Ronald C Desrosiers

Author PubWeight™ 98.04‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 HIV vaccine design and the neutralizing antibody problem. Nat Immunol 2004 9.48
2 Reversion of CTL escape-variant immunodeficiency viruses in vivo. Nat Med 2004 6.33
3 Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science 2004 5.31
4 Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed. PLoS Pathog 2006 4.80
5 Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat Med 2009 3.25
6 HIV vaccine design: insights from live attenuated SIV vaccines. Nat Immunol 2006 2.72
7 Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression following challenge with pathogenic SIVmac239. J Virol 2002 2.63
8 Viral persistence: HIV's strategies of immune system evasion. Annu Rev Med 2002 2.51
9 Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (HIV-1)-specific epitopes: replication, neutralization, and survey of HIV-1-positive plasma. J Virol 2006 2.33
10 Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques. J Virol 2005 2.01
11 A replication-competent, neutralization-sensitive variant of simian immunodeficiency virus lacking 100 amino acids of envelope. J Virol 2002 1.97
12 Assorted mutations in the envelope gene of simian immunodeficiency virus lead to loss of neutralization resistance against antibodies representing a broad spectrum of specificities. J Virol 2003 1.80
13 A comparative immunogenicity study in rabbits of disulfide-stabilized, proteolytically cleaved, soluble trimeric human immunodeficiency virus type 1 gp140, trimeric cleavage-defective gp140 and monomeric gp120. Virology 2006 1.67
14 Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication. J Virol 2002 1.67
15 CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity. J Virol 2002 1.66
16 ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge. PLoS Pathog 2012 1.60
17 Mucosal priming of simian immunodeficiency virus-specific cytotoxic T-lymphocyte responses in rhesus macaques by the Salmonella type III secretion antigen delivery system. J Virol 2003 1.60
18 Induction of a virus-specific effector-memory CD4+ T cell response by attenuated SIV infection. J Exp Med 2006 1.55
19 Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection. J Virol 2002 1.44
20 Modulation of Env content in virions of simian immunodeficiency virus: correlation with cell surface expression and virion infectivity. J Virol 2004 1.44
21 Cell tropism of simian immunodeficiency virus in culture is not predictive of in vivo tropism or pathogenesis. Am J Pathol 2004 1.43
22 Cloning and analysis of microRNAs encoded by the primate gamma-herpesvirus rhesus monkey rhadinovirus. Virology 2007 1.40
23 MHC heterozygote advantage in simian immunodeficiency virus-infected Mauritian cynomolgus macaques. Sci Transl Med 2010 1.38
24 Removal of N-linked glycosylation sites in the V1 region of simian immunodeficiency virus gp120 results in redirection of B-cell responses to V3. J Virol 2004 1.31
25 Determinants of increased replicative capacity of serially passaged simian immunodeficiency virus with nef deleted in rhesus monkeys. J Virol 2003 1.28
26 Vaccine protection by live, attenuated simian immunodeficiency virus in the absence of high-titer antibody responses and high-frequency cellular immune responses measurable in the periphery. J Virol 2008 1.27
27 Importance of B-cell responses for immunological control of variant strains of simian immunodeficiency virus. J Virol 2003 1.24
28 Direct relationship between suppression of virus-specific immunity and emergence of cytomegalovirus disease in simian AIDS. J Virol 2003 1.19
29 Immunization of macaques with single-cycle simian immunodeficiency virus (SIV) stimulates diverse virus-specific immune responses and reduces viral loads after challenge with SIVmac239. J Virol 2005 1.17
30 Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies. J Virol 2013 1.16
31 Virion envelope content, infectivity, and neutralization sensitivity of simian immunodeficiency virus. J Virol 2005 1.13
