Origin of new glial cells in intact and injured adult spinal cord.

PubWeight™: 2.23‹?› | Rank: Top 2%

🔗 View Article (PMID 20887953)

Published in Cell Stem Cell on October 08, 2010

Authors

Fanie Barnabé-Heider1, Christian Göritz, Hanna Sabelström, Hirohide Takebayashi, Frank W Pfrieger, Konstantinos Meletis, Jonas Frisén

Author Affiliations

1: Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.

Articles citing this

(truncated to the top 100)

Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron (2011) 8.06

The stem cell potential of glia: lessons from reactive gliosis. Nat Rev Neurosci (2011) 2.49

microRNA-21 regulates astrocytic response following spinal cord injury. J Neurosci (2012) 1.85

Functional regeneration beyond the glial scar. Exp Neurol (2014) 1.79

NG2-glia as multipotent neural stem cells: fact or fantasy? Neuron (2011) 1.67

Diversity of astrocyte functions and phenotypes in neural circuits. Nat Neurosci (2015) 1.50

Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination. Nature (2015) 1.49

Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury. J Neurosci (2013) 1.31

EphB signaling controls lineage plasticity of adult neural stem cell niche cells. Cell Stem Cell (2010) 1.17

Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke. J Neurosci (2012) 1.15

Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development (2012) 1.13

Glial cells in amyotrophic lateral sclerosis. Exp Neurol (2014) 1.11

Oligodendrocyte fate after spinal cord injury. Neurotherapeutics (2011) 1.09

Signaling pathways in reactive astrocytes, a genetic perspective. Mol Neurobiol (2011) 1.06

Nestin- and doublecortin-positive cells reside in adult spinal cord meninges and participate in injury-induced parenchymal reaction. Stem Cells (2011) 1.04

Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis. J Neurosci (2011) 1.03

Injury to the spinal cord niche alters the engraftment dynamics of human neural stem cells. Stem Cell Reports (2014) 0.98

Differentiated melanocyte cell division occurs in vivo and is promoted by mutations in Mitf. Development (2011) 0.97

Chondroitinase and growth factors enhance activation and oligodendrocyte differentiation of endogenous neural precursor cells after spinal cord injury. PLoS One (2012) 0.97

Astrogliosis. Cold Spring Harb Perspect Biol (2014) 0.97

β1-Integrin and integrin linked kinase regulate astrocytic differentiation of neural stem cells. PLoS One (2014) 0.96

Effects of bone marrow stromal cell transplantation through CSF on the subacute and chronic spinal cord injury in rats. PLoS One (2013) 0.95

Chronic oligodendrogenesis and remyelination after spinal cord injury in mice and rats. J Neurosci (2015) 0.94

Astrocyte activation is suppressed in both normal and injured brain by FGF signaling. Proc Natl Acad Sci U S A (2014) 0.93

Wnts are expressed in the spinal cord of adult mice and are differentially induced after injury. J Neurotrauma (2014) 0.92

Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Stem Cell Res Ther (2014) 0.91

Co-evolution of breast-to-brain metastasis and neural progenitor cells. Clin Exp Metastasis (2013) 0.91

Neural stem cell niches in health and diseases. Curr Pharm Des (2012) 0.91

Neurogenic and non-neurogenic functions of endogenous neural stem cells. Front Neurosci (2014) 0.91

Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions. PLoS One (2014) 0.90

Skeletal muscle neural progenitor cells exhibit properties of NG2-glia. Exp Cell Res (2012) 0.90

Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome-wide expression analysis. Glia (2015) 0.88

Differential regulation of proliferation and neuronal differentiation in adult rat spinal cord neural stem/progenitors by ERK1/2, Akt, and PLCγ. Front Mol Neurosci (2013) 0.88

Tissue sparing, behavioral recovery, supraspinal axonal sparing/regeneration following sub-acute glial transplantation in a model of spinal cord contusion. BMC Neurosci (2013) 0.87

Regenerative medicine for the treatment of spinal cord injury: more than just promises? J Cell Mol Med (2012) 0.87

NG2-glia and their functions in the central nervous system. Glia (2015) 0.87

A comparative view of regenerative neurogenesis in vertebrates. Development (2016) 0.87

Transgenic enrichment of mouse embryonic stem cell-derived progenitor motor neurons. Stem Cell Res (2011) 0.86

Endogenous proliferation after spinal cord injury in animal models. Stem Cells Int (2012) 0.85

Nestin-Positive Ependymal Cells Are Increased in the Human Spinal Cord after Traumatic Central Nervous System Injury. J Neurotrauma (2015) 0.85

Sonic hedgehog and neurotrophin-3 increase oligodendrocyte numbers and myelination after spinal cord injury. Integr Biol (Camb) (2014) 0.85

