Prenatal testosterone excess alters Sertoli and germ cell number and testicular FSH receptor expression in rams.

PubWeight™: 0.90‹?›

🔗 View Article (PMID 20858754)

Published in Am J Physiol Endocrinol Metab on September 21, 2010

Authors

Pedro P Rojas-García1, Mónica P Recabarren, Luis Sarabia, Jennifer Schön, Christoph Gabler, Ralf Einspanier, Manuel Maliqueo, Teresa Sir-Petermann, Rodolfo Rey, Sergio E Recabarren

Author Affiliations

1: Faculty of Veterinary Sciences, Univ. of Concepción, Casilla 537, Chillán, Chile. projasg@udec.cl

Articles citing this

Dehydroepiandrosterone Sulfate Stimulates Expression of Blood-Testis-Barrier Proteins Claudin-3 and -5 and Tight Junction Formation via a Gnα11-Coupled Receptor in Sertoli Cells. PLoS One (2016) 1.39

Sheep models of polycystic ovary syndrome phenotype. Mol Cell Endocrinol (2012) 1.07

Separate critical periods exist for testosterone-induced differentiation of the brain and genitals in sheep. Endocrinology (2011) 0.93

Hormonal programming across the lifespan. Horm Metab Res (2012) 0.91

Prenatal testosterone exposure leads to hypertension that is gonadal hormone-dependent in adult rat male and female offspring. Biol Reprod (2012) 0.87

Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in polycystic ovary syndrome. Endocrine (2012) 0.82

Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome. Hum Reprod (2014) 0.78

Gestational Hyperandrogenism in Developmental Programming. Endocrinology (2016) 0.78

Prenatal testosterone exposure worsen the reproductive performance of male rat at adulthood. PLoS One (2013) 0.78

Reproduction Symposium: developmental programming of reproductive and metabolic health. J Anim Sci (2014) 0.77

Excess Testosterone Exposure Alters Hypothalamic-Pituitary-Testicular Axis Dynamics and Gene Expression in Sheep Fetuses. Endocrinology (2016) 0.76

Developmental and Functional Effects of Steroid Hormones on the Neuroendocrine Axis and Spinal Cord. J Neuroendocrinol (2016) 0.76

Increased antimüllerian hormone levels and other reproductive endocrine changes in adult male relatives of women with polycystic ovary syndrome. Fertil Steril (2016) 0.75

Early prenatal androgen exposure reduces testes size and sperm concentration in sheep without altering neuroendocrine differentiation and masculine sexual behavior. Domest Anim Endocrinol (2017) 0.75

Articles by these authors

Discovering microRNAs from deep sequencing data using miRDeep. Nat Biotechnol (2008) 10.17

Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE). Arch Toxicol (2014) 2.91

Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II. J Exp Med (2004) 2.73

Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome. J Clin Endocrinol Metab (2009) 2.08

Nonalcoholic fatty liver disease in women with polycystic ovary syndrome. J Hepatol (2007) 1.78

miR-Q: a novel quantitative RT-PCR approach for the expression profiling of small RNA molecules such as miRNAs in a complex sample. BMC Mol Biol (2008) 1.42

Birth weight in offspring of mothers with polycystic ovarian syndrome. Hum Reprod (2005) 1.42

Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology (2004) 1.39

Integrated microRNA-mRNA-analysis of human monocyte derived macrophages upon Mycobacterium avium subsp. hominissuis infection. PLoS One (2011) 1.35

Deciphering the porcine intestinal microRNA transcriptome. BMC Genomics (2010) 1.30

Postnatal developmental consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone. Am J Physiol Endocrinol Metab (2005) 1.25

Aetiological diagnosis of male sex ambiguity: a collaborative study. Eur J Pediatr (2002) 1.22

Insulin attenuates the systemic inflammatory response to thermal trauma. Mol Med (2002) 1.22

Increased anti-Müllerian hormone serum concentrations in prepubertal daughters of women with polycystic ovary syndrome. J Clin Endocrinol Metab (2006) 1.05

Intestinal expression of TFF and related genes during postnatal development in a piglet probiotic trial. Cell Physiol Biochem (2009) 1.03

Testicular anti-Müllerian hormone: history, genetics, regulation and clinical applications. Pediatr Endocrinol Rev (2006) 1.03

Early metabolic derangements in daughters of women with polycystic ovary syndrome. J Clin Endocrinol Metab (2007) 1.02

Monozygotic twin model reveals novel embryo-induced transcriptome changes of bovine endometrium in the preattachment period. Biol Reprod (2005) 1.02

Anti-Müllerian hormone levels in peripubertal daughters of women with polycystic ovary syndrome. J Clin Endocrinol Metab (2007) 1.01

Testicular anti-Müllerian hormone: clinical applications in DSD. Semin Reprod Med (2012) 1.01

