Published in Eur J Pharmacol on September 18, 2010
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Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer Agents Med Chem (2012) 1.14
Crocin enhanced functional recovery after sciatic nerve crush injury in rats. Iran J Basic Med Sci (2013) 1.05
Crocin improved learning and memory impairments in streptozotocin-induced diabetic rats. Iran J Basic Med Sci (2013) 1.01
Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. PLoS One (2012) 0.96
Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report. J Transl Med (2013) 0.89
Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model. Inflamm Res (2012) 0.84
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Hepatoprotective effect of Crocus sativus (saffron) petals extract against acetaminophen toxicity in male Wistar rats. Avicenna J Phytomed (2014) 0.81
Crocin suppresses LPS-stimulated expression of inducible nitric oxide synthase by upregulation of heme oxygenase-1 via calcium/calmodulin-dependent protein kinase 4. Mediators Inflamm (2014) 0.81
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Anticancer effects of crocetin in human esophageal squamous cell carcinoma KYSE-150 cells. Oncol Lett (2015) 0.80
Suppressive effects of Mimosa pudica (L.) constituents on the production of LPS-induced pro-inflammatory mediators. EXCLI J (2014) 0.79
Effects of crocin and safranal, saffron constituents, on the formalin-induced orofacial pain in rats. Avicenna J Phytomed (2015) 0.79
Saffron ethanolic extract attenuates oxidative stress, spatial learning, and memory impairments induced by local injection of ethidium bromide. Res Pharm Sci (2015) 0.78
Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK. Int J Mol Med (2015) 0.77
Polyketides from the Mangrove-Derived Endophytic Fungus Nectria sp. HN001 and Their α-Glucosidase Inhibitory Activity. Mar Drugs (2016) 0.77
Effect of Crocin on Cell Cycle Regulators in N-Nitroso-N-Methylurea-Induced Breast Cancer in Rats. DNA Cell Biol (2015) 0.77
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Protective effects of the aqueous extract of Crocus sativus against ethylene glycol induced nephrolithiasis in rats. EXCLI J (2015) 0.77
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Tissue-Engineered Regeneration of Hemisected Spinal Cord Using Human Endometrial Stem Cells, Poly ε-Caprolactone Scaffolds, and Crocin as a Neuroprotective Agent. Mol Neurobiol (2016) 0.76
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Evaluation of the antidepressant-like effects of acute and sub-acute administration of crocin and crocetin in mice. Avicenna J Phytomed (2015) 0.76
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Neuroprotective effects of crocin on the histopathological alterations following brain ischemia-reperfusion injury in rat. Iran J Basic Med Sci (2014) 0.76
Antilithiatic effects of crocin on ethylene glycol-induced lithiasis in rats. Urolithiasis (2014) 0.75
The effects of crocin and safranal on the yawning induced by intracerebroventricular injection of histamine in rats. Avicenna J Phytomed (2016) 0.75
Antiproliferative Activity of Crocin Involves Targeting of Microtubules in Breast Cancer Cells. Sci Rep (2017) 0.75
Preventive effect of crocin on osteoporosis in an ovariectomized rat model. Evid Based Complement Alternat Med (2014) 0.75
Crocin attenuates lipopolysacchride-induced acute lung injury in mice. Int J Clin Exp Pathol (2015) 0.75
Anti-tumor activity of safranal against neuroblastoma cells. Pharmacogn Mag (2014) 0.75
Protective effect of crocin on gentamicin-induced nephrotoxicity in rats. Iran J Basic Med Sci (2016) 0.75
Crocin prevents haloperidol-induced orofacial dyskinesia: possible an antioxidant mechanism. Iran J Basic Med Sci (2016) 0.75
Inhibitory effect of corcin on aggregation of 1N/4R human tau protein in vitro. Iran J Basic Med Sci (2015) 0.75
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Crocin suppresses multidrug resistance in MRP overexpressing ovarian cancer cell line. Daru (2016) 0.75
Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats. Iran J Basic Med Sci (2017) 0.75
The Effects of Crocin on 6-OHDA-Induced Oxidative/Nitrosative Damage and Motor Behaviour in Hemiparkinsonian Rats. Malays J Med Sci (2016) 0.75
Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer's Disease. Front Aging Neurosci (2017) 0.75
Possible Role of Common Spices as a Preventive and Therapeutic Agent for Alzheimer's Disease. Int J Prev Med (2017) 0.75
Crocin Attenuates Joint Pain and Muscle Dysfunction in Osteoarthritis Rat. Inflammation (2017) 0.75
