Autoantibodies to cerebellum in children with autism associate with behavior.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMC 3039058)

Published in Brain Behav Immun on December 04, 2010

Authors

Paula Goines1, Lori Haapanen, Robert Boyce, Paul Duncanson, Daniel Braunschweig, Lora Delwiche, Robin Hansen, Irva Hertz-Picciotto, Paul Ashwood, Judy Van de Water

Author Affiliations

1: Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, United States.

Articles citing this

Consensus paper: pathological role of the cerebellum in autism. Cerebellum (2012) 2.32

The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun (2011) 2.24

Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain. Transl Psychiatry (2012) 1.35

Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment. Neurotoxicol Teratol (2012) 1.21

Immune mediators in the brain and peripheral tissues in autism spectrum disorder. Nat Rev Neurosci (2015) 1.13

Deficits in bioenergetics and impaired immune response in granulocytes from children with autism. Pediatrics (2014) 1.12

Biomarkers in autism spectrum disorder: the old and the new. Psychopharmacology (Berl) (2013) 1.01

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. BMC Med (2015) 0.94

Autism spectrum disorders and neuropathology of the cerebellum. Front Neurosci (2015) 0.93

Peptide sharing between influenza A H1N1 hemagglutinin and human axon guidance proteins. Schizophr Bull (2013) 0.93

Biomarkers in autism. Front Psychiatry (2014) 0.92

Increased anti-phospholipid antibodies in autism spectrum disorders. Mediators Inflamm (2013) 0.92

Markers of Celiac Disease and Gluten Sensitivity in Children with Autism. PLoS One (2013) 0.90

Anti-brain antibodies are associated with more severe cognitive and behavioral profiles in Italian children with Autism Spectrum Disorder. Brain Behav Immun (2014) 0.90

What is the role of vitamin D in autism? Dermatoendocrinol (2013) 0.89

Maternal and fetal antibrain antibodies in development and disease. Dev Neurobiol (2012) 0.86

Current progress and challenges in the search for autism biomarkers. Dis Markers (2013) 0.85

Does microglial dysfunction play a role in autism and Rett syndrome? Neuron Glia Biol (2012) 0.84

Neonatal Cytokine Profiles Associated with Autism Spectrum Disorder. Biol Psychiatry (2015) 0.83

Convergence of circuit dysfunction in ASD: a common bridge between diverse genetic and environmental risk factors and common clinical electrophysiology. Front Cell Neurosci (2014) 0.83

Interactions of innate and adaptive immunity in brain development and function. Brain Res (2014) 0.83

The Role of the Immune System in Autism Spectrum Disorder. Neuropsychopharmacology (2016) 0.82

Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes. Clin Med Insights Pediatr (2016) 0.82

HLA Immune Function Genes in Autism. Autism Res Treat (2012) 0.82

Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma. J Neuroimmunol (2015) 0.80

Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder. J Neuroinflammation (2013) 0.80

Autoimmunity, Autoantibodies, and Autism Spectrum Disorder. Biol Psychiatry (2016) 0.78

Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Samples: Association with Autism Spectrum Disorder and Intellectual Disability. Environ Health Perspect (2016) 0.77

Redefining the role of peripheral LPS as a neuroinflammatory agent and evaluating the role of hydrogen sulphide through metformin intervention. Inflammopharmacology (2016) 0.77

Is 'bench-to-bedside' realistic for autism? An integrative neuroscience approach. Neuropsychiatry (London) (2013) 0.75

Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants. G3 (Bethesda) (2017) 0.75

Peripheral Inflammatory Markers Contributing to Comorbidities in Autism. Behav Sci (Basel) (2016) 0.75

Endocannabinod Signal Dysregulation in Autism Spectrum Disorders: A Correlation Link between Inflammatory State and Neuro-Immune Alterations. Int J Mol Sci (2017) 0.75

Articles cited by this

Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord (1994) 42.80

The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord (2000) 37.47

Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol (2005) 5.95

A prospective study of the emergence of early behavioral signs of autism. J Am Acad Child Adolesc Psychiatry (2010) 4.10

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry (1998) 3.80

Autism spectrum disorders. Neuron (2000) 3.62

Proposed declassification of disease categories related to sexual orientation in the International Statistical Classification of Diseases and Related Health Problems (ICD-11). Bull World Health Organ (2014) 3.51

A clinicopathological study of autism. Brain (1998) 3.49

Diagnosing autism: analyses of data from the Autism Diagnostic Interview. J Autism Dev Disord (1997) 3.45

Cognition and immunity; antibody impairs memory. Immunity (2004) 3.40

Immunity and behavior: antibodies alter emotion. Proc Natl Acad Sci U S A (2006) 2.97

The immune response in autism: a new frontier for autism research. J Leukoc Biol (2006) 2.65

