Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Transforming growth factor-beta1 is a molecular target for the peroxisome proliferator-activated receptor delta.
|
Circ Res
|
2007
|
1.70
|
2
|
Iron released by sodium nitroprusside contributes to heme oxygenase-1 induction via the cAMP-protein kinase A-mitogen-activated protein kinase pathway in RAW 264.7 cells.
|
Mol Pharmacol
|
2006
|
1.58
|
3
|
Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells.
|
Int J Oncol
|
2008
|
1.24
|
4
|
Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice.
|
Br J Pharmacol
|
2011
|
1.16
|
5
|
HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride.
|
Cell Signal
|
2008
|
1.12
|
6
|
Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo.
|
Mol Pharmacol
|
2009
|
1.12
|
7
|
The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis.
|
Mol Nutr Food Res
|
2009
|
1.11
|
8
|
Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways.
|
Int Immunopharmacol
|
2006
|
1.10
|
9
|
Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules.
|
Carcinogenesis
|
2008
|
1.03
|
10
|
Protein kinase G-dependent heme oxygenase-1 induction by Agastache rugosa leaf extract protects RAW264.7 cells from hydrogen peroxide-induced injury.
|
J Ethnopharmacol
|
2005
|
1.02
|
11
|
Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage.
|
Free Radic Biol Med
|
2007
|
1.01
|
12
|
Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities.
|
J Pharmacol Exp Ther
|
2012
|
1.01
|
13
|
Effects of 13-alkyl-substituted berberine alkaloids on the expression of COX-II, TNF-alpha, iNOS, and IL-12 production in LPS-stimulated macrophages.
|
Life Sci
|
2003
|
1.00
|
14
|
Ran suppresses paclitaxel-induced apoptosis in human glioblastoma cells.
|
Apoptosis
|
2008
|
0.99
|
15
|
Mepivacaine-induced contraction is attenuated by endothelial nitric oxide release in isolated rat aorta.
|
Can J Physiol Pharmacol
|
2012
|
0.99
|
16
|
Role of heme oxygenase in preserving vascular bioactive NO.
|
Nitric Oxide
|
2010
|
0.99
|
17
|
Anthocyanins from soybean seed coat inhibit the expression of TNF-alpha-induced genes associated with ischemia/reperfusion in endothelial cell by NF-kappaB-dependent pathway and reduce rat myocardial damages incurred by ischemia and reperfusion in vivo.
|
FEBS Lett
|
2006
|
0.98
|
18
|
Direct effect of dexmedetomidine on rat isolated aorta involves endothelial nitric oxide synthesis and activation of the lipoxygenase pathway.
|
Clin Exp Pharmacol Physiol
|
2008
|
0.98
|
19
|
Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats.
|
Planta Med
|
2008
|
0.98
|
20
|
Resveratrol activates AMPK and suppresses LPS-induced NF-κB-dependent COX-2 activation in RAW 264.7 macrophage cells.
|
Anat Cell Biol
|
2011
|
0.97
|
21
|
Anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cylooxygenase-2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway.
|
J Agric Food Chem
|
2008
|
0.97
|
22
|
Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-alpha-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo.
|
Eur J Pharmacol
|
2009
|
0.96
|
23
|
Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction.
|
Antioxid Redox Signal
|
2011
|
0.96
|
24
|
Palmatine from Coptidis rhizoma reduces ischemia-reperfusion-mediated acute myocardial injury in the rat.
|
Food Chem Toxicol
|
2009
|
0.95
|
25
|
TMEM14A inhibits N-(4-hydroxyphenyl)retinamide-induced apoptosis through the stabilization of mitochondrial membrane potential.
|
Cancer Lett
|
2011
|
0.94
|
26
|
Tristetraprolin mediates anti-inflammatory effects of nicotine in lipopolysaccharide-stimulated macrophages.