32 A nucleotide substitution in the tRNA(Lys) primer binding site dramatically increases replication of recombinant simian immunodeficiency virus containing a human immunodeficiency virus type 1 reverse transcriptase. J Virol 2002 1.12
33 A genetic system for rhesus monkey rhadinovirus: use of recombinant virus to quantitate antibody-mediated neutralization. J Virol 2006 1.12
34 Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SIVmac239Deltanef. J Virol 2005 1.10
35 Importance of the V1/V2 loop region of simian-human immunodeficiency virus envelope glycoprotein gp120 in determining the strain specificity of the neutralizing antibody response. J Virol 2008 1.09
36 The tale of the long tail: the cytoplasmic domain of HIV-1 gp41. J Virol 2012 1.09
37 Small nuclear RNAs encoded by Herpesvirus saimiri upregulate the expression of genes linked to T cell activation in virally transformed T cells. Curr Biol 2005 1.07
38 The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1. Cell Host Microbe 2012 1.06
39 Envelope glycoprotein cytoplasmic domains from diverse lentiviruses interact with the prenylated Rab acceptor. J Virol 2002 1.05
40 A novel approach for producing lentiviruses that are limited to a single cycle of infection. J Virol 2004 1.03
41 Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. Virology 2006 1.02
42 Identification of two N-linked glycosylation sites within the core of the simian immunodeficiency virus glycoprotein whose removal enhances sensitivity to soluble CD4. J Virol 2005 0.99
43 Potent antibody-mediated neutralization and evolution of antigenic escape variants of simian immunodeficiency virus strain SIVmac239 in vivo. J Virol 2008 0.94
44 Vaccine protection against simian immunodeficiency virus in monkeys using recombinant gamma-2 herpesvirus. J Virol 2011 0.91
45 Diversity of envelope genes from an uncloned stock of SIVmac251. AIDS Res Hum Retroviruses 2010 0.91
46 Simian immunodeficiency virus from the sooty mangabey and rhesus macaque is modified with O-linked carbohydrate. J Virol 2010 0.90
47 Functional contributions of carbohydrate on AIDS virus glycoprotein. Yale J Biol Med 2010 0.87
48 Evidence against extracellular exposure of a highly immunogenic region in the C-terminal domain of the simian immunodeficiency virus gp41 transmembrane protein. J Virol 2011 0.87
49 An AIDS vaccine: no time to give up. Lancet 2004 0.86
50 Glycoprotein gene sequence variation in rhesus monkey rhadinovirus. Virology 2010 0.86
51 Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin. Virology 2007 0.85
52 Extreme dependence of gH and gL expression on ORF57 and association with highly unusual codon usage in rhesus monkey rhadinovirus. J Virol 2008 0.83
53 p6gag of human and simian immunodeficiency viruses is tolerant to small in-frame deletions downstream of the late domain. Virology 2005 0.83
54 Rhesus monkey rhadinovirus ORF57 induces gH and gL glycoprotein expression through posttranscriptional accumulation of target mRNAs. J Virol 2011 0.81
55 Neutralizing capacity of monoclonal antibodies that recognize peptide sequences underlying the carbohydrates on gp41 of simian immunodeficiency virus. J Virol 2012 0.81
56 Rhesus monkey rhadinovirus uses eph family receptors for entry into B cells and endothelial cells but not fibroblasts. PLoS Pathog 2013 0.81
57 Infectivity and neutralization of simian immunodeficiency virus with FLAG epitope insertion in gp120 variable loops. J Virol 2007 0.81
58 Infection and persistence of rhesus monkey rhadinovirus in immortalized B-cell lines. J Virol 2006 0.81
59 Fundamental difference in the content of high-mannose carbohydrate in the HIV-1 and HIV-2 lineages. J Virol 2010 0.79
60 PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation. J Gen Virol 2005 0.76
61 Localization of productively infected cells in the spleen and Peyer's patches of rhesus macaques during acute infection with SIVmac239Δnef-enhanced green fluorescent protein. AIDS Res Hum Retroviruses 2014 0.75
62 A plea for justice for jailed medical workers. Science 2006 0.75