Amino acids adjacent to the haemagglutinin cleavage site are relevant for virulence of avian influenza viruses of subtype H5.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMID 20881092)

Published in J Gen Virol on September 29, 2010

Authors

Sandra Gohrbandt1, Jutta Veits, Jana Hundt, Jessica Bogs, Angele Breithaupt, Jens P Teifke, Siegfried Weber, Thomas C Mettenleiter, Jürgen Stech

Author Affiliations

1: Friedrich-Loeffler-Institut, Institute of Molecular Biology, Greifswald-Insel Riems, Germany.

Articles citing this

Engineering H5N1 avian influenza viruses to study human adaptation. Nature (2012) 1.74

Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotype. Proc Natl Acad Sci U S A (2012) 1.19

Amino acid 316 of hemagglutinin and the neuraminidase stalk length influence virulence of H9N2 influenza virus in chickens and mice. J Virol (2012) 1.08

Reversion of PB2-627E to -627K during replication of an H5N1 Clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein. J Virol (2011) 1.03

Insertion of a multibasic cleavage site in the haemagglutinin of human influenza H3N2 virus does not increase pathogenicity in ferrets. J Gen Virol (2011) 0.93

A complete map of potential pathogenicity markers of avian influenza virus subtype H5 predicted from 11 expressed proteins. BMC Microbiol (2015) 0.82

A Unique Multibasic Proteolytic Cleavage Site and Three Mutations in the HA2 Domain Confer High Virulence of H7N1 Avian Influenza Virus in Chickens. J Virol (2015) 0.81

Genome Sequences of an H5N1 Highly Pathogenic Avian Influenza Virus Isolated from Vaccinated Layers in China in 2012. Genome Announc (2013) 0.80

Circulation of the low pathogenic avian influenza subtype H5N2 virus in ducks at a live bird market in Ibadan, Nigeria. Infect Dis Poverty (2014) 0.80

Prevalence of the C-terminal truncations of NS1 in avian influenza A viruses and effect on virulence and replication of a highly pathogenic H7N1 virus in chickens. Virulence (2016) 0.79

Genetic changes that accompanied shifts of low pathogenic avian influenza viruses toward higher pathogenicity in poultry. Virulence (2013) 0.79

The Neuraminidase Stalk Deletion Serves as Major Virulence Determinant of H5N1 Highly Pathogenic Avian Influenza Viruses in Chicken. Sci Rep (2015) 0.78

Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif. Rev Med Virol (2015) 0.78

Pathogenicity, Transmission and Antigenic Variation of H5N1 Highly Pathogenic Avian Influenza Viruses. Front Microbiol (2016) 0.78

Truncation and sequence shuffling of segment 6 generate replication-competent neuraminidase-negative influenza H5N1 viruses. J Virol (2013) 0.76

Cleavage site and Ectodomain of HA2 sub-unit sequence of three equine influenza virus isolated in Morocco. BMC Res Notes (2014) 0.75

Genetic Predisposition To Acquire a Polybasic Cleavage Site for Highly Pathogenic Avian Influenza Virus Hemagglutinin. MBio (2017) 0.75

A DNA vaccine that targets hemagglutinin to antigen presenting cells protects mice against H7 influenza. J Virol (2017) 0.75

Articles by these authors

Novel orthobunyavirus in Cattle, Europe, 2011. Emerg Infect Dis (2012) 7.62

The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat Neurosci (2004) 5.36

Pathogenesis and transmission of the novel swine-origin influenza virus A/H1N1 after experimental infection of pigs. J Gen Virol (2009) 3.09

The interacting UL31 and UL34 gene products of pseudorabies virus are involved in egress from the host-cell nucleus and represent components of primary enveloped but not mature virions. J Virol (2002) 2.98

Complete, annotated sequence of the pseudorabies virus genome. J Virol (2004) 2.35

A Variegated Squirrel Bornavirus Associated with Fatal Human Encephalitis. N Engl J Med (2015) 2.34

