The primary site of the acrocephalic feature in Apert Syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling.

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Published in Bone on December 01, 2010

Authors

Masaki Nagata1, Glen H Nuckolls, Xibin Wang, Lillian Shum, Yukie Seki, Tomoyuki Kawase, Katsu Takahashi, Kazuaki Nonaka, Ichiro Takahashi, Arhab A Noman, Kenji Suzuki, Harold C Slavkin

Author Affiliations

1: Department of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences, Gakkocho-dori 2-5274, Niigata 951-8514, Japan. nagata@dent.niigata-u.ac.jp

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