Plant Polyphenols and Exendin-4 Prevent Hyperactivity and TNF-α Release in LPS-Treated In vitro Neuron/Astrocyte/Microglial Networks. Front Neurosci (2017) 0.75
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Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson's disease. Parkinsonism Relat Disord (2012) 3.44
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SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-Infrared Imaging and Photothermal Heating. Adv Mater (2009) 1.79
AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells. J Biol Chem (2003) 1.68
Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells. Hepatology (2004) 1.57
Regulation of Hox gene activity by transcriptional elongation in Drosophila. Curr Biol (2009) 1.55
Stalled Hox promoters as chromosomal boundaries. Genes Dev (2009) 1.55
Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis (2008) 1.46
Oxidation-triggered release of fluorescent molecules or drugs from mesoporous Si microparticles. ACS Nano (2008) 1.44
Monoclonal and polyclonal gammopathy measured by serum free light chain and immunofixation subdivide the clinical outcomes of diffuse large B-cell lymphoma according to molecular classification. Ann Hematol (2014) 1.39
Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules. World J Gastroenterol (2005) 1.34
Nanoparticle-induced vascular blockade in human prostate cancer. Blood (2010) 1.30
Protease-triggered unveiling of bioactive nanoparticles. Small (2008) 1.30
5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages. Biochem Biophys Res Commun (2004) 1.29
Developmental trajectories of marijuana use from adolescence to adulthood: personality and social role outcomes. Psychol Rep (2011) 1.23
Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance. Biomaterials (2009) 1.19
Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. J Microbiol Biotechnol (2008) 1.19
Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress. J Cell Sci (2008) 1.17
Hybrid nanoparticles for detection and treatment of cancer. Adv Mater (2012) 1.16
Adult work commitment, financial stability, and social environment as related to trajectories of marijuana use beginning in adolescence. Subst Abus (2013) 1.13
Nanoparticle self-assembly gated by logical proteolytic triggers. J Am Chem Soc (2007) 1.11
Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53. J Biol Chem (2007) 1.11
TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation. J Allergy Clin Immunol (2005) 1.10
Assessment of the type D personality construct in the Korean population: a validation study of the Korean DS14. J Korean Med Sci (2010) 1.09
Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model. Neurochem Int (2007) 1.09
Neurite outgrowth induced by spicatoside A, a steroidal saponin, via the tyrosine kinase A receptor pathway. Eur J Pharmacol (2009) 1.08
Nox 2 stimulates muscle differentiation via NF-kappaB/iNOS pathway. Free Radic Biol Med (2005) 1.07
A surface-charge study on cellular-uptake behavior of F3-peptide-conjugated iron oxide nanoparticles. Small (2009) 1.07
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Lipopolysaccharide induces hypoxia-inducible factor-1 alpha mRNA expression and activation via NADPH oxidase and Sp1-dependent pathway in BV2 murine microglial cells. Neurosci Lett (2007) 1.05
Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells. Neurosci Lett (2005) 1.05
Short-term reactions to acupuncture treatment and adverse events following acupuncture: a cross-sectional survey of patient reports in Korea. J Altern Complement Med (2009) 1.05
Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads. Small (2010) 1.02
Widespread effects of nicotinic acid on gene expression in insulin-sensitive tissues: implications for unwanted effects of nicotinic acid treatment. Metabolism (2010) 1.00
Carthami-Semen acupuncture point injection for chronic daily headache: a pilot, randomised, double-blind, controlled trial. Complement Ther Med (2010) 0.99
5-Aminoimidazole-4-carboxamide-ribonucleoside enhances oxidative stress-induced apoptosis through activation of nuclear factor-kappaB in mouse Neuro 2a neuroblastoma cells. Neurosci Lett (2004) 0.99
AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma. J Biol Chem (2010) 0.99
Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kappaB: neuroprotective implications. Neuropharmacology (2008) 0.99
Mast cells play a key role in the development of late airway hyperresponsiveness through TNF-alpha in a murine model of asthma. Eur J Immunol (2007) 0.99
Melatonin attenuates amyloid beta25-35-induced apoptosis in mouse microglial BV2 cells. Neurosci Lett (2005) 0.99