Metabolic profile in sons of women with polycystic ovary syndrome. J Clin Endocrinol Metab (2008) 1.00

ACE inhibition lowers angiotensin II-induced chemokine expression by reduction of NF-kappaB activity and AT1 receptor expression. Biochem Biophys Res Commun (2004) 1.00

Acute regulation of translation initiation by gonadotropin-releasing hormone in the gonadotrope cell line LbetaT2. Mol Endocrinol (2004) 1.00

Short-term weightlessness produced by parabolic flight maneuvers altered gene expression patterns in human endothelial cells. FASEB J (2011) 1.00

Intestinal Salmonella typhimurium infection leads to miR-29a induced caveolin 2 regulation. PLoS One (2013) 0.99

Lack of androgen receptor expression in Sertoli cells accounts for the absence of anti-Mullerian hormone repression during early human testis development. J Clin Endocrinol Metab (2009) 0.99

Follicle-stimulating hormone increases testicular Anti-Mullerian hormone (AMH) production through sertoli cell proliferation and a nonclassical cyclic adenosine 5'-monophosphate-mediated activation of the AMH Gene. Mol Endocrinol (2003) 0.97

Degradation of Cry1Ab protein from genetically modified maize in the bovine gastrointestinal tract. J Agric Food Chem (2005) 0.97

Prenatal testosterone excess reduces sperm count and motility. Endocrinology (2008) 0.97

Testicular anti-mullerian hormone secretion is stimulated by recombinant human FSH in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab (2004) 0.96

Clomiphene citrate and ovulation induction. Reprod Biomed Online (2003) 0.96

Differential gene regulation under altered gravity conditions in follicular thyroid cancer cells: relationship between the extracellular matrix and the cytoskeleton. Cell Physiol Biochem (2011) 0.95

Maternal androgen excess reduces placental and fetal weights, increases placental steroidogenesis, and leads to long-term health effects in their female offspring. Am J Physiol Endocrinol Metab (2012) 0.94

Activation of melanocortin 4 receptors reduces the inflammatory response and prevents apoptosis induced by lipopolysaccharide and interferon-gamma in astrocytes. Endocrinology (2007) 0.94

Differentiation markers of Sertoli cells and germ cells in fetal and early postnatal human testis. Anat Embryol (Berl) (2004) 0.94

Screening of glucose/insulin metabolic alterations in men with multiple skin tags on the neck. J Dtsch Dermatol Ges (2008) 0.93

Proteome of metastatic canine mammary carcinomas: similarities to and differences from human breast cancer. J Proteome Res (2010) 0.93

Adrenal function during childhood and puberty in daughters of women with polycystic ovary syndrome. J Clin Endocrinol Metab (2009) 0.91

Differential regulation of ovarian anti-müllerian hormone (AMH) by estradiol through α- and β-estrogen receptors. J Clin Endocrinol Metab (2012) 0.91

Selected pro-inflammatory factor transcripts in bovine endometrial epithelial cells are regulated during the oestrous cycle and elevated in case of subclinical or clinical endometritis. Reprod Fertil Dev (2010) 0.90

Expression of hyaluronan synthases and corresponding hyaluronan receptors is differentially regulated during oocyte maturation in cattle. Biol Reprod (2003) 0.90

Concatameric cloning of porcine microRNA molecules after assembly PCR. Biochem Biophys Res Commun (2008) 0.90

Placental steroidogenesis in pregnant women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol (2012) 0.89

Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters. Fertil Steril (2011) 0.89

A fast, simple and sensitive method for the detection and quantification of detergent-resistant membranes. J Immunol Methods (2002) 0.89

Quantification and accurate normalisation of small RNAs through new custom RT-qPCR arrays demonstrates Salmonella-induced microRNAs in human monocytes. BMC Genomics (2012) 0.89

Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep. Biol Res (2008) 0.89

Relaxin supports implantation and early pregnancy in the marmoset monkey. Ann N Y Acad Sci (2009) 0.88

Tumor necrosis factor alpha in the bovine oviduct during the estrous cycle: messenger RNA expression and effect on secretion of prostaglandins, endothelin-1, and angiotensin II. Biol Reprod (2003) 0.88

Effects of birth weight on anti-mullerian hormone serum concentrations in infant girls. J Clin Endocrinol Metab (2009) 0.88

Testosterone-induced downregulation of anti-Müllerian hormone expression in granulosa cells from small bovine follicles. Endocrine (2009) 0.86

Altered expression of connexins 26 and 43 in Sertoli cells in seminiferous tubules infiltrated with carcinoma-in-situ or seminoma. J Pathol (2002) 0.86

Long-term culture of primary porcine oviduct epithelial cells: validation of a comprehensive in vitro model for reproductive science. Theriogenology (2013) 0.86

