Published in Chem Rev on November 05, 2010
Copper active sites in biology. Chem Rev (2014) 1.90
Biochemistry and theory of proton-coupled electron transfer. Chem Rev (2014) 1.17
Structure, function, and assembly of heme centers in mitochondrial respiratory complexes. Biochim Biophys Acta (2012) 1.16
Electron hopping through proteins. Coord Chem Rev (2012) 1.16
Metalloproteins containing cytochrome, iron-sulfur, or copper redox centers. Chem Rev (2014) 1.13
A switching cascade of hydrazone-based rotary switches through coordination-coupled proton relays. Nat Chem (2012) 1.11
Redox properties of tyrosine and related molecules. FEBS Lett (2011) 1.00
A designed functional metalloenzyme that reduces O2 to H2O with over one thousand turnovers. Angew Chem Int Ed Engl (2012) 1.00
A Mononuclear Nonheme Iron(III)-Peroxo Complex Binding Redox-Inactive Metal Ions. Chem Sci (2013) 0.96
Proton-coupled electron transfer reactions at a heme-propionate in an iron-protoporphyrin-IX model compound. J Am Chem Soc (2011) 0.95
Significant increase of oxidase activity through the genetic incorporation of a tyrosine-histidine cross-link in a myoglobin model of heme-copper oxidase. Angew Chem Int Ed Engl (2012) 0.94
Questioning the functional relevance of mitochondrial supercomplexes by time-resolved analysis of the respiratory chain. Proc Natl Acad Sci U S A (2011) 0.91
Electronic structure of a low-spin heme/Cu peroxide complex: spin-state and spin-topology contributions to reactivity. Inorg Chem (2011) 0.91
Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I. Proc Natl Acad Sci U S A (2014) 0.90
Electron flow through nitrotyrosinate in Pseudomonas aeruginosa azurin. J Am Chem Soc (2013) 0.89
Density functional study for the bridged dinuclear center based on a high-resolution X-ray crystal structure of ba3 cytochrome c oxidase from Thermus thermophilus. Inorg Chem (2013) 0.89
Changing hydration level in an internal cavity modulates the proton affinity of a key glutamate in cytochrome c oxidase. Proc Natl Acad Sci U S A (2013) 0.89
Biophysical investigation of the ironome of human jurkat cells and mitochondria. Biochemistry (2012) 0.88
A Euclidean Perspective on the Unfolding of Azurin: Spatial Correlations. Mol Phys (2013) 0.87
Computational study of the activated O(H) state in the catalytic mechanism of cytochrome c oxidase. Proc Natl Acad Sci U S A (2013) 0.86
Functions of the hydrophilic channels in protonmotive cytochrome c oxidase. J R Soc Interface (2013) 0.86
Glu-286 rotation and water wire reorientation are unlikely the gating elements for proton pumping in cytochrome C oxidase. Biophys J (2011) 0.86
Redox-controlled proton gating in bovine cytochrome c oxidase. PLoS One (2013) 0.86
Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome c oxidase. Proc Natl Acad Sci U S A (2015) 0.85
Computationally Efficient Multiscale Reactive Molecular Dynamics to Describe Amino Acid Deprotonation in Proteins. J Chem Theory Comput (2016) 0.85
Yeast cytochrome c oxidase: a model system to study mitochondrial forms of the haem-copper oxidase superfamily. Biochim Biophys Acta (2011) 0.85
Electron transfer interactome of cytochrome C. PLoS Comput Biol (2012) 0.85
Water molecule reorganization in cytochrome c oxidase revealed by FTIR spectroscopy. Proc Natl Acad Sci U S A (2011) 0.85
A high-valent heterobimetallic [Cu(III)(μ-O)2Ni(III)]2+ core with nucleophilic oxo groups. Angew Chem Int Ed Engl (2013) 0.85
Proton storage site in bacteriorhodopsin: new insights from quantum mechanics/molecular mechanics simulations of microscopic pK(a) and infrared spectra. J Am Chem Soc (2011) 0.85