The antistress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress. Pharmacol Res (2006) 0.98
A hydrophobic ligand-binding protein of the Taenia solium metacestode mediates uptake of the host lipid: implication for the maintenance of parasitic cellular homeostasis. Proteomics (2007) 0.97
Genipin inhibits the inflammatory response of rat brain microglial cells. Int Immunopharmacol (2010) 0.97
Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction. Exp Mol Med (2010) 0.97
Feedforward compensation mediated by the central and peripheral actions of a single neuropeptide discovered using representational difference analysis. J Neurosci (2010) 0.97
Melatonin stimulates glucose transport via insulin receptor substrate-1/phosphatidylinositol 3-kinase pathway in C2C12 murine skeletal muscle cells. J Pineal Res (2006) 0.97
Gintonin, a ginseng-derived novel ingredient, evokes long-term potentiation through N-methyl-D-aspartic acid receptor activation: involvement of LPA receptors. Mol Cells (2012) 0.97
Fecal metabolic activities of herbal components to bioactive compounds. Arch Pharm Res (2002) 0.96
Photothermal inhibition of neural activity with near-infrared-sensitive nanotransducers. ACS Nano (2014) 0.96
Course of comorbidity of tobacco and marijuana use: psychosocial risk factors. Nicotine Tob Res (2010) 0.96
Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Biol Pharm Bull (2004) 0.96
Cryptotanshinone sensitizes DU145 prostate cancer cells to Fas(APO1/CD95)-mediated apoptosis through Bcl-2 and MAPK regulation. Cancer Lett (2010) 0.95
Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice cultures. Can J Physiol Pharmacol (2009) 0.95
The withdrawal from TDF therapy could induce transient RLS. Prog Neuropsychopharmacol Biol Psychiatry (2009) 0.95
Critical roles for excretory-secretory cysteine proteases during tissue invasion of Paragonimus westermani newly excysted metacercariae. Cell Microbiol (2006) 0.95
Cryptotanshinone induces ER stress-mediated apoptosis in HepG2 and MCF7 cells. Apoptosis (2012) 0.94
Observation of the fast response of a magnetic resonance signal to neuronal activity: a snail ganglia study. Physiol Meas (2006) 0.94
Gut sensing of dietary K⁺ intake increases renal K⁺excretion. Am J Physiol Regul Integr Comp Physiol (2011) 0.94
Effect of nerve cell currents on MRI images in snail ganglia. Neuroreport (2004) 0.94
Continuous 24-h nicotinic acid infusion in rats causes FFA rebound and insulin resistance by altering gene expression and basal lipolysis in adipose tissue. Am J Physiol Endocrinol Metab (2011) 0.94
Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca(2+)-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells. Apoptosis (2014) 0.93
Concerted GABAergic actions of Aplysia feeding interneurons in motor program specification. J Neurosci (2003) 0.93
AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis (2004) 0.93
Endogenous hydrogen peroxide regulates glutathione redox via nuclear factor erythroid 2-related factor 2 downstream of phosphatidylinositol 3-kinase during muscle differentiation. Am J Pathol (2008) 0.92
Activation of microglial cells by ceruloplasmin. Brain Res (2007) 0.92
ATP stimulates glucose transport through activation of P2 purinergic receptors in C(2)C(12) skeletal muscle cells. Arch Biochem Biophys (2002) 0.92
Antispastic effect of electroacupuncture and moxibustion in stroke patients. Am J Chin Med (2003) 0.92
AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1. FEBS J (2014) 0.91
Oleic acid reduces lipopolysaccharide-induced expression of iNOS and COX-2 in BV2 murine microglial cells: possible involvement of reactive oxygen species, p38 MAPK, and IKK/NF-kappaB signaling pathways. Neurosci Lett (2009) 0.91
AMP kinase signaling determines whether c-Jun N-terminal kinase promotes survival or apoptosis during glucose deprivation. Carcinogenesis (2008) 0.91
Can acupuncture affect the circadian rhythm of blood pressure? A randomized, double-blind, controlled trial. J Altern Complement Med (2012) 0.91
The Association of Externalizing Behavior and Parent-Child Relationships: An Intergenerational Study. J Child Fam Stud (2012) 0.91
fMRI study of effect on brain activity according to stimulation method at LI11, ST36: painful pressure and acupuncture stimulation of same acupoints. J Altern Complement Med (2010) 0.91
RhoA/Rho kinase blocks muscle differentiation via serine phosphorylation of insulin receptor substrate-1 and -2. Mol Endocrinol (2007) 0.91
The association between suicidality and serotonergic dysfunction in depressed patients. J Affect Disord (2013) 0.91
Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival. J Biol Chem (2010) 0.91