Reciprocal modulation between microglia and astrocyte in reactive gliosis following the CNS injury. Mol Neurobiol (2013) 0.85

Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration. Elife (2015) 0.85

Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages. Neural Dev (2014) 0.85

Permissive Schwann cell graft/spinal cord interfaces for axon regeneration. Cell Transplant (2013) 0.85

Intrathecal Transplantation of Autologous Adherent Bone Marrow Cells Induces Functional Neurological Recovery in a Canine Model of Spinal Cord Injury. Cell Transplant (2014) 0.84

Regeneration of Xenopus laevis spinal cord requires Sox2/3 expressing cells. Dev Biol (2015) 0.84

NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury. Proc Natl Acad Sci U S A (2015) 0.84

The role of the immune system in central nervous system plasticity after acute injury. Neuroscience (2014) 0.84

The ependymal region of the adult human spinal cord differs from other species and shows ependymoma-like features. Brain (2015) 0.83

Myelin damage and repair in pathologic CNS: challenges and prospects. Front Mol Neurosci (2015) 0.83

Distribution and characterization of progenitor cells within the human filum terminale. PLoS One (2011) 0.83

Influence of the extracellular matrix on endogenous and transplanted stem cells after brain damage. Front Cell Neurosci (2014) 0.83

Endothelin Receptors, Mitochondria and Neurogenesis in Cerebral Ischemia. Curr Neuropharmacol (2016) 0.82

β1-Integrin alters ependymal stem cell BMP receptor localization and attenuates astrogliosis after spinal cord injury. J Neurosci (2015) 0.82

Oligodendrocyte Precursor Cells in Spinal Cord Injury: A Review and Update. Biomed Res Int (2015) 0.82

Bioactive DNA-peptide nanotubes enhance the differentiation of neural stem cells into neurons. Nano Lett (2014) 0.81

What is the potential of oligodendrocyte progenitor cells to successfully treat human spinal cord injury? BMC Neurol (2011) 0.81

Temporal Response of Endogenous Neural Progenitor Cells Following Injury to the Adult Rat Spinal Cord. Front Cell Neurosci (2016) 0.81

"Targeting astrocytes in CNS injury and disease: A translational research approach". Prog Neurobiol (2016) 0.81

Rat models of spinal cord injury: from pathology to potential therapies. Dis Model Mech (2016) 0.81

Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures. J Neuroinflammation (2012) 0.81

Spinal cord contusion. Neural Regen Res (2014) 0.80

Ecto-domain phosphorylation promotes functional recovery from spinal cord injury. Sci Rep (2014) 0.80

Tamoxifen Administration Immediately or 24 Hours after Spinal Cord Injury Improves Locomotor Recovery and Reduces Secondary Damage in Female Rats. J Neurotrauma (2016) 0.80

Beneficial effects of melatonin combined with exercise on endogenous neural stem/progenitor cells proliferation after spinal cord injury. Int J Mol Sci (2014) 0.79

The multifaceted effects of agmatine on functional recovery after spinal cord injury through Modulations of BMP-2/4/7 expressions in neurons and glial cells. PLoS One (2013) 0.79

Reshaping the chromatin landscape after spinal cord injury. Front Biol (Beijing) (2014) 0.79

Cholinergic Enhancement of Cell Proliferation in the Postnatal Neurogenic Niche of the Mammalian Spinal Cord. Stem Cells (2015) 0.79

Intertwining extracellular nucleotides and their receptors with Ca2+ in determining adult neural stem cell survival, proliferation and final fate. Philos Trans R Soc Lond B Biol Sci (2016) 0.79

Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE. J Neurol Sci (2013) 0.78

Neurogenesis in the Developing and Adult Brain-Similarities and Key Differences. Cold Spring Harb Perspect Biol (2016) 0.78

Distribution and phenotype of TrkB oligodendrocyte lineage cells in the adult rat spinal cord. Brain Res (2014) 0.78

Neurogenesis in the lamprey central nervous system following spinal cord transection. J Comp Neurol (2014) 0.78

Olfactory ensheathing cell-neurite alignment enhances neurite outgrowth in scar-like cultures. Exp Neurol (2015) 0.78

GABAergic responses of mammalian ependymal cells in the central canal neurogenic niche of the postnatal spinal cord. Neurosci Lett (2013) 0.78

In the presence of danger: The extracellular matrix defensive response to central nervous system injury. Neural Regen Res (2014) 0.78

NADPH oxidase in brain injury and neurodegenerative disorders. Mol Neurodegener (2017) 0.78

Plastic changes in the spinal cord in motor neuron disease. Biomed Res Int (2014) 0.77

Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury. J Physiol (2016) 0.77

Stem cells for spinal cord injury: Strategies to inform differentiation and transplantation. Biotechnol Bioeng (2016) 0.77