Kinetic studies of the reactions of O(2) and NO with reduced Thermus thermophilus ba(3) and bovine aa(3) using photolabile carriers. Biochim Biophys Acta (2011) 0.85
Ligand access to the active site in Thermus thermophilus ba(3) and bovine heart aa(3) cytochrome oxidases. Biochemistry (2013) 0.84
Reconstitution of respiratory oxidases in membrane nanodiscs for investigation of proton-coupled electron transfer. FEBS Lett (2011) 0.84
Cytochrome cbb3 of Thioalkalivibrio is a Na+-pumping cytochrome oxidase. Proc Natl Acad Sci U S A (2015) 0.84
Oxoferryl-porphyrin radical catalytic intermediate in cytochrome bd oxidases protects cells from formation of reactive oxygen species. J Biol Chem (2012) 0.83
Microscopic basis for kinetic gating in Cytochrome c oxidase: insights from QM/MM analysis. Chem Sci (2015) 0.83
Characterizing the proton loading site in cytochrome c oxidase. Proc Natl Acad Sci U S A (2014) 0.83
Mutation of a single residue in the ba3 oxidase specifically impairs protonation of the pump site. Proc Natl Acad Sci U S A (2015) 0.83
Defining the role of tyrosine and rational tuning of oxidase activity by genetic incorporation of unnatural tyrosine analogs. J Am Chem Soc (2015) 0.83
Role of aspartate 132 at the orifice of a proton pathway in cytochrome c oxidase. Proc Natl Acad Sci U S A (2013) 0.82
Direct observation of intermediates formed during steady-state electrocatalytic O2 reduction by iron porphyrins. Proc Natl Acad Sci U S A (2013) 0.82
Moving protons and electrons in biomimetic systems. Biochemistry (2015) 0.82
Redox-induced activation of the proton pump in the respiratory complex I. Proc Natl Acad Sci U S A (2015) 0.81
Molecular simulation of water and hydration effects in different environments: challenges and developments for DFTB based models. J Phys Chem B (2014) 0.80
A broken-symmetry density functional study of structures, energies, and protonation states along the catalytic O-O bond cleavage pathway in ba3 cytochrome c oxidase from Thermus thermophilus. Phys Chem Chem Phys (2016) 0.80
Using Biosynthetic Models of Heme-Copper Oxidase and Nitric Oxide Reductase in Myoglobin to Elucidate Structural Features Responsible for Enzymatic Activities. Isr J Chem (2016) 0.79
Regulatory role of the respiratory supercomplex factors in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2016) 0.79
Hopping Maps for Photosynthetic Reaction Centers(). Coord Chem Rev (2012) 0.79
Energetics and dynamics of proton transfer reactions along short water wires. Phys Chem Chem Phys (2011) 0.79
Enhanced catalytic four-electron dioxygen (O2) and two-electron hydrogen peroxide (H2O2) reduction with a copper(II) complex possessing a pendant ligand pivalamido group. J Am Chem Soc (2013) 0.79
Protonation-coupled redox reactions in planar antiaromatic meso-pentafluorophenyl-substituted o-phenylene-bridged annulated rosarins. Nat Chem (2012) 0.79
Monitoring Long-Range Electron Transfer Pathways in Proteins by Stimulated Attosecond Broadband X-ray Raman Spectroscopy. J Phys Chem Lett (2014) 0.78
Structural Changes and Proton Transfer in Cytochrome c Oxidase. Sci Rep (2015) 0.78
Significant Improvement of Oxidase Activity through the Genetic Incorporation of a Redox-active Unnatural Amino Acid. Chem Sci (2015) 0.78
Spectroscopic and kinetic investigation of the fully reduced and mixed valence states of ba3-cytochrome c oxidase from Thermus thermophilus: a Fourier transform infrared (FTIR) and time-resolved step-scan FTIR study. J Biol Chem (2012) 0.77