Pause on avian flu transmission research. Science (2012) 2.24

Pseudorabies virus UL36 tegument protein physically interacts with the UL37 protein. J Virol (2002) 2.24

Physical interaction between envelope glycoproteins E and M of pseudorabies virus and the major tegument protein UL49. J Virol (2002) 2.19

Tracing from fat tissue, liver, and pancreas: a neuroanatomical framework for the role of the brain in type 2 diabetes. Endocrinology (2005) 2.10

The UL48 tegument protein of pseudorabies virus is critical for intracytoplasmic assembly of infectious virions. J Virol (2002) 1.97

Molecular analysis of highly pathogenic avian influenza virus of subtype H5N1 isolated from wild birds and mammals in northern Germany. J Gen Virol (2007) 1.94

Vesicle formation from the nuclear membrane is induced by coexpression of two conserved herpesvirus proteins. Proc Natl Acad Sci U S A (2007) 1.93

Entry of pseudorabies virus: an immunogold-labeling study. J Virol (2005) 1.87

Characterization of African swine fever virus Caucasus isolate in European wild boars. Emerg Infect Dis (2011) 1.77

Essential function of the pseudorabies virus UL36 gene product is independent of its interaction with the UL37 protein. J Virol (2004) 1.73

Novel lyssavirus in Natterer's bat, Germany. Emerg Infect Dis (2011) 1.71

Schmallenberg virus as possible ancestor of Shamonda virus. Emerg Infect Dis (2012) 1.70

The pseudorabies virus UL11 protein is a virion component involved in secondary envelopment in the cytoplasm. J Virol (2003) 1.69

Newcastle disease virus expressing H5 hemagglutinin gene protects chickens against Newcastle disease and avian influenza. Proc Natl Acad Sci U S A (2006) 1.58

The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons. J Comp Neurol (2003) 1.56

Identification and characterization of the pseudorabies virus tegument proteins UL46 and UL47: role for UL47 in virion morphogenesis in the cytoplasm. J Virol (2002) 1.56

Cooperation between the hemagglutinin of avian viruses and the matrix protein of human influenza A viruses. J Virol (2002) 1.49

Selective parasympathetic innervation of subcutaneous and intra-abdominal fat--functional implications. J Clin Invest (2002) 1.46

Encephalitis in a rabbit caused by human herpesvirus-1. J Am Vet Med Assoc (2009) 1.46

Highly pathogenic avian influenza virus (H5N1) in experimentally infected adult mute swans. Emerg Infect Dis (2008) 1.45

Simultaneous deletion of pseudorabies virus tegument protein UL11 and glycoprotein M severely impairs secondary envelopment. J Virol (2004) 1.42

Composition of pseudorabies virus particles lacking tegument protein US3, UL47, or UL49 or envelope glycoprotein E. J Virol (2006) 1.41

Influenza B virus with modified hemagglutinin cleavage site as a novel attenuated live vaccine. J Infect Dis (2011) 1.40

The pseudorabies virus US3 protein is a component of primary and of mature virions. J Virol (2004) 1.39

Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickens. J Gen Virol (2007) 1.38

Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody. Proc Natl Acad Sci U S A (2010) 1.38

The capsid-associated UL25 protein of the alphaherpesvirus pseudorabies virus is nonessential for cleavage and encapsidation of genomic DNA but is required for nuclear egress of capsids. J Virol (2006) 1.38

Rapid and reliable universal cloning of influenza A virus genes by target-primed plasmid amplification. Nucleic Acids Res (2008) 1.36

Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing. Proc Natl Acad Sci U S A (2005) 1.36

Highly pathogenic avian influenza virus infection of mallards with homo- and heterosubtypic immunity induced by low pathogenic avian influenza viruses. PLoS One (2009) 1.35

Epidemiology of bluetongue virus serotype 8, Germany. Emerg Infect Dis (2009) 1.35

Oral exposure, reinfection and cellular immunity to Schmallenberg virus in cattle. Vet Microbiol (2013) 1.34