Immature spinal cord neurons are dynamic regulators of adult nociceptive sensitivity. J Cell Mol Med (2015) 0.77

The fate of proliferating cells in the injured adult spinal cord. Stem Cell Res Ther (2011) 0.77

Excitotoxic cell death induces delayed proliferation of endogenous neuroprogenitor cells in organotypic slice cultures of the rat spinal cord. Cell Death Dis (2013) 0.77

Thoracic rat spinal cord contusion injury induces remote spinal gliogenesis but not neurogenesis or gliogenesis in the brain. PLoS One (2014) 0.76

Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis. Acta Neuropathol Commun (2015) 0.76

Adult Neurogenesis and Gliogenesis: Possible Mechanisms for Neurorestoration. Exp Neurobiol (2016) 0.76

A Role for the Cannabinoid 1 Receptor in Neuronal Differentiation of Adult Spinal Cord Progenitors in vitro is Revealed through Pharmacological Inhibition and Genetic Deletion. Front Neurosci (2012) 0.76

Adult spinal cord ependymal layer: a promising pool of quiescent stem cells to treat spinal cord injury. Front Physiol (2013) 0.76

Macrophage Transcriptional Profile Identifies Lipid Catabolic Pathways That Can Be Therapeutically Targeted after Spinal Cord Injury. J Neurosci (2017) 0.75

Stem cells in the adult CNS revealed: examining their regulation by myelin basic protein. Neural Regen Res (2016) 0.75

Finding degrees of separation: experimental approaches for astroglial and oligodendroglial cell isolation and genetic targeting. J Neurosci Methods (2014) 0.75

Building a central nervous system: The neural stem cell lineage revealed. Neurogenesis (Austin) (2017) 0.75

EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury. Cell Death Dis (2015) 0.75

Purinergic signalling in a latent stem cell niche of the rat spinal cord. Purinergic Signal (2016) 0.75

Differences in the Cellular Response to Acute Spinal Cord Injury between Developing and Mature Rats Highlights the Potential Significance of the Inflammatory Response. Front Cell Neurosci (2017) 0.75

Nicotine modulates neurogenesis in the central canal during experimental autoimmune encephalomyelitis. Neuroscience (2015) 0.75

Growth Hormone (GH) and Rehabilitation Promoted Distal Innervation in a Child Affected by Caudal Regression Syndrome. Int J Mol Sci (2017) 0.75

Cytoprotective and anti-inflammatory effects of PAL31 overexpression in glial cells. J Biomed Sci (2014) 0.75

Regeneration strategies after the adult mammalian central nervous system injury-biomaterials. Regen Biomater (2016) 0.75

Articles by these authors

Evidence for cardiomyocyte renewal in humans. Science (2009) 14.17

Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature (2009) 11.74

Dynamics of fat cell turnover in humans. Nature (2008) 9.80

Retrospective birth dating of cells in humans. Cell (2005) 5.60

Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science (2007) 5.23

A pericyte origin of spinal cord scar tissue. Science (2011) 4.12

Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. Nat Neurosci (2005) 3.74

Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc (2010) 3.71

p53 suppresses the self-renewal of adult neural stem cells. Development (2006) 3.35

Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci U S A (2006) 3.08

Spinal cord injury reveals multilineage differentiation of ependymal cells. PLoS Biol (2008) 2.80

Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors. J Neurosci (2007) 2.80

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat Neurosci (2009) 2.74

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature (2012) 2.73

Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes (2009) 2.60

Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex. J Neurosci (2008) 2.49

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha. Brain (2010) 2.49

Forensics: age written in teeth by nuclear tests. Nature (2005) 2.36

The age of olfactory bulb neurons in humans. Neuron (2012) 2.25

EphB receptors coordinate migration and proliferation in the intestinal stem cell niche. Cell (2006) 2.22

Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron (2010) 2.08

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nat Neurosci (2012) 1.89

Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice. Science (2013) 1.88

Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan. Dev Dyn (2007) 1.81

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. Nat Neurosci (2012) 1.79

Axonal ephrin-As and odorant receptors: coordinate determination of the olfactory sensory map. Cell (2003) 1.77

RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus. J Neurosci (2010) 1.76

Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover. Exp Cell Res (2010) 1.69

Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell (2009) 1.68

Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells. Dev Biol (2006) 1.64

Stem cells for spinal cord repair. Cell Stem Cell (2008) 1.63

Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis. Genes Dev (2005) 1.56

Functional integration of adult-born neurons. Curr Biol (2002) 1.47

Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation. Development (2002) 1.46

Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes. Neuron (2003) 1.44

Ephrins and Eph receptors in stem cells and cancer. Curr Opin Cell Biol (2010) 1.42

Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron. Mol Cell Neurosci (2005) 1.37