The neurobiology of autism. Brain Pathol (2007) 2.63

Placental transport of immunoglobulin G. Vaccine (2003) 2.62

Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain Behav Immun (2008) 2.50

Immunity, neuroglia and neuroinflammation in autism. Int Rev Psychiatry (2005) 2.19

Autism: maternally derived antibodies specific for fetal brain proteins. Neurotoxicology (2007) 1.87

Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain Behav Immun (2009) 1.86

Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study. Arch Pediatr Adolesc Med (2005) 1.81

Maternal antibrain antibodies in autism. Brain Behav Immun (2006) 1.62

Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Ann N Y Acad Sci (2007) 1.55

Maternal mid-pregnancy autoantibodies to fetal brain protein: the early markers for autism study. Biol Psychiatry (2008) 1.54

Autoimmunity in autism. Curr Opin Investig Drugs (2009) 1.49

Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution. Brain Res (2004) 1.48

Diagnosing autism spectrum disorders in pre-school children using two standardised assessment instruments: the ADI-R and the ADOS. J Autism Dev Disord (2007) 1.48

Cerebellar disorders in childhood: cognitive problems. Cerebellum (2008) 1.41

Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. J Neuroimmunol (2008) 1.41

Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model. J Neuroimmunol (2009) 1.40

Anti-basal ganglia antibodies in acute and persistent Sydenham's chorea. Neurology (2002) 1.38

Is autism an autoimmune disease? Autoimmun Rev (2004) 1.37

Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms. Autism Res (2008) 1.37

Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders. Brain Behav Immun (2008) 1.34

Increased IgG4 levels in children with autism disorder. Brain Behav Immun (2008) 1.32

The broad autism phenotype: findings from an epidemiological survey. Autism (2004) 1.30

Antibrain antibodies in children with autism and their unaffected siblings. J Neuroimmunol (2006) 1.30

Macrophage migration inhibitory factor and autism spectrum disorders. Pediatrics (2008) 1.27

Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders. J Pediatr (1999) 1.25

Antibodies against fetal brain in sera of mothers with autistic children. J Neuroimmunol (2008) 1.24

Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10. J Clin Immunol (2004) 1.21

Regression in autistic spectrum disorders. Neuropsychol Rev (2008) 1.17

Autoantibody repertoires to brain tissue in autism nuclear families. J Neuroimmunol (2004) 1.17

Prevalence of serum antibodies to caudate nucleus in autistic children. Neurosci Lett (2004) 1.14

Autoantibodies in autism spectrum disorders (ASD). Ann N Y Acad Sci (2007) 1.11

Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders. J Neuroimmunol (2009) 1.11

Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutr Neurosci (2004) 1.07

Repetitive behavior and increased activity in mice with Purkinje cell loss: a model for understanding the role of cerebellar pathology in autism. Eur J Neurosci (2010) 1.06

Serum anti-nuclear antibodies as a marker of autoimmunity in Egyptian autistic children. Pediatr Neurol (2009) 1.03

Neuropathology of infantile autism. Mol Psychiatry (2002) 1.02

Corticotropin-releasing hormone and the blood-brain-barrier. Front Biosci (2007) 1.01

Extravasation of blood-borne immunoglobulin G through blood-brain barrier during adrenaline-induced transient hypertension in the rat. Int J Neurosci (2004) 1.01

Regression of language and non-language skills in pervasive developmental disorders. J Intellect Disabil Res (2008) 0.99

Pertussis toxin transiently affects barrier integrity, organelle organization and transmigration of monocytes in a human brain microvascular endothelial cell barrier model. Cell Microbiol (2006) 0.96

Psychiatry, neurology, and the role of the cerebellum. Psychiatry (Edgmont) (2010) 0.93

Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? J Autism Dev Disord (2007) 0.93

Roles of inhibitory interneurons in the cerebellar cortex. Ann N Y Acad Sci (2002) 0.87

Childhood serum anti-fetal brain antibodies do not predict autism. Pediatr Neurol (2009) 0.83

Bioethics. Helsinki's new clinical rules: fewer placebos, more disclosure. Science (2000) 0.77

Articles by these authors

The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environ Health Perspect (2006) 3.81

The rise in autism and the role of age at diagnosis. Epidemiology (2009) 3.44

Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology (2011) 3.15

Methods of covariate selection: directed acyclic graphs and the change-in-estimate procedure. Am J Epidemiol (2009) 2.77

The immune response in autism: a new frontier for autism research. J Leukoc Biol (2006) 2.65

Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain Behav Immun (2008) 2.50

Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun (2010) 2.44

Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment. Environ Health Perspect (2003) 2.41

Concern The significance of ileo-colonic lymphoid nodular hyperplasia in children with autistic spectrum disorder. Eur J Gastroenterol Hepatol (2005) 2.41

Arsenic exposure from drinking water and birth weight. Epidemiology (2003) 2.32

Consensus paper: pathological role of the cerebellum in autism. Cerebellum (2012) 2.32

Attenuation of exposure-response curves in occupational cohort studies at high exposure levels. Scand J Work Environ Health (2003) 2.27

