 promoter methylation and non-small cell lung cancer: a meta-analysis. J Thorac Dis (2014) 0.78
Latent Feature Decompositions for Integrative Analysis of Multi-Platform Genomic Data. IEEE/ACM Trans Comput Biol Bioinform (2014) 0.78
Promoter hypermethylation using 24-gene array in early head and neck cancer: better outcome in oral than in oropharyngeal cancer. Epigenetics (2014) 0.78
Identification of potential biomarkers from microarray experiments using multiple criteria optimization. Cancer Med (2013) 0.77
Methylation pattern analysis in prostate cancer tissue: identification of biomarkers using an MS-MLPA approach. J Transl Med (2016) 0.75
CaV channels and cancer: canonical functions indicate benefits of repurposed drugs as cancer therapeutics. Eur Biophys J (2016) 0.75
Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in oligodendroglial tumors. Cancer Med (2016) 0.75
Genomic alterations on 8p21-p23 are the most frequent genetic events in stage I squamous cell carcinoma of the lung. Exp Ther Med (2014) 0.75
Quantitative Detection of ID4 Gene Aberrant Methylation in the Differentiation of Myelodysplastic Syndrome from Aplastic Anemia. Chin Med J (Engl) (2015) 0.75
Overexpression of PHRF1 attenuates the proliferation and tumorigenicity of non-small cell lung cancer cells. Oncotarget (2016) 0.75
Clinical implications of the quantitative detection of ID4 gene methylation in myelodysplastic syndrome. Eur J Med Res (2015) 0.75
Identification of DLC-1 expression and methylation status in patients with non-small-cell lung cancer. Mol Clin Oncol (2015) 0.75
Expression deregulation of mir31 and CXCL12 in two types of oral precancers and cancer: importance in progression of precancer and cancer. Sci Rep (2016) 0.75
Voltage-gated calcium channels: Novel targets for cancer therapy. Oncol Lett (2017) 0.75
Cancer statistics, 2009. CA Cancer J Clin (2009) 83.57
The fundamental role of epigenetic events in cancer. Nat Rev Genet (2002) 30.05
Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med (2003) 18.04
Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleic Acids Res (2002) 16.02
Lung cancer. N Engl J Med (2008) 13.49
The epigenetic progenitor origin of human cancer. Nat Rev Genet (2006) 9.65
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet (2000) 8.58
The new World Health Organization classification of lung tumours. Eur Respir J (2001) 6.91
CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene (2002) 5.96
Gene-promoter hypermethylation as a biomarker in lung cancer. Nat Rev Cancer (2004) 3.10
Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay. Proc Natl Acad Sci U S A (2007) 2.91
Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences. Nucleic Acids Res (2005) 2.41
MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas. Lab Invest (2007) 2.06
DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas. Oncogene (2004) 1.90
DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. Cancer Epidemiol Biomarkers Prev (2008) 1.68
Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily. Cancer Res (2001) 1.47
CpG island methylation and expression of tumour-associated genes in lung carcinoma. Eur J Cancer (2005) 1.46
Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer. Biochem Biophys Res Commun (2004) 1.41
Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers. Cancer Sci (2003) 1.38
Sequential gene promoter methylation during HPV-induced cervical carcinogenesis. Br J Cancer (2007) 1.32
Methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) robustly detects and distinguishes 11p15 abnormalities associated with overgrowth and growth retardation. J Med Genet (2007) 1.30
Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis (2008) 1.29
Methylation of multiple genes as diagnostic and therapeutic markers in primary head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg (2007) 1.28
DNA methylation patterns in lung carcinomas. Semin Cancer Biol (2009) 1.25
Large genomic rearrangements and germline epimutations in Lynch syndrome. Int J Cancer (2009) 1.24
Lung cancer: from single-gene methylation to methylome profiling. Cancer Metastasis Rev (2010) 1.24
Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies. Int J Cancer (2005) 1.21
Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma. Eur J Cancer (2005) 1.18
Epigenetic events of disease progression in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg (2006) 1.16
Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma. Mol Cancer (2007) 1.14
Promoter hypermethylation of the p16 and Wif-1 genes as an independent prognostic marker in stage IA non-small cell lung cancers. Int J Oncol (2009) 1.14
Identification of DNA hypermethylation of SOX9 in association with bladder cancer progression using CpG microarrays. Br J Cancer (2007) 1.12
Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types. Mol Cancer Res (2004) 1.10
Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray. Cancer (2008) 1.08
Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes. Cancer Genet Cytogenet (2005) 1.06
Different histological types of non-small cell lung cancer have distinct folate and DNA methylation levels. Cancer Sci (2009) 1.05
Molecular characterization of chronic obstructive pulmonary disease-related non-small cell lung cancer through aberrant methylation and alterations of EGFR signaling. Ann Surg Oncol (2009) 1.02
Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer. Clin Cancer Res (2006) 1.01
Concurrent methylation of promoters from tumor associated genes predicts outcome in acute myeloid leukemia. Leuk Lymphoma (2008) 0.98
Epigenetic inactivation of the RUNX3 gene in lung cancer. Oncol Rep (2006) 0.98
Methylation of helicase-like transcription factor in serum of patients with colorectal cancer is an independent predictor of disease recurrence. Eur J Gastroenterol Hepatol (2009) 0.96
Individualized therapy in non-small-cell lung cancer: future versus current clinical practice. Oncogene (2009) 0.94
DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type. Lung Cancer (2009) 0.94
Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia. Mol Cancer (2009) 0.93
Methylation profiles in breast cancer. Cancer Invest (2009) 0.93
Aberrant methylation of the cyclin D2 promoter in primary small cell, nonsmall cell lung and breast cancers. Int J Cancer (2003) 0.93
DNA methylation in small lung adenocarcinoma with bronchioloalveolar carcinoma components. Lung Cancer (2009) 0.90
Molecular detection approaches for smoking associated tumors. Oncogene (2002) 0.88
Chromosomal and methylation alterations in sporadic and familial adenomatous polyposis-related duodenal carcinomas. Mod Pathol (2007) 0.86
Aberrant hypermethylation at the bcl-2 locus at 18q21 in human lung cancers. Cancer Res (1996) 0.85
MS-MLPA reveals progressive age-dependent promoter methylation of tumor suppressor genes and possible role of IGSF4 gene in colorectal carcinogenesis of microsatellite instable tumors. Cancer Invest (2010) 0.81
Methylation-specific multiplex ligation-dependent probe amplification in meningiomas. J Neurooncol (2008) 0.81
Recommendations for biomarker identification and qualification in clinical proteomics. Sci Transl Med (2010) 1.59
Evaluation of the methylation status of tumour suppressor genes for predicting bacillus Calmette-Guérin response in patients with T1G3 high-risk bladder tumours. Eur Urol (2011) 1.55
Genetic signatures of differentiation induced by 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells. Cancer Res (2003) 1.46
miR-143, miR-222, and miR-452 are useful as tumor stratification and noninvasive diagnostic biomarkers for bladder cancer. Am J Pathol (2012) 1.34
Identification of tumor-associated autoantigens for the diagnosis of colorectal cancer in serum using high density protein microarrays. Mol Cell Proteomics (2009) 1.24
Primary amelanotic melanoma of the esophagus. Int J Dermatol (2006) 1.07
Searching urinary tumor markers for bladder cancer using a two-dimensional differential gel electrophoresis (2D-DIGE) approach. J Proteome Res (2007) 1.03
Galectin-3 expression is associated with bladder cancer progression and clinical outcome. Tumour Biol (2010) 1.01
Differential protein expression profiling by iTRAQ-two-dimensional LC-MS/MS of human bladder cancer EJ138 cells transfected with the metastasis suppressor KiSS-1 gene. Mol Cell Proteomics (2010) 0.96
Molecular mechanisms of the effects of olive oil and other dietary lipids on cancer. Mol Nutr Food Res (2007) 0.92
KiSS-1 methylation and protein expression patterns contribute to diagnostic and prognostic assessments in tissue specimens for colorectal cancer. Tumour Biol (2012) 0.91
Multiplexed methylation profiles of tumor suppressor genes in bladder cancer. J Mol Diagn (2010) 0.91