Suppression of intestinal neoplasia by deletion of Dnmt3b. Mol Cell Biol (2006) 1.35

Centrosome motility is essential for initial axon formation in the neocortex. J Neurosci (2010) 1.29

Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear. Exp Cell Res (2005) 1.24

In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis. Mol Cell Neurosci (2005) 1.23

Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Res (2003) 1.20

New roles for astrocytes: regulation of CNS synaptogenesis. Trends Neurosci (2003) 1.19

EphB signaling controls lineage plasticity of adult neural stem cell niche cells. Cell Stem Cell (2010) 1.17

Transgenic mice for conditional gene manipulation in astroglial cells. Glia (2007) 1.17

Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation. Nat Methods (2008) 1.17

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats. J Neurochem (2009) 1.15

Role of glia-derived cholesterol in synaptogenesis: new revelations in the synapse-glia affair. J Physiol Paris (2002) 1.14

A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors. Nat Neurosci (2012) 1.12

Recording Notch signaling in real time. Dev Neurosci (2006) 1.12

Involvement of the Olig2 transcription factor in cholinergic neuron development of the basal forebrain. Dev Biol (2006) 1.10

Deconstructing stemness. EMBO J (2005) 1.09

PACAP promotes neural stem cell proliferation in adult mouse brain. J Neurosci Res (2004) 1.08

Ephrins are not only unattractive. Trends Neurosci (2002) 1.07

Evidence for a second wave of oligodendrogenesis in the postnatal cerebral cortex of the mouse. J Neurosci Res (2003) 1.06

Target selectivity of feedforward inhibition by striatal fast-spiking interneurons. J Neurosci (2013) 1.04

Genetic fate mapping of Olig2 progenitors in the injured adult cerebral cortex reveals preferential differentiation into astrocytes. J Neurosci Res (2008) 1.04

Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene. Proc Natl Acad Sci U S A (2010) 1.04

Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis. J Neurosci (2011) 1.03

Regional- and temporal-dependent changes in the differentiation of Olig2 progenitors in the forebrain, and the impact on astrocyte development in the dorsal pallium. Dev Biol (2008) 1.01

In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences. Mol Biol Cell (2008) 1.00

Gene delivery to adult neural stem cells. Exp Cell Res (2002) 0.99

High-density microwell chip for culture and analysis of stem cells. PLoS One (2009) 0.98

Amphiregulin is a mitogen for adult neural stem cells. J Neurosci Res (2002) 0.98

Neural stem cells and neurogenesis in the adult. Cell Stem Cell (2012) 0.98

From stem cell to progenitor and back again. Cell (2007) 0.97

Ephrins negatively regulate cell proliferation in the epidermis and hair follicle. Stem Cells (2010) 0.95

Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance. Glia (2007) 0.95

Genetic visualization of neurogenesis. Exp Cell Res (2006) 0.94

Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia. PLoS One (2011) 0.94

Lack of Niemann-Pick type C1 induces age-related degeneration in the mouse retina. Mol Cell Neurosci (2009) 0.94

Impaired hippocampal neurogenesis and vascular formation in ephrin-A5-deficient mice. Stem Cells (2010) 0.93

Dopamine controls neurogenesis in the adult salamander midbrain in homeostasis and during regeneration of dopamine neurons. Cell Stem Cell (2011) 0.93

Expression of the basic helix-loop-factor Olig2 in the developing retina: Olig2 as a new marker for retinal progenitors and late-born cells. Gene Expr Patterns (2006) 0.91

Evidence for the spontaneous production but massive programmed cell death of new neurons in the subcallosal zone of the postnatal mouse brain. Eur J Neurosci (2011) 0.91

Anti-human Olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomas. Am J Pathol (2004) 0.91

Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum. Development (2008) 0.90

Cardiomyocyte renewal in humans. Circ Res (2012) 0.90

NG2 and Olig2 expression provides evidence for phenotypic deregulation of cultured central nervous system and peripheral nervous system neural precursor cells. Stem Cells (2006) 0.89

Converse control of oligodendrocyte and astrocyte lineage development by Sonic hedgehog in the chick spinal cord. Dev Biol (2004) 0.89

Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex. Development (2011) 0.88

Synaptic plasticity, astrocytes and morphological homeostasis. J Physiol Paris (2006) 0.88

The potential to induce glial differentiation is conserved between Drosophila and mammalian glial cells missing genes. Development (2003) 0.88

Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction. PLoS One (2008) 0.87

Purification of embryonic stem cell-derived neurons by immunoisolation. FASEB J (2003) 0.87

Visualization of odor-induced neuronal activity by immediate early gene expression. BMC Neurosci (2012) 0.87

Olig2 transcription factor in the developing and injured forebrain; cell lineage and glial development. Mol Cells (2009) 0.86