Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Activated intrarenal renin-angiotensin system is correlated with high blood pressure in humans.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 3774210)

Published in J Appl Physiol (1985) on December 01, 2010

Authors

Hiroyuki Kobori1, Qi Fu, Steven D Crowley, Romer A Gonzalez-Villalobos, Ruy R Campos

Author Affiliations

1: Department of Medicine, Tulane University Health Sciences Center, LA, USA.

Articles cited by this

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA (2003) 97.28

Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet (2009) 10.53

Point: Chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension. J Appl Physiol (1985) (2010) 9.76

Counterpoint: Activation of the intrarenal renin-angiotensin system is the dominant contributor to systemic hypertension. J Appl Physiol (1985) (2010) 9.28

Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems. Nat Rev Genet (2008) 9.26

Blood pressure control--special role of the kidneys and body fluids. Science (1991) 4.48

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A (2006) 4.10

Neural control of renal function. Physiol Rev (1997) 4.00

Gender-selective interaction between aging, blood pressure, and sympathetic nerve activity. Hypertension (2005) 3.07

Preeclampsia -- a state of sympathetic overactivity. N Engl J Med (1996) 2.91

The genetic dissection of essential hypertension. Nat Rev Genet (2006) 2.77

Sympathetic nervous system overactivity and its role in the development of cardiovascular disease. Physiol Rev (2010) 2.74

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest (2005) 2.59

Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins. J Biol Chem (2010) 2.53

Persistent sympathetic activation during chronic antihypertensive therapy: a potential mechanism for long term morbidity? Hypertension (2005) 2.48

Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation. Hypertension (2009) 2.43

Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients. Hypertension (2010) 2.38

Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension (2003) 2.26

Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients. Hypertension (2008) 1.99

Role of baroreceptor reflex in daily control of arterial blood pressure and other variables in dogs. Circ Res (1973) 1.95

Mechanisms of obesity-induced hypertension. Hypertens Res (2010) 1.85

Vasoconstriction-volume analysis for understanding and treating hypertension: the use of renin and aldosterone profiles. Am J Med (1973) 1.82

Sympathetic activation in chronic renal failure. J Am Soc Nephrol (2008) 1.80

Vascular adrenergic responsiveness is inversely related to tonic activity of sympathetic vasoconstrictor nerves in humans. J Physiol (2006) 1.79

The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition. J Manag Care Pharm (2007) 1.76

Urinary angiotensinogen as a marker of intrarenal angiotensin II activity associated with deterioration of renal function in patients with chronic kidney disease. J Am Soc Nephrol (2007) 1.73

Splanchnic circulation is a critical neural target in angiotensin II salt hypertension in rats. Hypertension (2007) 1.71

Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation. J Am Coll Cardiol (2002) 1.68

Amplified respiratory-sympathetic coupling in the spontaneously hypertensive rat: does it contribute to hypertension? J Physiol (2008) 1.57

Pressor responses to antihypertensive drug types. Am J Hypertens (2010) 1.56

Central mechanisms underlying short- and long-term regulation of the cardiovascular system. Clin Exp Pharmacol Physiol (2002) 1.54

Is obesity a major cause of chronic kidney disease? Adv Ren Replace Ther (2004) 1.40

Chronic angiotensin II infusion causes differential responses in regional sympathetic nerve activity in rats. Hypertension (2010) 1.39

Structural and functional vascular alterations and incident hypertension in normotensive adults: the Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol (2009) 1.39

Remission of essential hypertension after renal transplantation. N Engl J Med (1983) 1.38

Neurovascular responses to mental stress. J Physiol (2005) 1.38

Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits. Hypertension (2010) 1.37

Primary role of renal homografts in setting chronic blood pressure levels in rats. Circ Res (1975) 1.34

The role of the sympathetic nervous system in obesity-related hypertension. Curr Hypertens Rep (2009) 1.29

Altered autonomic support of arterial blood pressure with age in healthy men. Circulation (2001) 1.28

Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats. Am J Physiol Heart Circ Physiol (2007) 1.27

Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. J Neurosci (2002) 1.25

Effects of dietary salt on intrarenal angiotensin system, NAD(P)H oxidase, COX-2, MCP-1 and PAI-1 expressions and NF-kappaB activity in salt-sensitive and -resistant rat kidneys. Am J Nephrol (2007) 1.25

Sustained suppression of sympathetic activity and arterial pressure during chronic activation of the carotid baroreflex. Am J Physiol Heart Circ Physiol (2010) 1.24

Exercise training restores baroreflex sensitivity in never-treated hypertensive patients. Hypertension (2007) 1.24

Kidney in hypertension: guyton redux. Hypertension (2008) 1.23

Angiotensin-converting enzyme-derived angiotensin II formation during angiotensin II-induced hypertension. Hypertension (2008) 1.20

Levels of renal and extrarenal sympathetic drive in angiotensin II-induced hypertension. Hypertension (2008) 1.20

Urinary angiotensinogen is correlated with blood pressure in men (Bogalusa Heart Study). J Hypertens (2010) 1.18

Exercise training increases baroreceptor gain sensitivity in normal and hypertensive rats. Hypertension (2000) 1.18

Enhanced responses to ganglion blockade do not reflect sympathetic nervous system contribution to angiotensin II-induced hypertension. J Hypertens (2009) 1.16

Neural control of the kidney: functionally specific renal sympathetic nerve fibers. Am J Physiol Regul Integr Comp Physiol (2000) 1.16

Oxidative stress in the sympathetic premotor neurons contributes to sympathetic activation in renovascular hypertension. Am J Hypertens (2009) 1.13

Cardiovascular and endocrine effects of acupuncture in hypertensive patients. Clin Exp Hypertens (1997) 1.13

Nervous kidney. Interaction between renal sympathetic nerves and the renin-angiotensin system in the control of renal function. Hypertension (2000) 1.11

Neural mechanism of electroacupuncture's hypotensive effects. Auton Neurosci (2010) 1.05

An arcuate-ventrolateral periaqueductal gray reciprocal circuit participates in electroacupuncture cardiovascular inhibition. Auton Neurosci (2010) 1.02

Hypothesis: set-points and long-term control of arterial pressure. A theoretical argument for a long-term arterial pressure control system in the brain rather than the kidney. Clin Exp Pharmacol Physiol (2005) 1.01

Fos-related antigen immunoreactivity after acute and chronic angiotensin II-induced hypertension in the rabbit brain. Hypertension (2007) 1.01

Genetic resistance to diet-induced obesity in chromosome substitution strains of mice. Mamm Genome (2010) 1.00

Arterial baroreceptor resetting: contributions of chronic and acute processes. Clin Exp Pharmacol Physiol Suppl (1989) 0.99

Angiotensin-induced hypertension in the rat. Sympathetic nerve activity and prostaglandins. Hypertension (1989) 0.98

Arterial baroreceptor input contributes to long-term control of blood pressure. Curr Hypertens Rep (2006) 0.96

Management of uncontrollable hypertension with a carotid sinus stimulation device. Hypertension (2007) 0.94

Sympathetic activation in cardiovascular and renal disease. J Nephrol (2009) 0.94

Mechanisms for perivascular adipose tissue-mediated potentiation of vascular contraction to perivascular neuronal stimulation: the role of adipocyte-derived angiotensin II. Eur J Pharmacol (2010) 0.91

Significance of urinary angiotensinogen in essential hypertension as a function of plasma renin and aldosterone status. J Hypertens (2005) 0.91

Effects of exercise training on baroreflex control of the cardiovascular system. Ann N Y Acad Sci (2001) 0.91

The kidney as a determinant of genetic hypertension: evidence from renal transplantation studies. Hypertension (2005) 0.91

Electroacupuncture enhances preproenkephalin mRNA expression in rostral ventrolateral medulla of rats. Neurosci Lett (2010) 0.91