Diagnostic and prognostic utility of methylation and protein expression patterns of myopodin in colon cancer. Tumour Biol (2012) 0.90
KISS1 methylation and expression as tumor stratification biomarkers and clinical outcome prognosticators for bladder cancer patients. Am J Pathol (2011) 0.89
Identification of PMF1 methylation in association with bladder cancer progression. Clin Cancer Res (2008) 0.88
Urine epigenomics: a promising path for bladder cancer diagnostics. Expert Rev Mol Diagn (2012) 0.87
Methylation of a novel panel of tumor suppressor genes in urine moves forward noninvasive diagnosis and prognosis of bladder cancer: a 2-center prospective study. J Urol (2013) 0.87
Myopodin methylation is associated with clinical outcome in patients with T1G3 bladder cancer. J Urol (2010) 0.86
Identification of prefoldin amplification (1q23.3-q24.1) in bladder cancer using comparative genomic hybridization (CGH) arrays of urinary DNA. J Transl Med (2013) 0.83
A quantitative proteomic analysis uncovers the relevance of CUL3 in bladder cancer aggressiveness. PLoS One (2013) 0.82
A common MicroRNA signature consisting of miR-133a, miR-139-3p, and miR-142-3p clusters bladder carcinoma in situ with normal umbrella cells. Am J Pathol (2013) 0.82
Pilot study of web-based bronchoscopy education using the Essential Bronchoscopist in developing countries (Mozambique and Mauritania). Respiration (2007) 0.81
Expression of inducible nitric oxide synthase in tumoral and non-tumoral epithelia from bladder cancer patients. Nitric Oxide (2004) 0.81
Methylation of tumor suppressor genes in a novel panel predicts clinical outcome in paraffin-embedded bladder tumors. Tumour Biol (2014) 0.80
Dietary olive oil and corn oil differentially affect experimental breast cancer through distinct modulation of the p21Ras signaling and the proliferation-apoptosis balance. Carcinogenesis (2009) 0.80
Case report: peritoneal sarcoidosis in an unusual location. Semin Respir Crit Care Med (2002) 0.80
A competency-based test of bronchoscopic knowledge using the Essential Bronchoscopist: an initial concept study. Respirology (2008) 0.79
Polyamine-modulated factor-1 methylation predicts Bacillus Calmette-Guérin response in patients with high-grade non-muscle-invasive bladder carcinoma. Eur Urol (2012) 0.79
Analysis of survival in 400 surgically resected non-small cell lung carcinomas: towards a redefinition of the T factor. J Thorac Oncol (2008) 0.78
[Tumor size and survival in lung cancer, stage IA]. Medicina (B Aires) (2008) 0.76
Inducible nitric oxide synthase and PPARγ are involved in bladder cancer progression. J Urol (2012) 0.76
Differential expression of H19 and vitamin D3 upregulated protein 1 as a mechanism of the modulatory effects of high virgin olive oil and high corn oil diets on experimental mammary tumours. Eur J Cancer Prev (2009) 0.76
Clinical impact of the use of the revised International Association for the Study of Lung Cancer staging system to operable non-small-cell lung cancers. Lung Cancer (2011) 0.76
High corn oil and high extra virgin olive oil diets have different effects on the expression of differentiation-related genes in experimental mammary tumors. Oncol Rep (2008) 0.76
Use of competency-based metrics to determine effectiveness of a postgraduate thoracoscopy course. Respiration (2010) 0.75
[Ethics as first philosophy: the ethics of responsibility as a rationale for health care]. Cuad Bioet (2010) 0.75
Juvenile xanthogranuloma of skull base. Case report and review of the literature. Acta Neurochir (Wien) (2013) 0.75
[Bilateral pneumothorax complicating cavitary pulmonary metastases in angiosarcoma]. Medicina (B Aires) (2014) 0.75
[Mechanical ventilation. Influence of the age in the outcome]. Medicina (B Aires) (2011) 0.75
[Bronchioalveolar carcinoma: five year survival]. Medicina (B Aires) (2006) 0.75
Democratization of medical knowledge and technology: brief commentary on implications for medical education. Simul Healthc (2006) 0.75
[Interstitial lymphoid pneumonia associated with common variable immunodeficiency]. Medicina (B Aires) (2011) 0.75
[Pulmonary tumor embolism: Report of two cases]. Rev Med Chil (2010) 0.75
Activation of the BRCA1/Chk1/p53/p21(Cip1/Waf1) pathway by nitric oxide and cell cycle arrest in human neuroblastoma NB69 cells. Nitric Oxide (2012) 0.75