The role of cysteine-rich secretory proteins in male fertility.

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Epididymosomes are involved in the acquisition of new sperm proteins during epididymal transit. Asian J Androl (2007) 1.48

Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. J Biol Chem (2003) 1.44

Association of cysteine-rich secretory protein 3 and beta-microseminoprotein with outcome after radical prostatectomy. Clin Cancer Res (2007) 1.38

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Crystal structure of the cysteine-rich secretory protein stecrisp reveals that the cysteine-rich domain has a K+ channel inhibitor-like fold. J Biol Chem (2004) 1.20

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Primary structure and properties of helothermine, a peptide toxin that blocks ryanodine receptors. Biophys J (1995) 1.12

Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma. Biochemistry (2004) 1.10

Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. Genomics (2006) 1.09

Identification of differentially expressed genes in normal and malignant prostate by electronic profiling of expressed sequence tags. Cancer Res (2002) 1.08

beta-Microseminoprotein binds CRISP-3 in human seminal plasma. Biochem Biophys Res Commun (2005) 1.07

Crystal structure of a CRISP family Ca2+ -channel blocker derived from snake venom. J Mol Biol (2005) 1.07

Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from Naja atra venom that targets the BKCa channel. Biochemistry (2005) 1.07

Cysteine-rich secretory protein-3: a potential biomarker for prostate cancer. Cancer Epidemiol Biomarkers Prev (2002) 1.06

Impaired sperm fertilizing ability in mice lacking Cysteine-RIch Secretory Protein 1 (CRISP1). Dev Biol (2008) 1.04

Immunohistochemical detection of cysteine-rich secretory protein 3 in tissue and in serum from men with cancer or benign enlargement of the prostate gland. Prostate (2006) 1.04

Isolation and characterization of helothermine, a novel toxin from Heloderma horridum horridum (Mexican beaded lizard) venom. Toxicon (1990) 1.04

Inhibition of capacitation-associated tyrosine phosphorylation signaling in rat sperm by epididymal protein Crisp-1. Biol Reprod (2003) 1.03

Redistribution of a rat sperm epididymal glycoprotein after in vitro and in vivo capacitation. Mol Reprod Dev (1992) 1.02

SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and a rodent sperm-coating glycoprotein. FEBS Lett (1996) 1.01

Helothermine, a lizard venom toxin, inhibits calcium current in cerebellar granules. Exp Brain Res (1996) 1.01

The identification of mouse sperm-surface-associated proteins and characterization of their ability to act as decapacitation factors. Biol Reprod (2005) 1.00

The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling. J Biol Chem (2005) 0.99

Novel cysteine-rich secretory protein in the buccal gland secretion of the parasitic lamprey, Lethenteron japonicum. Biochem Biophys Res Commun (2007) 0.99

Purification and cloning of toxins from elapid venoms that target cyclic nucleotide-gated ion channels. Biochemistry (2002) 0.99

Androgen-controlled specific proteins in rat epididymis. J Endocrinol (1976) 0.98

Characterization and localization of cysteine-rich secretory protein 3 (CRISP-3) in the human male reproductive tract. J Androl (2005) 0.97

Structure and function of epididymal protein cysteine-rich secretory protein-1. Asian J Androl (2007) 0.95

Cysteine rich secretory proteins in reproduction and venom. Soc Reprod Fertil Suppl (2007) 0.93

Structures of pseudechetoxin and pseudecin, two snake-venom cysteine-rich secretory proteins that target cyclic nucleotide-gated ion channels: implications for movement of the C-terminal cysteine-rich domain. Acta Crystallogr D Biol Crystallogr (2008) 0.93

The toxin helothermine affects potassium currents in newborn rat cerebellar granule cells. J Membr Biol (1994) 0.92

Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the Crisp family exclusively expressed in the epididymis in an androgen-dependent manner. Biol Reprod (2005) 0.91