Coadministered amlodipine and atorvastatin produces early improvements in arterial wall compliance in hypertensive patients with dyslipidemia. Am J Hypertens (2008) 0.91

Functional asymmetry in the descending cardiovascular pathways from dorsomedial hypothalamic nucleus. Neuroscience (2009) 0.89

Neurogenic hypertension. Exp Physiol (2010) 0.89

The role of renal sympathetic nerves in hypertension: has percutaneous renal denervation refocused attention on their clinical significance? Prog Cardiovasc Dis (2009) 0.89

Antihypertensive effects of central ablations in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol (2009) 0.86

Differential sympathetic and angiotensinergic responses in rats submitted to low- or high-salt diet. Regul Pept (2006) 0.85

Muscle sympathetic nerve activity is related to a surrogate marker of endothelial function in healthy individuals. PLoS One (2010) 0.85

Phenomenological analysis of renal regulation of sodium and potassium balance. Kidney Int (1985) 0.84

Sympathetic overactivity in renal failure controlled by ACE inhibition: clinical significance. Nephrol Dial Transplant (2000) 0.83

Sympathetic responses to stress and rilmenidine in 2K1C rabbits: evidence of enhanced nonvascular effector mechanism. Hypertension (2004) 0.83

Effects of chronic sympatho-inhibition on reflex control of renal blood flow and plasma renin activity in renovascular hypertension. Br J Pharmacol (2009) 0.83

Is it the blood pressure or the blood vessel? J Am Soc Hypertens (2010) 0.83

Renin secretion and total body sodium: pathways of integrative control. Clin Exp Pharmacol Physiol (2009) 0.82

Computer models of stress, allostasis, and acute and chronic diseases. Ann N Y Acad Sci (2008) 0.81

Renin-angiotensin system modulation for treatment and prevention of cardiovascular diseases: toward an optimal therapeutic strategy. Rev Cardiovasc Med (2007) 0.80

Aliskiren fails to lower blood pressure in patients who have either low PRA levels or whose PRA falls insufficiently or reactively rises. Am J Hypertens (2008) 0.80

Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Carotid stimulation studies support a prominent role for the sympathetic nervous system. J Appl Physiol (1985) (2010) 0.78

Pivotal role of the renin-angiotensin system in Lyon hypertensive rats. Am J Physiol (1997) 0.78

Catecholamines and essential hypertension. Scand J Clin Lab Invest (1982) 0.78

Blood pressure maintenance in hypertensive sympathectomized rats. I. Adrenal medullary catecholamines. Am J Physiol (1991) 0.77

Renin secretion in Lyon hypertensive rats. Clin Exp Hypertens (1997) 0.77

Plasma norepinephrine in humans: limitations in assessment of whole body norepinephrine kinetics and plasma clearance. Am J Physiol (1989) 0.76

Renal denervation does not prevent hypertension in Lyon hypertensive rats. Am J Physiol (1991) 0.76

Plasma noradrenaline concentration in hypertensive and normotensive forty-year-old individuals: relationship to plasma renin concentration. Scand J Clin Lab Invest (1980) 0.76

Articles by these authors

(truncated to the top 100)

Effect of aging and physical activity on left ventricular compliance. Circulation (2004) 2.68

Ovarian cycle and sympathoexcitation in premenopausal women. Hypertension (2012) 2.29

Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol (2008) 2.15

Intratubular renin-angiotensin system in hypertension. Hypertension (2011) 2.14

Losartan reduces oxidative stress within the rostral ventrolateral medulla of rats with renovascular hypertension. Am J Hypertens (2013) 2.04

Relationship between sympathetic baroreflex sensitivity and arterial stiffness in elderly men and women. Hypertension (2011) 1.80

Cerebral hemodynamics after short- and long-term reduction in blood pressure in mild and moderate hypertension. Hypertension (2007) 1.79

A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension. Circ Res (2012) 1.79

