Published in Dev Dyn on December 01, 2010
Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis. Proc Natl Acad Sci U S A (2013) 1.34
Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association. Sci Signal (2011) 1.32
GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation. J Biol Chem (2015) 1.27
Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad. Mol Pharmacol (2013) 0.93
Ric-8 regulation of heterotrimeric G proteins. J Recept Signal Transduct Res (2013) 0.85
Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time. Bioessays (2016) 0.85
The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1. Proc Natl Acad Sci U S A (2015) 0.83
Drosophila Ric-8 interacts with the Gα12/13 subunit, Concertina, during activation of the Folded gastrulation pathway. Mol Biol Cell (2013) 0.80
The Ric-8B gene is highly expressed in proliferating preosteoblastic cells and downregulated during osteoblast differentiation in a SWI/SNF- and C/EBPbeta-mediated manner. Mol Cell Biol (2011) 0.80
Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death. PLoS One (2013) 0.77
The impact of RGS and other G-protein regulatory proteins on Gαi-mediated signaling in immunity. Biochem Pharmacol (2016) 0.76
B Lymphocyte-Specific Loss of Ric-8A Results in a Gα Protein Deficit and Severe Humoral Immunodeficiency. J Immunol (2015) 0.76
Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα. Elife (2016) 0.75
Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis. PLoS One (2015) 0.75
Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQ(Q209L)-driven melanoma. Oncogenesis (2016) 0.75
Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A (2002) 1.29
Penetration without cells: membrane translocation of cell-penetrating peptides in the model giant plasma membrane vesicles. J Control Release (2011) 1.26
A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse. Nucleic Acids Res (2003) 1.20
Protein cargo delivery properties of cell-penetrating peptides. A comparative study. Bioconjug Chem (2004) 1.18
Cell-penetrating peptides as versatile vehicles for oligonucleotide delivery. Mol Ther (2012) 1.13
The membrane repair response masks membrane disturbances caused by cell-penetrating peptide uptake. FASEB J (2008) 1.11
Gata3 is required for early morphogenesis and Fgf10 expression during otic development. Mech Dev (2006) 1.07
Cell transduction pathways of transportans. Bioconjug Chem (2005) 1.06
Peptide-mediated protein delivery-which pathways are penetrable? Biochim Biophys Acta (2010) 1.00
Hearing loss following Gata3 haploinsufficiency is caused by cochlear disorder. Neurobiol Dis (2004) 1.00
Studying the uptake of cell-penetrating peptides. Nat Protoc (2006) 0.96
Partially overlapping expression of Gata2 and Gata3 during inner ear development. Dev Dyn (2004) 0.95
Heterozygous mice with Ric-8 mutation exhibit impaired spatial memory and decreased anxiety. Behav Brain Res (2005) 0.92
Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides. FASEB J (2011) 0.87
CPP-protein constructs induce a population of non-acidic vesicles during trafficking through endo-lysosomal pathway. J Control Release (2009) 0.87
Gene expression analysis of Gata3-/- mice by using cDNA microarray technology. Life Sci (2005) 0.84
Retro-inversion of certain cell-penetrating peptides causes severe cellular toxicity. Biochim Biophys Acta (2010) 0.84
Cell-penetrating peptide secures an efficient endosomal escape of an intact cargo upon a brief photo-induction. Cell Mol Life Sci (2013) 0.83
Expression of ric-8 (synembryn) gene in the nervous system of developing and adult mouse. Gene Expr Patterns (2003) 0.83
New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids. Biochim Biophys Acta (2013) 0.83
Lack of Gata3 results in conotruncal heart anomalies in mouse. Mech Dev (2008) 0.82
Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. Bioorg Med Chem Lett (2003) 0.82
The Embryonic Transcriptome of the Red-Eared Slider Turtle (Trachemys scripta). PLoS One (2013) 0.82
Direct translocation as major cellular uptake for CADY self-assembling peptide-based nanoparticles. PLoS One (2011) 0.82
Differential endosomal pathways for radically modified peptide vectors. Bioconjug Chem (2013) 0.82
Cell-penetrating peptides split into two groups based on modulation of intracellular calcium concentration. J Biol Chem (2012) 0.81
Insights into cell entry and intracellular trafficking of peptide and protein drugs provided by electron microscopy. Adv Drug Deliv Rev (2013) 0.79
Protein delivery with transportans is mediated by caveolae rather than flotillin-dependent pathways. Bioconjug Chem (2009) 0.79
S4(13)-PV cell-penetrating peptide forms nanoparticle-like structures to gain entry into cells. Bioconjug Chem (2010) 0.79
Epitope specificity of anti-FVIII antibodies during immune tolerance therapy with factor VIII preparation containing von Willebrand factor. Thromb Res (2002) 0.78
Alterations in opioid system of the rat brain after cat odor exposure. Neurosci Lett (2004) 0.78
Targeting of antisense PNA oligomers to human galanin receptor type 1 mRNA. Neuropeptides (2004) 0.78
S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: implications for cell internalization. Biochim Biophys Acta (2011) 0.77
Peptide-mediated delivery: an overview of pathways for efficient internalization. Ther Deliv (2014) 0.77
PepFect14 peptide vector for efficient gene delivery in cell cultures. Mol Pharm (2012) 0.77
Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death. PLoS One (2013) 0.77
Insight into cell-entry mechanisms of CPPs by electron microscopy. Methods Mol Biol (2011) 0.76
von Willebrand factor and transforming growth factor-beta modulate immune response against coagulation factor VIII in FVIII-deficient mice. Thromb Res (2007) 0.76
Adenosine-oligoarginine conjugate, a novel bisubstrate inhibitor, effectively dissociates the actin cytoskeleton. FEBS J (2008) 0.76
Unraveling the Mechanisms of Peptide-Mediated Delivery of Nucleic Acids Using Electron Microscopy. Methods Mol Biol (2015) 0.76
Cat odour exposure decreases exploratory activity and alters neuropeptide gene expression in CCK(2) receptor deficient mice, but not in their wild-type littermates. Behav Brain Res (2006) 0.75
Identification of the ability of highly charged nanomolar inhibitors of protein kinases to cross plasma membranes and carry a protein into cells. Bioorg Med Chem Lett (2002) 0.75
Von Willebrand factor-specific antibodies developing upon treatment of FVIII-deficient mice with different FVIII preparations. Acta Haematol (2008) 0.75
Mapping of protein transduction pathways with fluorescent microscopy. Methods Mol Biol (2011) 0.75