Evidence that human epididymal protein ARP plays a role in gamete fusion through complementary sites on the surface of the human egg. Biol Reprod (2001) 0.91

Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1). Genomics (1996) 0.91

Mouse androgen-dependent epididymal glycoprotein CRISP-1 (DE/AEG): isolation, biochemical characterization, and expression in recombinant form. Mol Reprod Dev (1995) 0.91

Epididymal secreted protein Crisp-1 and sperm function. Mol Cell Endocrinol (2006) 0.90

Identification of a rat testis-specific gene encoding a potential rat outer dense fibre protein. Mol Reprod Dev (1998) 0.89

Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding. Endocrinology (2010) 0.89

Evidence for the involvement of testicular protein CRISP2 in mouse sperm-egg fusion. Biol Reprod (2007) 0.89

Expression pattern, subcellular localization and structure--function relationship of rat Tpx-1, a spermatogenic cell adhesion molecule responsible for association with Sertoli cells. Dev Growth Differ (1999) 0.87

Structural and functional characterization of ryanodine receptor-natrin toxin interaction. Biophys J (2008) 0.87

Sperm protein "DE" mediates gamete fusion through an evolutionarily conserved site of the CRISP family. Dev Biol (2006) 0.87

A sperm chemoattractant is released from Xenopus egg jelly during spawning. Dev Biol (1998) 0.86

Purification and characterization of the primary acrosomal autoantigen of guinea pig epididymal spermatozoa. Biol Reprod (1988) 0.86

Molecular cloning of the rat Tpx-1 responsible for the interaction between spermatogenic and Sertoli cells. Biochem Biophys Res Commun (1998) 0.86

Characterization of gametogenetin 1 (GGN1) and its potential role in male fertility through the interaction with the ion channel regulator, cysteine-rich secretory protein 2 (CRISP2) in the sperm tail. Reproduction (2008) 0.85

Antibodies against epididymal glycoproteins block fertilizing ability in rat. J Reprod Fertil (1984) 0.85

cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells. Biochim Biophys Acta (1998) 0.85

Mouse sperm capacitation in vitro involves loss of a surface-associated inhibitory component. J Reprod Fertil (1984) 0.84

Participation of epididymal cysteine-rich secretory proteins in sperm-egg fusion and their potential use for male fertility regulation. Asian J Androl (2007) 0.84

Purification, radioimmunoassay, and immunohistochemical localization of a glycoprotein produced by the rat epididymis. Biol Reprod (1980) 0.84

Familial t(6;21)(p21.1;p13) translocation associated with male-only sterility. Clin Genet (2000) 0.84

Autoantigen 1 of the guinea pig sperm acrosome is the homologue of mouse Tpx-1 and human TPX1 and is a member of the cysteine-rich secretory protein (CRISP) family. Mol Reprod Dev (1996) 0.83

A comparative analysis of expression and processing of the rat epididymal fluid and sperm-bound forms of proteins D and E. Biol Reprod (2002) 0.83

A testis-specific gene Tpx-1 maps between Pgk-2 and Mep-1 on mouse chromosome 17. Immunogenetics (1989) 0.82

Biomarkers of in vivo fertility in sperm and seminal plasma of fertile stallions. Theriogenology (2010) 0.82

Identification of rat cysteine-rich secretory protein 4 (Crisp4) as the ortholog to human CRISP1 and mouse Crisp4. Biol Reprod (2006) 0.82

Differential androgen regulation of the murine genes for cysteine-rich secretory proteins (CRISP). Eur J Biochem (1997) 0.82

Studies on the binding of a 32K rat epididymal protein to rat epididymal spermatozoa. Biol Reprod (1982) 0.82

Distribution and site of production of specific proteins in the rat epididymis. Biol Reprod (1980) 0.82

Human testicular protein TPX1/CRISP-2: localization in spermatozoa, fate after capacitation and relevance for gamete interaction. Mol Hum Reprod (2005) 0.82