Elderly blacks have a blunted sympathetic neural responsiveness but greater pressor response to orthostasis than elderly whites. Hypertension (2012) 1.63

Transcranial Doppler estimation of cerebral blood flow and cerebrovascular conductance during modified rebreathing. J Appl Physiol (1985) (2006) 1.57

The effects of aging and physical activity on Doppler measures of diastolic function. Am J Cardiol (2007) 1.56

Upregulation of AT1R and iNOS in the rostral ventrolateral medulla (RVLM) is essential for the sympathetic hyperactivity and hypertension in the 2K-1C Wistar rat model. Am J Hypertens (2010) 1.52

Chronic antioxidant treatment improves arterial renovascular hypertension and oxidative stress markers in the kidney in Wistar rats. Am J Hypertens (2010) 1.50

Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db/db mice. Diabetes (2008) 1.45

Characterization of static and dynamic left ventricular diastolic function in patients with heart failure with a preserved ejection fraction. Circ Heart Fail (2010) 1.38

Costimulation with angiotensin II and interleukin 6 augments angiotensinogen expression in cultured human renal proximal tubular cells. Am J Physiol Renal Physiol (2008) 1.37

Diamagnetic levitation changes growth, cell cycle, and gene expression of Saccharomyces cerevisiae. Biotechnol Bioeng (2007) 1.37

Short-term exercise training improves the cardiovascular response to exercise in the postural orthostatic tachycardia syndrome. J Physiol (2012) 1.34

Effector mechanisms in transplant rejection. Immunol Rev (2003) 1.32

A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme. Pharmacol Rev (2012) 1.31

Natural regulatory T cells control coronary arteriolar endothelial dysfunction in hypertensive mice. Am J Pathol (2010) 1.25

Kidney in hypertension: guyton redux. Hypertension (2008) 1.23

Oxidative stress in the sympathetic premotor neurons contributes to sympathetic activation in renovascular hypertension. Am J Hypertens (2009) 1.13

Role of advanced glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice. Arterioscler Thromb Vasc Biol (2008) 1.10

Interferon-γ biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells. FASEB J (2012) 1.08

Sympathetic activation during early pregnancy in humans. J Physiol (2012) 1.08

Dose-response relationship of endurance training for autonomic circulatory control in healthy seniors. J Appl Physiol (1985) (2005) 1.08

Sex differences in the modulation of vasomotor sympathetic outflow during static handgrip exercise in healthy young humans. Am J Physiol Regul Integr Comp Physiol (2011) 1.07

Angiotensin II induced catabolic effect and muscle atrophy are redox dependent. Biochem Biophys Res Commun (2011) 1.07

IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells. Mol Cell Endocrinol (2009) 1.03

Vasoconstriction during venous congestion: effects of venoarteriolar response, myogenic reflexes, and hemodynamics of changing perfusion pressure. Am J Physiol Regul Integr Comp Physiol (2005) 1.03

Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. J Immunol (2003) 1.02

Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth. Am J Physiol Gastrointest Liver Physiol (2010) 1.02

Oxidative stress contributes to renovascular hypertension. Am J Hypertens (2008) 1.01

Kidney-induced hypertension depends on superoxide signaling in the rostral ventrolateral medulla. Hypertension (2010) 0.98

'Dynamic' Starling mechanism: effects of ageing and physical fitness on ventricular-arterial coupling. J Physiol (2008) 0.97

The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. Am J Respir Cell Mol Biol (2014) 0.95

Different in vivo functions of the two catalytic domains of angiotensin-converting enzyme (ACE). Curr Opin Pharmacol (2010) 0.93

Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis. J Clin Invest (2014) 0.92

Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans. Auton Neurosci (2002) 0.92

Classical Renin-Angiotensin system in kidney physiology. Compr Physiol (2014) 0.92

Chronic renin inhibition lowers blood pressure and reduces upright muscle sympathetic nerve activity in hypertensive seniors. J Physiol (2013) 0.90

