Alternative splicing of the human cytomegalovirus major immediate-early genes affects infectious-virus replication and control of cellular cyclin-dependent kinase.

Congenital cytomegalovirus infection: molecular mechanisms mediating viral pathogenesis. Infect Disord Drug Targets (2011) 0.85

Interaction network of proteins associated with human cytomegalovirus IE2-p86 protein during infection: a proteomic analysis. PLoS One (2013) 0.79

Cyclin A degradation by primate cytomegalovirus protein pUL21a counters its innate restriction of virus replication. PLoS Pathog (2013) 0.79

Alternate splicing of transcripts shape macrophage response to Mycobacterium tuberculosis infection. PLoS Pathog (2017) 0.75

The human cytomegalovirus UL133-138 gene locus attenuates the lytic viral cycle in fibroblasts. PLoS One (2015) 0.75

A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology (1973) 127.36

Structural analysis of the major immediate early gene of human cytomegalovirus. J Virol (1984) 6.67

Functional profiling of a human cytomegalovirus genome. Proc Natl Acad Sci U S A (2003) 5.21

Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1. J Virol (1985) 5.09

High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides. Proc Natl Acad Sci U S A (2001) 4.30

Human cytomegalovirus IE1 and IE2 proteins block apoptosis. J Virol (1995) 4.22

Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins. J Virol (1990) 4.01

Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes. J Virol (2001) 3.50

The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID. J Virol (1992) 3.28

Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAs. J Virol (2001) 3.22

Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest. J Virol (1995) 3.18

A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulation. Proc Natl Acad Sci U S A (1996) 3.14

Influence of RNA secondary structure on the pre-mRNA splicing process. Mol Cell Biol (2004) 3.07

Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant. J Virol (1998) 2.86

A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2. J Virol (1991) 2.80

The IE2 gene products of human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap site. J Virol (1990) 2.77

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc Natl Acad Sci U S A (2001) 2.75

The nuclear domain 10 (ND10) is disrupted by the human cytomegalovirus gene product IE1. Exp Cell Res (1996) 2.69

Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start site. J Virol (1991) 2.61

Human cytomegalovirus infection inhibits G1/S transition. J Virol (1997) 2.61

Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S. J Virol (1996) 2.41

Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein. EMBO J (1994) 2.25

Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML. Mol Cell Biol (1998) 2.21

Transcriptional activation by the human cytomegalovirus immediate-early proteins: requirements for simple promoter structures and interactions with multiple components of the transcription complex. J Virol (1994) 2.13

Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression. J Biomed Sci (2004) 2.11

The human cytomegalovirus 86K immediate early (IE) 2 protein requires the basic region of the TATA-box binding protein (TBP) for binding, and interacts with TBP and transcription factor TFIIB via regions of IE2 required for transcriptional regulation. J Gen Virol (1993) 2.03

Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function. Science (2008) 1.99

Expression of the acidic nuclear immediate-early protein (IE1) of human cytomegalovirus in stable cell lines and its preferential association with metaphase chromosomes. Virology (1989) 1.97

Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein. J Virol (1994) 1.94

The human cytomegalovirus IE86 protein can block cell cycle progression after inducing transition into the S phase of permissive cells. J Virol (2000) 1.92

Human cytomegalovirus UL69 protein is required for efficient accumulation of infected cells in the G1 phase of the cell cycle. Proc Natl Acad Sci U S A (2000) 1.91

Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation. Proc Natl Acad Sci U S A (2004) 1.90

Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein. Proc Natl Acad Sci U S A (2003) 1.88

Human cytomegalovirus pp71 stimulates cell cycle progression by inducing the proteasome-dependent degradation of the retinoblastoma family of tumor suppressors. Mol Cell Biol (2003) 1.87

Disruption of PML-associated nuclear bodies mediated by the human cytomegalovirus major immediate early gene product. J Gen Virol (1998) 1.87

Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication. Proc Natl Acad Sci U S A (2002) 1.77

Role of viral splicing elements and cellular RNA binding proteins in regulation of HIV-1 alternative RNA splicing. Curr HIV Res (2006) 1.75

The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter. J Virol (1996) 1.63

TAF-like functions of human cytomegalovirus immediate-early proteins. J Virol (1997) 1.54

An isoform variant of the cytomegalovirus immediate-early auto repressor functions as a transcriptional activator. Virology (1992) 1.51

Small internal deletions in the human cytomegalovirus IE2 gene result in nonviable recombinant viruses with differential defects in viral gene expression. J Virol (2004) 1.50

Effect of the human cytomegalovirus IE86 protein on expression of E2F-responsive genes: a DNA microarray analysis. Proc Natl Acad Sci U S A (2002) 1.49

Role of human cytomegalovirus immediate-early proteins in cell growth control. J Virol (2000) 1.48

Absence of IE1 p72 protein function during low-multiplicity infection by human cytomegalovirus results in a broad block to viral delayed-early gene expression. J Virol (2002) 1.48

A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling. Proc Natl Acad Sci U S A (2006) 1.43

Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production. J Virol (2004) 1.39

Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins. Proc Natl Acad Sci U S A (2006) 1.37

Viable human cytomegalovirus recombinant virus with an internal deletion of the IE2 86 gene affects late stages of viral replication. J Virol (2002) 1.31

Functional roles of the human cytomegalovirus essential IE86 protein. Curr Top Microbiol Immunol (2008) 1.30

Viral and cell cycle-regulated kinases in cytomegalovirus-induced pseudomitosis and replication. PLoS Pathog (2007) 1.29

Pre-mRNA secondary structure and the regulation of splicing. Bioessays (1993) 1.29

Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO. J Virol (2008) 1.25

Role of the proximal enhancer of the major immediate-early promoter in human cytomegalovirus replication. J Virol (2004) 1.22