Acid-induced mechanism change and overpotential decrease in dioxygen reduction catalysis with a dinuclear copper complex. J Am Chem Soc (2013) 0.77
Exploring O2 diffusion in A-type cytochrome c oxidases: molecular dynamics simulations uncover two alternative channels towards the binuclear site. PLoS Comput Biol (2014) 0.77
Spectroscopic and Crystallographic Evidence for the Role of a Water-Containing H-Bond Network in Oxidase Activity of an Engineered Myoglobin. J Am Chem Soc (2016) 0.77
Hydrogen bonding networks tune proton-coupled redox steps during the enzymatic six-electron conversion of nitrite to ammonia. Biochemistry (2014) 0.77
Energetic Mechanism of Cytochrome c-Cytochrome c Oxidase Electron Transfer Complex Formation under Turnover Conditions Revealed by Mutational Effects and Docking Simulation. J Biol Chem (2016) 0.77
Photochemical Tyrosine Oxidation with a Hydrogen-Bonded Proton Acceptor by Bidirectional Proton-Coupled Electron Transfer. Chem Sci (2012) 0.77
Rapid Electron Transfer within the III-IV Supercomplex in Corynebacterium glutamicum. Sci Rep (2016) 0.76
Design and engineering of artificial oxygen-activating metalloenzymes. Chem Soc Rev (2016) 0.76
Direct Interfacial Y731 Oxidation in α2 by a Photoβ2 Subunit of E. coli Class Ia Ribonucleotide Reductase. Chem Sci (2015) 0.76
Lewis acid-induced change from four- to two-electron reduction of dioxygen catalyzed by copper complexes using scandium triflate. J Am Chem Soc (2015) 0.76
QM/MM free energy simulations: recent progress and challenges. Mol Simul (2016) 0.76
Site-specific covalent attachment of heme proteins on self-assembled monolayers. J Biol Inorg Chem (2012) 0.76
Electrocatalytic O2-Reduction by Synthetic Cytochrome c Oxidase Mimics: Identification of a "Bridging Peroxo" Intermediate Involved in Facile 4e(-)/4H(+) O2-Reduction. J Am Chem Soc (2015) 0.76
Single Enzyme Experiments Reveal a Long-Lifetime Proton Leak State in a Heme-Copper Oxidase. J Am Chem Soc (2015) 0.76
Spectral identification of intermediates generated during the reaction of dioxygen with the wild-type and EQ(I-286) mutant of Rhodobacter sphaeroides cytochrome c oxidase. Biochemistry (2012) 0.76
Two Aromatic Rings Coupled a Sulfur-Containing Group to Favor Protein Electron Transfer by Instantaneous Formations of π∴S:π↔π:S∴π or π∴π:S↔π:π∴S Five-Electron Bindings. J Phys Chem C Nanomater Interfaces (2015) 0.75
Splitting of the O-O bond at the heme-copper catalytic site of respiratory oxidases. Sci Adv (2017) 0.75
OH cleavage from tyrosine: debunking a myth. J Synchrotron Radiat (2017) 0.75
All the O2 Consumed by Thermus thermophilus Cytochrome ba3 Is Delivered to the Active Site through a Long, Open Hydrophobic Tunnel with Entrances within the Lipid Bilayer. Biochemistry (2016) 0.75
Copper(I)-Dioxygen Adducts and Copper Enzyme Mechanisms. Isr J Chem (2016) 0.75
Proton-Coupled Electron Transfer in Organic Synthesis: Fundamentals, Applications, and Opportunities. Top Curr Chem (J) (2016) 0.75
Proton transfer in the K-channel analog of B-type Cytochrome c oxidase from Thermus thermophilus. Biophys J (2014) 0.75
Why copper is preferred over iron for oxygen activation and reduction in haem-copper oxidases. Nat Chem (2016) 0.75
Proton-coupled electron hopping in Ru-modified P. aeruginosa azurin. J Biol Inorg Chem (2016) 0.75
Expanding the view of proton pumping in cytochrome c oxidase through computer simulation. Biochim Biophys Acta (2011) 0.75
Radical Reactivity of the Fe(III)/(II) Tetramesitylporphyrin Couple: Hydrogen Atom Transfer, Oxyl Radical Dissociation, and Catalytic Disproportionation of a Hydroxylamine. Chem Sci (2014) 0.75