Cysteine-rich secretory proteins are not exclusively expressed in the male reproductive tract. Dev Dyn (2008) 0.81

Equine CRISP-3: primary structure and expression in the male genital tract. Biochim Biophys Acta (1998) 0.80

A novel protein, sperm head and tail associated protein (SHTAP), interacts with cysteine-rich secretory protein 2 (CRISP2) during spermatogenesis in the mouse. Biol Cell (2009) 0.80

Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm. Biol Reprod (2007) 0.80

Isolation, immunolocalization, and sperm-association of three proteins of 18, 25, and 29 kilodaltons secreted by the mouse epididymis. Biol Reprod (1992) 0.80

Rat epididymis-specific sperm maturation antigens. I. Evidence that the 26 kD 4E9 antigen found on rat caudal epididymal sperm tail is derived from a protein secreted by the epididymis. Mol Reprod Dev (1994) 0.80

Serotriflin, a CRISP family protein with binding affinity for small serum protein-2 in snake serum. Biochim Biophys Acta (2008) 0.80

Tpx-1 is a component of the outer dense fibers and acrosome of rat spermatozoa. Mol Reprod Dev (2001) 0.80

Studies on the participation of epididymal sperm protein DE/CRISP-1 in egg activation. Cell Mol Biol (Noisy-le-grand) (2003) 0.79

A polymorphism within the equine CRISP3 gene is associated with stallion fertility in Hanoverian warmblood horses. Anim Genet (2007) 0.79

Purification of rat epididymal proteins "D' and "E', demonstration of shared immunological determinants, and identification of regional synthesis and secretion. Int J Androl (1982) 0.78

Potential contraceptive use of epididymal proteins: immunization of male rats with epididymal protein DE inhibits sperm fusion ability. Biol Reprod (1998) 0.78

Potential contraceptive use of epididymal proteins: evidence for the participation of specific antibodies against rat epididymal protein DE in male and female fertility inhibition. J Reprod Immunol (1995) 0.78

Association of the protein D and protein E forms of rat CRISP1 with epididymal sperm. Biol Reprod (2008) 0.77

Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian men. Hum Reprod (2008) 0.77

Biochemical and conformational characterisation of HSP-3, a stallion seminal plasma protein of the cysteine-rich secretory protein (CRISP) family. FEBS Lett (1997) 0.76

A model of the complex between human beta-microseminoprotein and CRISP-3 based on NMR data. Biochem Biophys Res Commun (2008) 0.75

Association of epididymal secretory proteins showing alpha-lactalbumin-like activity with the plasma membrane of rat spermatozoa. Biochem J (1982) 0.75

Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci U S A (2005) 2.56

The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense. Endocr Rev (2008) 2.06

Spermiation: The process of sperm release. Spermatogenesis (2011) 1.78

Clinical Review#: State of the art for genetic testing of infertile men. J Clin Endocrinol Metab (2010) 1.39

Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype. J Immunol (2009) 1.32

Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'. Hum Reprod Update (2009) 1.22

Fat aussie--a new Alström syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Mol Endocrinol (2006) 1.18

The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice. Mol Cell Biol (2002) 1.18

Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction. Endocr Rev (2008) 1.10

Epigenetic regulation in male germ cells. Reproduction (2008) 1.08

A mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet (2002) 1.06

FGFR-1 [corrected] signaling is involved in spermiogenesis and sperm capacitation. J Cell Sci (2005) 1.05

Mouse models in male fertility research. Asian J Androl (2010) 1.01

Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function. Proc Natl Acad Sci U S A (2011) 1.01

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet (2012) 1.00

DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes. PLoS One (2012) 1.00

An essential role for katanin p80 and microtubule severing in male gamete production. PLoS Genet (2012) 0.99

The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling. J Biol Chem (2005) 0.99

Mouse models as tools in fertility research and male-based contraceptive development. Handb Exp Pharmacol (2010) 0.97