Inhibition of human cytomegalovirus replication by small interfering RNAs. J Gen Virol (2004) 1.20

Global analysis of host cell gene expression late during cytomegalovirus infection reveals extensive dysregulation of cell cycle gene expression and induction of Pseudomitosis independent of US28 function. J Virol (2004) 1.19

Infection of cells with human cytomegalovirus during S phase results in a blockade to immediate-early gene expression that can be overcome by inhibition of the proteasome. J Virol (2002) 1.19

Cyclin-dependent kinase activity is required for efficient expression and posttranslational modification of human cytomegalovirus proteins and for production of extracellular particles. J Virol (2006) 1.14

The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus. J Virol (2007) 1.14

Two Sp1/Sp3 binding sites in the major immediate-early proximal enhancer of human cytomegalovirus have a significant role in viral replication. J Virol (2005) 1.13

Subversion of cell cycle regulatory pathways. Curr Top Microbiol Immunol (2008) 1.09

Isolation and characterization of a low-abundance splice variant from the human cytomegalovirus major immediate-early gene region. J Virol (1995) 1.05

Inhibition of cellular DNA synthesis by the human cytomegalovirus IE86 protein is necessary for efficient virus replication. J Virol (2006) 1.04

Inhibition of cell division by the human cytomegalovirus IE86 protein: role of the p53 pathway or cyclin-dependent kinase 1/cyclin B1. J Virol (2005) 1.02

Cyclin-dependent kinase activity controls the onset of the HCMV lytic cycle. PLoS Pathog (2010) 1.00

Analysis of splice variants of the immediate-early 1 region of human cytomegalovirus. J Virol (2004) 1.00

The carboxyl-terminal region of human cytomegalovirus IE1491aa contains an acidic domain that plays a regulatory role and a chromatin-tethering domain that is dispensable during viral replication. J Virol (2005) 0.99

Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses. J Virol (2008) 0.98

Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis. PLoS Pathog (2010) 0.97

Novel immediate-early protein IE19 of human cytomegalovirus activates the origin recognition complex I promoter in a cooperative manner with IE72. J Virol (2002) 0.94

The autoregulatory and transactivating functions of the human cytomegalovirus IE86 protein use independent mechanisms for promoter binding. J Virol (2007) 0.91

Cellular repressor inhibits human cytomegalovirus transcription from the UL127 promoter. J Virol (2004) 0.90

Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcription. J Virol (2006) 0.89

Endonuclease activities, chromatin structure, and DNA degradation in apoptosis. Biochem Cell Biol (1995) 0.88

Effect of the human cytomegalovirus IE86 protein on expression of E2F-responsive genes: a DNA microarray analysis. Proc Natl Acad Sci U S A (2002) 1.49

The human cytomegalovirus major immediate-early enhancer determines the efficiency of immediate-early gene transcription and viral replication in permissive cells at low multiplicity of infection. J Virol (2003) 1.34

Role of the proximal enhancer of the major immediate-early promoter in human cytomegalovirus replication. J Virol (2004) 1.22

A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia. Proc Natl Acad Sci U S A (2005) 1.17

Two Sp1/Sp3 binding sites in the major immediate-early proximal enhancer of human cytomegalovirus have a significant role in viral replication. J Virol (2005) 1.13

Noncanonical TATA sequence in the UL44 late promoter of human cytomegalovirus is required for the accumulation of late viral transcripts. J Virol (2007) 1.13

The human cytomegalovirus gene products essential for late viral gene expression assemble into prereplication complexes before viral DNA replication. J Virol (2011) 1.12

The late promoter of the human cytomegalovirus viral DNA polymerase processivity factor has an impact on delayed early and late viral gene products but not on viral DNA synthesis. J Virol (2007) 1.10

Inhibition of cellular DNA synthesis by the human cytomegalovirus IE86 protein is necessary for efficient virus replication. J Virol (2006) 1.04

Ectopic expression of HCMV IE72 and IE86 proteins is sufficient to induce early gene expression but not production of infectious virus in undifferentiated promonocytic THP-1 cells. Virology (2007) 1.03

Inhibition of cell division by the human cytomegalovirus IE86 protein: role of the p53 pathway or cyclin-dependent kinase 1/cyclin B1. J Virol (2005) 1.02

A cis element between the TATA Box and the transcription start site of the major immediate-early promoter of human cytomegalovirus determines efficiency of viral replication. J Virol (2007) 0.98

The autoregulatory and transactivating functions of the human cytomegalovirus IE86 protein use independent mechanisms for promoter binding. J Virol (2007) 0.91

Role of regulatory elements and the MAPK/ERK or p38 MAPK pathways for activation of human cytomegalovirus gene expression. J Virol (2002) 0.90

Cellular repressor inhibits human cytomegalovirus transcription from the UL127 promoter. J Virol (2004) 0.90

The CREB site in the proximal enhancer is critical for cooperative interaction with the other transcription factor binding sites to enhance transcription of the major intermediate-early genes in human cytomegalovirus-infected cells. J Virol (2009) 0.85

The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene. PLoS One (2010) 0.81

Cellular homeoproteins, SATB1 and CDP, bind to the unique region between the human cytomegalovirus UL127 and major immediate-early genes. Virology (2007) 0.80

Coordination of late gene transcription of human cytomegalovirus with viral DNA synthesis: recombinant viruses as potential therapeutic vaccine candidates. Expert Opin Ther Targets (2012) 0.79

Cellular proteins bind to sequence motifs in the R1 element between the HCMV immune evasion genes. Exp Mol Pathol (2002) 0.76

Human cytomegalovirus. Preface. Curr Top Microbiol Immunol (2008) 0.76