Congestive heart failure with preserved ejection fraction is associated with severely impaired dynamic Starling mechanism. J Appl Physiol (1985) (2011) 0.89

Development of a 9600-clone procedure for oligonucleotide fingerprinting of rRNA genes: utilization to identify soil bacterial rRNA genes that correlate in abundance with the development of avocado root rot. J Microbiol Methods (2006) 0.88

Effects of exercise training on arterial-cardiac baroreflex function in POTS. Clin Auton Res (2010) 0.87

Nontraditional roles of angiotensin-converting enzyme. Hypertension (2012) 0.86

Abnormalities of Doppler measures of diastolic function in the healthy elderly are not related to alterations of left atrial pressure. Circulation (2005) 0.86

Pathophysiology of orthostatic hypotension after bed rest: paradoxical sympathetic withdrawal. Am J Physiol Heart Circ Physiol (2003) 0.86

Morning blood pressure surge is associated with arterial stiffness and sympathetic baroreflex sensitivity in hypertensive seniors. Am J Physiol Heart Circ Physiol (2013) 0.85

Sympathetic neural and hemodynamic responses to upright tilt in patients with pulsatile and nonpulsatile left ventricular assist devices. Circ Heart Fail (2012) 0.85

Mechanical vibration preserves bone structure in rats treated with glucocorticoids. Bone (2010) 0.84

Effect of rowing ergometry and oral volume loading on cardiovascular structure and function during bed rest. J Appl Physiol (1985) (2012) 0.84

Perinatal salt restriction: a new pathway to programming insulin resistance and dyslipidemia in adult wistar rats. Pediatr Res (2004) 0.84

Epigenetic mechanisms in fetal origins of health and disease. Clin Obstet Gynecol (2013) 0.83

Gene expression and survival changes in Saccharomyces cerevisiae during suspension culture. Biotechnol Bioeng (2006) 0.83

Cascade model of ventricular-arterial coupling and arterial-cardiac baroreflex function for cardiovascular variability in humans. Am J Physiol Heart Circ Physiol (2006) 0.83

Maternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene. J Nutr Metab (2012) 0.83

The increasing complexity of the intratubular Renin-Angiotensin system. J Am Soc Nephrol (2012) 0.83

Sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in rats. J Renin Angiotensin Aldosterone Syst (2011) 0.83

Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats. Am J Hypertens (2007) 0.83

Differential control of cardiac functions by the brain. Clin Exp Pharmacol Physiol (2006) 0.82

Differential sympathetic activation induced by intermittent hypoxia and sleep loss in rats: Action of angiotensin (1-7). Auton Neurosci (2010) 0.82

Mesenchymal stem cells (MSC) prevented the progression of renovascular hypertension, improved renal function and architecture. PLoS One (2013) 0.82

Increased angiotensin II-induced hypertension and inflammatory cytokines in mice lacking angiotensin-converting enzyme N domain activity. Hypertension (2011) 0.82

Renal angiotensin-converting enzyme and blood pressure control. Curr Opin Nephrol Hypertens (2014) 0.81

The role of type 1 angiotensin receptors on T lymphocytes in cardiovascular and renal diseases. Curr Hypertens Rep (2013) 0.81

Changes in baroreflex control of renal sympathetic nerve activity in high-fat-fed rats as a predictor of hypertension. Obesity (Silver Spring) (2012) 0.81

Electroacupuncture and moxibustion decrease renal sympathetic nerve activity and retard progression of renal disease in rats. Kidney Blood Press Res (2012) 0.81

Cardioprotective actions of ascorbic acid during isoproterenol-induced acute myocardial infarction in rats. Pharmacology (2009) 0.81

Role of endogenous angiotensin II on glutamatergic actions in the rostral ventrolateral medulla in Goldblatt hypertensive rats. Hypertension (2003) 0.81

JAK-STAT and the renin-angiotensin system: The role of the JAK-STAT pathway in blood pressure and intrarenal renin-angiotensin system regulation. JAKSTAT (2012) 0.81

