Published in BMC Genet on December 10, 2010
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest (2004) 11.05
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem (2000) 8.52
Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem (2000) 8.39
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet (2006) 8.32
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A (2001) 5.77
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A (2002) 4.64
Interleukin-6 induces hepcidin expression through STAT3. Blood (2006) 4.24
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet (2002) 4.19
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest (2007) 4.09
The serine protease TMPRSS6 is required to sense iron deficiency. Science (2008) 3.70
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest (2007) 3.40
The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab (2008) 2.36
Anemia of inflammation: the hepcidin link. Curr Opin Hematol (2005) 1.65
HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype. Blood (2003) 1.52
Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol (2005) 1.52
The regulation of hepcidin and its effects on systemic and cellular iron metabolism. Hematology Am Soc Hematol Educ Program (2008) 1.46
Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. Hum Mol Genet (2003) 1.40
A new mutation in the hepcidin promoter impairs its BMP response and contributes to a severe phenotype in HFE related hemochromatosis. Haematologica (2009) 1.35
Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera. Br J Haematol (2006) 1.31
Orchestration of iron homeostasis. N Engl J Med (2005) 1.23
Cis and trans regulation of hepcidin expression by upstream stimulatory factor. Blood (2006) 1.22
HAMP promoter mutation nc.-153C>T in 785 HEIRS study participants. Haematologica (2009) 0.97
Association of hepcidin promoter c.-582 A>G variant and iron overload in thalassemia major. Haematologica (2009) 0.92
Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines. Hepatol Res (2005) 0.87
Hepcidin, the recently identified peptide that appears to regulate iron absorption. J Nutr (2004) 0.86
Gene by environment interaction: the -159C/T polymorphism in the promoter region of the CD14 gene modifies the effect of alcohol consumption on serum IgE levels. Alcohol Clin Exp Res (2006) 0.82
The -582A>G variant of the HAMP promoter is not associated with high serum ferritin levels in normal subjects. Haematologica (2009) 0.78
HAMP promoter mutation nc.-153C>T in non p.C282Y homozygous patients with iron overload. Haematologica (2009) 0.77
[Liver abnormalities in adult celiac disease. Clinicopathologic characterization and outcome after therapy]. Gastroenterol Hepatol (2006) 2.02
Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6. Am J Hum Genet (2011) 2.02
[Prevalence of cardiovascular risk factors in the Spanish working population]. Rev Esp Cardiol (2006) 1.65
Influence of superimposed alcoholic hepatitis on the outcome of liver transplantation for end-stage alcoholic liver disease. J Hepatol (2002) 1.64
The exon 3-deleted growth hormone receptor is associated with better response to pegvisomant therapy in acromegaly. J Clin Endocrinol Metab (2009) 1.52
Kallmann's syndrome with a novel missense mutation in the KAL1 gene that modifies the major cell adhesion site of the anosmin-1 protein. J Pediatr Endocrinol Metab (2005) 1.44
Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J Med Chem (2002) 1.24
Occupation-related differences in the prevalence of metabolic syndrome. Diabetes Care (2008) 1.22
Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity. PLoS One (2013) 1.15
Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells. Oncogene (2003) 1.13
Hypochondroplasia and Acanthosis nigricans: a new syndrome due to the p.Lys650Thr mutation in the fibroblast growth factor receptor 3 gene? Eur J Endocrinol (2008) 1.05
Higher red blood cell distribution width is associated with the metabolic syndrome: results of the Ibermutuamur CArdiovascular RIsk assessment study. Diabetes Care (2010) 1.04
The -159C/T polymorphism in the promoter region of the CD14 gene is associated with advanced liver disease and higher serum levels of acute-phase proteins in heavy drinkers. Alcohol Clin Exp Res (2005) 1.04
Functional consequences of seven novel mutations in the CYP11B1 gene: four mutations associated with nonclassic and three mutations causing classic 11{beta}-hydroxylase deficiency. J Clin Endocrinol Metab (2010) 0.99