The elimination of fox rabies from Europe: determinants of success and lessons for the future. Philos Trans R Soc Lond B Biol Sci (2013) 1.32

High prevalence of amantadine resistance among circulating European porcine influenza A viruses. J Gen Virol (2009) 1.30

Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin. FASEB J (2009) 1.28

Egress of alphaherpesviruses. J Virol (2006) 1.27

Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes. J Immunol (2011) 1.26

Schmallenberg virus challenge models in cattle: infectious serum or culture-grown virus? Vet Res (2012) 1.22

Complex formation between the UL16 and UL21 tegument proteins of pseudorabies virus. J Virol (2005) 1.21

Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotype. Proc Natl Acad Sci U S A (2012) 1.19

Contribution of the length of the HN protein and the sequence of the F protein cleavage site to Newcastle disease virus pathogenicity. J Gen Virol (2003) 1.17

Alpha-herpesvirus glycoprotein D interaction with sensory neurons triggers formation of varicosities that serve as virus exit sites. J Cell Biol (2006) 1.17

Determination of the complete genomic sequence and analysis of the gene products of the virus of Spring Viremia of Carp, a fish rhabdovirus. Virus Res (2002) 1.15

Glycoproteins required for entry are not necessary for egress of pseudorabies virus. J Virol (2008) 1.14

Experimental infection and natural contact exposure of dogs with avian influenza virus (H5N1). Emerg Infect Dis (2008) 1.11

Mutagenesis of the active-site cysteine in the ubiquitin-specific protease contained in large tegument protein pUL36 of pseudorabies virus impairs viral replication in vitro and neuroinvasion in vivo. J Virol (2008) 1.11

A pseudorabies virus recombinant simultaneously lacking the major tegument proteins encoded by the UL46, UL47, UL48, and UL49 genes is viable in cultured cells. J Virol (2003) 1.10

Acquisition of a polybasic hemagglutinin cleavage site by a low-pathogenic avian influenza virus is not sufficient for immediate transformation into a highly pathogenic strain. J Virol (2009) 1.09

Functional analysis of the pseudorabies virus UL51 protein. J Virol (2005) 1.08

Ducks as sentinels for avian influenza in wild birds. Emerg Infect Dis (2009) 1.08

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP. PLoS Pathog (2008) 1.08

Effects of simultaneous deletion of pUL11 and glycoprotein M on virion maturation of herpes simplex virus type 1. J Virol (2008) 1.08

Transmission studies resume for avian flu. Science (2013) 1.07

Correlative VIS-fluorescence and soft X-ray cryo-microscopy/tomography of adherent cells. J Struct Biol (2011) 1.06

Highly pathogenic H5N1 influenza viruses carry virulence determinants beyond the polybasic hemagglutinin cleavage site. PLoS One (2010) 1.05

Efficacy of three inactivated vaccines against bluetongue virus serotype 8 in sheep. Vaccine (2009) 1.05

Partial functional complementation of a pseudorabies virus UL25 deletion mutant by herpes simplex virus type 1 pUL25 indicates overlapping functions of alphaherpesvirus pUL25 proteins. J Virol (2008) 1.04

Schmallenberg virus experimental infection of sheep. Vet Microbiol (2013) 1.04

Identification of functional domains within the essential large tegument protein pUL36 of pseudorabies virus. J Virol (2007) 1.04

Reversion of PB2-627E to -627K during replication of an H5N1 Clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein. J Virol (2011) 1.03

Influenza A(H5N8) Virus Similar to Strain in Korea Causing Highly Pathogenic Avian Influenza in Germany. Emerg Infect Dis (2015) 1.03

Protection and virus shedding of falcons vaccinated against highly pathogenic avian influenza A virus (H5N1). Emerg Infect Dis (2007) 1.03

Entry of herpes simplex virus type 1 (HSV-1) into the distal axons of trigeminal neurons favors the onset of nonproductive, silent infection. PLoS Pathog (2012) 1.02

Characterization of White bream virus reveals a novel genetic cluster of nidoviruses. J Virol (2006) 1.00