|
J Biol Chem
|
2011
|
0.94
|
27
|
Propofol limits rat myocardial ischemia and reperfusion injury with an associated reduction in apoptotic cell death in vivo.
|
Vascul Pharmacol
|
2008
|
0.93
|
28
|
Anthocyanins from black soybean seed coats stimulate wound healing in fibroblasts and keratinocytes and prevent inflammation in endothelial cells.
|
Food Chem Toxicol
|
2009
|
0.93
|
29
|
Resveratrol induces hepatic mitochondrial biogenesis through the sequential activation of nitric oxide and carbon monoxide production.
|
Antioxid Redox Signal
|
2013
|
0.93
|
30
|
β₁-adrenergic receptor-mediated HO-1 induction, via PI3K and p38 MAPK, by isoproterenol in RAW 264.7 cells leads to inhibition of HMGB1 release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice.
|
Biochem Pharmacol
|
2011
|
0.92
|
31
|
Higenamine reduces apoptotic cell death by induction of heme oxygenase-1 in rat myocardial ischemia-reperfusion injury.
|
Apoptosis
|
2006
|
0.92
|
32
|
Protective effect of anthocyanins from black soybean seed coats on UVB-induced apoptotic cell death in vitro and in vivo.
|
J Agric Food Chem
|
2008
|
0.91
|
33
|
Anthocyanins from black soybean seed coats preferentially inhibit TNF-alpha-mediated induction of VCAM-1 over ICAM-1 through the regulation of GATAs and IRF-1.
|
J Agric Food Chem
|
2009
|
0.91
|
34
|
EP2 receptor activation by prostaglandin E2 leads to induction of HO-1 via PKA and PI3K pathways in C6 cells.
|
Biochem Biophys Res Commun
|
2009
|
0.91
|
35
|
Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways.
|
Apoptosis
|
2012
|
0.91
|
36
|
Rutin from Lonicera japonica inhibits myocardial ischemia/reperfusion-induced apoptosis in vivo and protects H9c2 cells against hydrogen peroxide-mediated injury via ERK1/2 and PI3K/Akt signals in vitro.
|
Food Chem Toxicol
|
2009
|
0.90
|
37
|
PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells.
|
Atherosclerosis
|
2010
|
0.90
|
38
|
Upregulation of PTEN by CKD712, a synthetic tetrahydroisoquinoline alkaloid, selectively inhibits lipopolysaccharide-induced VCAM-1 but not ICAM-1 expression in human endothelial cells.
|
Atherosclerosis
|
2009
|
0.90
|
39
|
Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways.
|
J Ethnopharmacol
|
2010
|
0.90
|
40
|
Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo.
|
Atherosclerosis
|
2011
|
0.90
|
41
|
Carbon monoxide from CORM-2 reduces HMGB1 release through regulation of IFN-β/JAK2/STAT-1/INOS/NO signaling but not COX-2 in TLR-activated macrophages.
|
Shock
|
2010
|
0.89
|
42
|
2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction.
|
J Ethnopharmacol
|
2011
|
0.89
|
43
|
Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
|
Food Chem Toxicol
|
2013
|
0.89
|
44
|
Activation of PPAR-gamma by carbon monoxide from CORM-2 leads to the inhibition of iNOS but not COX-2 expression in LPS-stimulated macrophages.
|
Inflammation
|
2009
|
0.89
|
45
|
Ethyl pyruvate induces heme oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animals.
|
Antioxid Redox Signal
|
2012
|
0.88
|
46
|
Peroxisome proliferator-activated receptor {delta} regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-{beta}1/Smad3.
|
Circ Res
|
2009
|
0.88
|
47
|
Anti-inflammatory action of methanol extract of Carthamus tinctorius involves in heme oxygenase-1 induction.
|
J Ethnopharmacol
|
2010
|
0.88
|
48
|
Identification of a truncated alternative splicing variant of human PPARgamma1 that exhibits dominant negative activity.