The role of inbreeding in the extinction of a European royal dynasty. PLoS One (2009) 0.96
Genetic diagnosis of X-linked dominant Hypophosphatemic Rickets in a cohort study: tubular reabsorption of phosphate and 1,25(OH)2D serum levels are associated with PHEX mutation type. BMC Med Genet (2011) 0.94
TGF-beta-induced apoptosis in human thyrocytes is mediated by p27kip1 reduction and is overridden in neoplastic thyrocytes by NF-kappaB activation. Oncogene (2003) 0.94
High variability in CYP21A2 mutated alleles in Spanish 21-hydroxylase deficiency patients, six novel mutations and a founder effect. Clin Endocrinol (Oxf) (2006) 0.93
Highly efficient system to deliver taxanes into tumor cells: docetaxel-loaded chitosan oligomer colloidal carriers. Biomacromolecules (2008) 0.93
Safe oxygen saturation targeting and monitoring in preterm infants: can we avoid hypoxia and hyperoxia? Acta Paediatr (2014) 0.92
PLGA:poloxamer and PLGA:poloxamine blend nanoparticles: new carriers for gene delivery. Biomacromolecules (2005) 0.92
Influence of glutathione S-transferase M1 and T1 homozygous null mutations on the risk of antituberculosis drug-induced hepatotoxicity in a Caucasian population. Liver Int (2008) 0.91
Detoxifying antitumoral drugs via nanoconjugation: the case of gold nanoparticles and cisplatin. PLoS One (2012) 0.90
Serum TNF-alpha levels in relation to alcohol consumption and common TNF gene polymorphisms. Alcohol (2008) 0.89
Bilateral adrenal metastases from hepatocellular carcinoma after liver transplantation. Hepatogastroenterology (2002) 0.89
A new seipin-associated neurodegenerative syndrome. J Med Genet (2013) 0.88
A simple and robust quantitative PCR assay to determine CYP21A2 gene dose in the diagnosis of 21-hydroxylase deficiency. Clin Chem (2007) 0.87
Determination of the action spectrum of the blue-light hazard for different intraocular lenses. J Opt Soc Am A Opt Image Sci Vis (2007) 0.86
Hepatitis B virus genotyping based on cluster analysis of the region involved in lamivudine resistance. J Virol Methods (2004) 0.85
Serum levels of cytokeratin-18 (tissue polypeptide-specific antigen) in liver diseases. Liver Int (2006) 0.85
Functional characterization of three CYP21A2 sequence variants (p.A265V, p.W302S, p.D322G) employing a yeast co-expression system. Hum Mutat (2009) 0.85
Pituitary stalk dysgenesis-induced hypopituitarism in adult patients: prevalence, evolution of hormone dysfunction and genetic analysis. Neuroendocrinology (2011) 0.84
Pendred syndrome in two Galician families: insights into clinical phenotypes through cellular, genetic, and molecular studies. J Clin Endocrinol Metab (2007) 0.84
Amniotic membrane as support for human retinal pigment epithelium (RPE) cell growth. Acta Ophthalmol Scand (2003) 0.83
Growth inhibition, G(1)-arrest, and apoptosis in MCF-7 human breast cancer cells by novel highly lipophilic 5-fluorouracil derivatives. Invest New Drugs (2004) 0.83
High frequency of copy number variations and sequence variants at CYP21A2 locus: implication for the genetic diagnosis of 21-hydroxylase deficiency. PLoS One (2008) 0.83
5-fluorouracil derivatives induce differentiation mediated by tubulin and HLA class I modulation. Med Chem (2007) 0.83
Gene by environment interaction: the -159C/T polymorphism in the promoter region of the CD14 gene modifies the effect of alcohol consumption on serum IgE levels. Alcohol Clin Exp Res (2006) 0.82
Pegvisomant-induced liver injury is related to the UGT1A1*28 polymorphism of Gilbert's syndrome. J Clin Endocrinol Metab (2010) 0.82
Abnormal cell cycle regulation in primary human uveal melanoma cultures. J Cell Biochem (2004) 0.82
[Ménétrier's disease and gastric cancer]. Cir Esp (2007) 0.81
A hydrogen peroxide detoxification system in the nucleus of wheat seed cells: protection or signaling role? Plant Signal Behav (2009) 0.81
Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers. Alcohol (2005) 0.81
LIF, a Novel STAT5-Regulated Gene, Is Aberrantly Expressed in Myeloproliferative Neoplasms. Genes Cancer (2011) 0.80
Spectral and geometrical variation of the bidirectional reflectance distribution function of diffuse reflectance standards. Appl Opt (2012) 0.80
Association of moderate and severe hypertriglyceridemia with obesity, diabetes mellitus and vascular disease in the Spanish working population: results of the ICARIA study. Atherosclerosis (2009) 0.80
