PubRank

Arthur Weiss

Author PubWeight™ 142.84‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N Engl J Med 2004 7.04
2 CD45: a critical regulator of signaling thresholds in immune cells. Annu Rev Immunol 2001 4.13
3 Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 2004 3.63
4 Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell 2009 3.47
5 Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2002 3.38
6 Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature 2011 3.32
7 Jurkat T cells and development of the T-cell receptor signalling paradigm. Nat Rev Immunol 2004 2.85
8 Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Cell 2007 2.68
9 Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature 2012 2.64
10 ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood 2004 2.30
11 A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol 2005 2.16
12 Overview of the Alliance for Cellular Signaling. Nature 2002 2.15
13 The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes. Nat Immunol 2008 2.12
14 Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A 2008 2.06
15 Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol 2007 2.05
16 The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3. Immunol Rev 2003 2.02
17 The structure, regulation, and function of ZAP-70. Immunol Rev 2009 2.01
18 ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia. Blood 2007 2.00
19 ZAP-70: an essential kinase in T-cell signaling. Cold Spring Harb Perspect Biol 2010 1.88
20 Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity 2007 1.83
21 Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells. Immunity 2013 1.81
22 PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J Immunol 2009 1.79
23 Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. J Clin Invest 2002 1.78
24 Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity 2002 1.77
25 Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature 2012 1.73
26 Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal 2013 1.73
27 Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest 2012 1.72
28 Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases. Mol Cell Biol 2005 1.64
29 DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet 2013 1.64
30 Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms. Nat Immunol 2002 1.59
31 Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization. J Immunol 2003 1.58
32 Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity 2008 1.54
33 It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation. Trends Immunol 2002 1.52
34 T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol 2003 1.49
35 A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol 2010 1.42
36 Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Proc Natl Acad Sci U S A 2008 1.41
37 Pillars article: Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science. 1994. 263: 1136-1139. J Immunol 2014 1.40
38 Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. Mol Cell Biol 2002 1.39
39 CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity 2010 1.39
40 STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol 2011 1.37
41 Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. Nat Immunol 2005 1.35
42 Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res 2013 1.33
43 Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nat Immunol 2005 1.32
44 Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc Natl Acad Sci U S A 2006 1.30
45 The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J Cell Biol 2003 1.25
46 Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec. Mol Cell Biol 2004 1.24
47 Distinct roles for Syk and ZAP-70 during early thymocyte development. J Exp Med 2007 1.24
48 Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation. J Cell Biol 2005 1.21
49 The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells. Cell Growth Differ 2002 1.20
50 The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity 2005 1.19
51 T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization. J Exp Med 2004 1.19
52 Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila. PLoS Pathog 2009 1.19
53 A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J Exp Med 2009 1.17
54 Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. J Biol Chem 2008 1.15
55 The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood 2009 1.13
56 Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4. J Exp Med 2006 1.13
57 Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. J Histochem Cytochem 2007 1.11
58 SRC-like adaptor protein regulates B cell development and function. J Immunol 2006 1.10
59 Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains. J Biol Chem 2003 1.09
60 A proline-rich motif in the C terminus of Akt contributes to its localization in the immunological synapse. J Immunol 2004 1.09
61 Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nat Immunol 2004 1.08
62 Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response. Proc Natl Acad Sci U S A 2009 1.04
63 Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Sci Signal 2011 1.04
64 SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking. Immunol Rev 2009 0.99
65 Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. Mol Cell Biol 2013 0.99
66 Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate. Proc Natl Acad Sci U S A 2010 0.97
67 Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner. Proc Natl Acad Sci U S A 2006 0.97
68 Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival. Proc Natl Acad Sci U S A 2011 0.97
69 Regulation of thymocyte positive selection and motility by GIT2. Nat Immunol 2010 0.96
70 The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T-mediated virulence. J Clin Invest 2007 0.95
71 SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. J Biol Chem 2004 0.94
72 Alternative splicing of CD45: the tip of the iceberg. Immunity 2008 0.94
73 Regulated expression of the receptor-like tyrosine phosphatase CD148 on hemopoietic cells. J Immunol 2004 0.93
74 Antigen receptor signaling in the rheumatic diseases. Arthritis Res Ther 2009 0.91
75 Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148. J Biol Chem 2011 0.90
76 Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases. J Cell Biol 2007 0.90
77 Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases. Blood 2011 0.89
78 SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. Mol Cell Biol 2011 0.88
79 Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes. Sci Signal 2009 0.87
80 Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. Immunity 2011 0.87
81 The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest 2013 0.86
82 Twisting tails exposed: the evidence for TCR conformational change. J Exp Med 2005 0.86
83 The membrane environment can promote or suppress bistability in cell signaling networks. J Phys Chem B 2012 0.86
84 Ca-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells. Small GTPases 2011 0.86
85 B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency. J Exp Med 2008 0.84
86 Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL. Elife 2014 0.84
87 The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation. J Immunol 2011 0.84
88 Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses. Proc Natl Acad Sci U S A 2009 0.83
89 Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. J Clin Invest 2011 0.83
90 Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. PLoS One 2011 0.83
91 Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation. J Clin Immunol 2015 0.82
92 Chemotherapy for bone sarcoma does not affect fertility rates or childbirth. Clin Orthop Relat Res 2004 0.79
93 The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity. J Immunol 2013 0.79
94 Kinases and phosphatases of the immune system. Immunol Rev 2009 0.79
95 Requirement for CD45 in fine-tuning mast cell responses mediated by different ligand-receptor systems. Cell Signal 2009 0.78
96 Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Mol Cell Biol 2014 0.78
97 Lymphocyte signaling: a Tuscan affair. Nat Immunol 2011 0.75
98 Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature 2016 0.75
99 A clue to antigen receptor tails. J Immunol 2014 0.75