PubRank

Philippe Hantraye

Author PubWeight™ 78.15‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study. Lancet Neurol 2006 2.99
2 Sustained effects of nonallele-specific Huntingtin silencing. Ann Neurol 2009 2.05
3 Three-dimensional reconstruction of stained histological slices and 3D non-linear registration with in-vivo MRI for whole baboon brain. J Neurosci Methods 2007 1.78
4 In vivo evidence for the selective subcortical degeneration in Huntington's disease. Neuroimage 2009 1.56
5 Dopaminergic function and dopamine transporter binding assessed with positron emission tomography in Parkinson disease. Arch Neurol 2002 1.54
6 11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation. J Nucl Med 2007 1.53
7 Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin. Mol Biol Cell 2006 1.51
8 Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J Clin Invest 2006 1.44
9 Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging. J Neurosci 2012 1.37
10 In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects. Hum Mol Genet 2010 1.34
11 Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease. PLoS One 2008 1.34
12 Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia. Sci Transl Med 2009 1.25
13 Engineered lentiviral vector targeting astrocytes in vivo. Glia 2009 1.24
14 Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation. Neuron 2004 1.15
15 Decreased TCA cycle rate in the rat brain after acute 3-NP treatment measured by in vivo 1H-[13C] NMR spectroscopy. J Neurochem 2002 1.14
16 A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin. Hum Mol Genet 2013 1.13
17 Applications of lentiviral vectors for biology and gene therapy of neurological disorders. Curr Gene Ther 2008 1.12
18 Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease. J Neurosci 2003 1.12
19 Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults. J Neurosci 2007 1.11
20 Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration. J Neurosci 2002 1.10
21 Striatal neural grafting improves cortical metabolism in Huntington's disease patients. Brain 2003 1.09
22 Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies. Acta Neuropathol Commun 2014 1.09
23 Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistribution. Hum Gene Ther 2009 1.06
24 Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3? Hum Mol Genet 2010 1.06
25 Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease. Neurobiol Aging 2011 1.06
26 Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo. J Neurosci 2006 1.04
27 Age-associated cerebral atrophy in mouse lemur primates. Neurobiol Aging 2009 1.00
28 Arterial input function measurement without blood sampling using a beta-microprobe in rats. J Nucl Med 2004 0.99
29 Isoflurane strongly affects the diffusion of intracellular metabolites, as shown by 1H nuclear magnetic resonance spectroscopy of the monkey brain. J Cereb Blood Flow Metab 2006 0.97
30 In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3. J Biol Chem 2003 0.96
31 Glycolysis versus TCA cycle in the primate brain as measured by combining 18F-FDG PET and 13C-NMR. J Cereb Blood Flow Metab 2005 0.95
32 Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates. Mol Ther 2007 0.94
33 Transgenic expression of CTLA4-Ig by fetal pig neurons for xenotransplantation. Transgenic Res 2005 0.93
34 Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue. Mov Disord 2003 0.93
35 A new sequence for single-shot diffusion-weighted NMR spectroscopy by the trace of the diffusion tensor. Magn Reson Med 2012 0.92
36 Quantitative validation of voxel-wise statistical analyses of autoradiographic rat brain volumes: application to unilateral visual stimulation. Neuroimage 2007 0.92
37 Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease. Neuroimage 2010 0.91
38 Anomalous diffusion of brain metabolites evidenced by diffusion-weighted magnetic resonance spectroscopy in vivo. J Cereb Blood Flow Metab 2012 0.91
39 Multimodal neuroimaging provides a highly consistent picture of energy metabolism, validating 31P MRS for measuring brain ATP synthesis. Proc Natl Acad Sci U S A 2009 0.90
40 Brain mitochondrial defects amplify intracellular [Ca2+] rise and neurodegeneration but not Ca2+ entry during NMDA receptor activation. FASEB J 2006 0.89
41 Neuroprotective effect of zVAD against the neurotoxin 3-nitropropionic acid involves inhibition of calpain. Neuropharmacology 2005 0.89
42 Corticostriatopallidal neuroprotection by adenovirus-mediated ciliary neurotrophic factor gene transfer in a rat model of progressive striatal degeneration. J Neurosci 2002 0.89
43 Fully automated and adaptive detection of amyloid plaques in stained brain sections of Alzheimer transgenic mice. Med Image Comput Comput Assist Interv 2007 0.89