Novel mutation involving the translation initiation codon of the growth hormone receptor gene (GHR) in a patient with Laron syndrome. J Pediatr Endocrinol Metab (2002) 0.80
Serum concentrations of interleukin-8 in relation to different levels of alcohol consumption. Cytokine (2007) 0.78
Principal components analysis of the photoresponse nonuniformity of a matrix detector. Appl Opt (2007) 0.78
Exploring the binding of Pt drugs to gold nanoparticles for controlled passive release of cisplatin. J Control Release (2010) 0.78
Inhibition of Cdk4 activity enhances translation of p27kip1 in quiescent Rb-negative cells. J Biol Chem (2003) 0.78
Anaphylaxis to Cyphomandra betacea Sendth (tamarillo) in an obeche wood (Triplochiton scleroxylon)--allergic patient. Ann Allergy Asthma Immunol (2006) 0.77
Choline kinase inhibitory effect and antiproliferative activity of new 1,1',1"-(benzene-1,3,5-triylmethylene)tris[4-[(disubstituted)amino]pyridinium] tribromides. Eur J Med Chem (2003) 0.77
Sternocleidomastoid and pectoralis major pyomyositis in an immunocompetent patient. Orthopedics (2008) 0.77
Estimating the glomerular filtration rate in the Spanish working population: chronic kidney disease prevalence and its association with risk factors. J Hypertens (2014) 0.77
A new chemical tool (C0036E08) supports the role of adenosine A(2B) receptors in mediating human mast cell activation. Biochem Pharmacol (2008) 0.76
Strategy to estimate risk progression of chronic kidney disease, cardiovascular risk, and referral to nephrology: the EPIRCE Study. Nefrologia (2013) 0.76
Ectopic adrenocorticotropic hormone production by a noncatecholamine secreting pheochromocytoma. J Urol (2002) 0.76
Antitumoural properties of benzannelated seven-membered 5-fluorouracil derivatives and related open analogues. Molecular markers for apoptosis and cell cycle dysregulation. Farmaco (2005) 0.75
CAMT in a female with developmental delay, facial malformations and central nervous system anomalies. Pediatr Blood Cancer (2010) 0.75
Liver enzyme levels in relation to a common polymorphism in the CD14 promoter gene. Eur J Gastroenterol Hepatol (2007) 0.75
[Prevalence of respiratory disorders during sleep and associated factors]. Aten Primaria (2007) 0.75
Occupational asthma to fresh sea lavender and cross-reactivity to sweet vernal grass pollen. Ann Allergy Asthma Immunol (2007) 0.75
[Malaria in the area of Santiago de Compostela, Spain (1985-2007)]. Enferm Infecc Microbiol Clin (2009) 0.75
Neurodevelopment of very low birth weight infants in the first two years of life in a Havana tertiary care hospital. MEDICC Rev (2015) 0.75
[Giant cell arteritis with epididymal involvement]. Med Clin (Barc) (2009) 0.75
Actual targets in cytodifferentiation cancer therapy. Curr Top Med Chem (2004) 0.75
[Collision tumor consisting in a metastatic adenocarcinoma and follicular lymphoma in the same lymph node. Report of one case]. Rev Med Chil (2009) 0.75
[Mumps virus infection in adulthood]. Enferm Infecc Microbiol Clin (2006) 0.75
Spectral BRDF-based determination of proper measurement geometries to characterize color shift of special effect coatings. J Opt Soc Am A Opt Image Sci Vis (2013) 0.75
Synthesis and NMR studies on a C3-symmetrical triquinolina triscationic bicyclophane. J Org Chem (2005) 0.75
[Epidemiology of human immunodeficiency virus (HIV) in Santiago de Compostela (Galicia-Spain): changing picture along 1989-2004]. Med Clin (Barc) (2006) 0.75
Synthesis, biological activity, and quantitative structure-activity relationship study of azanaphthalimide and arylnaphthalimide derivatives. J Med Chem (2004) 0.75
Visibility of sparkle in metallic paints. J Opt Soc Am A Opt Image Sci Vis (2015) 0.75
Variables separation of the spectral BRDF for better understanding color variation in special effect pigment coatings. J Opt Soc Am A Opt Image Sci Vis (2012) 0.75
Serum concentrations of mast cell tryptase are reduced in heavy drinkers. Alcohol Clin Exp Res (2015) 0.75
Differentiation: an encouraging approach to anticancer therapy. Ital J Anat Embryol (2006) 0.75
[X-linked Kallmann's syndrome: intra and interfamilial heterogeneity]. Med Clin (Barc) (2007) 0.75
Lowering infant mortality in Cuba: Fernando Domínguez MD PhD. Neonatologist, Ramón González Coro University Maternity Hospital, Havana. MEDICC Rev (2015) 0.75
[Influence of donor age and recipient gender on survival in transplantation due to hepatocarcinoma]. Gastroenterol Hepatol (2008) 0.75