The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun (2011) 2.24

Traffic-related air pollution, particulate matter, and autism. JAMA Psychiatry (2013) 2.24

Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics (2012) 2.18

Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr (2012) 2.14

Mitochondrial dysfunction in autism. JAMA (2010) 2.04

Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells. J Exp Med (2002) 2.00

Residential proximity to freeways and autism in the CHARGE study. Environ Health Perspect (2010) 1.92

The faroes statement: human health effects of developmental exposure to chemicals in our environment. Basic Clin Pharmacol Toxicol (2008) 1.91

Autism: maternally derived antibodies specific for fetal brain proteins. Neurotoxicology (2007) 1.87

Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain Behav Immun (2009) 1.86

The human placenta methylome. Proc Natl Acad Sci U S A (2013) 1.86

Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study. Arch Pediatr Adolesc Med (2005) 1.81

Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain Behav Immun (2008) 1.79

Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: a population-based study. J Sleep Res (2008) 1.72

Indoor coal use and early childhood growth. Arch Pediatr Adolesc Med (2011) 1.71

Self-reported heavy bleeding associated with uterine leiomyomata. Obstet Gynecol (2003) 1.68

Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis. J Clin Invest (2002) 1.65

Epidemiologic measures of the course and outcome of pregnancy. Epidemiol Rev (2002) 1.62

Psychosocial factors and preterm birth among African American and White women in central North Carolina. Am J Public Health (2004) 1.60

A new look at XXYY syndrome: medical and psychological features. Am J Med Genet A (2008) 1.59

Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders. Hum Mol Genet (2004) 1.56

Regression in autism: prevalence and associated factors in the CHARGE Study. Ambul Pediatr (2008) 1.56

Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Ann N Y Acad Sci (2007) 1.55

Apotopes and the biliary specificity of primary biliary cirrhosis. Hepatology (2009) 1.55

Gene expression changes in children with autism. Genomics (2007) 1.55

Maternal mid-pregnancy autoantibodies to fetal brain protein: the early markers for autism study. Biol Psychiatry (2008) 1.54

Neurodevelopmental disorders and prenatal residential proximity to agricultural pesticides: the CHARGE study. Environ Health Perspect (2014) 1.54

Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology (2010) 1.53

The onset of autism: patterns of symptom emergence in the first years of life. Autism Res (2008) 1.53

Altered T cell responses in children with autism. Brain Behav Immun (2010) 1.53

Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: A case-control study. Mol Autism (2011) 1.51

Project TENDR: Targeting Environmental Neuro-Developmental Risks The TENDR Consensus Statement. Environ Health Perspect (2016) 1.50

Determinants of serum polychlorinated biphenyls and organochlorine pesticides measured in women from the child health and development study cohort, 1963-1967. Environ Health Perspect (2002) 1.50

Autoimmunity in autism. Curr Opin Investig Drugs (2009) 1.49

Ultra Low Density and Highly Crosslinked Biocompatible Shape Memory Polyurethane Foams. J Polym Sci B Polym Phys (2012) 1.48

Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. J Neuroimmunol (2010) 1.46

Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. J Neuroimmunol (2008) 1.41

Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome. Genomics (2006) 1.39

PBDEs in 2-5 year-old children from California and associations with diet and indoor environment. Environ Sci Technol (2010) 1.38

Is autism an autoimmune disease? Autoimmun Rev (2004) 1.37

Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms. Autism Res (2008) 1.37

Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis. Hepatology (2005) 1.37

Maternal lifestyle and environmental risk factors for autism spectrum disorders. Int J Epidemiol (2014) 1.36

Conditions for bias from differential left truncation. Am J Epidemiol (2006) 1.35

Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBS) in pregnant women from eastern Slovakia. Environ Health Perspect (2007) 1.35

Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders. Brain Behav Immun (2008) 1.34

Gene-environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop. Genet Epidemiol (2011) 1.33

Increased IgG4 levels in children with autism disorder. Brain Behav Immun (2008) 1.32

The immune system's role in the biology of autism. Curr Opin Neurol (2010) 1.31

Gastrointestinal problems in children with autism, developmental delays or typical development. J Autism Dev Disord (2014) 1.26

Is maternal influenza or fever during pregnancy associated with autism or developmental delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) study. J Autism Dev Disord (2013) 1.25

Tipping the balance of autism risk: potential mechanisms linking pesticides and autism. Environ Health Perspect (2012) 1.25

Associations of abdominal fat with perceived racism and passive emotional responses to racism in African American women. Am J Public Health (2007) 1.24

Global increases in both common and rare copy number load associated with autism. Hum Mol Genet (2013) 1.24

Immune dysfunction in autism: a pathway to treatment. Neurotherapeutics (2010) 1.22

Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism. Biol Psychiatry (2013) 1.21

Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies. J Immunol (2003) 1.21

Month of conception and risk of autism. Epidemiology (2011) 1.21