Prototype development and preclinical immunogenicity analysis of a novel minimally invasive electroporation device.

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🔗 View Article (PMID 20962869)

Published in Gene Ther on October 21, 2010

Authors

K E Broderick1, X Shen, J Soderholm, F Lin, J McCoy, A S Khan, J Yan, M P Morrow, A Patel, G P Kobinger, S Kemmerrer, D B Weiner, N Y Sardesai

Author Affiliations

1: Inovio Pharmaceuticals, Research and Development, San Diego, CA, USA.

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Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys (1999) 4.72

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science (2000) 4.57

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UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V. Proc Natl Acad Sci U S A (1999) 4.24

The frequency of uterine leiomyomas. Am J Clin Pathol (1990) 4.00

Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis. Nature (2000) 3.95

First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response. J Infect Dis (1998) 3.60

ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol (2001) 3.55

Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1993) 3.49

Identification of a human population infected with simian foamy viruses. Nat Med (1998) 3.47

Ebola virus can be effectively neutralized by antibody produced in natural human infection. J Virol (1999) 3.44

Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. Emerg Infect Dis (2001) 3.42

The bacteriorhodopsin gene. Proc Natl Acad Sci U S A (1981) 3.40

Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo. Commission de Lutte contre les Epidémies à Kikwit. J Infect Dis (1999) 3.36

Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: determinants of survival. J Infect Dis (1999) 3.34

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J Biol Chem (2001) 3.32

Adoption of pharmacogenomic testing by US physicians: results of a nationwide survey. Clin Pharmacol Ther (2012) 3.22

Reye's syndrome in the United States from 1981 through 1997. N Engl J Med (1999) 3.20

Randomized clinical trial of early laparoscopy in the management of acute non-specific abdominal pain. Br J Surg (1999) 3.18

Two entities in angiolipoma. A study of 459 cases of lipoma with review of literature on infiltrating angiolipoma. Cancer (1974) 3.14

Age-related changes in the collagen network and toughness of bone. Bone (2002) 3.13

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Induction of cell differentiation by human immunodeficiency virus 1 vpr. Cell (1993) 2.90

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Ebola hemorrhagic fever, Kikwit, Democratic Republic of the Congo, 1995: risk factors for patients without a reported exposure. J Infect Dis (1999) 2.27

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Endogenous murine leukemia proviral long terminal repeats contain a unique 190-base-pair insert. Proc Natl Acad Sci U S A (1983) 2.10

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Specific hybridization probes demonstrate fewer xenotropic than mink cell focus-forming murine leukemia virus env-related sequences in DNAs from inbred laboratory mice. J Virol (1986) 2.08

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Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1994) 2.00

Neutral-lipid storage disease: a new disorder of lipid metabolism. Br Med J (1975) 1.97

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Negative control region at the 5' end of murine leukemia virus long terminal repeats. Mol Cell Biol (1989) 1.88

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CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. J Clin Invest (1998) 1.87

The human immunodeficiency virus type 1 gag gene encodes an internal ribosome entry site. J Virol (2001) 1.87

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Smads bind directly to the Jun family of AP-1 transcription factors. Proc Natl Acad Sci U S A (1999) 1.81

The incubation period of hantavirus pulmonary syndrome. Am J Trop Med Hyg (2000) 1.81

The natural history of untreated asymptomatic hips in patients who have non-traumatic osteonecrosis. J Bone Joint Surg Am (1997) 1.80

Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation. Brain Res Mol Brain Res (2000) 1.80

Molecular characterization of a polymerase mutant human immunodeficiency virus. Virology (1987) 1.76

p185neu expression in human lung adenocarcinomas predicts shortened survival. Cancer Res (1990) 1.75

Respiratory syncytial virus morbidity and mortality estimates in congenital heart disease patients: a recent experience. Crit Care Med (1992) 1.75

Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency. J Virol (1995) 1.74

Speed of onset of 'corner pocket supraclavicular' and infraclavicular ultrasound guided brachial plexus block: a randomised observer-blinded comparison. Anaesthesia (2009) 1.71

An outbreak of hantavirus pulmonary syndrome in western Paraguay. Am J Trop Med Hyg (1997) 1.68

Recombinant human monoclonal antibodies to Ebola virus. J Infect Dis (1999) 1.65

Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr. J Virol (1997) 1.65

Biochemical basis for fluorouracil neurotoxicity. The role of Krebs cycle inhibition by fluoroacetate. Arch Neurol (1970) 1.64

Expression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigs. J Exp Med (1995) 1.63