|
Biochem Biophys Res Commun
|
2006
|
0.87
|
49
|
Anti-apoptotic effect of magnolol in myocardial ischemia and reperfusion injury requires extracellular signal-regulated kinase1/2 pathways in rat in vivo.
|
Exp Biol Med (Maywood)
|
2008
|
0.87
|
50
|
(S)-1-(alpha-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712) reduces rat myocardial apoptosis against ischemia and reperfusion injury by activation of phosphatidylinositol 3-kinase/Akt signaling and anti-inflammatory action in vivo.
|
J Pharmacol Exp Ther
|
2009
|
0.87
|
51
|
c-Jun NH₂-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle.
|
Yonsei Med J
|
2011
|
0.87
|
52
|
PPARdelta promotes wound healing by up-regulating TGF-beta1-dependent or -independent expression of extracellular matrix proteins.
|
J Cell Mol Med
|
2009
|
0.86
|
53
|
Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways.
|
Blood
|
2012
|
0.86
|
54
|
Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
|
Phytother Res
|
2011
|
0.86
|
55
|
Bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of VCAM-1 expression.
|
Int Immunopharmacol
|
2008
|
0.85
|
56
|
Regulation of lipopolysaccharide-induced inducible nitric-oxide synthase expression through the nuclear factor-kappaB pathway and interferon-beta/tyrosine kinase 2/Janus tyrosine kinase 2-signal transducer and activator of transcription-1 signaling cascades by 2-naphthylethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (THI 53), a new synthetic isoquinoline alkaloid.
|
J Pharmacol Exp Ther
|
2006
|
0.85
|
57
|
High concentrations of ascorbic acid induces apoptosis of human gastric cancer cell by p38-MAP kinase-dependent up-regulation of transferrin receptor.
|
Cancer Lett
|
2008
|
0.85
|
58
|
Enantioselective synthesis of (R)-(+)- and (S)-(-)-higenamine and their analogues with effects on platelet aggregation and experimental animal model of disseminated intravascular coagulation.
|
Bioorg Med Chem Lett
|
2008
|
0.85
|
59
|
Honokiol exerts an anticancer effect in T98G human glioblastoma cells through the induction of apoptosis and the regulation of adhesion molecules.
|
Int J Oncol
|
2012
|
0.85
|
60
|
Enantiomers of higenamine inhibit LPS-induced iNOS in a macrophage cell line and improve the survival of mice with experimental endotoxemia.
|
Int Immunopharmacol
|
2005
|
0.85
|
61
|
Daidzein administration in vivo reduces myocardial injury in a rat ischemia/reperfusion model by inhibiting NF-kappaB activation.
|
Life Sci
|
2008
|
0.85
|
62
|
Carbon monoxide (from CORM-2) inhibits high glucose-induced ICAM-1 expression via AMP-activated protein kinase and PPAR-gamma activations in endothelial cells.
|
Atherosclerosis
|
2009
|
0.85
|
63
|
Anti-inflammatory effects of anthocyanins from black soybean seed coat on the keratinocytes and ischemia-reperfusion injury in rat skin flaps.
|
Microsurgery
|
2012
|
0.84
|
64
|
Effects of higenamine and its 1-naphthyl analogs, YS-49 and YS-51, on platelet TXA2 synthesis and aggregation.
|
Thromb Res
|
2006
|
0.84
|
65
|
Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear factor-kappaB.
|
Pharmacol Res
|
2008
|
0.83
|
66
|
Identification of cytochrome c oxidase subunit 6A1 as a suppressor of Bax-induced cell death by yeast-based functional screening.
|
Biochem Biophys Res Commun
|
2008
|
0.83
|
67
|
The obligatory role of COX-2 expression for induction of HO-1 in ischemic preconditioned rat brain.
|
Biochem Biophys Res Commun
|
2008
|
0.83
|
68
|
Honokiol inhibits U87MG human glioblastoma cell invasion through endothelial cells by regulating membrane permeability and the epithelial-mesenchymal transition.