Deletion of the Parkin co-regulated gene causes defects in ependymal ciliary motility and hydrocephalus in the quakingviable mutant mouse. Hum Mol Genet (2010) 0.96

Changes in circulating and testicular levels of inhibin A and B and activin A during postnatal development in the rat. Endocrinology (2004) 0.94

The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis. Endocrinology (2004) 0.94

Identification of a novel testis-specific member of the phosphatidylethanolamine binding protein family, pebp-2. Biol Reprod (2002) 0.93

Cysteine rich secretory proteins in reproduction and venom. Soc Reprod Fertil Suppl (2007) 0.93

Molecular analysis of the PArkin co-regulated gene and association with male infertility. Fertil Steril (2009) 0.89

Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding. Endocrinology (2010) 0.89

Glucocorticoid-induced leucine zipper (GILZ) regulates testicular FOXO1 activity and spermatogonial stem cell (SSC) function. PLoS One (2013) 0.88

Genome-wide ENU mutagenesis for the discovery of novel male fertility regulators. Syst Biol Reprod Med (2010) 0.88

Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism. Endocrinology (2010) 0.88

KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility. PLoS Genet (2012) 0.88

Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae. Dev Biol (2011) 0.87

Normal live birth after testicular sperm extraction and intracytoplasmic sperm injection in variant primary ciliary dyskinesia with completely immotile sperm and structurally abnormal sperm tails. Fertil Steril (2011) 0.86

Characterization of gametogenetin 1 (GGN1) and its potential role in male fertility through the interaction with the ion channel regulator, cysteine-rich secretory protein 2 (CRISP2) in the sperm tail. Reproduction (2008) 0.85

The generation of live offspring from vitrified oocytes. PLoS One (2011) 0.85

Generation of stable pluripotent stem cells from NOD mouse tail-tip fibroblasts. Diabetes (2011) 0.85

Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse. Biol Reprod (2008) 0.84

Genetic screening of infertile men. Reprod Fertil Dev (2004) 0.84

TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction. J Cell Physiol (2011) 0.84

Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo. Am J Pathol (2008) 0.84

Utilising the resources of the International Knockout Mouse Consortium: the Australian experience. Mamm Genome (2015) 0.83

Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition. Mol Hum Reprod (2012) 0.83

Cell-specific expression of betaC-activin in the rat reproductive tract, adrenal and liver. Mol Cell Endocrinol (2004) 0.82

The response of testicular leukocytes to lipopolysaccharide-induced inflammation: further evidence for heterogeneity of the testicular macrophage population. Cell Tissue Res (2002) 0.82

Loss of the nuclear receptor corepressor SLIRP compromises male fertility. PLoS One (2013) 0.81

Cysteine-rich secretory proteins are not exclusively expressed in the male reproductive tract. Dev Dyn (2008) 0.81

Sox8 and Sertoli-cell function. Ann N Y Acad Sci (2007) 0.80

Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm. Biol Reprod (2007) 0.80

A novel protein, sperm head and tail associated protein (SHTAP), interacts with cysteine-rich secretory protein 2 (CRISP2) during spermatogenesis in the mouse. Biol Cell (2009) 0.80

Human sperm associated antigen 4 (SPAG4) is a potential cancer marker. Cell Tissue Res (2003) 0.80

DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription. PLoS One (2011) 0.78

Constitutive expression of prostaglandin-endoperoxide synthase 2 by somatic and spermatogenic cells is responsible for prostaglandin E2 production in the adult rat testis. Biol Reprod (2007) 0.78

Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse. PLoS One (2013) 0.78

A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse. PLoS One (2013) 0.75

Correction: HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse. PLoS Genet (2015) 0.75

Meeting Review: Joint Prince Henry's Institute of Medical Research and Monash Institute of Reproduction and Development Symposium - Reproductive Genomics. Comp Funct Genomics (2002) 0.75