Multiscale simulations reveal key features of the proton-pumping mechanism in cytochrome c oxidase. Proc Natl Acad Sci U S A (2016) 0.75
How periplasmic thioredoxin TlpA reduces bacterial copper chaperone ScoI and cytochrome oxidase subunit II (CoxB) prior to metallation. J Biol Chem (2014) 0.75
Critical Aspects of Heme-Peroxo-Cu Complex Structure and Nature of Proton Source Dictate Metal-Operoxo Breakage versus Reductive O-O Cleavage Chemistry. J Am Chem Soc (2016) 0.75
The dual function of flavodiiron proteins: oxygen and/or nitric oxide reductases. J Biol Inorg Chem (2016) 0.75
Cytochrome c Oxidase Biogenesis and Metallochaperone Interactions: Steps in the Assembly Pathway of a Bacterial Complex. PLoS One (2017) 0.75
Phenol-Induced O-O Bond Cleavage in a Low-Spin Heme-Peroxo-Copper Complex: Implications for O2 Reduction in Heme-Copper Oxidases. J Am Chem Soc (2017) 0.75
A New Domain of Reactivity for High-Valent Dinuclear [M(μ-O)2 M'] Complexes in Oxidation Reactions. Angew Chem Int Ed Engl (2016) 0.75
Reactivity of the copper(iii)-hydroxide unit with phenols. Chem Sci (2016) 0.75
Symmetry-related proton transfer pathways in respiratory complex I. Proc Natl Acad Sci U S A (2017) 0.75
Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature. Proc Natl Acad Sci U S A (2017) 0.75
A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing. Cell (2008) 6.98
Water-gated mechanism of proton translocation by cytochrome c oxidase. Biochim Biophys Acta (2003) 2.26
The cytochrome bd respiratory oxygen reductases. Biochim Biophys Acta (2011) 2.05
Proton-coupled electron transfer drives the proton pump of cytochrome c oxidase. Nature (2006) 1.65
Exploring the proton pump mechanism of cytochrome c oxidase in real time. Proc Natl Acad Sci U S A (2007) 1.63
Mechanism and energetics of proton translocation by the respiratory heme-copper oxidases. Biochim Biophys Acta (2007) 1.60
Adaptive evolution of cytochrome c oxidase: Infrastructure for a carnivorous plant radiation. Proc Natl Acad Sci U S A (2004) 1.56
The catalytic cycle of cytochrome c oxidase is not the sum of its two halves. Proc Natl Acad Sci U S A (2003) 1.41
Real-time electron transfer in respiratory complex I. Proc Natl Acad Sci U S A (2008) 1.33
Glutamic acid 242 is a valve in the proton pump of cytochrome c oxidase. Proc Natl Acad Sci U S A (2008) 1.31
Time-resolved single-turnover of ba3 oxidase from Thermus thermophilus. Biochim Biophys Acta (2007) 1.29
Conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase (Complex I). Biochim Biophys Acta (2008) 1.20
Molecular mechanism of proton translocation by cytochrome c oxidase. Antioxid Redox Signal (2008) 1.16
The identity of the transient proton loading site of the proton-pumping mechanism of cytochrome c oxidase. Biochim Biophys Acta (2010) 1.12
Metal-bridging mechanism for O-O bond cleavage in cytochrome C oxidase. Inorg Chem (2003) 1.09
Time-resolved ATR-FTIR spectroscopy of the oxygen reaction in the D124N mutant of cytochrome c oxidase from Paracoccus denitrificans. Biochemistry (2007) 1.06
Towards the mechanism of proton pumping by the haem-copper oxidases. Biochim Biophys Acta (2006) 1.05
Proton and electron pathways in the bacterial nitric oxide reductase. Biochemistry (2002) 1.05
Mechanistic stoichiometry of proton translocation by cytochrome cbb3. Proc Natl Acad Sci U S A (2012) 1.03
Kinetic models of redox-coupled proton pumping. Proc Natl Acad Sci U S A (2007) 1.02
Redox titration of all electron carriers of cytochrome c oxidase by Fourier transform infrared spectroscopy. Biochemistry (2006) 1.01