|
Int J Oncol
|
2013
|
0.83
|
69
|
Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells.
|
Int Immunopharmacol
|
2008
|
0.83
|
70
|
A synthetic isoquinoline alkaloid, 1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (YS 51), reduces inducible nitric oxide synthase expression and improves survival in a rodent model of endotoxic shock.
|
J Pharmacol Exp Ther
|
2002
|
0.83
|
71
|
YS 49, 1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1.
|
Life Sci
|
2007
|
0.83
|
72
|
Agastache rugosa leaf extract inhibits the iNOS expression in ROS 17/2.8 cells activated with TNF-alpha and IL-1beta.
|
Arch Pharm Res
|
2005
|
0.82
|
73
|
Etomidate attenuates phenylephrine-induced contraction in isolated rat aorta.
|
Can J Anaesth
|
2005
|
0.82
|
74
|
Akt-dependent heme oxygenase-1 induction by NS-398 in C6 glial cells: a potential role for CO in prevention of oxidative damage from hypoxia.
|
Neuropharmacology
|
2007
|
0.82
|
75
|
(+)-Nootkatone and (+)-valencene from rhizomes of Cyperus rotundus increase survival rates in septic mice due to heme oxygenase-1 induction.
|
J Ethnopharmacol
|
2011
|
0.82
|
76
|
Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death.
|
Cancer Lett
|
2008
|
0.82
|
77
|
Role of thrombotic and fibrinolytic disorders in the etiology of Perthes' disease.
|
Clin Orthop Relat Res
|
2002
|
0.82
|
78
|
Hemin inhibits hypertensive rat vascular smooth muscle cell proliferation through regulation of cyclin D and p21.
|
Arch Pharm Res
|
2009
|
0.82
|
79
|
Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells.
|
Biochem Biophys Res Commun
|
2011
|
0.81
|
80
|
Expression of a peroxisome proliferator-activated receptor gamma 1 splice variant that was identified in human lung cancers suppresses cell death induced by cisplatin and oxidative stress.
|
Clin Cancer Res
|
2007
|
0.81
|
81
|
A tetrahydroisoquinoline alkaloid THI-28 reduces LPS-induced HMGB1 and diminishes organ injury in septic mice through p38 and PI3K/Nrf2/HO-1 signals.
|
Int Immunopharmacol
|
2013
|
0.80
|
82
|
Heme oxygenase-1 induction by (S)-enantiomer of YS-51 (YS-51S), a synthetic isoquinoline alkaloid, inhibits nitric oxide production and nuclear factor-kappaB translocation in ROS 17/2.8 cells activated with inflammatory stimulants.
|
Int Immunopharmacol
|
2007
|
0.80
|
83
|
Valsartan independent of AT₁ receptor inhibits tissue factor, TLR-2 and -4 expression by regulation of Egr-1 through activation of AMPK in diabetic conditions.
|
J Cell Mol Med
|
2014
|
0.80
|
84
|
Genipin Selectively Inhibits TNF-α-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-γ in Human Endothelial Cells.
|
Korean J Physiol Pharmacol
|
2011
|
0.80
|
85
|
7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells.
|
Food Chem Toxicol
|
2010
|
0.80
|
86
|
Expression and activity of heme oxygenase-1 in artificially induced low-flow priapism in rat penile tissues.
|
J Sex Med
|
2008
|
0.80
|
87
|
DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells.
|
Korean J Physiol Pharmacol
|
2009
|
0.80
|
88
|
NS-398, a selective COX-2 inhibitor, inhibits proliferation of IL-1beta-stimulated vascular smooth muscle cells by induction of HO-1.
|
Biochem Biophys Res Commun
|
2008
|
0.80
|
89
|
Phorbol ester potentiates the growth inhibitory effects of troglitazone via up-regulation of PPARgamma in A549 cells.