Expression of steroid receptors and proteins related to apoptosis in endometria of women with polycystic ovary syndrome. Fertil Steril (2003) 0.86

In vitro mimicking of estrous cycle stages in porcine oviduct epithelium cells: estradiol and progesterone regulate differentiation, gene expression, and cellular function. Biol Reprod (2013) 0.85

Interleukin-4 supports interleukin-12-induced proliferation and interferon-gamma secretion in human activated lymphoblasts and T helper type 1 cells. Immunology (2006) 0.84

Time-dependent mRNA expression of selected pro-inflammatory factors in the endometrium of primiparous cows postpartum. Reprod Biol Endocrinol (2010) 0.84

Polymorphism T --> C (-34 base pairs) of gene CYP17 promoter in women with polycystic ovary syndrome is associated with increased body weight and insulin resistance: a preliminary study. Metabolism (2008) 0.84

Identification of differentially expressed proteins in ruminal epithelium in response to a concentrate-supplemented diet. Am J Physiol Gastrointest Liver Physiol (2011) 0.84

Differential expression of cyclooxygenase 1 and cyclooxygenase 2 in the bovine oviduct. J Endocrinol (2006) 0.83

Glycine-terminated dendritic amphiphiles for nonviral gene delivery. Biomacromolecules (2012) 0.83

Pituitary and testicular function in sons of women with polycystic ovary syndrome from infancy to adulthood. J Clin Endocrinol Metab (2008) 0.82

Inhibition of sphingolipid synthesis impairs cellular activation, cytokine production and proliferation in human lymphocytes. Biochem Pharmacol (2005) 0.82

Establishment and characterization of a differentiated epithelial cell culture model derived from the porcine cervix uteri. BMC Vet Res (2012) 0.82

Is there a malignant progression associated with a linear change in protein expression levels from normal canine mammary gland to metastatic mammary tumors? J Proteome Res (2011) 0.82

Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in polycystic ovary syndrome. Endocrine (2012) 0.82

Differential in vitro actions of nitric oxide on human endometrial cell survival. Fertil Steril (2004) 0.82

Subcellular and molecular mechanisms regulating anti-Müllerian hormone gene expression in mammalian and nonmammalian species. DNA Cell Biol (2004) 0.81

Differences in the hepatic signal transcription pathway and cytokine expression between thermal injury and sepsis. Shock (2003) 0.81

Gonadal function in low birth weight infants: a pilot study. J Pediatr Endocrinol Metab (2007) 0.81

Metabolic parameters in cord blood of newborns of women with polycystic ovary syndrome. Fertil Steril (2008) 0.81

Seasonal expression of INSL3 and Lgr8/Insl3 receptor transcripts indicates variable differentiation of Leydig cells in the roe deer testis. Biol Reprod (2004) 0.81

Hypogonadotropic hypogonadism as a model of post-natal testicular anti-Müllerian hormone secretion in humans. Mol Cell Endocrinol (2003) 0.81

Altered testicular development as a consequence of increase number of sertoli cell in male lambs exposed prenatally to excess testosterone. Endocrine (2012) 0.80

Insulin secretion in women who have polycystic ovary syndrome and carry the Gly972Arg variant of insulin receptor substrate-1 in response to a high-glycemic or low-glycemic carbohydrate load. Nutrition (2004) 0.80

Insulin resistance and polycystic ovary syndrome through life. Curr Pharm Des (2012) 0.80

Expression of epidermal growth factor receptor (EGF-R), vascular endothelial growth factor receptor (VEGF-R) and fibroblast growth factor receptor (FGF-R) systems in porcine oviduct and endometrium during the time of implantation. J Reprod Dev (2004) 0.80

Resveratrol is not as effective as physical exercise for improving reproductive and metabolic functions in rats with dihydrotestosterone-induced polycystic ovary syndrome. Evid Based Complement Alternat Med (2013) 0.80

Cry1Ab treatment has no effects on viability of cultured porcine intestinal cells, but triggers Hsp70 expression. PLoS One (2013) 0.79

Structural analysis of microRNA-target interaction by sequential seed mutagenesis and stem-loop 3' RACE. PLoS One (2013) 0.79

Changes in the expression of pluripotency-associated genes during preimplantation and peri-implantation stages in bovine cloned and in vitro produced embryos. Zygote (2010) 0.79

Hormonal profile in women with polycystic ovarian syndrome with or without type 1 diabetes mellitus. J Clin Endocrinol Metab (2007) 0.79

Anti-HLA-DR-triggered monocytes mediate in vitro T cell anergy. Int Immunol (2008) 0.79

Apoptosis is not the cause of seasonal testicular involution in roe deer. Cell Tissue Res (2006) 0.79