Kinetic gating of the proton pump in cytochrome c oxidase. Proc Natl Acad Sci U S A (2009) 1.01
Sequence analysis of the cbb3 oxidases and an atomic model for the Rhodobacter sphaeroides enzyme. Biochemistry (2006) 0.97
The proton donor for O-O bond scission by cytochrome c oxidase. Proc Natl Acad Sci U S A (2008) 0.97
Redox properties of the prosthetic groups of Na(+)-translocating NADH:quinone oxidoreductase. 2. Study of the enzyme by optical spectroscopy. Biochemistry (2009) 0.97
Redox properties of the prosthetic groups of Na(+)-translocating nadh:quinone oxidoreductase. 1. Electron paramagnetic resonance study of the enzyme. Biochemistry (2009) 0.97
Mechanism and energetics by which glutamic acid 242 prevents leaks in cytochrome c oxidase. Biochim Biophys Acta (2009) 0.96
Identification of a histidine-tyrosine cross-link in the active site of the cbb3-type cytochrome c oxidase from Rhodobacter sphaeroides. Proc Natl Acad Sci U S A (2006) 0.96
Nanosecond electron tunneling between the hemes in cytochrome bo3. Proc Natl Acad Sci U S A (2007) 0.96
Time-resolved electrometric and optical studies on cytochrome bd suggest a mechanism of electron-proton coupling in the di-heme active site. Proc Natl Acad Sci U S A (2005) 0.96
An elementary reaction step of the proton pump is revealed by mutation of tryptophan-164 to phenylalanine in cytochrome c oxidase from Paracoccus denitrificans. Biochemistry (2005) 0.95
Electrostatic interactions between FeS clusters in NADH:ubiquinone oxidoreductase (Complex I) from Escherichia coli. Biochemistry (2008) 0.95
Probing the mechanistic role of the long α-helix in subunit L of respiratory Complex I from Escherichia coli by site-directed mutagenesis. Mol Microbiol (2011) 0.95
Aerobic respiratory chain of Escherichia coli is not allowed to work in fully uncoupled mode. Proc Natl Acad Sci U S A (2011) 0.94
ATR-FTIR spectroscopy of the P(M) and F intermediates of bovine and Paracoccus denitrificans cytochrome c oxidase. Biochemistry (2003) 0.93
Primary steps of the Na+-translocating NADH:ubiquinone oxidoreductase catalytic cycle resolved by the ultrafast freeze-quench approach. J Biol Chem (2008) 0.92
Proton translocation by cytochrome c oxidase in different phases of the catalytic cycle. Biochim Biophys Acta (2002) 0.91
Redox-dependent sodium binding by the Na(+)-translocating NADH:quinone oxidoreductase from Vibrio harveyi. Biochemistry (2007) 0.91
Thermodynamic properties of the redox centers of Na(+)-translocating NADH:quinone oxidoreductase. Biochemistry (2006) 0.91
Dynamics of the glutamic acid 242 side chain in cytochrome c oxidase. Biochim Biophys Acta (2007) 0.90
Elementary steps of proton translocation in the catalytic cycle of cytochrome oxidase. Biochim Biophys Acta (2006) 0.90
Role of the conserved arginine 274 and histidine 224 and 228 residues in the NuoCD subunit of complex I from Escherichia coli. Biochemistry (2007) 0.89
Kinetics of the spectral changes during reduction of the Na+-motive NADH:quinone oxidoreductase from Vibrio harveyi. Biochim Biophys Acta (2002) 0.89
Structural and chemical changes of the P(M) intermediate of paracoccus denitrificans cytochrome c oxidase revealed by IR spectroscopy with labeled tyrosines and histidine. Biochemistry (2006) 0.89
The spin distribution in low-spin iron porphyrins. J Am Chem Soc (2002) 0.88
Active site of cytochrome cbb3. J Biol Chem (2009) 0.88
Plasticity of proton pathway structure and water coordination in cytochrome c oxidase. J Biol Chem (2007) 0.87