|
Biochem Biophys Res Commun
|
2006
|
0.80
|
90
|
Diazepam attenuates phenylephrine-induced contractions in rat aorta.
|
Anesth Analg
|
2006
|
0.79
|
91
|
Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation.
|
Free Radic Biol Med
|
2010
|
0.79
|
92
|
The effects of higenamine on LPS-induced experimental disseminated intravascular coagulation (DIC) in rats.
|
Planta Med
|
2002
|
0.79
|
93
|
Down-regulation of aldose reductase renders J774A.1 cells more susceptible to acrolein- or hydrogen peroxide-induced cell death.
|
Free Radic Res
|
2008
|
0.79
|
94
|
YS 51, 1-(beta-naphtylmethyl)-6,7-dihydroxy-1,2,3,4,-tetrahydroisoquinoline, protects endothelial cells against hydrogen peroxide-induced injury via carbon monoxide derived from heme oxygenase-1.
|
Biochem Pharmacol
|
2007
|
0.79
|
95
|
Inhibitory effect of tramadol on vasorelaxation mediated by ATP-sensitive K+ channels in rat aorta.
|
Can J Anaesth
|
2007
|
0.79
|
96
|
Tanshinone IIA inhibits TNF-α-mediated induction of VCAM-1 but not ICAM-1 through the regulation of GATA-6 and IRF-1.
|
Int Immunopharmacol
|
2012
|
0.78
|
97
|
The heme oxygenase-1 inducer THI-56 negatively regulates iNOS expression and HMGB1 release in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
|
PLoS One
|
2013
|
0.78
|
98
|
Indigo carmine enhances phenylephrine-induced contractions in an isolated rat aorta.
|
Korean J Anesthesiol
|
2011
|
0.78
|
99
|
P2Y2 R activation by nucleotides promotes skin wound-healing process.
|
Exp Dermatol
|
2014
|
0.78
|
100
|
Relaxation of canine corporal smooth muscle relaxation by ginsenoside saponin Rg3 is independent from eNOS activation.
|
Life Sci
|
2005
|
0.78
|
101
|
Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells.
|
Neurosci Lett
|
2010
|
0.76
|
102
|
Kinetic Changes of COX-2 Expression during Reperfusion Period after Ischemic Preconditioning Play a Role in Protection Against Ischemic Damage in Rat Brain.
|
Korean J Physiol Pharmacol
|
2008
|
0.76
|
103
|
Involvement of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells.
|
Int J Biochem Cell Biol
|
2005
|
0.76
|
104
|
A supraclinical dose of tramadol stereoselectively attenuates endothelium-dependent relaxation in isolated rat aorta.
|
Anesth Analg
|
2006
|
0.75
|
105
|
(S)-1-α-naphthylmethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD712), promotes wound closure by producing VEGF through HO-1 induction in human dermal fibroblasts and mouse skin.
|
Br J Pharmacol
|
2013
|
0.75
|
106
|
Selective activation of adrenergic beta1 receptors induces heme oxygenase 1 production in RAW264.7 cells.
|
FEBS Lett
|
2005
|
0.75
|
107
|
MKP-7, a negative regulator of JNK, regulates VCAM-1 expression through IRF-1.
|
Cell Signal
|
2011
|
0.75
|
108
|
NS398 protects cells from sodium nitroprusside-mediated cytotoxicity through enhancing HO-1 induction independent of COX-2 inhibition.
|
Arch Pharm Res
|
2009
|
0.75
|
109
|
Induction of manganese-superoxide dismutase by YS 51, a synthetic 1-(beta-naphtylmethyl)6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline alkaloid: implication for anti-inflammatory actions.
|
Pharmacology
|
2004
|
0.75
|
110
|
Effects of two tetrahydroisoquinolines (YS-49 and YS-51) on experimental disseminated intravascular coagulation induced by lipopolysaccharide in rats.
|
Arzneimittelforschung
|
2004
|
0.75
|