PubRank

Madhavi N L Nalam

Author PubWeight™ 17.66‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces. Structure 2010 1.65
2 HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants. J Am Chem Soc 2008 1.43
3 Programming peptidomimetic syntheses by translating genetic codes designed de novo. Proc Natl Acad Sci U S A 2003 1.38
4 Molecular Basis for Drug Resistance in HIV-1 Protease. Viruses 2010 1.20
5 Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands. J Med Chem 2006 1.17
6 Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis. Chem Biol Drug Des 2007 1.12
7 Specificity of translation for N-alkyl amino acids. J Am Chem Soc 2007 1.06
8 Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. J Am Chem Soc 2012 0.99
9 Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres. J Med Chem 2007 0.97
10 Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease. ACS Chem Biol 2012 0.96
11 Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones. J Med Chem 2010 0.93
12 Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease. J Am Chem Soc 2014 0.85
13 Efficient Computation of Small-Molecule Configurational Binding Entropy and Free Energy Changes by Ensemble Enumeration. J Chem Theory Comput 2013 0.82
14 Testing the substrate-envelope hypothesis with designed pairs of compounds. ACS Chem Biol 2013 0.81
15 Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50. J Virol 2013 0.80
16 TMC310911, a novel human immunodeficiency virus type 1 protease inhibitor, shows in vitro an improved resistance profile and higher genetic barrier to resistance compared with current protease inhibitors. Antimicrob Agents Chemother 2011 0.79
17 Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance. J Med Chem 2012 0.79