Renal generation of angiotensin II and the pathogenesis of hypertension. Curr Hypertens Rep (2014) 0.80

Menstrual cycle phase does not affect sympathetic neural activity in women with postural orthostatic tachycardia syndrome. J Physiol (2015) 0.79

Effects of sex and gender on adaptation to space: cardiovascular alterations. J Womens Health (Larchmt) (2014) 0.79

Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics. Physiol Genomics (2011) 0.79

MicroRNA as Regulators of Cancer Stem Cells and Chemoresistance in Colorectal Cancer. Curr Cancer Drug Targets (2016) 0.78

Association of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c. PLoS One (2013) 0.78

Effects of graded load of artificial gravity on cardiovascular functions in humans. Environ Med (2002) 0.78

Ascorbic acid prevents acute myocardial infarction induced by isoproterenol in rats: role of inducible nitric oxide synthase production. J Mol Histol (2009) 0.78

Effects of angiotensin blockade in the rostral ventrolateral medulla on maintenance of hypertension induced by chronic L-NAME treatment. Brain Res (2002) 0.78

Effects of pericardial constraint and ventricular interaction on left ventricular hemodynamics in the unloaded heart. Am J Physiol Heart Circ Physiol (2011) 0.78

Effects of the traditional Chinese medicine Yi Shen Jian Gu granules on aromatase inhibitor-associated musculoskeletal symptoms: a study protocol for a multicenter, randomized, controlled clinical trial. Trials (2014) 0.78

Brain nitric oxide production by a proline-rich decapeptide from Bothrops jararaca venom improves baroreflex sensitivity of spontaneously hypertensive rats. Hypertens Res (2010) 0.78

Association of calcaneal quantitative ultrasound parameters with metabolic syndrome in middle-aged and elderly Chinese: a large population-based cross-sectional study. BMC Endocr Disord (2014) 0.78

Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension. J Diabetes Res (2013) 0.78

Attenuated thermoregulatory sweating and cutaneous vasodilation after 14-day bed rest in humans. J Appl Physiol (1985) (2003) 0.77

Why do young women (donors) faint? Transfusion (2010) 0.77

Amitriptyline inhibits currents and decreases the mRNA expression of voltage-gated sodium channels in cultured rat cortical neurons. Brain Res (2010) 0.77

Exercise, the Brain, and Hypertension. Curr Hypertens Rep (2015) 0.77

Gene expression profiles linked to AT1 angiotensin receptors in the kidney. Physiol Genomics (2010) 0.77

Hemodynamic parameters during normal and hypertensive pregnancy in rats: evaluation of renal salt and water transporters. Hypertens Pregnancy (2008) 0.77

Prehypertension and chronic kidney disease: the ox or the plow? Kidney Int (2012) 0.77

Association between calcaneus quantitative ultrasound (QUS) parameters and thyroid status in middle-aged and elderly Chinese men with euthyroidism: a population-based cross-sectional study. Endocrine (2014) 0.77

Microneurographic study of C fiber discharges induced by CO2 laser stimulation in humans. Neurosci Lett (2003) 0.76

Asian women have attenuated sympathetic activation but enhanced renal-adrenal responses during pregnancy compared to Caucasian women. J Physiol (2015) 0.76

Interconnectivity of sympathetic and sleep networks is mediated through reduction of gamma aminobutyric acidergic inhibition in the paraventricular nucleus. J Sleep Res (2013) 0.76

Effects of sex and hypertension subtype on haemodynamics and left ventricular diastolic function in older patients with stage 1 hypertension. J Hypertens (2013) 0.76

Crosstalk between the renal sympathetic nerve and intrarenal angiotensin II modulates proximal tubular sodium reabsorption. Exp Physiol (2015) 0.76

Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line. Am J Physiol Renal Physiol (2007) 0.76

More than hormones: sex differences in cardiovascular parameters after sleep loss in rats. Prog Neuropsychopharmacol Biol Psychiatry (2013) 0.76