PubRank

H Peter Spielmann

Author PubWeight™ 30.09‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging. Proc Natl Acad Sci U S A 2007 2.24
2 Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated. J Clin Invest 2008 1.40
3 Tools to analyze protein farnesylation in cells. Bioconjug Chem 2005 1.35
4 An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. Hum Mol Genet 2010 1.26
5 Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase. J Am Chem Soc 2002 1.19
6 A model for initial DNA lesion recognition by NER and MMR based on local conformational flexibility. DNA Repair (Amst) 2004 1.17
7 Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin. Hum Mol Genet 2010 1.09
8 Hydrophilic anilinogeranyl diphosphate prenyl analogues are Ras function inhibitors. Biochemistry 2006 1.03
9 Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J Cell Sci 2010 1.01
10 Structural differences in the NOE-derived structure of G-T mismatched DNA relative to normal DNA are correlated with differences in (13)C relaxation-based internal dynamics. J Mol Biol 2002 1.01
11 Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria. J Lipid Res 2009 1.01
12 Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity. Chembiochem 2008 0.99
13 A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells. J Biol Chem 2008 0.99
14 A tagging-via-substrate approach to detect the farnesylated proteome using two-dimensional electrophoresis coupled with Western blotting. Mol Cell Proteomics 2010 0.97
15 Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues. Biochemistry 2007 0.93
16 Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. J Biol Chem 2010 0.90
17 Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis. Org Lett 2005 0.89
18 Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. J Biol Chem 2013 0.88
19 Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24. J Lipid Res 2012 0.88
20 Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase. Biochemistry 2012 0.88
21 Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides. Hum Mol Genet 2009 0.88
22 Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate. Bioorg Med Chem Lett 2004 0.87
23 Insight into G[bond]T mismatch recognition using molecular dynamics with time-averaged restraints derived from NMR spectroscopy. J Am Chem Soc 2004 0.87
24 The structure of a mixed LNA/DNA:RNA duplex is driven by conformational coupling between LNA and deoxyribose residues as determined from 13C relaxation measurements. J Am Chem Soc 2005 0.83
25 Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release. Biochemistry 2007 0.83
26 Synthesis of Farnesol Analogues Containing Triazoles in Place of Isoprenes through 'Click Chemistry' Synlett 2012 0.81
27 Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome. J Lipid Res 2008 0.80
28 Syntheses of deuterium labeled prenyldiphosphate and prenylcysteine analogues for in vivo mass spectrometric quantification. J Labelled Comp Radiopharm 2013 0.78
29 Modulation of anthracycline-induced cytotoxicity by targeting the prenylated proteome in myeloid leukemia cells. J Mol Med (Berl) 2011 0.77
30 Identification of a farnesol analog as a Ras function inhibitor using both an in vivo Ras activation sensor and a phenotypic screening approach. Mol Cell Biochem 2013 0.76
31 Anticancer activity of novel unnatural synthetic isoprenoids. Anticancer Res 2010 0.75
32 Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity. Farmaco 2003 0.75
33 Trends in chemical shift dispersion in fullerene derivatives. Local strain affects the magnetic environment of distant fullerene carbons. J Org Chem 2003 0.75
34 A (13)C INADEQUATE and HF-GIAO study of C(60)H(2) and C(60)H(6) identification of ring currents in a 1,2-dihydrofullerene. J Am Chem Soc 2002 0.75
35 Alkylation of dihydrofullerenes. J Org Chem 2002 0.75