44 Quantitative gene expression profiling of mouse brain regions reveals differential transcripts conserved in human and affected in disease models. Physiol Genomics 2008 0.89
45 Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy. J Neurosci 2009 0.88
46 Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons. Neurobiol Dis 2004 0.88
47 Potential involvement of cannabinoid receptors in 3-nitropropionic acid toxicity in vivo. Neuroreport 2004 0.88
48 In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa). Eur J Nucl Med Mol Imaging 2010 0.87
49 Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate. Neuroreport 2003 0.87
50 Normal aging modulates the neurotoxicity of mutant huntingtin. PLoS One 2009 0.87
51 Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II. Hum Mol Genet 2008 0.86
52 NMR measurement of brain oxidative metabolism in monkeys using 13C-labeled glucose without a 13C radiofrequency channel. Magn Reson Med 2004 0.86
53 pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study. J Cereb Blood Flow Metab 2012 0.86
54 In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution beta +-sensitive microprobe. Proc Natl Acad Sci U S A 2002 0.86
55 Integrating fetal neural transplants into a therapeutic strategy: the example of Huntington's disease. Brain 2004 0.85
56 Up-regulation of glutamate concentration in the putamen and in the prefrontal cortex of asymptomatic SIVmac251-infected macaques without major brain involvement. J Neurochem 2004 0.84
57 Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice. Neurobiol Aging 2011 0.84
58 Optimized diffusion-weighted spectroscopy for measuring brain glutamate apparent diffusion coefficient on a whole-body MR system. NMR Biomed 2005 0.84
59 Quantitative assessment of transcriptome differences between brain territories. Genome Res 2003 0.83
60 Decrease of nicotinic receptors in the nigrostriatal system in Parkinson's disease. J Cereb Blood Flow Metab 2009 0.83
61 Restricted transgene expression in the brain with cell-type specific neuronal promoters. Hum Gene Ther Methods 2012 0.83
62 Automated three-dimensional analysis of histological and autoradiographic rat brain sections: application to an activation study. J Cereb Blood Flow Metab 2007 0.83
63 In vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin. PLoS One 2012 0.82
64 IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats. Neurosci Lett 2007 0.82
65 Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain. Mol Ther 2013 0.82
66 Chronic systemic treatment with a high-dose proteasome inhibitor in mice produces akinesia unrelated to nigrostriatal degeneration. Neurobiol Aging 2009 0.81
67 Multiinjection approach for D2 receptor binding quantification in living rats using [11C]raclopride and the beta-microprobe: crossvalidation with in vitro binding data. J Cereb Blood Flow Metab 2005 0.81
68 Simplified (13)C metabolic modeling for simplified measurements of cerebral TCA cycle rate in vivo. Magn Reson Med 2009 0.80
69 Decreased metabolic response to visual stimulation in the superior colliculus of mice lacking the glial glutamate transporter GLT-1. Eur J Neurosci 2005 0.79
70 Insulin growth factor-1 protects against excitotoxicity in the rat striatum. Neuroreport 2004 0.79
71 Fetal neural grafts for Huntington's disease: a prospective view. Mov Disord 2002 0.78
72 B(0) homogeneity throughout the monkey brain is strongly improved in the sphinx position as compared to the supine position. J Magn Reson Imaging 2006 0.77
73 A standardized method to automatically segment amyloid plaques in Congo Red stained sections from Alzheimer transgenic mice. Conf Proc IEEE Eng Med Biol Soc 2007 0.77
74 Diffusion-weighted NMR spectroscopy allows probing of 13C labeling of glutamate inside distinct metabolic compartments in the brain. Magn Reson Med 2008 0.77
75 Automated indexation of metabolic changes in Alzheimer's mice using a voxel-wise approach combined to an MRI-based 3D digital atlas. Conf Proc IEEE Eng Med Biol Soc 2010 0.77
76 Clinical relevance of electrophysiological tests in the assessment of patients with Huntington's disease. Mov Disord 2002 0.76
77 IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates. PLoS One 2013 0.76
78 Imaging in cell-based therapy for neurodegenerative diseases. Eur J Nucl Med Mol Imaging 2005 0.75
79 Dopamine D1 receptor imaging in the rodent and primate brain using the isoquinoline +-[11C]A-69024 and positron emission tomography. J Pharm Sci 2008 0.75
80 Segmentation of small animal PET/CT mouse brain scans using an MRI-based 3D digital atlas. Conf Proc IEEE Eng Med Biol Soc 2010 0.75