| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Most efficient cocaine hydrolase designed by virtual screening of transition states.
|
J Am Chem Soc
|
2008
|
2.33
|
|
2
|
Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity.
|
Mol Pharmacol
|
2008
|
1.60
|
|
3
|
Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.
|
Mol Pharmacol
|
2010
|
1.48
|
|
4
|
Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats.
|
J Pharmacol Exp Ther
|
2009
|
1.19
|
|
5
|
Structural analysis of thermostabilizing mutations of cocaine esterase.
|
Protein Eng Des Sel
|
2010
|
1.10
|
|
6
|
Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies.
|
Eur J Pharmacol
|
2007
|
1.09
|
|
7
|
Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates.
|
J Pharmacol Exp Ther
|
2012
|
1.07
|
|
8
|
Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.
|
Neuropsychopharmacology
|
2011
|
1.06
|
|
9
|
Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.
|
Pain
|
2009
|
1.05
|
|
10
|
The role of central gastrin-releasing peptide and neuromedin B receptors in the modulation of scratching behavior in rats.
|
J Pharmacol Exp Ther
|
2011
|
1.00
|
|
11
|
Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.
|
Neuropsychopharmacology
|
2011
|
0.98
|
|
12
|
The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability.
|
ACS Chem Neurosci
|
2012
|
0.94
|
|
13
|
Effects of butorphanol on morphine-induced itch and analgesia in primates.
|
Anesthesiology
|
2007
|
0.94
|
|
14
|
The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys.
|
Psychopharmacology (Berl)
|
2010
|
0.89
|
|
15
|
Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
|
Mol Pharmacol
|
2011
|
0.89
|
|
16
|
Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys.
|
Psychoneuroendocrinology
|
2008
|
0.89
|
|
17
|
Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice.
|
PLoS One
|
2013
|
0.88
|
|
18
|
PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity.
|
J Control Release
|
2009
|
0.88
|
|
19
|
Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain.
|
Psychopharmacology (Berl)
|
2013
|
0.87
|
|
20
|
Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.
|
Drug Alcohol Depend
|
2011
|
0.87
|
|
21
|
Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/μ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain.
|
J Pharmacol Exp Ther
|
2013
|
0.86
|
|
22
|
The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.
|
Anesth Analg
|
2008
|
0.84
|
|
23
|
Electrospray sample deposition for matrix-assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI mass spectrometry with attomole detection limits.
|
Rapid Commun Mass Spectrom
|
2004
|
0.84
|
|
24
|
Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.
|
J Pharmacol Exp Ther
|
2012
|
0.83
|
|
25
|
The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination.
|
J Pharmacol Exp Ther
|
2011
|
0.82
|
|
26
|
Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice.
|
Neurosci Lett
|
2013
|
0.80
|
|
27
|
Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.
|
J Pharmacol Exp Ther
|
2007
|
0.76
|