Cytochrome bd from Azotobacter vinelandii: evidence for high-affinity oxygen binding. Biochemistry (2007) 0.87
Discovery of the true peroxy intermediate in the catalytic cycle of terminal oxidases by real-time measurement. J Biol Chem (2007) 0.87
Proton-coupled electron equilibrium in soluble and membrane-bound cytochrome c oxidase from Paracoccus denitrificans. Biochemistry (2006) 0.87
Computational study of the activated O(H) state in the catalytic mechanism of cytochrome c oxidase. Proc Natl Acad Sci U S A (2013) 0.86
Dynamic water networks in cytochrome cbb3 oxidase. Biochim Biophys Acta (2011) 0.86
Initiation of the proton pump of cytochrome c oxidase. Proc Natl Acad Sci U S A (2010) 0.86
Prevention of leak in the proton pump of cytochrome c oxidase. Biochim Biophys Acta (2008) 0.86
Glutamate 107 in subunit I of cytochrome bd from Escherichia coli is part of a transmembrane intraprotein pathway conducting protons from the cytoplasm to the heme b595/heme d active site. Biochemistry (2008) 0.85
The protonation state of the cross-linked tyrosine during the catalytic cycle of cytochrome c oxidase. J Biol Chem (2008) 0.85
Oxygenated complex of cytochrome bd from Escherichia coli: stability and photolability. FEBS Lett (2005) 0.84
ATR-FTIR spectroscopy and isotope labeling of the PM intermediate of Paracoccus denitrificans cytochrome c oxidase. Biochemistry (2004) 0.84
Activation of isolated NADH:ubiquinone reductase I (complex I) from Escherichia coli by detergent and phospholipids. Recovery of ubiquinone reductase activity and changes in EPR signals of iron-sulfur clusters. Biochemistry (2005) 0.84
The D-channel of cytochrome oxidase: an alternative view. Biochim Biophys Acta (2011) 0.83
Protolytic reactions on reduction of cytochrome c oxidase studied by ATR-FTIR spectroscopy. Biochemistry (2007) 0.83
A combined quantum chemical and crystallographic study on the oxidized binuclear center of cytochrome c oxidase. Biochim Biophys Acta (2011) 0.83
Modulation of the active site conformation by site-directed mutagenesis in cytochrome c oxidase from Paracoccus denitrificans. J Inorg Biochem (2009) 0.83
The K-pathway revisited: a computational study on cytochrome c oxidase. Biochim Biophys Acta (2006) 0.82
Elevated proton leak of the intermediate OH in cytochrome c oxidase. Biophys J (2009) 0.82
Urocanate reductase: identification of a novel anaerobic respiratory pathway in Shewanella oneidensis MR-1. Mol Microbiol (2012) 0.81
Role of Ca(2+) in structure and function of Complex I from Escherichia coli. Biochim Biophys Acta (2010) 0.81
Time-resolved OH-->EH transition of the aberrant ba3 oxidase from Thermus thermophilus. Biochim Biophys Acta (2009) 0.81
High affinity cation-binding sites in Complex I from Escherichia coli. Biochim Biophys Acta (2009) 0.80
Heme/heme redox interaction and resolution of individual optical absorption spectra of the hemes in cytochrome bd from Escherichia coli. Biochim Biophys Acta (2009) 0.80
Modeling the active-site structure of the cbb3-type oxidase from Rhodobacter sphaeroides. Biochemistry (2008) 0.78
Time-resolved single-turnover of caa(3) oxidase from Thermus thermophilus. Fifth electron of the fully reduced enzyme converts O(H) into E(H) state. Biochim Biophys Acta (2011) 0.78
Stabilization of the peroxy intermediate in the oxygen splitting reaction of cytochrome cbb(3). Biochim Biophys Acta (2011) 0.78
Change in electron and spin density upon electron transfer to haem. Biochim Biophys Acta (2002) 0.77
Ascorbic acid against reperfusion injury in human renal transplantation. Transpl Int (2003) 0.77